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All Journal MEDISAINS KOVALEN: Jurnal Riset Kimia CHEMPUBLISH JOURNAL Lantanida Journal Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) As-syifaa Jurnal Farmasi Justek : Jurnal Sains Dan Teknologi Pharmasipha Jurnal Farmasi Higea Health Sciences and Pharmacy Journal INTEGRITAS : Jurnal Pengabdian Jurnal ABDINUS : Jurnal Pengabdian Nusantara Jurnal Inovasi Farmasi Indonesia Medicra (Journal of Medical Laboratory Science/Technology) Prosiding Conference on Research and Community Services MAHESA : Malahayati Health Student Journal Environmental and Toxicology Management (ETM) CHEDS: Journal of Chemistry, Education, and Science Indonesian Journal of Chemistry and Environment Jurnal Kesehatan Kusuma Husada Jurnal Pengabdian Sosial Lestari: Jurnal Pengabdian Kepada Masyarakat JI-KES (Jurnal Ilmu Kesehatan)
Ngibad, Khoirul
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Journal : MEDISAINS

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Sub-acute toxicity evaluation of Ziziphus spina-christi and Adenanthera pavonina leaf extracts combination in rats: an in vivo study Ngibad, Khoirul; Ayu , Patricia Gaby; Fafa , Angelica Rosia; Tria , Novitasari; Farichatul , Wachda
MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Vol. 23 No. 3 (2025)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v23i3.27311

Abstract

Background: The safety of combined herbal extracts remains underexplored, particularly for Ziziphus spina-christi and Adenanthera pavonina, which contain bioactive compounds with potential toxic effects. Objective: To evaluate the sub-acute toxicity of combined leaf extracts on hematological, biochemical, and organ morphology parameters in Wistar rats. Method: Thirty male and female rats were randomized into five groups receiving vehicle control or extract doses of 4000, 8000, and 10,000 mg/kg BW for 21 days following OECD 407. Blood hematology, renal biomarkers, bilirubin levels, organ weight, and morphology were analyzed. Results: Mortality increased dose-dependently, reaching 20% in males and 10% in females at 10,000 mg/kg BW. Hematology and renal biomarkers showed no significant differences (p>0.05). Total bilirubin increased at the highest dose. Morphological abnormalities, including pale discoloration and dark foci, were observed in liver and kidneys at higher doses. Conclusion: The combination extract is safe up to 8000 mg/kg BW, while 10,000 mg/kg BW induces organ alterations and increased mortality.
Co-Authors Adhiba, Eka Indira Afidatul Muadifah Aldimas, Reven Ali Abraham, Ali Amanda, Lyrra Mirna Andriansyah, Firman Angge, Bagas Anton Sumarpo Ardiansah, Prianggara Arif Santoso Arif, Donny Arnando, Rasi Andante Arrafi, David Khalik As Syukri, Khoirul Anam Aulia, Rizza Fatma Ayu , Patricia Gaby Basyori, Imam Caesaria, Vica Ayu Candra Aldiansyah, Rio Chaniroh, St. Lutfi Choifin, Mochamad Cholik, Dimas Satria Nur Damayanti, Alvina Datin An Nisa Sukmawati Dianto, Annando Kusuma Dony Perdana Efawati, Susi Fadila, Ulfatul Fafa , Angelica Rosia Fahrudin, Ahmad Dani Farichatul , Wachda Farkhan, M. Farkhan, Muhammad Fernanda, Sofia Ayu Firdania Firdaus Rosyida Galuh Puspita Sari Indra Lasmana Tarigan Islami, Putri Nova Nur Jannah Triarini, Lailatul Jannah, Elok Faiqotul Karel Damayanti, Novita Khairil Anam, Khairil Kholifah, Siti Nurriyatul Kisdiati, Putri Yoggy Mayssa Kristijono, Ary Laila Fitria Lilla Puji Lestari LINGGAWAN, STEPHANI Lukman Hakim Margalin, Brilliant Maulana, Nabilah Rosdiana Melinda, Selvina Dwi Merlina, Diana Mey Miftahul Jannah Miftakhul Huda Muadifah , Afidatul Muadifah, Afidatul Muhammad Aziz Munandar, David Khalik Arrafi Muzakiyah, Nur Aini Nuardani, Hanifah Delima NURUL AZIZAH Oktaviani, Galuh Anggun Patricia, Gaby Ayu Pradana, Muhammad Sungging Pratama, Agung Firman Priambodo, Sigit Putra, Bayu Charisma Putri, Intan Syahrani RAHARJO, BUDIONO Rahma Diyan Martha Rahmatullah, Ilham Ramadani, Ade Ramadhina, Amanda Putri Ramadhini, Ananda Putri Rifqiyah, Jazilatur Rini, Yenny Puspa Rivaldo, M Ario Rizki Amalia, Laily Rodli, Achmad Fathoni Rosidin, Mochammad Khoirul Salsabila, Nabila Putri Saputra, Ahmad Bayu Saputra, Ifan Dwi Sari, Renny Nirwana Sari, Yuke Pramudita Savitri , Lisa Sembilu, Nambi Setiawan Setiawan Sowe, Momodou Salieu Sukmawati , Datin An Nisa Sungging Pradana, Muhammad Tilarso, Dara Pranidya Tria , Novitasari Valenata, Valenata Wahyu Ningtias, Titis Wijayanti, Cicik Winarti, Siti Sri WULAN PURNAMASARI, WULAN Yanto, Fauzan Tri Yucha, Nikma Yuliantari, Sonia Devi Yusmiati, Siti Nur Husnul