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Stability Study Of Paracetamol Drops Mixed With Date Juice Concentrate During 24 Hours Of Storage Under Room Temperature (≤30 °C) And Refrigerated Temperature (2–8 °C) Patihul Husni; Rina Haryani; Ginayanti Hadisoebroto; Norisca Aliza Putriana; Mikhania Christiningtyas Eryani
JURNAL FARMASI GALENIKA Vol 13 No 2 (2026): August 2026
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v13i2.463

Abstract

Parents occasionally mix paracetamol drops with date juice concentrate before administration a paracetamol drops to children to mask the bitter taste of the paracetamol. Such a practice may result in interactions between paracetamol and the chemical constituents present in date juice concentrate, potentially affecting the drug's stability. This study aimed to evaluate the stability of paracetamol concentration in paracetamol drops after being mixed with date juice concentrate under different storage conditions. Paracetamol drops were mixed with date juice concentrate and stored at room temperature (≤30°C) and refrigerated conditions (2–8°C). Organoleptic properties and paracetamol concentration were evaluated at 0, 5, 10, 15, 20, 30, 45, 60, 120, 180, and 1440 minutes using UV–Visible spectrophotometer. The organoleptic evaluation demonstrated that the mixture remained stable as a dark brown liquid with the characteristic odor for up to 24 hours under both storage conditions. Results showed a decrease in paracetamol concentration during 24 hours of storage; however, because the study did not include a paracetamol-only control group, this decrease cannot be definitively attributed to date juice concentrate, and the interpretation should therefore be limited to the observed change in paracetamol concentration in the mixture during storage. Under room temperature and refrigerated conditions, the remaining paracetamol concentrations after 24 hours were 43.291 ± 0.437% and 38.527 ± 0.019%, respectively. Statistical analysis indicated no significant difference in the reduction of paracetamol concentration between the two storage conditions. In conclusion, mixing of paracetamol drops with foods or beverages, such as date juice concentrate, may affect paracetamol stability and can cause reducing of paracetamol concentration.
PENGARUH VARIASI KONSENTRASI HPMC TERHADAP SIFAT FISIK GEL EKSTRAK KULIT PISANG AGUNG SEMERU (Musa paradisiaca L.) Mikhania Christiningtyas Eryani; Hadi Barru Hakam Fajar Siddiq; Dewi Rashati; Risma Khoiro Safitri
Jurnal Riset Kefarmasian Indonesia Vol. 5 No. 1 (2023): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v5i1.320

Abstract

The aims of this study was to determine the effect of HPMC variation concentration to the physical properties of Semeru Agung banana (Musa paradisiaca L.) skin extract gel. Gel was formulated with various HPMC concentration namely F1 (2%), F2 (3%) and F3 (4%). Gel was evaluated organoleptic, homogeinity, pH, viscosity, spreadbility and adhesion value. The results showed that F2 meet the organoleptic requirements while F1 and F3 did not meet. All formulas are homogeneous. The results of the pH test showed that the pH value of F1 was 5.9 ± 0; F2 of 5.8± 0 ; F3 of 5.9 ± 0. The results of the viscosity test showed that the viscosity value of F1 was 150 ± 0 dPas; F2 of 250 ± 0 dPas; F3 of 300 ± 0 dPas. The results of the dispersion test showed that the dispersion value of F1 was 5.6 ± 0.06 cm; F2 of 5.3 ± 0.29 cm ; F3 is 4.0 ± 0.12 cm. The results of the adhesion test showed that the value of the F1 adhesiveness was 11.04 ± 0.43 seconds; F2 of 17.4 ± 1.47 seconds; F3 is 24.2 ± 2.44 seconds. It is known that variations in HPMC concentration affect gel texture, viscosity, spreadability and adhesion, and have no effect on gel smell, color and pH.
Co-Authors AA Sudharmawan, AA Adelia Firandi Adi Prayitno Adifa, Wildan Hanifatul Aditama, Agnis Agnis Pondineka Ria Aditama Amaliyah Nurul Hidayah Ameliana, Lidya Anies Rohman anies Rohman Dwijayanti Ardian Baitariza, Ardian Asa Falahi Asa Falahi Asa Falahi Asa Falahi Ayuk Lestari Ayuning Trias, Diah Azizah Azizah Azizah Azizah Azizah, Fatiya Balqis, Aura Inzalna Barikah, Kuni Zu’aimah Budianto, Muhamad Oke Budipratiwi Wisudyaningsih Choiroh, Afifahtul Claudia Fortunata, Florensia Grace Denok Risky Ayu Paramita Dewi Isadiartuti Dewi Rashati Dewi Rashati Dewi Riskha Nurmalasari Dinar Rizqika Fauza Dyan Maulani Eka Deddy Irawan Eka Yulia Agustin Erika Herawati, Irma Fachry Abda El Rahman Faisal Akhmal Muslikh Hadi Barru Hakam Fajar Siddiq Hadisoebroto, Ginayanti Hanif, Mohammad Ainul Fakhruddin Helmy Yusuf Hery Diar Febryanto Hery Febrianto Ika Norcahyanti Januarti, Melinda Judy Handojo, Kukuh Kukuh Judy Handojo Kuni Barikah Kusumawardani, Arine Giovani Lestari, Tirtawati Putri Lina Winarti Lubis, Maralodia Almira Lusia Oktora Ruma Kumala Sari Mardani, Alya Eka Dhyra Mayang Kusuma Dewi Melinda Januarti Muhammad Asrofi, Muhammad Muthi'atul, Bannan Muzayanah, Arifatul Nina Wijiani Nina Wijiani Ningsih, Anita Dwi Rahayu Noer Layla Fitri Ani Norisca Aliza Putriana Nur Patihul Patihul Husni Permatasari, Lina Putri perwita, tista rashati Dewi Rashati, Dewi Rina Haryani Rini Silviya Risma Khoiro Safitri Ryad Alati Safitri, Manzil Saleh Wikarsa Sari, Lusia Siti Nur Azizah Siti Nur Azizah, Siti Nur Siti Rohmah Fadilah Soemirtapura, Yeyet Cahyati Suryaningsih, Farida Syuhuriah, Ainin Tanfidz Alishlah, Tanfidz Tasya, Pradiva Julias Tryani Sutisna Putri, Sussy Uswatul Hasanah Viddy Agustian Rosyidi Wahyuni, Ela Wardhani, Firdha Aprillia Yeyet Cahyati Soemirtapura Yudi Wicaksono Zulvania, Clarissa Najwa