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All Journal Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Journal of Food and Pharmaceutical Science Jurnal Ilmu Dasar Pharmaciana: Jurnal Kefarmasian Jurnal Florea Acta Pharmaceutica Indonesia Journal of Islamic Pharmacy Science and Technology Indonesia IDJP (Indonesian Journal of Pharmaceutics) Jurnal Biodjati Jurnal Informasi Kesehatan Indonesia (JIKI) JSFK (Jurnal Sains Farmasi & Klinis) Abdimas: Jurnal Pengabdian Masyarakat Universitas Merdeka Malang Jurnal Riset Kefarmasian Indonesia Abdimasku : Jurnal Pengabdian Masyarakat Borneo Journal Of Pharmascientech Medfarm: Jurnal Farmasi dan Kesehatan Jurnal Pengabdian UNDIKMA Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang Jurnal Ilmiah Farmasi Akademi Farmasi Jember Jurnal Ilmiah Farmasi Simplisia Journal of Food and Pharmaceutical Sciences Journal of Agropharmacy Jurnal Farmasi Galenika Sadewa: Jurnal Pengabdian Masyarakat
Eryani, Mikhania Christiningtyas
Bagian Farmasetika, Fakultas Farmasi Universitas Jember; Program Magister Farmasi, Fakultas Farmasi Universitas Jember
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Enhancing Photoprotective Performance of Sunscreen Lip Tint Through Factorial Design Optimization of Naringenin and Titanium Dioxide Eryani, Mikhania Christiningtyas; Azizah, Fatiya; Ameliana, Lidya; Sari, Lusia; Ryad Alati
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 11 No. 1 (2026)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v11i1.44130

Abstract

The sun emits various types of radiation, including ultraviolet (UV) radiation, which can damage skin structure, triggering premature aging, irritation, sunburn, and pigmentation disorders. Naringenin and titanium dioxide are known to have protective effects against UV radiation. This study aimed to evaluate the effects of naringenin and titanium dioxide concentrations and their interactions on the physical quality and in vitro sunscreen efficacy of lip tint formulations, and to determine the optimal formulation using Design-Expert software. This study is the first to optimize lip tint sunscreen using factorial design with naringenin and TiO₂.The results showed that the optimal formulation achieved an SPF of 38.23, %TE of 0.0562, and viscosity of 16,166 mPas at 2.1% naringenin and 10% titanium dioxide. Furthermore, higher concentrations of both active ingredients increased the SPF value and decreased the %TE and %TP values. Statistical analysis using a one-sample T-test showed no significant difference between the predicted and experimental results (p > 0.05), confirming the validity of the optimization model.
Crystal Engineering of Ibuprofen and Caffeine by Cocrystal Formation Using Solvent Evaporation and Slurry Methods Mikhania Christiningtyas Eryani; Yudi Wicaksono; Budipratiwi Wisudyaningsih; Kuni Barikah; Hery Febrianto
JSFK (Jurnal Sains Farmasi & Klinis) Vol 13 No 1 (2026): J Sains Farm Klin 13(1), April 2026
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.13.1.15-20.2026

Abstract

Ibuprofen is a pharmaceutical active compound used to treat mild to moderate pain and fever. However, ibuprofen has low solubility in water. One method to increase solubility is cocrystal formation. The ibuprofen cocrystal was prepared in this study using caffeine as a coformer at a 1:1 molar ratio via solvent evaporation and slurry methods. The results of the XRD and thermal analysis of the sample indicate that a new solid phase is formed in the specific sa mple, which is different from both of its constituent components. Morphologically, the resulting cocrystals show a change in shape from their constituent compounds as well as a change in size. The solubility test results show that cocrystal formation is able to increase the solubility of ibuprofen. The conclusion of this study is that ibuprofen cocrystals can be formed with the coformer caffeine at a molar ratio of 1:1 using the slurry method and solvent evaporation.
Potential of Lactic Acid Bacteria From Tape and Jember Tempeh as a Probiotic Candidate Siti Nur Azizah; Mikhania Christiningtyas Eryani; Azizah Azizah
Jurnal Biodjati Vol 6 No 2 (2021): November
Publisher : UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/biodjati.v6i2.12393

Abstract

Probiotics are microbes in fermented foods that have beneficial effects on health. Microbes that act as probiotics are lactic acid bacteria (LAB) that can produce metabolites such as lactic acid, hydrogen peroxide, and bacteriocins. This study aimed to obtain lactic acid bacterial isolates from tape and tempeh, and to test the potential of LAB as a probiotic candidate by activity test as an antidiarrhea and its resistance to gastric pH and bile salts. The fermentation products used as a source of LAB isolates are tempeh sumber mas merk, and yellow cassava tape, sari madu merk from Jember. The results of the first stage regarding the isolation of LAB using GYP media showed that there were 2 LAB isolates (TaJ.14 and TaJ.15) from the tape and 4 LAB isolates (TeJ.18, TeJ.22, TeJ.24, and TeJ.25) from tempeh. The results of the antidiarrheal test using the disc diffusion method (oxoid) showed that TaJ.14 and TaJ.15 isolates were able to inhibit Bacillus subtilis, Escherichia coli, and Shigella dysentriae, while TeJ.18, TeJ.22, TeJ.24, TeJ.25, and Lactobacillus casei (control) was only able to inhibit B. subtilis and E. coli. The results of LAB resistance to gastric pH showed that the TeJ.25 isolate had the highest percentage of pH 3 and 2.5 resistance (51.13 and 33.03%) compared to other isolates and controls. LAB resistance test results against bile salts (oxgal) showed that the TeJ.22 isolate had the highest percentage of resistance (75.10%) compared to other isolates although was still higher in control (75.99%).
BIJAK MENGGUNAKAN KOSMETIK DAN SUPLEMEN KESEHATAN rashati Dewi; Asa Falahi; anies Rohman Dwijayanti; Mikhania Christiningtyas Eryani
Jurnal SADEWA Vol 4 No 01 (2026): Sadewa: Jurnal Pengabdian Masyarakat
Publisher : LPPM Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/sadewa.v4i01.1096

Abstract

Teenagers are the next generation and the determining factor of the nation's future. The use of supplements and cosmetics is an important matter for teenagers to fulfill. The consumption of supplements by teenagers is a form of daily nutritional fulfillment activity. The use of cosmetics also attracts the attention of teenagers. The aim of this community service is to provide education on SMK Farmasi dr. Soebandi student to be wise in using cosmetics and health supplements. The method in this activity using explanation method and quantitative questionnaire data collection. This activity has a positive impact on increasing student knowledge also awareness of the importance of choosing and using cosmetics and supplements safely. That can be seen the increase pre-post test score from 63 to 80. Although the increase knowledge statistically is not significant, but this activity enhances participants understanding and encourages more rational consumer behavior.
Pengembangan Lotion Anti Nyamuk Ekstrak Daun Kenikir (Tagetes erecta L.) Dengan Variasi Konsentrasi Setil Alkohol Mikhania Christiningtyas Eryani; Dewi Rashati; Asa Falahi; Patihul Husni; Eka Yulia Agustin
JURNAL FARMASI GALENIKA Vol 13 No 1 (2026): Jurnal Farmasi Galenika Volume 13 No 1
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v13i1.423

Abstract

The use of chemical-based mosquito repellents has excellent repellent power, but their use can cause hypersensitivity and irritation. In Indonesia, there are several plants that contain essential oils and have mosquito repellent effects. One of them is cosmos (Tagetes erecta L). Cosmos leaf extract is formulated into a lotion preparation so that it can adhere to the skin for a longer time, thus providing longer-lasting mosquito repellent properties. This research aims to determine the effect of varying cetyl alcohol concentrations on the physical properties of lotion. There are 3 lotion formulas used with cetyl alcohol concentrations of 2% (F1), 2.5% (F2), and 3% (F3). The research results show that F1 has a thick texture and brownish-yellow color, F2 has a thick texture and green color, and F3 has a very thick texture and green color. All formulas are homogeneous. F1, F2, and F3 had pH values of 7.5±0, 7.5±0, and 7.9±0, respectively. F1, F2, and F3 have respective viscosities of 20±0 dPas, 30±0 dPas, and 35±0 dPas. F1, F2, and F3 had spreadability values of 8.48±0.51 cm, 7.81±0.05 cm, and 7.10±0.37 cm, respectively. The conclusion of this study is that variations in cetyl alcohol concentration affect the texture, color, pH, viscosity, and spreadability of the lotion.
Pengaruh Variasi Konsentrasi Cocamidopropyl Betaine Pada Karakteristik Fisik Sampo Ekstrak Kering Teh Hijau Patihul Husni; Rini Silviya; Uswatul Hasanah; Mikhania Christiningtyas Eryani; Mayang Kusuma Dewi; Norisca Aliza Putriana; Melinda Januarti
JURNAL FARMASI GALENIKA Vol 13 No 1 (2026): Jurnal Farmasi Galenika Volume 13 No 1
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v13i1.435

Abstract

Hair growth–promoting preparations are used to prevent hair damage problems. Compounds contained in green tea extract have activity as hair growth promoters. This study aimed to obtain data on the effect of variations in cocamidopropyl betaine concentration on the physical characteristics of shampoo containing dry green tea extract. The formulations were prepared in three formulas (F1, F2, and F3) containing different concentrations of cocamidopropyl betaine (8.25%, 8.5%, and 8.75%). The research stages included formulation followed by physical evaluation, including organoleptic properties, homogeneity, pH, viscosity, and foam stability. The results showed that the shampoo preparations were viscous liquids, brown in color, with a characteristic odor, pH of 7–8, viscosity of 250–300 cPs, and foam stability of 15–20 cm. The conclusion of this study is that variations in cocamidopropyl betaine concentration affect the physical characteristics of shampoo containing dry green tea extract. The concentration of cocamidopropyl betaine greatly influences the physical stability of the shampoo, with F3 as the best formula based on physical evaluation, which contains 8.75% cocamidopropyl betaine.
Formulation Study of Acetosal Suppositories Using PEG 400 and PEG 6000: Impact on Physical Properties Dewi Rashati; Dinar Rizqika Fauza; Mikhania Christiningtyas Eryani; Asa Falahi; Anies Rohman
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 15 No 1 (2026): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v15i1.754

Abstract

Acetosal suppositories are rectal dosage forms that can be used as an alternative route of administration to minimize gastrointestinal irritation associated with oral acetosal therapy. The suppository base plays an important role in determining the physical characteristics of the preparation. The objective of this study was to evaluate how varying concentrations of polyethylene glycol (PEG) 400 and PEG 6000 affect the physical properties of acetosal suppository formulations. Three formulations were prepared using PEG 400:PEG 6000 ratios of F1 (3:7), F2 (1:1), and F3 (7:3). Physical evaluations included organoleptic properties, weight uniformity, melting time, melting point, and hardness. All formulations exhibited similar organoleptic characteristics, namely solid shape, pale white color, and characteristic odor. The average weight uniformity values were 2594.3 ± 61.9 mg (F1), 2526.9 ± 83.1 mg (F2), and 2315.7 ± 45.4 mg (F3), with significant differences among formulations (p<0.05). The average melting times were 25.1 ± 0.981 min, 19.5 ± 0.574 min, and 15.9 ± 0.508 min for F1, F2, and F3, respectively (p<0.05). The average melting points were 36.3 ± 0.577°C, 35.7 ± 0.577°C, and 34.3 ± 0.577°C for F1, F2, and F3, respectively (p=0.014). Hardness values were 1.93 ± 0.115 kg (F1), 1.87 ± 0.115 kg (F2), and 1.53 ± 0.115 kg (F3), with significant differences among formulations (p<0,05). In conclusion, variations in PEG 400 and PEG 6000 concentrations significantly affected weight uniformity, melting time, melting point, and hardness, while organoleptic properties remained unchanged. Formulations F1 and F2 fulfilled all physical quality requirements and were considered optimal. Keywords: Acetosal, suppositories, PEG 400, PEG 6000
Duck Egg Shell and Bay Leaf Extracts (Syzygium polyanthum [Wight] Walp.) Toothpaste Development Using Sodium CMC as a Binder ERYANI, MIKHANIA; perwita, tista; aditama, agnis; rashati, dewi; husni, patihul; wijiani, nina
Pharmaceutical Journal of Indonesia Vol. 11 No. 2 (2026)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/

Abstract

Background: Toothpaste is a semi-solid preparation that helps shield teeth from bacterial harm by including abrasive compounds and other helpful elements. Duck eggshells are one of the natural materials that contain calcium carbonate as an abrasive, while bay leaves are a plant that hassantibacterial properties. Objectives: This study aims to formulate duck egg shell toothpaste and bay leaf extract (Syzygium polyanthum [Wight] Walp.) with sodium CMC variation concentrations. Methods: toothpaste is formulated with variation CMC concentration are 3% for F1; 4.5% for F2; and 6% for F3 and evaluate its physical properties. The physical properties tests conducted included organoleptic tests, homogeneity, pH, viscosity, spreadability, and foam height. Results: From the research results, there is an effect of varying sodium CMC concentrations on the physical properties of pH, viscosity, spreadability, and foam height, but no effect of varying sodium CMC concentrations on the organoleptic and homogeneity properties. Conclusions: The research indicate that all formulas meet the requirements for the physical property tests of duck egg shell toothpaste and bay leaf extract.
Formulation and Characterization of Curcumin Micellar Powder Sublingual Tablets Nina Wijiani; Helmy Yusuf; Dewi Isadiartuti; Mikhania Christiningtyas Eryani
Journal of Food and Pharmaceutical Sciences Vol 14, No 4 (2026): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.28325

Abstract

Curcumin is the most active compound contained in turmeric rhizome (Curcuma longa). Curcumin has low solubility in water, which affects its bioavailability. Efforts to increase curcumin solubility are made in micelle systems. However, micelle solutions have the short shelf life, so they need to be to be converted to dry micelle powder by spray drying. Curcumin micelle powder was formulated into sublingual tablets to provide a convenient dosage form, which may improve patient compliance due to ease of administration and avoidance of swallowing difficulties. This study aims to manufacture sublingual tablets containing curcumin micelles prepared with varying concentrations of sucrose and casein and to characterize them. Tablets were prepared by direct compression method. Tablet characterization carried out included tablet hardness, tablet friability, tablet disintegration time, and dissolution. The results showed that all formulas met the requirements for hardness, friability, disintegration time, and dissolution. This study concludes that variations in casein and sucrose concentrations affect the friability, disintegration time, and dissolution of sublingual tablets but do not affect tablet hardness.
Formulation and Characterization of Curcumin Micellar Powder Sublingual Tablets Nina Wijiani; Helmy Yusuf; Dewi Isadiartuti; Mikhania Christiningtyas Eryani
Journal of Food and Pharmaceutical Sciences Vol 14, No 4 (2026): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.28325

Abstract

Curcumin is the most active compound contained in turmeric rhizome (Curcuma longa). Curcumin has low solubility in water, which affects its bioavailability. Efforts to increase curcumin solubility are made in micelle systems. However, micelle solutions have the short shelf life, so they need to be to be converted to dry micelle powder by spray drying. Curcumin micelle powder was formulated into sublingual tablets to provide a convenient dosage form, which may improve patient compliance due to ease of administration and avoidance of swallowing difficulties. This study aims to manufacture sublingual tablets containing curcumin micelles prepared with varying concentrations of sucrose and casein and to characterize them. Tablets were prepared by direct compression method. Tablet characterization carried out included tablet hardness, tablet friability, tablet disintegration time, and dissolution. The results showed that all formulas met the requirements for hardness, friability, disintegration time, and dissolution. This study concludes that variations in casein and sucrose concentrations affect the friability, disintegration time, and dissolution of sublingual tablets but do not affect tablet hardness.
Co-Authors AA Sudharmawan, AA Adelia Firandi Adi Prayitno Adifa, Wildan Hanifatul Aditama, Agnis Agnis Pondineka Ria Aditama Amaliyah Nurul Hidayah Ameliana, Lidya Anies Rohman anies Rohman Dwijayanti Ardian Baitariza, Ardian Asa Falahi Asa Falahi Asa Falahi Asa Falahi Ayuk Lestari Ayuning Trias, Diah Azizah Azizah Azizah Azizah Azizah, Fatiya Balqis, Aura Inzalna Barikah, Kuni Zu’aimah Budianto, Muhamad Oke Budipratiwi Wisudyaningsih Choiroh, Afifahtul Claudia Fortunata, Florensia Grace Denok Risky Ayu Paramita Dewi Isadiartuti Dewi Rashati Dewi Rashati Dewi Riskha Nurmalasari Dinar Rizqika Fauza Dyan Maulani Eka Deddy Irawan Eka Yulia Agustin Erika Herawati, Irma Fachry Abda El Rahman Faisal Akhmal Muslikh Hadi Barru Hakam Fajar Siddiq Hadisoebroto, Ginayanti Hanif, Mohammad Ainul Fakhruddin Helmy Yusuf Hery Diar Febryanto Hery Febrianto Ika Norcahyanti Januarti, Melinda Judy Handojo, Kukuh Kukuh Judy Handojo Kuni Barikah Kusumawardani, Arine Giovani Lestari, Tirtawati Putri Lina Winarti Lubis, Maralodia Almira Lusia Oktora Ruma Kumala Sari Mardani, Alya Eka Dhyra Mayang Kusuma Dewi Melinda Januarti Muhammad Asrofi, Muhammad Muthi'atul, Bannan Muzayanah, Arifatul Nina Wijiani Nina Wijiani Ningsih, Anita Dwi Rahayu Noer Layla Fitri Ani Norisca Aliza Putriana Nur Patihul Patihul Husni Permatasari, Lina Putri perwita, tista rashati Dewi Rashati, Dewi Rina Haryani Rini Silviya Risma Khoiro Safitri Ryad Alati Safitri, Manzil Saleh Wikarsa Sari, Lusia Siti Nur Azizah Siti Nur Azizah, Siti Nur Siti Rohmah Fadilah Soemirtapura, Yeyet Cahyati Suryaningsih, Farida Syuhuriah, Ainin Tanfidz Alishlah, Tanfidz Tasya, Pradiva Julias Tryani Sutisna Putri, Sussy Uswatul Hasanah Viddy Agustian Rosyidi Wahyuni, Ela Wardhani, Firdha Aprillia Yeyet Cahyati Soemirtapura Yudi Wicaksono Zulvania, Clarissa Najwa