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All Journal Jurnal EDUCATIO: Jurnal Pendidikan Indonesia Jurnal Biomedika dan Kesehatan UMI Medical Journal Borneo Journal of Medical Laboratory Technology Jurnal Kesehatan Tambusai MAHESA : Malahayati Health Student Journal Journal La Lifesci Wal'afiat Hospital Journal Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Indonesian Community Journal Innovative: Journal Of Social Science Research WAL'AFIAT HOSPITAL JOURNAL
Amrizal Muchtar
Fakultas Kedokteran Universitas Muslim Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Efektifitas Pemberian Bifidobacterium Longum Terhadap Pertumbuhan Klebsiella Pneumonia Pada Mencit Syarkawi, M. Fathir Faisal Thahir; Wiriansya, Edward Pandu; Murfat, Zulfitriani; Muchtar, Amrizal; Anggita, Dwi
MAHESA : Malahayati Health Student Journal Vol 5, No 8 (2025): Volume 5 Nomor 8 (2025)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mahesa.v5i8.19120

Abstract

ABSTRACT This study aims to evaluate the effectiveness of Bifidobacterium longum administration on the growth of Klebsiella pneumoniae in mice (Mus musculus). A true experimental design with a post-test approach was employed. Mice were divided into five treatment groups: preventive, curative, supportive, positive control, and negative control. Bifidobacterium longum was administered orally at a dose of 10⁷ CFU/ml, while Klebsiella pneumoniae was inoculated intraperitoneally at a dose of 10⁶ CFU/ml. Bacterial colony counts were determined using blood cultures on MacConkey agar medium and a colony counter. The results showed that Bifidobacterium longum was ineffective in preventing Klebsiella pneumoniae growth in a preventive manner. However, Bifidobacterium longum demonstrated effectiveness in inhibiting Klebsiella pneumoniae after infection, making it a promising potential curative and supportive therapy. Bifidobacterium longum shows potential as a probiotic agent to inhibit Klebsiella pneumoniae infections, supporting the development of alternative and supportive therapies to combat infections and antibiotic resistance. Keywords: Bifidobacterium longum, Klebsiella pneumoniae, Probiotics, Antibacterial, Mice.  ABSTRAK Penelitian ini bertujuan untuk mengevaluasi efektivitas pemberian Bifidobacterium longum terhadap pertumbuhan Klebsiella pneumoniae pada mencit (Mus musculus). Kami menggunakan true experimental dengan desain post-test. Mencit dibagi menjadi lima kelompok perlakuan: preventif, kuratif, suportif, kontrol positif, dan kontrol negatif. Pemberian Bifidobacterium longum dilakukan secara oral dengan dosis 10⁷ CFU/ml, sedangkan Klebsiella pneumoniaediinokulasikan secara intraperitoneal dengan dosis 106CFU/ml. Jumlah koloni bakteri dihitung melalui kultur darah pada medium MacConkey menggunakan colony counter. Hasil menunjukkan bahwa Bifidobacterium longum tidak efektif dalam mencegah pertumbuhan klebsiella pneumoniae secara preventif. Namun Bifidobacterium longummenunjukkan efektivitas dalam menghambat klebsiella pneumoniae setelah infeksi terjadi, menjadikannya potensi terapi kuratif dan suportif yang menjanjikan. Bifidobacterium longum memiliki potensi sebagai agen probiotik untuk menghambat infeksi Klebsiella pneumoniae mendukung pengembangan terapi alternatif dan supportif untuk mengatasi infeksi dan resistensi antibiotik. Kata Kunci: Bifidobacterium Longum, Klebsiella Pneumoniae, Probiotics, Antibacterial, Mice.
Comparison of The Sensitivity of Generic and Branded Ciprofloxacin Antibiotics Against Salmonella Typhi Wulandari, Mustika; Arsal, Andi Sitti Fahirah; Sodiqah, Yani; Fattah, Nurfachanti; Hadele, Amrizal Muchtar
Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Vol. 11 No. 3 (2025)
Publisher : Faculty of Medicine, Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/htj.v11i3.1659

Abstract

Background. Salmonella typhi is the leading cause of typhoid fever, a gastrointestinal infection that resulted in about 9 million cases and 110,000 deaths globally in 2019. One of the drugs that is currently often used in the treatment of this disease is ciprofloxacin. Over time, more and more bacteria are experiencing drug resistance, including to these drugs. In addition, many patients also doubt the quality of generic ciprofloxacin drugs because they are cheaper than branded drugs. In fact, the Regulation of the Minister of Health No. HK.02.02/MENKES/068/I/2010 requires the use of generic drugs in government health facilities. Primary Objective: This study aimed to see and compare the sensitivity of generic and branded ciprofloxacin antibiotics in inhibiting Salmonella typhi. Methodology: This study was an antibiotic sensitivity test by the agar diffusion method (Kirby Bauer). Results: The results showed that one generic ciprofloxacin and seven branded classes still had sensitive inhibitory power and there was no significant difference between the generic and branded groups. Conclusions: There was no significant difference between generic and branded antibiotics between generic and branded antibiotics ciprofloxacin against Salmonella typhi.
Efektivitas kalender elektronik google calendar dalam mengelola aktivitas kuliah kerja nyata Hadele, Amrizal Muchtar; Sitti Fahirah Arsal, Andi; Hadi, Santriani; Maulidhany Tahir, Akina; Sulfiani Herawaty, Andi; Husni Esa Darussalam, Andi
Jurnal EDUCATIO: Jurnal Pendidikan Indonesia Vol. 11 No. 1 (2025): Jurnal EDUCATIO: Jurnal Pendidikan Indonesia
Publisher : Indonesian Institute for Counseling, Education and Therapy (IICET)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29210/1202525306

Abstract

Kuliah Kerja Nyata (KKN) adalah mata kuliah program studi strata satu yang dilaksanakan di luar kampus dengan tujuan sebagai wadah mahasiswa untuk mengaplikasikan ilmunya di masyarakat. Di sini, mahasiswa akan memprogramkan banyak kegiatan untuk masyarakat selama 1-3 bulan. Tentunya dibutuhkan sebuah media kalender bersama yang bisa membantu penjadwalan kegiatan supaya pelaksanaan KKN bisa lebih efektif. Pada penelitian ini, diterapkan suatu kalender elektronik Google Calendar (GC) untuk membantu manajemen KKN. Adapun metodenya yaitu dengan mewajibkan mahasiswa mengikuti jadwal KKN sesuai yang sudah disepakati bersama lewat aplikasi yang bisa diinstal di ponsel. Setelah satu bulan, mereka diminta kesediaan mengisi kuesioner dan diwawancarai untuk mengetahui tingkat kepuasan mereka dalam memakai aplikasi GC. Hasil yang didapatkan adalah bahwa aplikasi GC ini efektif (91,9%) dan tingkat kepuasan responden mencapai 94,6%.
Co-Authors Adrian Adrian Ahmad, Izhar Fitrah Andi Sitti Fahirah Arsal Anggita, Dwi Annisa Salsabilah Salam Anshary, Suci Noviyanah Aprilani Hattah, Dhian Karina Arif Rahman Arsal, Andi St. Fahirah Azizah, Namirah Nurjiranah Cantika Carmelia, Andi Dila Dzul Ikram Dzul Ikram Faisal, M. Fathir Fattah, Nurfachanti Fazdlurrahman, Fazdlurrahman Firiansyah, Alief Rezeky Hadi, Santriani Hasbi, Berry Erida Husni Esa Darussalam, Andi Husnul Khatimah Ikram, Dzul Irna Diyana Kartika Kanang, Indah Lestari Daeng Karim, Marzelina Mardiyyah Hasnawi Masdipa, Andi Maulidhany Tahir, Akina Muhammad Ilham Muhammad Jabal Nur, Muhammad Jabal Musa, Inna Mutmainnah Nasrun, Muhammad Fikri Nesyana Nurmadilla Nur Alam Paku Bumi Nur Alifah Salsabila Yani Nurmadilla, Nesyana P.Amir, Suliati Prema Hapsari Hidayati Rachmat Faisal Syamsu Sitti Fahirah Arsal, Andi Sodiqah, Yani Sulfiani Herawaty, Andi Syamsu Rijal Syarkawi, M. Fathir Faisal Thahir Taufan, Wa Ode Sri Apriani Usman, Muh. Muflih Wa Ode Sri Apriani Taufan Wiriansya , Edward Pandu Wiriansya, Edward Pandu Wulandari, Mustika Yani Sodiqah Yusriani Mangarengi Zulfitriani Murfat