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All Journal Universa Medicina Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Biomedika dan Kesehatan Jurnal ABDINUS : Jurnal Pengabdian Nusantara Jurnal Aisyah : Jurnal Ilmu Kesehatan Bioscientist : Jurnal Ilmiah Biologi International Journal of Multidisciplinary: Applied Business and Education Research JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Jurnal Penelitian dan Karya Ilmiah Lembaga Penelitian Universitas Trisakti JURNAL ABDI MASYARAKAT INDONESIA (JAMIN) Jurnal Indonesia Sosial Sains Room of Civil Society Development Jurnal Pengabdian Nasional (JPN) Indonesia Room of Civil Social Development
Monica Dwi Hartanti, Monica Dwi
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Vitamin D receptor polymorphism associated with obesity in productive age population: A cross-sectional study Yohana; Meiyanti; Hartanti, Monica Dwi; Margo, Eveline; Zuraida, Reni
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 16, No 1, (2025)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol16.Iss1.art6

Abstract

Background: Obesity is influenced by genetic factors, lifestyle, and environmental factors. This increase in obesity gives rise to various chronic disease problems.Objectives: This study aimed to identify genetic variations of Vitamin D receptors and determine the relationship to obesity in terms of body mass index and body fat percentage in the working group.Methods: This study is an analytical observational study with a cross-sectional research design approach in the Jembatan Dua area, Angke sub-district, West Jakarta. The research instrument used was a questionnaire to obtain characteristic data, as well as an examination of VDR gene variations rs1544410, rs2228570, rs7975232, and PCR examination to obtain data on gene variation.Results: The results obtained are as follows: the average age of subjects was 42.24, with 58.1% females. A total of 39 (69.1%) are Javanese. Thirty-one (50%) subjects were included in the category of obesity (BMI> 25), and 41 (66.1%) subjects were obese category based on the body fat percentage. The results of bivariate analysis obtained SNP VDR FoxI gene obtained a significant relationship with body mass index with a p-value of 0.047, while the VDR BsmI gene obtained a statistically meaningful relationship with body fat percentage with a p-value of 0.043.Conclusion: FoxI and BsmI VDR polymorphisms are associated with body mass index and body fat percentage.
Perbandingan Respons Antibodi setelah Vaksinasi COVID-19 antara Individu dengan dan tanpa Komorbiditas Bella, Isa; Khariri, Khariri; Hartanti, Monica Dwi; Sisca, Sisca; Thabit, Jihan Samira; Effendi, Ida; Devita, Arleen; Robertus, Thomas
Jurnal Biomedika dan Kesehatan Vol 8 No 2 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background Vaccination is a Crucial public health strategy for reducing the transmission of viral infections and protecting populations from severe illness. COVID-19 vaccines have played a significant role in decreasing the incidence and mortality rates linked to the virus. However, immune responses to vaccination may differ among individuals, especially those with comorbidies that could alter immune function. This study aimed to compare antibody responses in adults with and without comorbidities, 18 months after receiving the COVID-19 vaccine. Methods This was a cohort study with two sampling time points: before vaccination and 18 months after vaccination. The study was conducted in Yogyakarta, Indonesia. Data were collected through self-administered questionnaires and venous blood sampling. Antibody titers were measured to evaluate the humoral immune response in participants with and without comorbidities. Results Before vaccination, the highest proportion of positive antibody titers was found among females (40.2%), individuals aged 18–44 years (44.7%), those with a senior high school education (48.1%), and individuals with normal body weight (44.3%). A Comparison of antibody levels at baseline and 18 months after vaccination between groups with and without comorbidities showed no statistically significant difference, with a p-value of 0.992.   Conclusions Although no significant difference was found in antibody responses between individuals with and without comorbidities, comorbid conditions may still influence immune response depending on their type and severity. These findings suggest the need for further research to examine the specific effects of various comorbidities on long-term vaccine-induced immunity.
Early Marriage and Mental Health: A Case-Control Study of Psychological Outcomes Hartanti, Monica Dwi; Adiningsih, Setyo; Isnawati, Rina; Poetranto, Anna Lystia; Puetri, Nona Rahmaida; Desem, Muhammad Ibrahim; Saputra, Fery Surahman; Hidayat, Yance
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 9, No 2 (2024): September
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30604/jika.v9i2.2847

Abstract

Background: Bengkulu Province is one of the provinces in Indonesia that has the greatest incidence of early marriages. It is well knowledge that women in this province are more likely to be victims of crimes such as domestic violence, problems during pregnancy, and even death during childbirth. It is possible for moms who enter into early marriages to develop psychiatric illnesses, which can not only be a forerunner to a variety of health impacts in later life but also have the potential to have a detrimental impact on their children and families. Objective: This study seeks to examine the factors related to psychological issues in early marriage in Bengkulu Province. Method: For this investigation, a case-control study design is utilized, and the groups are separated according to geography. The group under consideration is a rural region with a greater rate of marriages occurring at a younger age. The control group, on the other hand, is urban. One hundred and thirty-seven mothers who had been married off at a young age made up the study's target sample. Each of the groups had 137 responses, ensuring that the ratio was one to one. The research instrument that was utilized in this study was a questionnaire, and the application Stata 14 was utilized for both univariate test analysis and logistic regression. Results: The husband's perspective (OR: 6.5; 95% CI: 2.1–13.2; P-value: less than 0.001) and societal stigma (OR: 6.4; 95% CI: 1.1–13.4; P-value: less than 0.001) were significant factors associated with elevated stress levels, correlating with the highest scores. The control group comprised quality of life (OR: 6.7; 95% CI: 2.1-11.9; P-value: 0.001) and family support (OR: 6.2; 95% CI: 2.1-11.4; P-value: less than 0.001). In the depressed symptoms component, the variables that exhibited a significant conclusive association with the highest score were the spouse's perception (OR 6.4; 95% CI: 2.1-11.7; P-value: less than 0.001) and quality of life (OR: 6.2; 95% CI: 1.6-13.1; P-value: less than 0.001). The control group exhibited poor health literacy (OR: 4.3; 95% CI: 1.3-7.7; P-value: 0.0033) and inadequate family support (OR: 4.1; 95% CI: 2.1-7.5; P-value: less than 0.001). Conclusion: As a conclusion, the findings of this study highlight the critical importance of implementing comprehensive strategies to address the issue of child marriage and the mental health repercussions that it can have. In order to effectively address the complex interaction of socioeconomic, cultural, and psychological variables that contribute to early marriage, these approaches need to prioritize prevention, intervention, and support services.
Karakteristik gejala Computer Vision Syndrom (CVS) pada pekerja bidang pendidikan Prasetyaningsih, Noviani; Hartanti, Monica Dwi; Adiwardhani, Anggraeni; Samira, Jihan
Jurnal Biomedika dan Kesehatan Vol 5 No 2 (2022)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2022.v5.125-131

Abstract

BACKGROUNDThe frequency and duration of using electronic devices have increased rapidly due to working from home during the Covid19 pandemic. This causes many complaints of vision such as tired eyes, heat, blur, foreign body sensation in the eyes and various other symptoms. All of these are known as Computer Vision Syndrome (CVS) symptoms, which could happen in and/or outside the eye. This study aims to analyze the relationship between the use of electronic devices with CVS symptoms felt by employees of the Faculty of Medicine, Universitas Trisakti, Jakarta. METHODSFifty-three employees aged 25-60; were recruited for this cross-sectional study. A complete questionnaire consisting of several questions, including the type and number of electronic devices used, how many hours of use in a day, and complaints felt when using electronic devices, was applied to determine the CVS symptoms. In addition, a visual inspection was conducted to determine the visual acuity. Fisher's exact test was used for analyzing the statistics. RESULTSMore than half of the subjects (52.8%) used 3-4 electronic devices for more than 6 hours daily (56.6%). Multiple CVS symptoms were complaint by 52.83% of subjects, such as tired eyes, blurred vision, and dry eyes observed in 71.7%, 45.3%, and 33.9% of subjects, respectively. Bivariate analysis using Fisher's exact test assessed the relationship between risk factors, such as the use of electronic devices, gender, age, number of electronic devices used, duration of usage in a day, visual acuity, and the incidence of CVS complaints. There was no significant relationship between the various risk factors with CVS complaints, indicated by p>0.05 in all variables. CONCLUSIONUsers of electronic devices often feel various complaints in their eyes when using these devices. Although there was no association between the risk factors studied and complaints of CVS, it is still critical to investigate other factors that may be associated with the incidence of CVS due to its multifactorial pathogenesis. KEYWORDS: Computer Vision Syndrom, CVS, Electronic Devices, Vision
mRNA Relative Expression Catalase in Hypertension Yohana, Yohana; Faradilla, Meutia Atika; Meiyanti, Meiyanti; Hartanti, Monica Dwi; Margo, Eveline; Anastasya, Karina Shasri
Bioscientist : Jurnal Ilmiah Biologi Vol. 12 No. 2 (2024): December
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bioscientist.v12i2.12825

Abstract

Hypertension is number one worldwide disease which lead to death. Initially hypertension is caused by changes in the walls of blood vessels. These vascular changes are due to the accumulation of ROS (Reactive Oxygen Species). ROS is the result of the balance between antioxidants and oxidants, but uncontrolled conditions will cause vascular damage. One of ROS product from metabolism which could played role in downregulation antioxidant gene expression is hydrogen peroxide. Hydrogen peroxide could be neutralized by catalase enzyme. Studies about catalase expression in hypertension subject is still limited. This research aims to determine mRNA relative expression catalase in hypertension. In this case control study, thrity subject hypertension and normotension subject were recruited within the age of 50-60 years. Hypertension subject was chosen according to JNC 8. Two millilitres vein blood was isolated into RNA. mRNA expression was detected by qRT PCR with 2 steps. Relative expression was determined using livak method. The data was analyzed using Mann Withney test with GraphPad software. Research results show that (1) catalase mRNA relative expression was 0,6 fold in hypertension; (2) catalase relative expression was not significantly lower in hypertension; (3) other antioxidants might have other mechanism to detoxify ROS and prevent hypertension.
PROFIL SUBKLAS IGG PADA INDIVIDU PENERIMA VAKSIN COVID19 PLATFORM VEKTOR VIRUS Mahardieni, Karlina; Samira, Jihan; Hartanti, Monica Dwi; Sisca, Sisca; Kurniawan, Yani; Hidayat, Syarif
Jurnal Ilmu Kedokteran dan Kesehatan Vol 12, No 1 (2025): Volume 12 Nomor 1
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v12i1.16313

Abstract

Respon imun pasca vaksinasi COVID19 beragam dikarenakan proses pembuatan vaksin yang dipercepat untuk mengatasi pandemi COVID19 yang ada. Tujuan penelitian adalah untuk mendapatkan data respon imun seluler individu pasca vaksinasi COVID19 vektor virus sebagai data penunjang kebijakan vaksinasi COVID19 di Indonesia. Metode penelitian yang akan dilaksanakan adalah penggunaan bahan baku tersimpan (BBT) berupa plasma dari individu yang menerima vaksin COVID19 vektor virus yang diambil pada enak titik waktu yang berbeda. Metode Elisa digunakan untuk menilai kadar subklas immunoglobulin G yang ada dalam plasma individu yang menerima vaksinasi COVID19. Uji repeated one-way ANOVA atau Uji Firedman digunakan untuk menganalisa rerata beda kadar subklas IgG pada 4 kelompok berdasarkan waktu. Hasil menunjukkan bahwa subklas IgG1 mendominasi kadar keseluruhan subklas IgG pada keenam titik point waktu.  Terdapat perbedaan yang bermakna kadar IgG1 dan IgG2 berdasarkan waktu (p<0,0001), namun tidak ditemukan perbedaan yang bermakna pada subklas IgG3 (p=0,276) dan IgG4 (p=0,967). Penelitian ini menunjukkan bahwa kadar subklas IgG1 dan IgG2 dapat dijadikan penanda peningkatan imunitas individu penerima vaksin COVID19 vektor virus.
Exploring the Relationship Between Sod1, 2 And 3 Gene Polymorphisms With Post-Covid19 Symptoms Thabit, Jihan Samira; Sisca, Sisca; Hartanti, Monica Dwi; Prasetyaningsih, Noviani; Kogoya, Alvionita; Devita, Arleen; Bela, Isa; Effendi, Ida
Jurnal Indonesia Sosial Sains Vol. 5 No. 04 (2024): Jurnal Indonesia Sosial Sains
Publisher : CV. Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/jiss.v5i04.1097

Abstract

The coronavirus disease 19 (COVID-19) has become a challenge for the media world. Even though they have been declared cured, some Covid-19 survivors still have health complaints. Abnormal symptoms, signs, or clinical parameters that persist two weeks or more after the onset of COVID-19 and do not return to their initial healthy state are potentially considered long-term effects of the disease. Although such changes are primarily reported in people with severe and critical illness, lasting effects also occur in individuals with mild infections that do not require hospitalization. This study aims to explore the role of antioxidants on the pathogenesis of Covid19 and its relationship with SOD1, 2 and 3 genomic variations. Getting alternative biomarkers for long covid19 detection. Research Method: The research sample is blood and questionnaires that will be taken from respondents affected by Covid19 a maximum of 6 months before data collection is held. Furthermore, DNA isolation, DNA amplification, cutting with restriction enzymes, and DNA band documentation with gel electrophoresis will be carried out. Symptoms related to systemic are the most common symptoms found in respondents with Long Covid19. A total of 8 respondents had systemic related symptoms, namely weakness, lethargy and sweating, while skin-related complaints were found in three respondents and one respondent had lung-related complaints. The average SOD activity value of respondents was 2.19 U/ml. In this study, more symptoms of long COVID-19 were found associated with systemic and cardiovascular symptoms. The complaints were not differentiated by the sex of the respondents. The output draft will be processed immediately after getting other results.
Pengukuran suhu, pH dan kadar substrat terhadap aktivitas enzim Galactose-1-Phosphate Uridyltransferase Sisca, Sisca; Parwanto, Edy; Hartanti, Monica Dwi; Tjahyadi, David
Jurnal Indonesia Sosial Sains Vol. 5 No. 07 (2024): Jurnal Indonesia Sosial Sains
Publisher : CV. Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/jiss.v5i07.1177

Abstract

Galactose-1-phosphate uridyltransferase (GALT) is an important enzyme involved in galactose metabolism. Understanding the factors influencing GALT activity is critical to elucidate its physiological role and potential therapeutic implications in galactosemia. In developing new drugs, chicken intestine/liver powder can be used as an enzyme source, GALT, to treat galactosemia. Therefore, it is necessary to research the characterization of the GALT enzyme in chicken intestine and liver powder. In this study, we investigated the influence of temperature, pH, and substrate level on GALT enzyme activity using an experimental approach in vitro. The optimum pH extraction results show that the optimum pH for the extraction of the chicken intestine and liver GALT is pH 7, with activity values ​​of 0.47 units/mL and 0.3953 units/mL, respectively. The optimum temperature for the extraction of chicken intestine and liver GALT is 37℃ with substrate hydrolysis capabilities of 0.48 U/mL and 0.57 U/mL, respectively. Meanwhile, the optimum substrate content is 400x. These insights provide a valuable foundation for further research aimed at comprehensively understanding GALT function, developing targeted interventions for disorders of galactose metabolism, and possible application in the development of new drugs for galactosemia
Penyuluhan dan Pelayanan Kesehatan Sebagai Upaya Memperbaiki Manajemen Hipertensi Pada Lansia Di Kelurahan Jembatan Lima Kecamatan Tambora Jakarta Sisca, Sisca; Hartanti, Monica Dwi; Setyaningrum, Dyah Ayu Woro; Lestari, Indah Widya; Ilona, Florinda; Chendrasari, Julian; Parwanto, ML Edy
Jurnal ABDINUS : Jurnal Pengabdian Nusantara Vol 4 No 1 (2020): Volume 4 Nomor 1 Tahun 2020
Publisher : Universitas Nusantara PGRI Kediri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29407/ja.v4i1.13977

Abstract

The incidence of hypertension increases with age. Alterations in function and structure in peripheral vascular system are thought to be the cause of high prevalence of hypertension in the elderly. Holistic, patient-centered management of hypertension is needed to prevent deaths from heart failure. This community service aimed to find out the level of knowledge about hypertension in residents of Jembatan Lima Sub-district, Tambora District, West Jakarta. Using a questionnaire, the level of knowledge was studied in 48 participants cross-sectionally. Blood pressure measurements were also carried out to describe the incidence of hypertension in that area. There was a low level of knowledge about hypertension among participants and this had an impact on increasing the risk of hypertension. Fifty-two percent of participants had normal blood pressure, whereas 48% participants were diagnosed as hypertension. Based on demographic data of participants obtained during the event, age, sex, education level and type of work were significantly increasing the risk of hypertension. Results from this community service conclude that the lack of knowledge of hypertension especially in the elderly can increase the risk of hypertension. In order to improve the quality of managing hypertension in the elderly in Jembatan Lima Village, Tambora District, West Jakarta, it is recommended that counseling and discussion groups to be held annually, especially among the elderly.
Co-Authors Adiningsih, Setyo Anastasya, Karina Shasri Anggraeni Adiwardhani Bela, Isa Bella, Isa Chendrasari, Julian David Tjahyadi Desem, Muhammad Ibrahim Devita, Arleen Effendi, Ida Ellyamurti, Devanti Octavia Erlani Kartadinata, Erlani Eveline Margo, Eveline Faradilla, Meutia Atika Hartini Hidayat, Yance Husnun Amalia Ilona, Florinda Ingrid A. Tirtadjaja, Ingrid A. Khariri Khariri Kogoya, Alvionita Lestari, Indah Widya Mahardieni, Karlina Meiyanti Meiyanti Meiyanti, Meiyanti ML Edy Parwanto Nona Rahmaida Puetri, Nona Rahmaida Orliando Roeslan, Muhamad Parwanto, Edy Poetranto, Anna Lystia Prasetyaningsih, Noviani Reni Zuraida Rina Fitriana, Rina Rina Isnawati, Rina Robertus, Thomas Samira, Jihan SAPUTRA, FERY SURAHMAN Setyaningrum, Dyah Ayu Woro sisca Sisca Sisca, Sisca Suryani Suryani Syarif Hidayat THABIT, JIHAN SAMIRA Wegig Murwonugroho Yani Kurniawan, Yani Yohana Yohana Yohana Yohana