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All Journal Jurnal Ilmu Pertanian Indonesia Jurnal Riset Kesehatan Biology, Medicine, & Natural Product Chemistry Majalah Obat Tradisional Jurnal Surya Medika Jurnal Ilmu Kedokteran dan Kesehatan PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Ilmu Kefarmasian Indonesia Journal of Experimental and Clinical Pharmacy (JECP) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Pengabdian Ilung (Inovasi Lahan Basah Unggul) JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Pharmaceutical Sciences and Research (PSR) Jurnal Farmasi Indonesia Barigas: Jurnal Riset Mahasiswa
Elsa Trinovita
Department Of Pharmacotherapy, Faculty Of Medicine, University Of Palangka Raya, Palangka Raya, Central Kalimantan
Agriculture, Biological Sciences & Forestry Arts Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Evaluation of the combination patch of betel leaf extract (Piper sp.) - ultrasonic assisted extraction as a transdermal delivery system on fibroblast cell formation and collagen density Valencia, Regina; Trinovita, Elsa; Shinta, Herlina Eka; Toemon, Angeline Novia; Ysrafil, Ysrafil
JURNAL ILMU KEFARMASIAN INDONESIA Vol 23 No 1 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i2.1687

Abstract

The combination of red betel (Piper crocatum) and green betel (Piper betle L.) leaves is believed to act synergistically in enhancing wound healing. Transdermal patches offer advantages over conventional topical forms due to their sustained drug release, ease of application, and prolonged therapeutic effect. This study evaluated the histopathological effects of a combination patch containing betel leaf extracts for incision wound treatment in Wistar rats. The studies used an true experimental post-test-only control group design, five groups were tested: a blank patch (K−), a povidone-iodine patch (K+), and combination extract patches at concentrations of 7.5% (K1), 15% (K2), and 30% (K3), applied over 14 days with six animals per group. Patch characteristics were assessed through organoleptic tests, thickness, weight uniformity, folding endurance, and pH, while wound healing was evaluated through histological analysis of fibroblast cell counts and collagen density. Statistical analysis was conducted using the Kruskal-Wallis test followed by Mann-Whitney post-hoc tests. The 30% combination patch (K3) showed the most significant healing effect, with fibroblast counts exceeding 50 cells and dense collagen formation scoring +3. These results indicate that a transdermal patch combining Piper crocatum and Piper betle L. extracts effectively promotes wound healing by enhancing fibroblast proliferation and collagen synthesis.
Uji Aktivitas Antibakteri Herba Meniran (Phyllanthus niruri Linn) Terhadap Bakteri Propionibacterium acnes dan Staphylococcus epidermidis Saputra, Aldi Aditya; Hanasia, Hanasia; Fatmaria, Fatmaria; Martani, Natalia Sri; Trinovita, Elsa
Jurnal Ilmu Kedokteran dan Kesehatan Vol 12, No 6 (2025): Volume 12 Nomor 6
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

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Abstract

Jerawat merupakan infeksi kulit yang sering berlangsung terutama pada wajah, dikarenakan bakteri Propionibacterium acnes juga Staphylococcus epidermidis. Jerawat umumnya diobati dengan antibiotik, tetapi resistensi antibiotik mampu mengakibatkan infeksi yang lebih serius dan sulit disembuhkan. Meniran ialah tanaman herbal berpotensi jadi obat karena dapat menghasilkan metabolit sekunder yang bersifat antibakteri. Penelitian ini tujuannya membuktikan bahwa ekstrak herba meniran (Phyllanthus niruri Linn.) dapat menghalangi perkembangan Propionibacterium acnes dan Staphylococcus epidermidis secara in vitrodan mengetahui konsentrasi efektif terhadap Propionibacterium acnes juga Staphylococcus epidermidis. Ekstrak herba meniran di ekstraksi menggunakan Ultrasonic-assisted extraction (UAE) memanfaatkan pelarut etanol 96%. Ekstrak dibuat menjadi beberapa konsentrasi 5%, 25%, 50%, 75%, 100% dengan aquadest jadi kontrol negatif juga doksisiklin jadi kontrol positif. Uji antibakteri dilaksanakan menggunakan metode difusi cakram. Ekstrak herba meniran (Phyllanthus niruri Linn.) menghalangi pertumbuhan bakteri Propionibacterium acnes pada konsentrasi 50%, 75%, dan 100%. Staphylococcus epidermidis pada seluruh konsntrasi. Konsentrasi efektif Propionibacterium acnes pada konsentrasi 50% dan Staphylococcus epidermidis pada konsentrasi 5%.
Gastroprotective Potential of Medicinal Plant From Central Kalimantan: Sungkai Leaves (Peronema canescens Jack)-Ultrasonic Assisted Extraction in Rats Induced with Absolute Ethanol Savitri, Dilasari; Trinovita, Elsa; Widayati, Ratna; Handayani, Septi; Nugrahini, Sintha
Pharmaceutical Sciences and Research Vol. 12, No. 1
Publisher : UI Scholars Hub

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Abstract

Peptic ulcer disease is a gastrointestinal disorder associated with significant morbidity and mortality. Enhancing the quality of life of patients with peptic ulcers often involves integrating conventional treatments with complementary alternative therapies. One such alternative therapy is herbal remedies, which local communities have long recognized. Sungkai leaves (Peronema canescens Jack) contain various bioactive components, including flavonoids, alkaloids, saponins, tannins, steroids, and phenolic compounds. This study aimed to assess the gastroprotective properties of sungkai leaf extract (Peronema canescens Jack) by analyzing the average size of gastric lesions in male Wistar rats exposed to absolute ethanol. The research used a true experimental design with a posttest-only control group approach involving six treatment groups, each consisting of four rats. Gastroprotective activity was macroscopically evaluated by measuring the average size of the gastric lesions. Statistical analyses were conducted using the Kruskal-Wallis and Mann-Whitney tests for post hoc comparisons. Results showed that the normal group had an average lesion size of 0 mm, the negative control group had 115.37±50.53 mm, and the positive control group had 7.40±2.57 mm. For the groups treated with sungkai leaf extract, the 100 mg/kgBW dose resulted in 6.86±3.83 mm lesions, the 200 mg/kgBW dose in 9.65±10.27 mm, and the 400 mg/kgBW dose in 29.50±19.68 mm. Statistical analysis using SPSS 26 revealed a significant difference between the groups,with a Kruskal-Wallis test result of p=0.002. These findings show that sungkai leaf extract exhibits gastroprotective activity compared with omeprazole, as seen by the smaller average size of gastric lesions in male Wistar rats treated with absolute ethanol.
The Antivirulence Mechanisms of Phytate Against Pathogenic Bacteria in Skin Infections Zhofiroh, Nabilatul; Praja, Rian Ka; Trinovita, Elsa; Ysrafil, Ysrafil; Surbakti, Ranintha BR
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.731-738

Abstract

Skin infections caused by the bacteria Staphylococcus aureus, Streptococcus pyogenes, and Propionibacterium acnes are often a common health problem. One treatment is antibiotics, but the cases of antibiotic resistance are increasing. Thus, new treatment alternatives are needed. This study aimed to analyze the molecular mechanism of phytate antivirulence against pathogenic bacteria of skin infection. This study used a bioinformatics approach involving analysis of phytate interactions with bacterial virulent proteins via STITCH, functional classification of proteins with VICMpred, and prediction of virulence properties using VirulentPred. B-cell and MHC epitopes were analyzed using IEDB, while protein subcellular location was determined through PSORTb. The results showed that phytate interacted specifically with virulent proteins in all three bacteria, most of which functioned in cellular and metabolic processes. These virulent proteins also have immunologically relevant epitopes. Subcellular location analysis showed that phytate protein targets were dispersed in the cytoplasmic membrane and cytoplasm. These findings indicated that phytate has a significant antivirulence mechanism by targeting virulent proteins of skin pathogenic bacteria, thus potentially becoming a therapeutic agent to treat skin infections while reducing antibiotic resistance.
Efektivitas Antibakteri Krim Ekstrak Daun Sirih Merah (Piper crocatum) Terhadap Beberapa Bakteri Renaldy, Renaldy; Trinovita, Elsa; Furtuna, Dewi Klarita; Fatmaria, Fatmaria; Turnip, Oktaviani Naulita
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 17 No. 1 (2025): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v17i1.264

Abstract

The prevalence of infectious diseases is increasing in developing countries such as Indonesia, and they have become a health problem. One infectious disease caused by Staphylococcus aureus and Escherichia coli bacteria is necrotizing fasciitis. The subcutaneous tissues and fascia necrosis characterize necrotizing fasciitis. Antibiotic therapy is one way to prevent the growth and development of bacteria, but continuous use can cause resistance to bacteria. This research aimed to determine the antibacterial effectiveness of red betel leaf extract in cream preparations against the growth activity of Staphylococcus aureus and Escherichia coli bacteria using the ditch plate method. Red betel leaves were extracted using the UAE method (temperature 600 C for 15 minutes), then made into a cream dosage form with a formulation of 20% extract concentration (F1), 40% extract concentration (F2), and 80% extract concentration (F3) then tested evaluation of cream preparations and antibacterial activity test using the ditch plate method. The extraction of red betel leaves used the UAE method in concentrations of 20%(F1), concentrations of 40%(F2), and concentrations of 80% (F3) in cream preparation form. The cream was evaluated, and antibacterial activity was tested using the ditch plate method. The red betel leaf extract cream inhibits Staphylococcus aureus growth by the ditch plate method but does not have antibacterial activity on Escherichia coli.
Pengaruh Fraksi Metanol Ekstrak Saluang Belum (Luvunga Sarmentosa) Terhadap Motilitas Spermatozoa In Vitro: Effect of Methanolic Fraction of Beginning Salunag Extract (Luvunga Sarmentosa) on Spermatozoa Motility In Vitro Tasya, Tasya; Permatasari, Silvani; Fadhiyatulqalbi Ahmad, Farah Fauziyah; Handayani, Septi; Trinovita, Elsa
Jurnal Surya Medika (JSM) Vol. 10 No. 2 (2024): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v10i2.6220

Abstract

Salah satu penyebab infertilitas adalah penurunan kualitas sperma yang disebabkan oleh stress oksidatif. Pemberian antioksidan eksogen yang didapatkan dari akar saluang belum (Luvunga sarmentosa) dapat menurunkan stres oksidatif. Penelitian terkait bioaktivitas Luvunga sarmentosa terhadap motilitas spermatozoa in vitro masih terbatas. Untuk mengetahui pengaruh fraksi metanol ekstrak akar saluang belum terhadap motilitas spermatozoa secara in vitro dan konsentrasi efektif untuk meningkatkan motilitas spermatozoa. Sampel yang digunakan adalah spermatozoa manusia in vitro sebanyak 15 sampel yang dicuci dan ditambahkan medium BWW (Biggers, Whitten, and Whittingham) kemudian diinkubasi pada suhu 37℃ selama 1 jam dengan fraksi methanol ekstrak akar Saluang Belum dengan konsentrasi 100, 500, 1000, 5000 ng/ml serta kelompok kontrol (BWW). Selanjutnya, dilakukan pemeriksaan di mikroskop untuk melihat gerak motilitas spermatozoa. Hasil penelitian menunjukkan bahwa fraksi metanol ekstrak akar Luvunga sarmentosa mengandung senyawa seperti alkaloid, amino acid, phenylpropanoid, dan terpenoid. Motilitas spermatozoa meningkat secara signifikan pada konsentrasi 100, 500, 1000 dan 5000 ng/mL dan kelompok kontrol. Fraksi metanol akar Luvunga sarmentosa efektif pada konsentrasi 100 ng/mL.. Fraksi metanol akar saluang belum Luvunga Sarmentosa meningkatkan motilitas spermatozoa. Fraksi metanol, saluang belum, motilitas spermatozoa.
Co-Authors Agnes Frethernety Agnes Frethernety Agnes Frethernety Alexandra, Francisca Diana Amelia, Rosa Angeline Novia Toemon Angeline Novia Toemon, Angeline Novia Anna Marthea Veronica Arif Rahman Jabal Astri Widiarti Augustina, Indria Clarissa Ester Diana Putri Dewi Klarita Furtuna Dian Mutiasari, Dian Egi Claudia Pratiwi Elma, Pransiska Ervi Audina Munthe Fadhiyatulqalbi Ahmad, Farah Fauziyah Fatmaria Fatmaria Fatmaria Fatmaria Fatmaria Fatmaria Fatmaria Fatmaria, Fatmaria Fiska, Friskilla Andia Francisca Diana Alexandra Francisca Diana Alexandra Frethernety, Agnes Furtuna, Dewi Klarita Galih Indra Permana Hanasia, Hanasia Handayani, Septi Hasnawati Hasnawati Immanuela Toemon, Agnes Indria Augustina Jesika, Debora Lelia Pebriani Mikko Uriamapas Ludjen Muhammad Noer Perdana Sakti Widodo Muntir Guru Singa Natalia Sri Martani Ni Nyoman Sri Yuliani Ni Nyoman Sri Yuliani Nugrahini, Sintha Patricia, Tisha Permatasari, Silvani Pratama, Daniel Ari Ranintha br Surbakti Ranti, Dalia Ratna Widayati Ratna Widayati Renaldy, Renaldy Rian Ka Praja Saputra, Aldi Aditya Savitri, Dilasari Silvani Permatasari Tasya, Tasya Toemon, Agnes Immanuela Triawanti Triawanti Trilianty Lestarisa Turnip, Oktaviani Naulita Valencia, Regina Widayati, Ratna Widiarti, Astri Ysrafil, Ysrafil Yudi Y Ambeng Zhofiroh, Nabilatul