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All Journal Majalah Kedokteran Bandung Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Althea Medical Journal Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Jurnal Farmasi Klinik Indonesia Global Medical and Health Communication INDONESIAN JOURNAL OF PHARMACY Jurnal Sistem Kesehatan Journal of Medicine and Health Molecular and Cellular Biomedical Sciences (MCBS) Journal Of Vocational Health Studies Indonesian Journal of Rheumatology Jurnal Pendidikan dan Pelayanan Kebidanan Indonesia (Indonesian Journal of Education and Midwifery Care) Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education Jurnal Ilmu Kefarmasian Indonesia Majalah Kedokteran Andalas Medika Kartika : Jurnal Kedokteran dan Kesehatan Health Information : Jurnal Penelitian Jurnal Aisyah : Jurnal Ilmu Kesehatan JK Unila (Jurnal Kedokteran Universitas Lampung) JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Journal of Medicine and Health
Achadiyani
Departemen Anatomi, Fisiologi, Dan Biologi Seluler, Fakultas Kedokteran, Universitas Padjadjaran, Bandung
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Dentistry Economics, Econometrics & Finance Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Journal : INDONESIAN JOURNAL OF PHARMACY

 1 
Protective Effect of Ethanolic Extract Tempuyung Leaf (Sonchus arvensis L.) in Gentamicin-induced Acute Tubular Necrosis on Wistar Rats Imelda, Imelda -; Achadiyani, Achadiyani -; Sekarwana, Nanan -
Indonesian Journal of Pharmacy Vol 29 No 2, 2018
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1561.235 KB) | DOI: 10.14499/indonesianjpharm29iss2pp86

Abstract

  Acute tubular necrosis (ATN) is the most common histopathologic findings of acute kidney injury (AKI). AKI is marked by the decrement of glomerular filtration rate, causing waste metabolism retention (creatinine). Gentamicin is used as it is the most common nephrotoxic agent in inducing ATN. Tempuyung (Sonchus arvensis L.) has been used in folklore medicine to ameliorate kidney problems as it contains antioxidants, two of which are flavonoid and phenolic acid. Yet, these active substances’ benefit on gentamicin induced ATN has not been investigated in Indonesia. This research aims to analyze protective effect of ethanolic extract tempuyung leaf (EET) on gentamicin-induced ATN based on histopathological study and creatinine serum level.     True experimental laboratoric study was done with simple random design on male wistar rats, randomly divided into 4 groups (n=4). Control group (CMC 0.5% aquadest); Induction group (Gentamicin 80 mg/kgBW); 1st treatment group (EET 100 mg/kgBW + Gentamicin 80 mg/kgBW) and 2nd treatment group (EET 200 mg/kgBW + Gentamicin 80 mg/kgBW) for ten days. On the 11th day, blood was taken for creatinine measurement and kidneys collection for histopathological study.     Histopathological examination on gentamicin-treated rats revealed degenerative changes in kidney tubules. Aside from that, gentamicin-treated rats also showed increment in  creatinine serum level. Conversely, simultaneous administration of EET with Gentamicin ameliorated the nephrotoxic effects of gentamicin as confirmed from the significant improvement on histopathological changes and normalization of creatinine serum level.     Co-administration of EET and gentamicin provides protection on gentamicin-induced ATN, based on histopathological feature and creatinine serum level.
Co-Authors A.R. -, Dewi, A.R. Ahmad Faried Alfarafisa, Nayla Majeda Alfiah Rahmawati Amelia, Rachel Andrew Citrawan Andri Rezano Anggraini, Dita Maulida Anindita Laksmi Anita Deborah Anwar Ardella Tri Novianti Astrid F. Khairani Astrid Feinisa Khairani Bashari, Muhammad Hasan Cherry Azaria Cherry Azaria, Cherry Chou, Yoan Dany Hilmanto Deni K Sunjaya Dewi, A.R. - Dimas Erlangga Dini, Dini Dita Maulida Anggraini Dolvy Girawan E. -, Nurdiamah, E. Eko Fuji Ariyanto Endang Sutedja Endang Sutedja Endang Sutedja Endry Septiadi Enny Rohmawaty Farid Husin Firdaus, Muhammad Bintang Firman Fuad Wirakusumah Fitri Aulia Gaga Irawan Nugraha Hamsiah binti Halim Hamsiah binti Halim Hardisiswo Soedjana Hartati Purbo Dharmadji, Hartati Purbo Hendra Gunawan Hendrikus Masang Ban Bolly Herry Herman Ida Kinasih Ika Friscila Imelda, Imelda - Indah, Astrina Rosaria Insi Farisa Arya Insi Farisa Arya, Insi Farisa Irma Ruslina Ishak Abdulhak Ivanna Valentina Jansen Budiono Jansen Budiono Julaecha Julaecha Kamilah, Mutiara Mila Kartika Farahdilla Fitri Kurnia Wahyudi Laniyati Hamijoyo, Laniyati Latama, Zahra Nabila Lia Faridah Meita Dhamayanti Michael V.L Tumbol Mohammad Ghozali Monita Sugianto Muhammad Begawan Bestari Muhammad Zafrullah Arifin Nadifa, Safira Nanan Sekarwana Nani Murniati Nikla Sekar Salsabila Nur Atik Nur Ramadani Meliani Syukri Nurdiamah, E. - Oki Suwarsa Pitaloka, Pritha Pratiwi, Auria Ekanti Putri Halleyana Rahman Rachel Amelia Ramadhani Eka Putra Ratumanan, Samuel Permana Reni Farenia Reni Farenia Reni Farenia Rina Puspasari Herdiawan Rizqy Dimas Monica Ronny Lesmana Rovina Ruslami, Rovina Sadeli Masria Sari Puspa Dewi Savira Ekawardhani Sharon Noor Alya Shelly Iskandar Silvana Anggreini Rosa Sudigdo Adi Sudigdo Adi Sudigdo Adi Sunarjati Sudigdo Adi Sunaryati S. Adi Susi Susanah Tenny Putri Teresa Lucretia Teresa Lucretia, Teresa Tjahjodjati Tri Hanggono Achmad Tri Hanggono Achmad Tryando Bhatara Uci Ary Lantika Uni Gamayani Vita Murniati Tarawan Vitriana Vitriana Yuli Kurniawati Yuni Susanti Pratiwi Yuni Susanti Pratiwi Yuni Susanti Pratiwi, Yuni Susanti Yuniarti