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All Journal Jurnal Farmasi Udayana Indonesian Journal of Pharmaceutical Science and Technology Planta Tropika E-Dimas: Jurnal Pengabdian kepada Masyarakat Jurnal Kesehatan Bakti Tunas Husada JMM (Jurnal Masyarakat Mandiri) SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Journal of Pharmacopolium Jurnal Kreativitas PKM PREPOTIF : Jurnal Kesehatan Masyarakat Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Jurnal Ilmiah Farmako Bahari Borneo Journal Of Pharmascientech J-ABDIPAMAS (Jurnal Pengabdian Kepada Masyarakat) Jurnal Kesehatan Bakti Tunas Husada Jurnal Medika: Medika Indonesian Journal of Jamu
Vera Nurviana
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Control & Systems Engineering Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Journal : Jurnal Farmasi Udayana

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Potensi Antidioksidan Sediaan Nanopartikel Ekstrak Kernel Biji Limus (Mangifera foetida Lour) Vera Nurviana
Jurnal Farmasi Udayana Spesial Issue, Desember 2020
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2020.v09.i03.p02

Abstract

The antioxidants are compounds that have the ability to inhibit free radical activity that causes degenerative diseases. One source of natural ingredients known to have antioxidant activity is limus (Mangifera foetida Lour.), One of mango species from the Anacardiaceae tribe which is a local Indonesian fruit. Limus seed kernel extract (EBL) has been shown to have antioxidant activity. Antioxidant activity can be increased by making nanoparticle preparations. This study aims to increase the antioxidant activity of limus seeds by modifying the extract into nanoparticle preparations. The preparation of nanoparticles was carried out by the ionic gelation method and to ensure the formation of extract nanoparticles, characterization was carried out including particle size, polydispersion index and zeta potential value. The increase in antioxidant activity of limus seed extract (NEBL) nanoparticles was carried out by comparing the IC50 value with the IC50 EBL value, and to see its potential by comparing it with vitamins. The method of measuring antioxidant activity used is the DPPH (2,2-diphenyl-1-picrylhydrazyl) method. IC50 data were analyzed using the One Way Annova test and post-hoc LSD test with a confidence level of 95%. Based on the research results, it was obtained that limus seed extract nanoparticles were prepared which had characteristics including; The particle size was 2.91 nm, the polydispersion index value was 0.456 and the zeta potential value was +56 mV and the IC50 value was 1.166 ± 0.021 µg/mL. The IC50 value of the EBL is 9.127 ± 0.022 µg/mL and Vitamin C is 3.933 ± 0.013. µg/mL Modification of EBL into NEBL preparations can increase antioxidant activity and has excellent potential as a natural antioxidant because it has stronger antioxidant activity than vitamin C (p <0.05). Keywords: Antioxidant, Limus, Mangifera foetida Lour, Nonoparticle
Co-Authors Abdilah, Rizki Fuzia Putra Ade Yeni Aprilia Agustiani, Cica Alifia Nurfadhilah S Alifiar, Ilham Anindita Tri Kusuma Pratita Anindita Tri Kusuma Pratita Anindita Tri Kusuma Pratita Anindita Tri Kusuma Pratita Anindita Tri Kusuma Pratita Anisa Pebiansyah Anna Yuliana, Anna Annisa Pebiansyah Annisa Pebiansyah Arif, Kirana Johar Arifan, Ihsan Nur Aulia Nurlatifah Az-zahra, Nurtsalits Azahra, Fildza Fathila Cahyani, Regita Putri Cahyani, Sabila Pradina Citra Dewi Salasanti Deliani Deliani Dewi, Riska Nurmala Diana Sri Zustika Diana Sri Zustika, Diana Sri Dini Febianeu Eka Kartika Nuraini FAJAR SETIAWAN Faridah, Ida Fathurohman, Mochamad Firman Gustaman Fuzi Khoirurifa Gatut Ari Wardani Gina Yulias Triyani Gunarti, Neni Sri HAMIDAH, MIDA Hanjani, Hani Hendy Suhendy Hermanto, Fauzi Juniawan Ilham Alifiar Ilham Alifiar Ilham Alifiar Indra, Indra Ira Rahmiyani Ira Rahmiyani Jannah, Gina Raudatul Keni Idacahyati Keni Idacahyati Khoeruman, Elan Korry Novitriani, Korry Leandra, Dhea Lilis Tuslinah Lilis Tuslinah, Lilis Lusi Nurdianti, Lusi M. Faturohman Maryatisna, Mardiyah Nur Asrie Maulida, Zahra Annisa Mentari, Nur Samsi Mida Hamidah Mitha Anggitha Mitha Anggitha Mochamad Fathurahman Mochamad Fathurohman Muhammad, Alif Naufal Muharam Priatna Muharam Priatna Nabila, Safira Qolbun Nugraha, Genta Nur Laili Dwi Hidayati Nur Rahayuningsih Nur Rahayuningsih, Nur Nuraeni, Tania Nurfadhillah, Siti Nurhasanah, Hana Nurliawati, Fadhillathul Pratama, Arryza Azriel Pratita, Anindita Tri Kusuma Rahma, Anita Fauziah Rahmawati Rahmawati Ratna Wulandari Rivaldi Muhsin Rukmana, Dea Helyani Ruswanto, Ruswanto Saeful Amin Sulistia, Chinda Taufik Hidayat Tira Mutiara Utami Tita Nofianti Tita Nofianti Tita Nofianti Tita Nofianti, Tita Tita Puspitasari Tresna Lestari, Tresna Ummahat, Sayla Amaliatul Wildan Rizki Asilmi Winda Trisna Wulandari Yadi Aditya Prawira