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All Journal Biomedical Journal of Indonesia Promotif: Jurnal Kesehatan Masyarakat JURNAL GALUNG TROPIKA Pendas : Jurnah Ilmiah Pendidikan Dasar JURNAL ILMIAH PETERNAKAN TERPADU Economics and Digital Business Review Jurnal Midwifery Abdimas: Papua Journal Of Community Service Jurnal Pengabdian Kepada Masyarakat Patikala Jurnal Kolaboratif Sains AJAD : Jurnal Pengabdian kepada Masyarakat Gemakes: Jurnal Pengabdian Kepada Masyarakat Cons-Iedu: Islamic Guidance and Counseling Journal AGRI-SOSIOEKONOMI IKHLAS: Jurnal Pengabdian Dosen dan Mahasiswa Jurnal Panrita Makkareso : Riset Pengabdian Masyarakat Al-Qalam: Jurnal Kajian Islam Dan Pendidikan Biomedika IECON: International Economics and Business Conference PENGABDIAN KEPADA MASYARAKAT (JUPENGMAS) Eco Forest Journal Islamic Financial And Accounting Review Masterpiece Journal Society Service Insight
Sulfiana
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Journal : Biomedical Journal of Indonesia

 1 
Hypolipidemic Effect of Galoba Fruit (Hornstedtia sp.) Extract on LDL-Cholesterol in Hypercholesterolemic Mice Rahmah, Nadia Fathiyatur; Agustin, Rachmawati; Latief, Rahmi; Sanaky, Marliyati; Latuconsina, Vina Zakiah; Sulfiana
Biomedical Journal of Indonesia Vol. 12 No. 1 (2026): Vol 12, No 1, 2026 (In Press)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v12i1.289

Abstract

Introduction. Elevated low-density lipoprotein cholesterol (LDL-C), particularly in its oxidized form, contributes to atherosclerosis and increases the risk of cardiovascular disease. Galoba fruit (Hornstedtia sp.) contains antioxidant phytochemicals that may support lipid regulation. This study evaluated the hypolipidemic effect of Hornstedtia sp. extract in hypercholesterolemic mice. Methods. Twenty-five male mice were randomly assigned to five groups: normal control (KN), negative control (K–, high-fat diet only), positive control (K+, simvastatin 10 mg/kg BW), and two treatment groups receiving Galoba fruit extract at doses of 200 mg/kg BW (P1) and 400 mg/kg BW (P2). Hypercholesterolemia was induced with a high-fat diet, and the extract was prepared by ethanol maceration. Because of limited serum volume, LDL-C levels were estimated indirectly using the Anandaraja equation based on total cholesterol and triglyceride concentrations. Results. LDL-C levels decreased in the extract-treated groups compared with the negative control. The Kruskal–Wallis test showed significant differences among groups (p < 0.05; overall p = 0.000). The greatest reduction was observed in P1 (11.90 mg/dL), followed by P2 (16.60 mg/dL), although neither exceeded the effect of K+ (7.90 mg/dL). Conclusion. Hornstedtia sp. extract demonstrated potential in lowering LDL-C in hypercholesterolemic mice, suggesting its role as a natural adjunct for lipid control. However, the use of indirect LDL-C estimation and the small sample size warrant cautious interpretation. Further studies with direct lipid profiling and mechanistic exploration are recommended before translational application.
Co-Authors A. Anniza Putri Aulia Abu, Nur Afnil Agus Masykur Agustin, Rachmawati Ahmad AHMAD FAHRIZAL Alihkzan, Dedi Ameilany Dwi Anjani Amir, Annisa Umniya Andi Ardani, Mutiara Cahya Puspita Andi Nursiah Angkejaya, Ony W Anieq Mumthi’ah Al Kautzar AR, Irmayanti Arminah, St Arsylawati, Hajrah Asmayani Charles Y. Konjol Chatarina Umbul Wahyuni Darwin K. Inggamer de Lima, Filda Vionita Irene Dewi Rizky Purnama Dhiya Alfiah Dylan Tamalsir Dzaky Arif, Muh. Fadhil Eka Astuty Erwing Fachry Abda El Rahman Fadliah, Rizkah Ferawati Taherong Fitrayadi, Andi Ghela, Maria Marselina Gusnawati, Yesi Hardianti A, Fatimah Hasnawati Amqam Hasriani Hasrianti Hasrina Helda Ibrahim Hermimin Ida Suryani Ilham Ilham Indo Santalia Isnar, Irsandy Jumria Saet Katiandagho, Theodora Maulina Kayatun, Siti Nur Kelibay, Amirula Kiki La Ibal Latief, Rahmi Latuconsina, Vina Zakiah M. Zain, Majdah MARIA BINTANG Masniar Maweikere, Audrey Julia Maria Muh. Judrah Muhammad Jufri Pusung Muhammad Junan Muhammad Sabir Muhammad Saleh murni murni Mus, Rosdiana Musdalipa Muslimin, Istyqamah Mutmainnah Abbas Nahdatunnisa Asry Natsir, Muh. Fajaruddin Neneng Suarno Kalidi Nurfadillah.s Nurfin Moha Nurhasanah Nurhayati Nurliana Nurul Faizah Kamaruddin Nurul Islamiah Nurul Ulmi P, Sudirman Panessai, Muhammad Kesnal Ramdan Putri Firda Y. Lestari Putri Nabila Rahayu, Andi Rahmah, Nadia Fathiyatur Rahmi Ratna ReshiHadriyahrahmadana Rikasari Riska Dewi Riska Yanti Rismawati Sanaky, Marliyati Serliana Sherlie G.L.Weyai Sinta Sirajuddin Sirajuddin Subakti, Ervin Suci Syahrawani Sufardin Suherdi Sulfiani, Besse Suriyati ., Suriyati Syahrani Astuti, Nia Syamsurijal, Vivi Alfina Damayanti Tanasali, Fadalia Tengku Riza Zarzani N Tuanaya, Syafira Arfani Usman, Mahyudin Wijhah Zaenab