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All Journal CHEMISTRY PROGRESS JURNAL KIMIA SAINS DAN APLIKASI Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Journal of Mathematical and Fundamental Sciences INDONESIAN JOURNAL OF PHARMACY JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Fitofarmaka Indonesia Jurnal Penelitian Kesehatan Suara Forikes Jurnal Wiyata : Penelitian Sains dan Kesehatan Majalah Farmaseutik Indonesian Journal of Chemistry PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Farmasi Indonesia Jurnal Ilmu Kefarmasian Indonesia Jurnal Aisyah : Jurnal Ilmu Kesehatan Sainstech Farma: Jurnal Ilmu Kefarmasian Jurnal Ilmiah Medicamento Medfarm: Jurnal Farmasi dan Kesehatan Jurnal Farmasi dan Sains Indonesia (JFSI) Journal Pharmasci (Journal of Pharmacy and Science) Open Access Indonesian Journal of Medical Reviews Archives of The Medicine and Case Reports Medical Sains : Jurnal Ilmiah Kefarmasian J-ABDIPAMAS (Jurnal Pengabdian Kepada Masyarakat) Jurnal Etnofarmasi Journal of Health Management and Pharmacy Exploration (JOHMPE) International Journal of Global Sustainable Research Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Pharma Bhakta International Journal of Contemporary Sciences (IJCS)

R, Herowati

Fakultas Farmasi Universitas Setia Budi Jl. Let. Jend. Soetoyo, Mojosongo, Surakarta.

Author-ID : 938083

Religion Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Faktor yang Mempengaruhi Biaya Terapi Pada Pasien Fraktur Radius Ulna Dengan Pembedahan Orif dan Kesesuaian Dengan Tarif INA-CBG’S Di RSUD Kabupaten Sukoharjo Mayang Aditya Ayuning Siwi; Tri Murti Andayani; Rina Herowati
Jurnal Farmasi Indonesia Vol 13 No 2 (2016): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Drug management is an important aspect in pharmaceutical services. Drug procurement is one stage in the hospital drug management. The purpose of this study is to obtain an overview and analyze drug procurement in pharmacy department of RSUD Gambiran Kota Kediri period 2016. This research is a descriptive study with data collection by retrospective based on period 2016 for primary data and for secondary data interview with relevant department drug management on procurement analyzed by Depkes RI and research results before. The result showed that the drug procurement in RSUD Gambiran Kota Kediri using the financial resources BLUD, DAU and DBHCT with direct method and E-procurement. The results analysis drug procurement shows: percentage of the funds available at the overral required 99,12%, percentage of the allocation drug procurement 16,53%, frequency of the procurement of each drug items 4 times/ year by 94,96%, 16 times/ year by 7,73% and 32 times/ year by 3,22%, and long delays payment to the specified time 22 day

Uji Aktivitas Analgetika Fraksi-Fraksi Ekstrak Etanol Daun Gandarusa (Justicia gendarussaBurm. f) dengan Metode Tail Flick Rosa Juwita Hesturini; Rina Herowati; Gunawan Pamudji Widodo
Jurnal Farmasi Indonesia Vol 15 No 1 (2018): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

ABSTRACTGandarusa (Justicia gendarussa Burm. f) is a potential plant as analgetic activities.The aim of the present research was to investigate the analgetic activity with tail flick method onrat models of ethanol extract and the fractions of gandarusa leaf.Partitioned fractinations isolated from ethanolic extract of gandarusaleaves with nheksana,etil asetat and water. Dosage extracts and fractions gandarusa leaf, respectively, are250 mg/kg bw, 500 mg/kg bw, n-hexane fraction of 314 mg/kg bw, the fraction of 41,05 mg/kgbw and water fractions 144,8 mg/kg bw, the negative control group CMC and aspirin 360 mg/kgbw. The results showed the n-heksana fraction has optimal analgesic activity withantinociceptive percentage 94,58% comparable to aspirin.The preliminary phytochemical analisys showed the presence of active phytochemicalsuch as flavonoids, alkaloids, saponins, steroids dan tannins and these compound might beresponsible for analgetic mechanism. The possibility analgetic mechanism of the gandarussa itsstimulate lipomodulin protein biosynthesis which inhibit the action of phospolipase enzimaticthat affecting the enzyme activity arachidonic acid but there is also has gastroprotective activitywith increased mucus production and prevents the release of histamine.

Analisis Biaya Terapi pada Pasien Infeksi Saluran Kemih Rawat Inap di RSUD Dr. Moewardi Surakarta pada Tahun 2016 Windi Astuti; Gunawan Pamudji Widodo; Rina Herowati
Jurnal Farmasi Indonesia Vol 15 No 1 (2018): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Urinary tract infection is one of the infectious diseases that occur due to the presenceof microorganisms in the urine. Urinary tract infection financing was regulated in the INA-CBG’srates. The study purpose was determined the conformity of real cost to the INA-CBG’s rates inhospitalized of national health insurance patients with urinary tract infection disease in Dr.Moewardi hospital Surakarta in 2016.This study was an observational study using a cross sectional design. Retrospectivedata collection method. Data were analyzed to see the treatment pattern of patients duringhospitalization, to find the difference in real costs with INA-CBG's rates using the one sample ttest,and to see factors related to real costs using the bivariate correlation test.The result showed that the treatment pattern for hospitalized patients with urinary tractinfection are using Ceftriaxone (40,8%), Cefixime (7,1%), Ceftazidime (10,2%), Ciprofloxacin(26,5%), Levofloxacin (9,2%), Amoxicillin (3,1%), Ampicillin (1,0%), and Gentamicin (2,0%). Theanalysis of real cost to the INA-CBG’s rates showed the differences between real cost and INACBG’srate of national health insurance patients with urinary tract infection disease.This difference shows a positive condition, where the total real costs are lower than the INACBG'srates. The factor related to the real cost of urinary tract infection treatment including ofLOS, secondary diagnoses, and treatment classes.

Analisis Docking Molekuler Senyawa Derivat Phthalimide sebagai Inhibitor Non-Nukleosida HIV-1 Reverse Transcriptase Tiara Ajeng Listyani; Rina Herowati
Jurnal Farmasi Indonesia Vol 15 No 2 (2018): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Phthalimide derivate compounds was reported as a new class of nonnucleoside reverse tranckriptase inhibitors. Docking molekuler analysis in phthalimide derivative compounds against reverse transcriptase enzym necessary to determine the affinity and interaction patterns between the above compounds with reverse transcriptase enzym. Derived compounds phthalimide geometry optimized using VegaZZ software then performed by way of target preparation, ligand preparation, docking method validation, and analysis of docking using PyRx-Python0.8 - AutoDock vina so we get to the target ligand interactions, free energy bonding, hydrogen bonding, and interaction patterns. Interaction pattern seen in thirty-three phthalimide derivatives with reverse transcriptase enzym showed hydrogen bonding with amino acids Lys101 where the interaction is similar to the interaction of TIBO R 86183 compounds which are the original ligands of the target protein.

Optimasi Formula Lotion Ekstrak Etanol Bunga Krisan (Crhysanthemum cinerariaefolium (Trevir.)Vis.) menggunakan Kombinasi Asam Stearat dan Setil Alkohol sebagai Repelan dengan Metode Simplex Lattice Design Rifkarosita Putri Ginaris; Rina Herowati; TN Saifullah Sulaiman
Jurnal Farmasi Indonesia Vol 19 No 1 (2022): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v19i1.857

Chrysanthemum flower (Crhysanthemum cinerariaefolium (Trevir.) Vis.) contains flavonoids, saponins and polyphenols which are efficacious as repellents against Aedes aegypti mosquitoes. Lotions with a combination of stearic acid and cetyl alcohol are used to improve adhesion and thickening. The purpose of this study was to make a lotion preparation using a combination of stearic acid and cetyl alcohol to obtain optimum physical quality and obtain an effective concentration of chrysanthemum flower extract as a repellant lotion against A. aegypti mosquitoes and a safe effect on the skin. Chrysanthemum extraction was carried out using 70% ethanol. Chrysanthemum ethanol extract was then dose oriented with a concentration of 1.2%. Chrysanthemum flower ethanol extract lotion formulations were made into 7 formulations using stearic acid and stearic acid bases, Formula I 9.00: 8.00%, Formula II 15.00: 2.00%, Formula III 11.00: 6.00 %, Formula IV 15.00: 2.00%, Formula V 13.00: 4.00%, Formula VI 7.00: 10.00%, Formula VII 11.00: 6.00%. Determination of the optimum formula using the Simplex Lattice Design method using the Design Expert program. The optimum formula is obtained, then tested for physical stability including viscosity, adhesion, dispersion and pH. Physical stability was tested using the One Way Anova method followed by Tuckey HSD. Irritation test with the method of Human 4-hour patch test and hedonic test by giving questions to probandus. Chrysanthemum extract concentration of 1.2% has pharmacological activity that functions as a repellent power of mosquitoes. The optimum combination of stearic acid and cetyl alcohol, 7% stearic acid and 10% cetyl alcohol, get optimum physical quality with the Simplex Lattice Design method. The optimum formula of chrysanthemum flower ethanol extract lotion does not have good physical quality stability based on the parameters of adhesion, dispersion, pH and viscosity during 30-day storage. The lotion irritation test results obtained an irritation index of 0, so it can be concluded that the optimum formula of chrysanthemum extract lotion extract does not cause skin irritation and is quite acceptable to probandus.

Desain Vaksin Berbasis Epitop dengan Pendekatan Bioinformatika untuk Menekan Glikoprotein Spike SARS-CoV-2 M Afrizal Firmansyah; Aris Susilo; Septina D Haryanti; Rina Herowati
Jurnal Farmasi Indonesia Vol 18 No 2 (2021): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v18i2.1351

Vaccination is one of the main prevention of the spread of Covid-19. Technological engineering based on virus attenuation has been applied in vaccine development. This study aims to obtain an epitope-based vaccine design with low risk of allergic reactions, safe, and inexpensive. The design of the vaccine was conducted by the collection of SARS-CoV-2 sequence data, phylogenetic analysis, prediction of protein antigenicity, and identification of CD 8+ T cell epitopes. Furthermore, epitope conservation and immunogenicity prediction, as well as molecular docking analysis were carried out to see the interaction between epitopes and alleles. The next step was B cell epitope prediction, population coverage prediction, construction and visualization of vaccine design, structural analysis and validation, interaction analysis between vaccines with TLR 3 and TLR 4, and evaluation of vaccine design immunogenicity. All stages were carried out using the appropriate webserver. The designed vaccine had an antigenicity of 0.5134, not toxic, and not allergenic. The physicochemical parameters met the requirements except for the molecular weight which was less than 40 KDa. The designed vaccine was predicted to have a population coverage of 95.14% for the Indonesian population. The results of the immunogenicity prediction of the vaccine design showed an increase of IgM and IgG until day 35.

Efek Hipoglikemik Kombinasi Infus D GUNAWAN PAMUDJI WIDODO; RINA HEROWATI; BETA K. PRAMUDYAWARDHANI
JURNAL ILMU KEFARMASIAN INDONESIA Vol 10 No 2 (2012): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1237.257 KB)

Talok (Muntingia calabura L.) leaf is a traditional medicinal plant which empirically used to treat diabetes mellitus. This research aimed to know hypoglycemic effect of combination dose of talak leaves infuse-metformin and glibenclamide on Na2EDTA induced-diabetic rats. Diabetic animal model were conducted by induction of Na2EDTA dose of 70 mg kg bw for 3 days. The test groups divided into six groups which were treated with: 50 mg kg bw CMC-Na suspension (negative control 1st group), 0.9 mg kg bw glibenclamide (2nd group), metformin 90 mg kg bb (3rd group), 900 mg kg bw talok leaves infuse (4th group), combination of talok leaves infuse-glibenclamide (450 mg : 0.45 mg/kg bw) (5th group), combination of talok leaves infuse-metformin (450 mg : 45 mg kg bw) (6th group). The levels of blood glucose were examined in all 6 experimental groups on day 0, 4th and 7th. The data obtained were analyzed by one way ANOVA (p < 0.05). The results showed that all of combination could decrease the blood glucose levels significantly. The combination treatment of talok leaves infuse-glibenclamide showed a higher hypoglycemic effect than either drug alone, while combination treatment of talok leaves infuse-metformin showed a similar hypoglycemic effect to either drug alone.

Perbaikan Stres Oksidatif Ekstrak Etanol dan Fraksi Bunga Cengkeh (Syzygium aromaticum L.) pada Tikus yang Diinduksi Streptozotosin-Nikotinamid Wahyu Nuraini Hasmar; Rina Herowati; Gunawan Pamudji
SAINSTECH FARMA Vol 13 No 1 (2020): Sainstech Farma: Jurnal Ilmu Kefarmasian
Publisher : FAKULTAS FARMASI, INSTITUT SAINS DAN TEKNOLOGI NASIONAL

Peningkatan stres oksidatif pada kondisi diabetes melitus (DM) dapat menyebabkan penurunan aktivitas pertahanan antioksidan dalam tubuh sehingga tubuh tidak mampu melawan radikal bebas dan memicu terjadinya kerusakan sel. Salah satu sumber antioksidan alami yaitu bunga cengkeh (Syzygium aromaticum L.). Tujuan dari penelitian ini adalah untuk mengetahui aktivitas antihiperglikemik dan peningkatan aktivitas enzim antioksidan SOD, GPx, serta penurunan kadar MDA. Penelitian ini menggunakan rancangan post test only group design. Tikus putih jantan galur Wistar (Rattus norvegicus) dikondisikan DM tipe 2 dengan induksi streptozotosin 60 mg/kg BB dan nikotinamid 150 mg/kg BB. Pengujian dilakukan berdasarkan aktivitas enzim antioksidan SOD, GPx, MDA. Hasil penelitian menunjukkan bahwa ekstrak etanol dan fraksi-fraksi bunga cengkeh (Syzygium aromaticum L.) mempunyai aktivitas sebagai antihiperglikemik. Fraksi n-heksan bunga cengkeh (Syzygium aromaticum L.) dosis 50 mg/kg BB mempunyai aktivitas yang paling baik sebagai antihiperglikemik, menigkatkan aktivitas enzim SOD, GPx dan menurunkan kadar MDA.

Studi Docking Molekuler Senyawa Dalam Minyak Atsiri Pala (Myristica fragrans H.) Dan Senyawa Turunan Miristisin Terhadap Target Terapi Kanker Kulit Alfian Bagas Pratama; Rina Herowati; Hery Muhamad Ansory
Majalah Farmaseutik Vol 17, No 2 (2021)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v17i2.59297

Kanker kulit adalah penyakit di mana kulit kehilangan kemampuannya untuk regenerasi dan tumbuh secara normal. Penyebab umum terjadinya kanker kulit adalah intesitas paparan sinar UVB. Penelitian terdahulu telah membuktikan kandungan senyawa di dalam minyak atsiri pala (Myristica fragrans H.) khususnya miri stsin memiliki khasiat sebagai antioksidan dan efek cytotoxic. Telah dilakukan skrining target molekuler dari kandungan kimia minyak atsiri pala beserta turunan miristisin-nya terhadap target molekuler antikanker kulit antara lain Heat Shock Protein 90 (HSP90A), Prostaglandin Synthase 2 (PTGS2) dan Dihydroorotate Dehidrogenase (DHODH), dan memprediksi interaksi senyawa dari ke 61 ligan uji dengan target molekuler tersebut, kemudian dilakukan docking molekuler menggunakan perangkat lunak PyRx 0.8. Hasil penelitian menunjukkan bahwa senyawa dalam minyak atsiri pala yaitu Guanicin memiliki nilai ΔGbind yang baik pada HSP90A dengan nilai -8,2 kkal/mol. Hasil docking antara protein PTGS2 dan DHODH dengan ligan baik dari senyawa dalam minyak atsiri pala maupun senyawa turunan miristisin menunjukkan bahwa hampir semua ligan dapat berinteraksi dengan kedua target dengan ligan yang nilai ΔGbind paling kecil dan memiliki model interaksi terbaik dari senyawa minyak atisi pala adalah asam dihidroguaiaretik, dengan nilai ΔGbind secara berurut-urut sebesar -8,1 kkal/mol dan -9,3 kkal/mol.

SYNTHESIS AND CYTOTOXIC ACTIVITY OF CHALCONE DERIVATIVES ON HUMAN BREAST CANCER CELL LINES Nuraini Harmastuti; Rina Herowati; Dyah Susilowati; Harno Dwi Pranowo; Sofia Mubarika
Indonesian Journal of Chemistry Vol 12, No 3 (2012)
Publisher : Universitas Gadjah Mada

Chalcone, an α,β-unsaturated ketone, has been shown have many biological activities such as anticancer and antifungi. This research was conducted to synthesize the chalcone derivatives and to obtain their cytotoxic activity on human cervix cancer cell lines. Synthesis of chalcone and its derivatives, 4II-methylchalcone, 4II-methoxychalcone, and 3II,4II-dichlorochalcone was carried out using starting materials of benzaldehide and acetofenon, p-methylacetophenone, p-methoxyacetophenone, as well as m,p-dichloroacetophenone through Claisen Schmidt condensation catalized by NaOH in ethanol at 15 °C. The purity of synthesized compounds were analyzed by thin layer chromatography, melting range, and gas chromatography. Structure elucidations were conducted by UV spectrophotometer, IR spectrometer, 1H-NMR spectrometer, as well as mass spectrometer. Cytotoxic activities were determined by 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) microculture tetrazolium viability assay. The results showed that chalcone and derivatives compounds have been able to be synthesized and purified and had the same structure as a predicted structure. Chalcone had highest cytotoxic activity compared to that of its derivatives, with the IC50 values of chalcone, 4II-methylchalcone, 4II-methoxychalcone, and 3II,4II-dichlorochalcone were 9.49, 14.79, 11.48, and 24.26 µg/mL respectively. It was concluded that methyl, methoxy as well as chlorine substitution at 3 II and 4II position decrease the cytotoxic activity of chalcone.

Co-Authors admaja, wika Alfian Bagas Pratama Ana Indrayati Andri Prasetiyo Arief Nurrochmad Aris Susilo Ayuning Siwi, Mayang Aditya Bahi, Rizky Resvita R. BETA K. PRAMUDYAWARDHANI Dewi, Lucia Vita Inandha Dini Afriliza Dwi Ningsih, Dwi Dyah Susilowati Eka Fitriani Eleonora Maryeta Toyo Elly Suoth Endang Sri Rejeki firdaus, alshol Franz June Navirius Gunawan Pamudji Gunawan Pamudji Gunawan Pamudji Widodo Gunawan Pamuji Widodo Gusdinar, Tutus Harno Dwi Pranowo Harsono, Samuel Budi Harsono, Samuel Budi Hasan, Rahmawaty Hasmar, Wahyu Nuraini I Ketut Adnyana Ika Purwidyaningrum Ismi Rahmawati Jausi Jannah Kartasasmita, R. E. Keswara, Yane Dila Kusniawati, Mega Ayu Lalu Sanik Wahyu Fadil Amrulloh Listyani, Tiara Ajeng M Afrizal Firmansyah M. Wahyu Ariawan M. Yogi Riyantama Isjoni Madyo Adrianto Muhamad Ansory, Hery Nugroho Wisnu Putro Nuraini Harmastuti Nuraini Harmastuti NURAINI HARMASTUTI Okky Intan Mawarni Pamudji, Gunawan Pratamaa, Yuga Purnamasari, Nur Aini Dewi Rahadi, I Wayan Surya Rahmadani Rahmadani Rahmana Emran Kartasasmita Rahmana Emran Kartasasmita Rifkarosita Putri Ginaris Rosa Juwita Hesturini Samuel Budi H Septina D Haryanti Setiaji Wisnu Wardana Sofia Mubarika Sunarti Sunarti Supriyadi T.N Saifullah Sulaiman TN Saifullah Sulaiman Tri Murti Andayani Tuti Alawiyah Tutus Gusdinar Tutus Gusdinar Kartawinata Widia Wati Widiastuti Widiastuti Widyasari, Meylinda Widyasti, Jena Hayu Widyastuti, Lita Windi Astuti Wisnu, M. Ari Wiwin Herdwiani

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