Article Per Year (5 Year)
p-Index From 2021 - 2026
2.422
P-Index
This Author published in this journals
All Journal Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Fitofarmaka Indonesia Jurnal Penelitian Kesehatan Suara Forikes Jurnal Farmasi Indonesia Jurnal Aisyah : Jurnal Ilmu Kesehatan Open Access Indonesian Journal of Medical Reviews Archives of The Medicine and Case Reports Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Etnofarmasi Journal of Health Management and Pharmacy Exploration (JOHMPE) International Journal of Global Sustainable Research Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Pharma Bhakta
R, Herowati
Fakultas Farmasi Universitas Setia Budi Jl. Let. Jend. Soetoyo, Mojosongo, Surakarta.
Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Veterinary Other

Published : 17 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 17 Documents
Search

 1   2 
Differences in drug availability levels before and during the covid19 pandemic in the pharmaceutical installation of NTB provincial hospital Wisnu, M. Ari; Herowati, Rina; Harsono, Samuel Budi
Journal of Health Management and Pharmacy Exploration Vol. 2 No. 1 (2024): February 2024
Publisher : Surya Hijau Manfaat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52465/johmpe.v2i1.192

Abstract

Health services are now increasingly needed during the COVID-19 pandemic which threatens public health. The need for public medicines that must be available such as flu, cough, vitamin c, antibiotics and antimalarials and antivirals for health services makes hospitals must try to fulfil and currently the COVID-19 pandemic situation is still continuing so hospitals must be ready to provide health services to patients.This study aims to determine the differences in drugs in the Pharmacy Installation of the NTB Provincial Hospital before the COVID-19 pandemic in 2019 and during the COVID-19 pandemic in 2020. This study is a descriptive-evaluative study with retrospective data collection in 2019 which represents the period before the COVID-19 pandemic and 2020 which represents the COVID-19 pandemic. The samples used in the study consisted of drug data from the Pharmacy Installation of the NTB Province Regional General Hospital (RSUD) and were analyzed using the Wilcoxon test. The results obtained are the level of drug availability in the pharmaceutical installation of the NTB Provincial Hospital obtained based on the results of observing data in 2019 and 2020, namely 19 and 37 months. There is a significant difference (Asymp. Sig (2-tailed) 0.000) the level of drug availability in the Pharmacy Installation of the NTB Provincial Hospital before and during the COVID-19 pandemic in 2020 with a difference of 18 months.
Molecular Docking and Pharmacokinetic Studies of Moringa oleifera As Angiotensin-Converting Enzyme Inhibitors Hasan, Rahmawaty; Herowati, Rina
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 11 No. 1 (2024): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v11i12024.80-88

Abstract

Background: Hypertension in pregnancy is a vascular disorder that occurs before pregnancy or arises during pregnancy that there were 30% of cases of maternal death. Moringa oleifera's potential to lower blood pressure can be utilized as an alternative antihypertensive during pregnancy, minimizing the risk of preeclampsia. Objective: The purpose of this study was to determine the molecular target of Moringa oleifera is intended to optimize pharmacodynamic activity based on the interaction pattern of the compounds with the ACE inhibitor (PDB ID: 1O86). Methods: Molecular docking is carried out using Autodock 4.0 program (AutoDock Tools). Results: According to the binding energy value and ACE inhibitory interaction, a-Rhamnopyranosyl, b-Sitosterol, and Sinalbin are prospective Moringa oleifera compounds as alternative antihypertensive. These potential compounds can inhibit ACE with binding energy -8.23; -9.27; -9.14 kcal/mol. Pharmacokinetic predictions reported that the potential compounds are absorbed in the intestine and indicates as molecules are tightly bound to plasma proteins and, as well as CYP3A4 and CYP2C9 inhibitors. The prediction of toxicity indicates that the potential compounds are classified as drug-induced acute liver failure with low carcinogens. Conclusion: a-Rhamnopyranosyl, b-Sitosterol and Sinalbin can be suitable lead compounds for synthetic drugs for antihypertensive agents.
Aktivitas Gastroprotektif Kombinasi Madu Dan Virgin Coconut Oil (Cocos nucifera) Pada Model Tikus Tukak Lambung Widyastuti, Lita; Herowati, Rina; Ariawan, M Wahyu; Purwidyaningrum, Ika
Jurnal Fitofarmaka Indonesia Vol 11, No 1 (2024): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v11i1.1064

Abstract

Gastric ulcers are damage that occurs to the mucosal tissue, submucosa and the muscle layer of the stomach, this condition is caused by hypersecretion of stomach acid. The substance content of VCO has a gastroprotective effect because it includes flavonoid compounds, phenols, catalase, ascorbic acid, and vitamin E, while VCO includes octanoic acid, δ-Octalactone, dodecanoic acid, δ-Decalactone, acetic acid. The aim of this research is to understand the gastroprotective activity resulting from giving a combination of honey and VCO to aspirin-induced rats. Honey and VCO in single administration include one dose, namely 14 ml/kgBW honey and 10 ml/kgBW VCO, while in combination treatment three doses are given, namely 10.5; 7; 3.5 ml/kgBB honey and 7.5; 5; 2.5 ml/kgBB VCO. Then in the combined treatment, 5 variations of doses were given, namely honey and VCO (7:7.5); (7:5); (7:2.5); (10.5:5); (3.5:5) ml/kgBB. TNFα levels before being induced by aspirin, after being induced by aspirin, after honey and VCO therapy, and macroscopic observations on a single treatment showed that administration of honey and VCO at doses of 10.5 ml/kgBW and 5 ml/kgBW showed a gastroprotective effect compared to other doses. Then, in histopathological testing, doses with gastroprotective effects can restore mucosal cell cohesion which has been previously damaged due to erosion. The combination of honey and VCO showed gastroprotective results at a dose of 10.5 ml/kgBB honey and 5 ml/kgBB VCO.
Network Pharmacology Approach to Acalypha indica L. and Plumbago zeylanica L. As Anti-Rheumatoid Arthritis Candidates Dini Afriliza; Rina Herowati; Ana Indrayati
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 11 No. 2 (2024): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v11i22024.204-218

Abstract

Background: Rheumatoid arthritis (RA) is a chronic autoimmune disease that can reduce quality of life. Currently, the goal of therapy is to achieve remission and prevent joint damage and disability. Acalypha indica L. and Plumbago zeylanica L. are known to be involved in rheumatoid pathogenesis. Objective: This study aimed to determine the compounds in Acalypha indica L. and Plumbago zeylanica L. that correlate with target proteins and anti-rheumatoid arthritis mechanisms. Methods: Plant compound data were collected from the KNApSAcK and IMPPAT databases, target protein data were collected using the KEGG pathway, validated using UniProt, and protein-protein interactions were analyzed using STRING. Target protein prediction using SwissTarget Prediction and SEA. Visualization of network pharmacology profiles using Cytoscape software based on the correlation between plant compounds and target proteins. Results: Acalypha indica L., which correlates with target proteins, contained quinine, gallotannin, 1,4 benzoquinone, chrysin, and kaempferol. For Plumbago zeylanica L., the compounds were vanillic acid, cinnamic acid, plumbagin, isoaffinetin, isoorientin, isovitexin, methylnaphthazarin, l-tryptophan, beta-sitosterol, stigmasterol, ficusin, suberosin, and quercetin 3-ol-rhamnoside. Conclusion: Network pharmacology visualization results showed that both Acalypha indica L. and Plumbago zeylanica L. correlated with disease target proteins in their respective rheumatoid arthritis signaling pathways.
Analisis Biaya Medik Langsung dan Utilitas Pasien Asma Rawat Jalan di Rumah Sakit Umum Daerah Dr. Agoesdjam Hospital Ketapang Widiastuti Widiastuti; Tri Murti Andayani; Rina Herowati
Jurnal Penelitian Kesehatan SUARA FORIKES 2023
Publisher : FORIKES

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/sf14nk212

Abstract

Asthma is a chronic disease that imposes a heavy burden on patients, is responsible for high costs in health care and can reduce quality of life. The aim of this study was to determine the direct medical costs of outpatient asthma patients at RSUD Dr. Agoesdjam Ketapang and what cost components are dominant, utility value, as well as factors that can influence utility value and direct medical costs for asthma patients. This research was an observational study with a cross-sectional design. Data collection was carried out concurrently and retrospectively. The materials used were medical records, a list of financial and pharmaceutical costs to see direct medical costs, the EQ-5D-5L questionnaire used to see the utility value of asthma patients, and the Asthma Control Test (ACT) questionnaire. The research subjects consisted of 80 patients. Data processing includes patient demographic data, ACT scores, comorbidities, therapy patterns, direct medical costs and utilities which are analyzed using non-parametric tests. The results of the study showed that the direct medical costs for outpatient asthma patients were IDR. 19,493,603.00 with the average direct medical costs for asthma patients being IDR 243,670.00. The highest cost component was pharmaceutical costs Rp. 16,493,603.00 (84.61%). The average utility value was 0.65, while the significant p values for each factor were gender = 0.028, education = 0.010, level of asthma control based on ACT score = 0.000 and therapy pattern = 0.000. It was concluded that factors influencing patient utility were gender, education and level of asthma control; while the factor for medical costs is the therapy pattern.Keywords: direct medical costs; asthma; utility ABSTRAK Asma merupakan penyakit kronis yang memberikan beban berat terhadap pasien, bertanggung jawab atas pengeluaran biaya yang tinggi dalam perawatan kesehatan dan dapat menurunkan kualitas hidup. Tujuan penelitian ini adalah untuk mengetahui biaya medik langsung pasien asma rawat jalan di RSUD Dr. Agoesdjam Ketapang dan komponen biaya apa yang dominan, nilai utilitas, serta faktor-faktor yang dapat memengaruhi nilai utilitas dan biaya medik langsung pasien asma. Penelitian ini merupakan penelitian observasional dengan rancangan cross-sectional. Pengambilan data dilakukan dengan cara concurent dan retrospektif. Bahan yang digunakan yaitu catatan rekam medik, daftar biaya keuangan dan farmasi untuk melihat biaya medik langsung, kuesioner EQ-5D-5L digunakan untuk melihat nilai utilitas pasien asma, dan kuesioner Asthma Control Test (ACT). Subyek penelitian berjumlah 80 pasien. Pengolahan data meliputi data demografi pasien, skor ACT, komorbid, pola terapi, biaya medik langsung dan utilitas yang dianalisis menggunakan uji non parametrik. Hasil penelitian menunjukkan bahwa besar biaya medik langsung pasien asma rawat jalan sebesar Rp. 19.493.603,00 dengan rata-rata besar biaya medik langsung pasien asma adalah Rp.243.670,00. Komponen biaya tertinggi adalah biaya farmasi Rp 16.493.603,00 (84,61%). Nilai rata-rata utilitas adalah 0,65, sedangkan nilai p yang signifikan untuk masing-masing faktor adalah jenis kelamin = 0,028, pendidikan = 0,010, tingkat kontrol asma yang bedasarkan skor ACT = 0,000 dan pola terapi =0,000. Disimpulkan bahwa faktor yang memengaruhi utilitas pasien adalah jenis kelamin, pendidikan dan tingkat kontrol asma; sedangkan faktor bagi biaya medik adalah pola terapi.Kata kunci: biaya medik langsung; asma; utilitas
Analysis of Molecular Docking and Dynamics Simulation of Mahogany (Swietenia macrophylla King) Compounds Against the PLpro Enzyme SARS-COV-2 Lalu Sanik Wahyu Fadil Amrulloh; Nuraini Harmastuti; Andri Prasetiyo; Rina Herowati
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 10 No. 3 (2023): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v10i32023.347-359

Abstract

Background: Using natural ingredients as antivirals can be considered a treatment for SARS-CoV-2. One of the potential plants, mahogany (Swietenia macrophylla King), is widely used in various countries as an antiviral treatment. Paparin-like protease (PLpro) is an essential cysteine "‹"‹protease that regulates viral replication and interferes with the regulation of immune sensing. Objective: This study aims to predict which compounds in the mahogany plant have good affinity, patterns, and stability interaction against the target protein of SARS-CoV-2. Methods: The drug-likeness parameter using SwissADME was used to screen compounds that will be docked against PLpro using the Autodock program. The parameters observed in molecular docking analysis are the value of bond energy and interaction model to amino acid residues. The compounds in mahogany plants that have the best interactions were then analyzed using molecular dynamics simulation methods to determine the stability of their bonds based on the values of Root Mean Square Deviation (RMSD) and Root Mean Square Fluctuation (RMSF). Results: Twenty-two compounds met the drug-likeness requirements. Molecular docking analysis showed that the compounds predicted to have the best binding affinity and have an interaction pattern similar to natural ligands towards the molecular target of PLpro are 7-deacetoxy-7-oxogedunin and 3β-hydroxy-stigmast-5-en-7-one. The molecular dynamics simulation results revealed that based on the RMSD and RMSF values, the compound 3β-hydroxy-stigmast-5-en-7-one showed higher stability than 7-deacetoxy-7-oxogedunin. Conclusion: 3β-hydroxy-stigmast-5-en-7-one and 7-deacetoxy-7-oxogedunin were predicted to have good interaction with PLPro; however, 3β-hydroxy-stigmast-5-en-7-one showed the higher interaction stability.
Development of Pocketbooks as an Education and Compliance Module for Diabetes Mellitus Patients at the Kaliwungu Health Center, Kudus, Indonesia Fitriani, Eka; Rina Herowati; Lucia Vita Inandha Dewi
Open Access Indonesian Journal of Medical Reviews Vol. 3 No. 4 (2023): Open Access Indonesian Journal of Medical Reviews
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/oaijmr.v3i4.351

Abstract

Diabetes mellitus (DM) is a chronic disease that requires long-term treatment. Management of DM patients is one of them by providing education. This study aimed to determine the product trial of developing a pocketbook as an educational module using the assessment parameters of experts and DM patients who meet the eligibility criteria at Kaliwungu Health Center, Kudus. This study used qualitative and quantitative analysis. Qualitative analysis in the form of suggestions and input from experts, and quantitative analysis in the form of assessment scores. The method used in this research is research and development. Product development with Borg and Gall procedures. Product trials of pocket book development as a DM patient education module at Kaliwungu Health Center, Kudus, using expert parameters including media experts at 100%, material expert I with a value of 84%, material expert II with a value of 92.3%, material expert III with a value of 100%, expert practitioners with a value of 100% and DM patients with an average value of 80.5% in the category worth using with revision.
Co-Authors Ana Indrayati Andri Prasetiyo Dewi, Lucia Vita Inandha Dini Afriliza Dwi Ningsih, Dwi Eka Fitriani Franz June Navirius Gunawan Pamudji Gunawan Pamudji Widodo Harsono, Samuel Budi Harsono, Samuel Budi Hasan, Rahmawaty Ika Purwidyaningrum Kusniawati, Mega Ayu Lalu Sanik Wahyu Fadil Amrulloh M. Wahyu Ariawan Madyo Adrianto Nugroho Wisnu Putro NURAINI HARMASTUTI Okky Intan Mawarni Rifkarosita Putri Ginaris Rosa Juwita Hesturini Samuel Budi H Setiaji Wisnu Wardana TN Saifullah Sulaiman Tri Murti Andayani Widiastuti Widiastuti Widyasari, Meylinda Widyastuti, Lita Wisnu, M. Ari Wiwin Herdwiani