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Anti-inflammatory activity test of matoa fruit peel ethanol extract (Pometia pinnata J. R. Forst. & G. Forst.) on carrageenan edema model of white rats Irene Eunike Tanod; A. M. Muslihin; Lukman Hardia
Science Midwifery Vol 14 No 3 (2026): August: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v14i3.2414

Abstract

Background: Inflammation is a protective biological response to tissue injury or infection; however, excessive inflammation may lead to tissue damage and chronic disease. Matoa fruit peel (Pometia pinnata J.R.Forst. & G.Forst.) contains bioactive compounds, including Flavonoids, saponins, tannins, and phenolics, which are known to have anti-inflammatory properties, are present in the plant. Objective: This study sought to assess the anti-inflammatory efficacy of the ethanol extract derived from the matoa fruit peel through the utilization of a carrageenan-induced paw edema model in male white rats. Methods: In an experiment, we used male white rats (Rattus norvegicus) and split them into five groups. We had a negative control, a positive control, and three treatment groups. The treatment groups got ethanol extract at different doses—100, 200, and 300 mg/kg of body weight. To get the inflammation going, we gave them a 1% carrageenan injection under their skin. Paw edema volume was measured periodically using a plethysmometer to determine the anti-inflammatory effect. Results: The initial volume of edema of the whole group was homogeneous (0.06 ± 0.00–0.01 mL). Ethanol extract of matoa fruit peel at doses of 100, 200, and 300 mg/kgBB showed anti-inflammatory activity by gradually reducing edema until the 6th hour. The dose of 100 mg/kgBB provided the highest edema inhibition effect (42.06 ± 8.36%), followed by the 300 mg/kgBB dose (41.27 ± 13.75%) and 200 mg/kgBB (31.75 ± 2.75%), while positive control showed the largest inhibition (61.11 ± 9.62%). Statistical analysis showed that all treatment groups differed significantly from negative controls (p < 0.05), but still had lower effectiveness than positive controls.Conclusion:Ethanol extract of matoa fruit peel demonstrates promising anti-inflammatory activity in carrageenan-induced male white rats and may serve as a potential natural source for anti-inflammatory drug development. Further studies are needed to identify the active compounds, clarify the molecular mechanisms, and evaluate the extract's safety.
PROFIL PENGGUNAAN ANTIBIOTIK PADA PASIEN INFEKSI SALURAN PERNAPASAN AKUT DI PUSKESMAS KABUPATEN SORONG Nazila Galela; Angga Bayu Budiyanto; Lukman Hardia; Innal Saitis
Jurnal Kesehatan Tambusai Vol. 7 No. 2 (2026): JUNI 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v7i2.57891

Abstract

Infeksi Saluran Pernapasan Akut (ISPA) tetap menjadi masalah kesehatan global dengan angka morbiditas yang tinggi, khususnya di negara berkembang. Penelitian ini bertujuan untuk mengetahui profil penggunaan antibiotik pada pasien ISPA di Puskesmas Kabupaten Sorong. Jenis penelitian ini adalah observasional deskriptif dengan pendekatan retrospektif. Pengambilan sampel dilakukan menggunakan teknik total sampling terhadap rekam medis pasien ISPA periode Juli–Desember 2025 yang memenuhi kriteria inklusi. Data dianalisis secara univariat untuk mendeskripsikan karakteristik pasien (usia dan jenis kelamin) serta profil penggunaan antibiotik (jenis, dosis, dan bentuk sediaan). Hasil penelitian menunjukkan mayoritas pasien ISPA adalah perempuan (57,69%) dan didominasi oleh kelompok usia dewasa 26-45 tahun (55,49%). Jenis antibiotik yang paling banyak digunakan adalah amoksisilin sebesar 63,74% (116 pasien), diikuti sefadroksil (27,47%), kotrimoksazol (6,59%), dan siprofloksasin (2,20%). Rejimen dosis yang paling dominan adalah amoksisilin 500 mg frekuensi 3x1 (54,95%). Seluruh antibiotik diberikan dalam sediaan oral padat, dengan bentuk kaplet sebagai sediaan yang paling sering diresepkan (63,74%). Mayoritas pasien ISPA adalah perempuan (57,69%) dan didominasi oleh kelompok usia dewasa 26-45 tahun (55,49%). Penggunaan antibiotik pada pasien ISPA di Puskesmas Kabupaten Sorong didominasi oleh amoksisilin dosis 500 mg dalam bentuk sediaan kaplet.
Efektivitas Analgesik Ekstrak Etanol Daun Pegagan (Centella asiatica) Terhadap Mencit Putih (Mus musculus) Siti Rahmadani; Lukman Hardia; Angga Bayu Budiyanto
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1602

Abstract

Background: Pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage, representing a major health problem that requires effective management. Although synthetic analgesics are widely used, their long-term administration is often associated with adverse effects, particularly gastrointestinal disturbances, thus driving the search for safer alternatives from natural sources. Centella asiatica (pegagan) is a medicinal plant traditionally used for various ailments, containing bioactive compounds with potential analgesic properties. Objective: This study aimed to evaluate the analgesic activity of ethanol extract of Centella asiatica leaves in male white mice (Mus musculus) and to determine the most effective dose. Methods: A true experimental study with pretest-posttest control group design was conducted involving 25 male mice randomly assigned into five groups (n=5 each): positive control (paracetamol 65 mg/kgBW), negative control (1% Na-CMC), and three treatment groups receiving ethanol extract at doses of 100, 150, and 200 mg/kgBW. The extract was prepared by maceration using 70% ethanol and subjected to phytochemical screening. Analgesic activity was evaluated using the tail flick method, with latency time measured at 30, 60, 90, and 120 minutes post-administration. Data were analyzed using Wilcoxon signed-rank test and Mann-Whitney U test at 95% confidence level. Results: Phytochemical analysis revealed the presence of alkaloids, flavonoids, saponins, and tannins in the extract, while steroids were not detected. The 100 mg/kgBW dose demonstrated the most consistent and significant analgesic activity, with statistically significant differences (p < 0.05) observed at 60, 90, and 120 minutes compared to pre-test values. This dose achieved the highest percentage of analgesia (63.09%) at 120 minutes, which was significantly superior to the positive control group. The 150 mg/kgBW dose showed inconsistent effects, while the 200 mg/kgBW dose exhibited comparable activity but with less consistency. Conclusion: The ethanol extract of Centella asiatica leaves possesses significant analgesic activity in mice, with the optimal dose of 100 mg/kgBW. The analgesic effect is likely mediated through the inhibition of cyclooxygenase enzymes and subsequent reduction of prostaglandin synthesis, supported by the presence of flavonoids, alkaloids, and triterpenoid compounds. These findings support the potential development of Centella asiatica as a standardized herbal analgesic agent.
Studi In-Vivo Potensi Ekstrak Daun Akway (Drimys cf. piperita) Sebagai Antihiperglikemia Risanyel Elsan Tuturop; A. M. Muslihin; Lukman Hardia
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1623

Abstract

Background : Hyperglycemia is a metabolic condition characterized by an increase in blood glucose levels above normal limits and is the main characteristic of diabetes mellitus, a chronic disease with a prevalence that continues to increase in various countries. The akway plant (Drimys cf piperita.) is endemic to the Sorong Mountains, Southwest Papua . Its leaves are known to contain various bioactive compounds such as flavonoids, tannins, saponins, and alkaloids. Purpose: This study aims to test the ability of akway leaf extract to lower blood sugar levels in vivo in white mice that were previously raised glucose levels through glucose solution. Method : This study design is an experimental laboratory with five treatment groups, namely negative control (Na-CMC 0.5 mg), positive control (glibenclamide 3 mg), and three groups of akway leaf extracts, each at doses of 100, 200, and 400 mg/kg BW. Hyperglycemia was induced for 7 days using a glucose solution. Blood glucose measurements were performed at 30, 60, 90, 120, and 150 minutes using a glucometer. Data analysis used One-Way ANOVA followed by a post -LSD test. Results: Akway leaf extract at a dose of 200 mg/kg BW provided the highest reduction in blood glucose, namely 54.24%, which was statistically significant (<0.05) and even better than glibenclamide (51.15%). Meanwhile, a dose of 400 mg/kBW actually produced lower effectiveness (45.85%). Implications: Akway leaf extract has been proven to have antihyperglycemic activity with an optimal dose of 200 mg/kgBW.
Pengaruh Perbedaan Metode Ekstraksi Terhadap Kadar Total Flavonoid dan Alkaloid Bonggol Buah Merah (Pandanus conoideus L.) Innal Saitis; A.M. Muslihin; Lukman Hardia; Angga Bayu Budiyanto; Irwandi Irwandi; Marzella Dea Rossardy; Wahyuni Watora; Justitia Cahyani Fadli; Wiwit Ayu Fitrianti
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1666

Abstract

Background: Red fruit (Pandanus conoideus L.) is an endemic plant of Papua that has been traditionally used to treat various diseases. Its biological activities are associated with the presence of secondary metabolites, particularly flavonoids and alkaloids. Objective: This study aimed to identify the secondary metabolites and evaluate the effect of different extraction methods on the total flavonoid and alkaloid contents of ethanolic extracts of red fruit (Pandanus conoideus L.) stem core. Methods: Extraction was performed using three different methods, namely maceration, Soxhlet extraction, and reflux extraction with ethanol as the solvent. Secondary metabolites were identified qualitatively, while total flavonoid and alkaloid contents were determined spectrophotometrically. Results: Phytochemical screening revealed the presence of alkaloids, flavonoids, terpenoids, steroids, and tannins in the ethanolic extract of red fruit stem core. The total flavonoid contents obtained by maceration, Soxhlet extraction, and reflux extraction were 218.966 mgQE/g (21.89%), 104.023 mgQE/g (10.40%), and 247.701 mgQE/g (24.77%), respectively. The total alkaloid contents obtained by maceration, Soxhlet extraction, and reflux extraction were 145.770 mgAE/g (14.58%), 65.767 mgAE/g (6.58%), and 76.433 mgAE/g (7.64%), respectively. Conclusion: The extraction method affected the total flavonoid and alkaloid contents obtained from the sample. Reflux extraction produced the highest total flavonoid content (247.701 mgQE/g), whereas maceration produced the highest total alkaloid content (145.770 mgAE/g). Therefore, reflux was the most effective method for flavonoid extraction, while maceration was the most effective method for alkaloid extraction from the stem core of red fruit (Pandanus conoideus L.).
OPTIMIZATION OF MANGROVE UTILIZATION AS A FOOD RESOURCE AND STRENGTHENING THE ECONOMY OF COASTAL COMMUNITIES Muh. Agus Salim; Lukman Hardia; Justitia Cahyani Fadli; Sitti Hadija Samual; Ica Damayanti; Mika Tri Kumala Swandari
Mitra Mahajana: Jurnal Pengabdian Masyarakat Vol. 7 No. 2 (2026): Volume 7 Nomor 2 Tahun 2026
Publisher : LPPM Universitas Flores

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37478/mahajana.v7i2.7982

Abstract

The coastal area of Klawalu Village possesses abundant mangrove ecosystem potential; however, its utilization by the community remains limited to ecological functions and has not been optimized as a source of food, health products, or economic improvement. This community service program aimed to enhance community knowledge and skills in mangrove utilization through education, training, and mentoring approaches based on multidisciplinary collaboration. The implementation methods included socialization on the benefits of mangroves, training on mangrove-based food product processing, education on the use of mangroves as natural health ingredients, and assistance in product marketing strategies to support the coastal community’s economy. The activities involved community groups, small and medium enterprises (SMEs), and village officials as primary partners. The results demonstrated an increase in community understanding regarding the potential of mangroves as a source of functional food and natural health ingredients, as well as improved skills in processing economically valuable mangrove-based products. In addition, this program encouraged greater public awareness of the importance of preserving mangrove ecosystems as sustainable natural resources. This community service initiative is expected to become a model for coastal community empowerment based on local potential that supports health, food security, and sustainable economic strengthening.
Evaluation of the Use of Prophylactic Antibiotics in Sectio Caesarea Patients at Scholoo Keyen Hospital, South Sorong Regency in 2022 Nurwahyuni; Lukman Hardia; Angga Bayu Budiyanto
International Journal of Health, Economics, and Social Sciences (IJHESS) Vol. 6 No. 2: April 2024 - International Journal of Health, Economics, and Social Sciences (IJHESS)
Publisher : Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/ijhess.v6i2.4945

Abstract

A caesarean section is an attempt to remove the fetus through surgery on the uterine wall. Problems during surgery are infection, bleeding, surgical complications, and morbidly adherent placenta. Approximately 90% of postoperative morbidity is caused by ILO. Treatment for ILO is by administering antibiotics. Prophylactic are antibiotics given 30-60 minutes before a caesarean section. The aim of this research is to find out what antibiotics are given and how to evaluate the use of prophylactic in cesarean patients based on medical record data at Scholoo Keyen Hospital in 2022. This research is a descriptive evaluative method to get an idea of the presentation rate of rofile and characteristics of medical data records at Scholoo Keyen Hospital in 2022. Data analyzed using descriptive data. The results show that from 152 samples, the most widely used prophylactic was ceftriaxone (69.7%). Evaluation of the appropriateness the use of prophylactic in cesarean patients with the hospital formulary being appropriate and compared with Gudline POGI, and ASHP therapeutic. The results were obtained according to the right indication, the right patient, the right route of administration, and the right time of administration was appropriate. While the right medicine and the right dose is not appropriate.
Analgesic Effectiveness of ant Nest Ethanol Extract (Myrmecodia Pendens) on white Mice (Mus Musculus) Fajar Maulana; Lukman Hardia; Angga Bayu Budiyanto
International Journal of Health, Economics, and Social Sciences (IJHESS) Vol. 6 No. 4: October 2024 - International Journal of Health, Economics, and Social Sciences (IJHESS
Publisher : Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/ijhess.v6i4.5901

Abstract

Pain is an unpleasant sensation emotionally and subjectively, indicating damaged tissue such as inflammation or a more significant condition. Myalgia, or often known as muscle pain. In Indonesia, the percentage of Myalgia sufferers is around 45-59%. This study applies an experimental method with a pretest-posttest group design. In this study, 25 mice were used which were divided into 5 groups, namely negative control (Na CMC 1%), positive control (mefenamic acid) and 3 groups given a dose of ant nest extract (17.5 mg/kgBW, 35 mg/ kgBW, 70 mg/kgBW). The analgesic effectiveness test used was the hot plate method with the writhing response parameter measured for 3 hours with a measurement interval of every 30 minutes. The results showed that the ethanol extract of ant nests showed positive tannin, alkaloid and flavonoid compounds. Data analysis on the comparison of dose groups showed that the doses of 17.5 mg and 35 mg had a significant value of <0.05 with a dose of 70 mg, in the positive control group had a significant value of >0.05 compared to the 70 mg ant nest extract dose group, which means there is no significant difference between the two. On the contrary, the negative control group showed a significant value of <0.05 compared to all treatment groups, which indicates a significant difference. The conclusion of this study is that the dose of ethanol extract of ant nest 70 mg has good analgesic effectiveness, approaching the effectiveness of the positive control of mefenamic acid.
Potensi Antiinflamasi Daun Dollu (Dodonaea Viscosa L.): Studi In Vivo Pada Model Edema Karagenan Tikus Putih (Rattus Norvegicus) Azzahra Vivin Mahdiya Afandy; Angga Bayu Budiyanto; Lukman Hardia
Jurnal Ners Vol. 10 No. 4 (2026)
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i4.62070

Abstract

potential plant is dollu leaf (Dodonaea viscosa L.), which reportedly contains a variety of secondary metabolites, such as flavonoids, alkaloids, tannins, saponins, and phenolic compounds that are thought to play a role in inhibiting the inflammatory response. Objective to assess the anti-inflammatory activity of dollu leaf ethanol extract (D. viscosa L.) in male white rats with carrageenan-induced inflammation. Methods the study was conducted using a laboratory experimental design with a model of foot edema induced by a 1% carrageenan solution. The experimental animals were divided into five groups, namely negative control, positive control, and three treatment groups that received dollu leaf ethanol extract with doses of 125, 250, and 500 mg/kg body weight. Observation of edema volume was carried out every one hour for six hours using a plethysmometer. All data were statistically analyzed using the One-Way ANOVA test followed by the Least Significant Difference follow-up test at the significance level of p < 0.05. Results dollu leaf ethanol extract showed increased anti-inflammatory activity over observation time. Compared to negative controls, doses of 125 and 250 mg/kgBB showed significant differences from the first hour (p=0.024 and p=0.006), while all doses showed very significant edema inhibition from the third hour to the sixth hour (p<0.001). Against positive controls, the dose of 250 mg/kgBB still showed a difference in the first to fourth hours (p=0.010–0.045), but at the fifth and sixth hours the entire dose did not differ significantly (p>0.05), showing an efficacy of the extract comparable to standard drugs in the advanced inflammatory phase. The dose of 250 mg/kg BB provides the most consistent anti-inflammatory response compared to other doses. Conclusion dollu leaf ethanol extract (D.  viscose L.) It has been proven to provide a significant anti-inflammatory effect in suppressing the formation of edema due to carrageenan induction in male white rats. This activity is mainly seen in the advanced inflammatory phase and the dose of 250 mg/kg BB is the dose that shows the most optimal effectiveness, so this extract has the potential to be developed as an anti-inflammatory phytopharmaceutical candidate.
Analisis Potensi Interaksi Obat Pada Resep Pasien Hipertensi Lansia di Puskesmas Dabatan Misool Selatan, Raja Ampat Nurul Maghfirah1; Lukman Hardia; Angga Bayu Budiyanto
Jurnal Ners Vol. 10 No. 4 (2026)
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i4.62242

Abstract

Elderly people with hypertension generally receive combination therapy to control blood pressure and manage comorbidities, so they are at risk of experiencing potential drug interactions. This study aims to analyze the potential for drug interactions in the prescriptions of elderly hypertension patients at the South Dabatan Misool Health Center, Raja Ampat Regency. Methods this study was a non-experimental observational study with a retrospective descriptive approach. The research sample used a total sampling technique of 130 prescriptions of elderly hypertension patients who met the inclusion criteria. Data were obtained from prescriptions and medical records, then analyzed descriptively based on the type of interaction, mechanism, and severity. Results the majority of patients were aged 60–65 years (53.85%) and were female (80.00%). Of the 130 prescriptions, 47 cases of potential drug interactions were found. The most common combination was amlodipine–simvastatin in 14 cases (29.79%), followed by amlodipine–mefenamic acid in 11 cases (23.40%). Most interactions were pharmacodynamic interactions of moderate severity, while major interactions were found in amlodipine–simvastatin and captopril–allopurinol combinations. Conclusion the potential for drug interactions in elderly hypertensive patients at the South Dabatan Misool Health Center is quite high, so it is necessary to screen drug interactions and evaluate therapy regularly to improve the safety and effectiveness of treatment.
Co-Authors A. M. Muslihin Achmad Noerkhaerin Putra Adriyani E. G. Sitanggang Agus sangka pratama Akrom Akrom Akrom, Akrom Alyssa Mileta Aponno Angga Bayu Budianto Angga Bayu Budiyanto Angga Bayu Budiyanto Angga Bayu Budiyanto Angga Bayu Budiyanto Angga Bayu Budiyanto Anisa, Meilinda Arif Budi Setianto Arif Radhika Mentari Arni, Veni Zafi Assem, Vincentia Santy Astuti, Ratih Arum Aulia Mifthakul Jannah Azzahra Vivin Mahdiya Afandy Budianto, Angga Bayu Carmel Josuhua Paulus Darmayanti Tumpu Diah Wulandari Dian Nur Khofifah Dika Rahayu Dion Fahcrul Rozi Eka Savira Ni'ma Arfiani Erawati, Rika Ernifan Ernifan Eva Maya Sari Fabanyo, Syahrul H. Fajar Maulana fania, vikafania Gilda Fransiska Hikmahtul Putri Utami Ica Damayanti Ikhwan Dahlan Rais Inda Dwi Yanti Indah Amelia Rizky Indah Diah Ningrum Innal Saitis Innal Saitis Irene Eunike Tanod Irwandi Irwandi Irwandi Irwandi Irwandi Irwandi Irwandi Irwandi Irwandi Jannah, Aulia Mifthakul Justitia Cahyani Fadli Laela Hayu Nurani Lanipi, Retna Parica Lanipi, Retna Paricca Levina Virginia M Natsir Djide M. Yogi Riyantama Isjoni Mansyur Arief Marzella Dea Rossardy Meilinda Anisa Mika Tri Kumala Swandari Muh Ishar Difinubun Muh. Dahlan Wael Muslih Anwar Nanik Sulistyani Nanik Sulistyani Nazila Galela Nazla Wati Sanaky Ningrum, Indah Diah Nuhidayah Sarifuddin Nuhidayah Sarifuddin Nur ‘Azah Nurkhasanah Nurkhasanah Nurul Maghfirah1 Nurwahyuni Paulus, Johan Kartino Prasasti Bintarum Pratama, Agus Sangka putri puspitawati, devyana Rahayu, Dika Rasi Fitri Yanti Tuasikal Retna Parica Lanipi Retna Parica Lanipi Retna Paricca Lanipi Risanyel Elsan Tuturop Rizqi Fadil Nadila SALIM, MUH.AGUS Sanaky, Nazla Wati Sarifuddin, Nuhidayah Selfiana Iek Serlin Marsela Sintya Sari Dwi Kusumaningrum Siska Siska Siti Fatma Z.F. Siti Rahmadani Sitti Hadija Samual Sun, Suny Syahrul H. Fabanyo Titiek Hidayati Titiek Suhardi Haripurnomo Kushadiwijaya Hidayati Tuasikal, Rasi Fitri Yanti Tunnazilah, Nurhikmah Tutuhatunewa, Priscillia Ryani ulandari, clarista windi Umpain, Agnes Nesa Vincentia Santy Assem Wa Ode Nurwahida Wahyuni Watora Wasaraka, Fadila Alfiah Wiwik Triyani Wiwik Wiwik, Wiwik Triyani Wiwit Ayu Fitrianti Yapsenang, Amar Jansen Yuniatri, Nur Khusna Yusnita La Goa Zf, Siti Fatma