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All Journal Medula Biosfer: Jurnal Tadris Biologi Biogenesis: Jurnal Ilmiah Biologi Jurnal Pengabdian Kepada Masyarakat Sakai Sambayan PENA SAINS ZOO INDONESIA Indonesian Journal of Guidance and Counseling: Theory and Application Jurnal Penelitian Sains Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Medika Malahayati Jurnal Ilmiah Biologi Eksperimen dan Keanekaragaman Hayati (J-BEKH) JURNAL PENELITIAN PERAWAT PROFESIONAL JK Unila (Jurnal Kedokteran Universitas Lampung) Zoo Indonesia Ruwa Jurai: Jurnal Kesehatan Lingkungan Hippocampus: Jurnal Pengabdian Kepada Masyarakat Journal of Pharmaceutical and Sciences. AMMA : Jurnal Pengabdian Masyarakat Berkala Ilmiah Biologi Bioma : Jurnal Biologi dan Pembelajaran Biologi JPM (Jurnal Pengabdian Masyarakat) Ruwa Jurai Berita Biologi Analit: Analytical And Environmental Chemistry
Endah Setyaningrum, Endah
Unknown Affiliation
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Education Energy Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Journal : Medula

 1 
Article Review: Risk of Lung Cancer in Patients with History of Pulmonary Tuberculosis and Chronic Obstructive Pulmonary Disease (COPD) Wahdah, Annisa Shohifatul; Windarti, Indri; Setyaningrum, Endah; Sukohar, Asep
Medula Vol 14 No 9 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i9.1344

Abstract

Kanker paru merupakan salah satu penyebab utama kematian akibat kanker di dunia, dengan angka kejadian yang sangat tinggi. Di Indonesia, kanker paru menduduki peringkat kedua setelah kanker payudara dengan jumlah kasus mencapai 38.904 pada tahun 2022. Penyakit ini lebih sering terjadi pada laki-laki dibandingkan perempuan. Berbagai faktor risiko berkontribusi terhadap kejadian kanker paru, termasuk kebiasaan merokok, paparan polusi udara, paparan radon, faktor genetik, serta riwayat penyakit paru seperti tuberculosis (TB) paru dan penyakit paru obstruktif kronik (PPOK). Tuberculosis paru adalah penyakit infeksi yang disebabkan oleh Mycobacterium tuberculosis dan masih menjadi masalah kesehatan utama di Indonesia, dengan lebih dari satu juta kasus pada tahun 2023. Infeksi TB dapat menyebabkan inflamasi kronik yang mengarah pada fibrosis jaringan paru, yang dapat meningkatkan risiko kanker paru. Inflamasi kronik ini juga memicu peningkatan Reactive Oxygen Species (ROS) dan sitokin proinflamasi, yang dapat menyebabkan kerusakan DNA serta memicu mutasi genetik yang berkontribusi terhadap karsinogenesis. PPOK, di sisi lain, merupakan penyakit tidak menular yang umumnya dikaitkan dengan paparan asap rokok dalam jangka panjang. PPOK ditandai dengan inflamasi kronik pada saluran napas yang menyebabkan penyempitan dan kerusakan alveoli secara ireversibel. Proses inflamasi ini melibatkan pelepasan berbagai mediator inflamasi seperti TNF-α, IL-6, dan IL-8, yang dapat memicu stress oksidatif dan mempercepat proses epithelial-mesenchymal transition (EMT), suatu mekanisme penting dalam perkembangan kanker paru. Hubungan erat antara TB paru, PPOK, dan kanker paru menunjukkan bahwa kedua penyakit paru ini bukan hanya sekadar faktor risiko, tetapi juga berkontribusi secara langsung dalam proses karsinogenesis melalui mekanisme inflamasi, fibrosis, dan mutasi genetik. Oleh karena itu, deteksi dini dan penanganan yang tepat terhadap TB paru dan PPOK dapat menjadi strategi penting dalam pencegahan kanker paru.
Identification of Active Compound and Effectiveness Test of 96% Tithonia diversifolia Ethanol Extract on Mortality of Aedes aegypti Mosquito A.P, Gadila; Mustofa, Syazili; Graharti, Risti; Setyaningrum, Endah
Medula Vol 16 No 1 (2026): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v16i1.1758

Abstract

Dengue Hemorrhagic Fever (DHF) remains a major public health problem in tropical regions, with Asia accounting for 70% of global cases and Indonesia reporting a massive 90,269 cases in 2024. Vector control is the primary mitigation strategy due to limitations in available therapies and vaccines, yet reliance on chemical insecticides poses ecological toxicity and resistance risks, driving the need for safer bioinsecticide alternatives. Tithonia diversifolia is known to contain active phytochemical constituents with insecticidal potential. This true experimental study used a Post Test Only with Control Group design conducted from August to September 2025 involving 25 Aedes aegypti per group with four replications. Leaf simplicia were extracted using 96% ethanol, followed by alcohol-free verification, qualitative phytochemical screening, and formulation into spray preparations at concentrations of 5%, 10%, 15%, 20%, and 25%. Mortality was assessed over 24 hours, and statistical evaluation included univariate, bivariate, and probit analyses to determine LC50, LC90, LT50, and LT90. Extraction produced a 12.53% yield containing saponins, flavonoids, phenols, tannins, alkaloids, and steroids. Mosquito mortality increased with rising concentrations, with the highest effectiveness observed at 25%. The Kruskal–Wallis test confirmed significant differences between groups, while LC50 and LC90 values were 2.77% and 5.37%, respectively. Although the highest mortality was observed at 25%, the 20% concentration was considered optimal because it met WHO efficacy standards while using a lower extract concentration.
Efektivitas Beberapa Ekstrak Tanaman sebagai Ovisida terhadap Aedes aegypti dalam Pencegahan Demam Berdarah Dengue Septiani, Linda; aflika happy, terza; Graharti, Risti; Andrifianie, Femmy; Setyaningrum, Endah
Medula Vol 15 No 4 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i4.1827

Abstract

Dengue Hemorrhagic Fever (DHF) remains a major public health concern, with Aedes aegypti serving as the primary vector. The continuous use of synthetic insecticides has led to resistance development and environmental concerns, highlighting the need for safer and sustainable alternatives. This review aims to evaluate the ovicidal potential of selected plant extracts against Aedes aegypti as an early-stage vector control strategy. A literature review was conducted using relevant national and international publications focusing on plant-based ovicides. The findings indicate that extracts from Piper nigrum L., Ocimum basilicum, Syzygium myrtifolium Walp., Tithonia diversifolia, Acorus calamus L., Solanum lycopersicum, and Euphorbia hirta L. effectively reduce egg hatchability of Aedes aegypti. The ovicidal activity is associated with secondary metabolites such as flavonoids, alkaloids, saponins, tannins, terpenoids, polyphenols, and essential oils, which disrupt egg membranes and inhibit embryonic development in a concentration-dependent manner. These findings suggest that plant extracts possess promising potential as natural ovicides and may serve as a basis for further pharmaceutical development and formulation in sustainable dengue vector control.
Co-Authors A.P, Gadila aflika happy, terza Alfahri, Farhan Dzaki Alhafizoh, Fatimah Andrifianie, Femmy Annasya, Benazhir Saninah Arief Darmawan Arifiyanto, Achmad Asep Sukohar Aslina, Enna Athma, Dwi Aji Dwi Budi Santoso Farisi, Salman Gina Dania Pratami, Gina Dania Hadibrata, Exsa Halimi, Sofwan Happy, Terza Aflika Hardianto, Devina Hasan, Moh. Dwi Kurniawan Hendri Busman Hidayat Hidayat Idris, Mohamad Indarto Indarto Indri Windarti Indriyani Intan Kusumaningtyas Jausal, Annisa Nuraisa Jhons Fatriyadi Suwandi Juliasih, Ni Luh Gede Ratna Kanedi, M. Kanedi, Muhammad L Widiastuti, Endang Lestari, Mutia Dinda Lidya Susanti, Nida Lili Chrisnawati, Lili Linirin Widiastuti, Endang Lusina, Septia Eva Marcellia, Selvi Masherni, Erniza Mayaguezz, Henky Muhammad Ilyas Mulya, Ireniza Pradevi Mumtazah, Dzul Fithria Novrianda, Nabila Tias Nukmal, Nismah Nuning Nurcahyani Pertiwi, Widya Ratna Primasari Pertiwi Priyambodo Priyambodo Puspita, Wana Putri, Sriana Qoyima, Allafia Ramdini, Dwi Aulia Reni Zuraida Risti Graharti Rosa, Emantis Sari, Galuh Retno Septiani, Linda Setiawan, Gigih SRW, Dyah Wulan Supriyo Supriyo Sutyarso Sutyarso Sutyarso Suwandi, Jhons Fatriayadi Syazili Mustofa Tugiyono Tugiyono Wahdah, Annisa Shohifatul Widiastuti, Endang Linirin Wiwi Febriani Wulandari, Kartika Dwi Yuandarru, Rhifana