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All Journal Jurnal NERS Jurnal Farmasi Klinik Indonesia JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Farmasi Sains dan Komunitas Universa Medicina AKSIOLOGIYA : Jurnal Pengabdian Kepada Masyarakat Abdimas Talenta : Jurnal Pengabdian Kepada Masyarakat Indonesian Journal of Medicine JFIOnline Jurnal Ners Indonesian Journal of Pharmaceutical and Clinical Research International Journal Of Science, Technology & Management (IJSTM) Unri Conference Series: Community Engagement JOURNAL LA MEDIHEALTICO Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Urip Harahap
Faculty Of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia
Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Education Electrical & Electronics Engineering Energy Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences Transportation Veterinary Other

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Journal : Jurnal Ners

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Cardio Protective Effect of Ethanolic Extract Vernonia Amygdalina Delile on Rats Induced L-NAME Rizki Doli Hartama Harahap; Urip Harahap; Aminah Dalimunthe
Jurnal Ners Vol. 9 No. 1 (2025): JANUARI 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v9i1.30981

Abstract

This study aimed to analyse the effects of ethanol extract of African leaves (Vernonia Amygdalina Del.) on the levels plasma renin, IL-6 and cardiac histopathology in L-NAME-induced rats. This research stage includes the preparation of ethanol extract of African leaves, standardization of extracts and testing the effectiveness of African leaves on rat heart damage. Data were analysed using one-way ANOVA with p<0.05. testing the cardioprotective effectiveness of ethanol extract of African leaves in hypertension model rats and then examining heart histopathology using HE staining and analysing parameters, namely plasma renin and IL-6 levels. This study used 6 groups, each group consisted of 5 male rats, namely the normal group, negative control by administering L-NAME 40 mg/kgBB, positive control by administering L-NAME plus lisinopril 2.5 mg/kgBB, EEDA 100 mg/kgBB, EEDA 300 mg/kgBB and EEDA 500 mg/kgBB. L-NAME responds to heart damage such as degeneration and necrosis of heart cells. In the negative group, plasma renin levels were 40.60 ± 9.98 ng/mL while the EEDA group with a dose of 500 mg/kgBB experienced the highest decrease in plasma renin compared to other EEDA groups and positive controls, namely 13.80 ± 1.30 ng/mL. The positive control group obtained plasma renin levels of 14.20 ±1.79 ng/mL. In the negative group, IL-6 levels were 4.80 ± 1.30 pg/mL while the group given EEDA, the group with a dose of 500 mg/kgBB experienced a decrease in IL-6, namely 1.52 ±0.96 ng/mL. The positive control group experienced a decrease in IL-6 levels of 0.77 ± 0.20 ng/mL. The result can be concluded that EEDA reduces plasma renin, IL-6 levels, improves the condition of cardiac cell degeneration and necrosis.
Formulasi Nanogel Kuersetin dan Evaluasi Stabilitas Fisik, Aktivitas Anti-Inflamasi Pada Tikus Yang Diinduksi Oleh Karagenan Arfayani Isna; Anayanti Arianto; Urip Harahap
Jurnal Ners Vol. 9 No. 4 (2025): OKTOBER 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v9i4.50816

Abstract

Inflamasi merupakan suatu respon jaringan terhadap rangsangan fisik atau kimiawi yang merusak. Rangsangan ini menyebabkan lepasnya mediator inflamasi yang menimbulkan reaksi radang berupa panas, nyeri, merah, bengkak dan disertai gangguan fungsi. Salah satu zat aktif yang dapat menghambat infiltrasi neutrofil dan mengurangi kadar plasma sitokin inflamasi adalah quersetin. Quercetin juga memiliki fungsi sebagai antioksidan. Dalam penelitian ini quersetin dibuat sediaan nanogel. Kelebihan nanogel lebih mudah penetrasi kedalam kulit sehingga efektivitas antiinflamasinya lebih baik. Untuk mengetahui konsetrasi quersetin dapat diformulasi menjadi nanogel dengan menggunakan karbopol 940 sebagai bahan pembentuk gel serta mennguji memenuhi syarat karakteristik dari gel dan menguji efektivitas anti-inflamasi pada kaki tikus yang diinduksi karagenan. Quersetin dengan konsentrasi 0,06%, 0,08%, dan 0,1% diformulasikan menjadi sediaan nanogel. Diuji aktivitas anti-inflamasi pada tikus yang diinjeksikan dengan karagenan 1% untuk mengetahui dosis topikal yang efektif. Tahap awal formulasi adalah pembuatan nanosuspensi dengan konsentrasi quersetin 0,06g (F1), 0,08g (F2), 0,1g (F3). Nanosuspensi ditambahkan kedalam basis gel dengan pengadukan menggunakan homogenizer untuk mendapatkan nanogel. Nanogel dievaluasi stabilitas fisik dengan penyimpanan pada berbagai suhu selama 12 minggu dan cycling test. Setelah itu diuji anti-inflamasinya pada tikus dibandingkan dengan voltaren emulgel. Nanogel quersetin stabil selama penyimpanan 12 minggu dari organoleptis, homogenitas, pH (4,5-6,0), viskositas (7031-9894 m.Pa.s), daya sebar (4,5-7,1 cm2), ukuran partikel (40-70nm). Efek anti-inflamasi nanogel F3 menunjukan adanya penghambat anti-inflamasi 80,87±3.70%. Berdasarkan hasi penelitian ini nanogel quersetin yang memiliki aktivitas anti -inflamasi pada tikus yang lebih efektif adalah pada konsetrasi quersetin 0,1% (F3) pada tikus dibanding F1 dan F2. kata kunci : quersetin, nanogel, anti-inflamasi Abstract Inflammation is a tissue response to damaging physical or chemical stimuli. This stimulus causes the release of inflammatory mediators, which cause an inflammatory reaction in the form of heat, pain, redness, swelling, and impaired function. One active substance that can inhibit neutrophil infiltration and reduce plasma levels of inflammatory cytokines is quercetin. Quercetin also functions as an antioxidant. In this study, quercetin was made into a nanogel preparation. The advantage of nanogel is that it penetrates the skin more easily, thus improving its anti-inflammatory effectiveness. To determine the concentration of quercetin that can be formulated into nanogel using carbopol 940 as a gel-forming agent and to test whether it meets the characteristics of the gel and to test the anti-inflammatory effectiveness on carrageenan-induced rat paws. Quercetin with concentrations of 0.06%, 0.08%, and 0.1% was formulated into nanogel preparations. Anti-inflammatory activity was tested in mice injected with 1% carrageenan to determine the effective topical dose. The initial stage of the formulation was the preparation of nanosuspensions with quercetin concentrations of 0.06g (F1), 0.08g (F2), 0.1g (F3). The nanosuspensions were added to the gel base with stirring using a homogenizer to obtain nanogels. The nanogels were evaluated for physical stability by storage at various temperatures for 12 weeks and cycling tests. After that, their anti-inflammatory properties were tested in mice compared to voltaren emulgel. Quercetin nanogel was stable during 12 weeks of storage from organoleptic, homogeneity, pH (4.5-6.0), viscosity (7031-9894 m.Pa.s), spreadability (4.5-7.1 cm2), particle size (40-70nm). The anti-inflammatory effect of F3 nanogel showed an anti-inflammatory inhibitor of 80.87±3.70%. Based on the results of this study, quercetin nanogel which has more effective anti-inflammatory activity in mice is at a quercetin concentration of 0.1% (F3) in mice compared to F1 and F2.
Co-Authors Ade Sri Rohani Ambali Azwar Siregar Aminah Dalimunthe Anayanti Arianto Ardinata, Dedi - Arfayani Isna Azmi Sarriff Br Turnip, Nur Ulina M Cahya, Cucu Arum Dwi Dasopang, Eva S. Delyuzar, Delyuzar Denny Satria, Denny dharma Lindarto, dharma Dharmawan, Hariyadi Edy Fachrial Eka Lestari Mahyuni Embun Suci Nasution Eva S. Dasopang Febriady, Andy Fitri, Raissa Hakim Bangun* Harahap, Ikhsanuddin Ahmad Harahap, Mawandha Sari Harefa, Herman Syukur HARI PURNOMO Hari Purnomo4 Hasibuan, Poppy Anjelisa Zaitun Husori, Dadang Irfan Jansen Silalahi Julia Reveny Julia Reveny Julianti, Maelani Khairunnisa Khairunnisa Khairunnisa Khairunnisa Khairunnisa Khairunnisa Khairunnisa Leo, Natassya Manda Linda Margata Lokot Donna Lubis Mahyuni, Eka Lestari Mardianto Mardianto Mardianto Mardianto Muhammad Rizki Nadroh br Sitepu Nasri Nasri Nasri, Nasri Nasution, Azizah Nasution, M. Pandapotan Nasution, Salli Roseffi Nasution, Salli Roseffi Ningrum, Siti Rahmi Novidawati Boru Situmorang Nurmaini Nurmaini Poppy Anjelisa Z. Hasibuan Purba, Novandi R. Hamdani Harahap R. Hamdani Harahap Ricke Loesnihari Rifda Amaliya Ma’ruf Rizki Doli Hartama Harahap Rumanda Nurhasanah Sanjaya, Angga Nugraha Siahaan, Jekson Martiar Siregar, Ambali Azwar Siti Morin Sinaga Sitorus, Panal Sri Wahyuni Suci Wulandari Sunarti Sunarti Syukur Berkat Waruwu Tanjung, Hari Ronaldo Tarigan, Betharina Br Tri Widyawati Yuandani Yustika Wirda Ningsih Ziza Putri Aisyia Fauzi Zulmai Rani