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Problems Treatment Type II Diabetes Mellitus Patients with PCNE 9.1 and Correlation to Therapy Outcomes Okky Intan Mawarni; Rina Herowati; Samuel Budi Harsono
International Journal of Global Sustainable Research Vol. 1 No. 3 (2023): November 2023
Publisher : MultiTech Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59890/ijgsr.v1i3.805

Abstract

Drug-Related Problems in T2DM patients based on patient therapy patterns with or without comorbidities. DRP analysis is based on PCNE 9.1 guidelines analysing the domains causing problems in treatment, then bivariate data analysis (chi-square) to test the relationship between results and DRP type and continued with a multivariate test to see the connection between results and DRP type. The research results were three related variables related to DRPs and LOS, 15 cases of errors in drug selection, and eight instances of errors of treatment duration due to the absence of initiation of maintenance doses. Dose selection errors occurred in year 16, caused by an amount too low. It is recommended to research analysis prospectively so that the status of DRPs can be determined.
AKTIVITAS ANTIDIABETES EKSTRAK ETANOL DAUN SIRIH MERAH (Piper crocatum) PADA TIKUS PUTIH RETINOPATI DIABETIK: ANTIDIABETIC ACTIVITY ETHANOL EXTRACT OF RED BETEL LEAVES (Piper crocatum) IN DIABETIC RETINOPATHY WHITE RATS Madyo Adrianto; Gunawan Pamudji widodo; Rina Herowati
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 1 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i1.719

Abstract

Salah satu komplikasi mikrovaskuler pada kondisi diabetes yakni retinopati diabetik dimana terjadi akibat kerusakan sel endotel pada pasien diabetes yang dapat meningkatkan ekspresi VEGF. VEGF mampu menginduksi adhesi leukosit sel endotel retina yang mengakibatkan kerusakan retina. Penelitian ini bertujuan guna mengetahui aktivitas ekstrak etanol daun sirih merah (EDDSM) dalam menurunkan kadar glukosa darah serta aktivitasnya pada kadar VEGF plasma tikus putih retinopati diabetik. Daun sirih merah dikeringkan dan dibuat serbuk halus lalu diekstraksi menggunakan pelarut etanol 70% dengan metode remaserasi. Pengujian dilakukan pada 35 ekor tikus yang terbagi dalam 5 kelompok perlakuan yakni kelompok kontrol negatif, kontrol positif (Glibenklamid), EEDSM dosis 50, 100 dan 200 mg/kgBB. Metode uji antidiabetes menggunakan induksi STZ-NA secara intraperitonial kemudian mengukur kadar glukosa, VEGF awal dan setelah perlakuan pada setiap kelompok kemudian dilakukan analisa menggunakan uji oneway Anova. Berdasarkan hasil pengukuran kadar glukosa darah dan VEGF plasma diperoleh perbedaan yang bermakna diantara kelompok kontrol negatif dengan kontrol positif serta EEDSM dengan nilai signifikan (p<0,05). Hasil penelitian diperoleh EEDSM dosis 100 mg/kgBB ialah dosis efektif dalam menurunkan kadar glukosa darah dengan % PKGD yaitu 18,22%. EEDSM dosis 200 mg/kgBB ialah dosis efektif guna menurunan VEGF plasma tikus retinopati diabetik sebesar 31,20%.
AKTIVITAS ANTI-INFLAMASI FRAKSI-FRAKSI EKSTRAK ETANOL DAUN GANDARUSSA (Justicia gendarussa Burm. F) PADA TIKUS PUTIH Rosa Juwita Hesturini; Rina Herowati; Gunawan Pamudji Widodo
JURNAL PHARMA BHAKTA Vol 2 No 1 (2022): Juni 2022
Publisher : FAKULTAS FARMASI, INSTITUT ILMU KESEHATAN BHAKTI WIYATA

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Abstract

Latar belakang: Salah satu tanaman potensial Indonesia yang telah diketahui kegunaannya sebagai analgetika dan anti-inflamasi dengan penggunaan secara empiris adalah Gandarusa (Justicia gendarussa). Gandarusa diketahui mengandung steroid, terpenoid, alkaloid, dan flavonoid. Tujuan: Mengetahui aktivitas anti-inflamasi fraksi-fraksi ekstrak etanol gandarusa dengan penginduksi λ-karagenan. Metode: Ekstrak etanol daun gendarussa difraksinasi dengan pelarut n-heksana, etil asetat dan air. Uji anti-inflamasi dilakukan dengan induksi λ-karagenan pada bagian subplantar kaki belakang dan diamati pembengkakan dengan plestimometer. Dosis ekstrak dan fraksi daun gandarusa berturut-turut yaitu 250 mg/kgbb, 500 mg/kgbb, fraksi n-heksana 314 mg/kgbb, fraksi etil asetat 41,05 mg/kgbb dan fraksi air 144,8 mg/kgbb dengan kontrol negatif CMC 0,5% dan kontrol positif asetosal 360 mg/kgbb. Hasil : Hasil penelitian menunjukkan aktivitas anti-inflamasi dimunculkan pada ekstrak etanol, fraksi n-heksana, fraksi etil asetat dan fraksi air. Fraksi etil asetat 144,8 mg/kgbb menunjukkan aktivitas anti-inflamasi yang sebanding dengan asetosal. Analisa kandungan senyawa pada penelitian sebelumnya menunjukkan adanya kandungan fitokimia aktif yaitu flavonoid, alkaloid, saponin, steroid dan tanin yang diduga bertanggung jawab sebagai anti-inflamasi dengan mekanisme yaitu merangsang biosintesis protein lipomodulin yang menghambat kerja enzimatik fosfolipase yang mempengaruhi aktivitas metabolisme enzim asam arakhidonat. Simpulan: Aktivitas optimal ditunjukkan oleh fraksi etil asetat 41,05 mg/kgbb dengan penurunan udema pada kaki tikus.
The correlations of interpersonal communication pharmacists with compliance medication in patientof diabetes mellitus type 2 Meylinda Widyasari; Rina Herowati; Samuel Budi H
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 8, No 2: June 2023
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (629.408 KB) | DOI: 10.30604/jika.v8i2.1995

Abstract

Drug compliance is often associated with interpersonal relationships. Good interpersonal relationships depend on how interpersonal communication is established. This study aims to identify the relationship between interpersonal communication of pharmacists and drug compliance of Type 2 Diabetes Mellitus (DM) outpatients and identify the most dominant interpersonal and communication factors influencing drug compliance and its external factors. The samples of this study were patients who met the inclusion criteria. Data were obtained from questionnaires, observations, and medical records. The data were tested for validity and reliability using univariate analysis, bivariate analysis using chi-square, and multivariate analysis using multiple logistic regression. The results of the study showed characteristics that affect drug compliance are DM drugs used and the number of drugs received. The results of bivariate analysis p-value less than 0.05 mean there was a relationship between the interpersonal communication of pharmacists (openness, empathy, supportive behavior, positive behavior, and equality) and drug compliance of Type 2 DM outpatients at RSUD Jaraga Sasameh. The most dominant interpersonal communication factor was positive behavior with an exp (B) value of 16.013. External factors affecting were supporting facilities, and time. Abstrak: Kepatuhan minum obat seringkali dikaitkan dengan hubungan interpersonal. Hubungan  interpersonal yang baik tergantung bagaimana sebuah komunikasi interpersonal dibangun. Penelitian ini bertujuan untuk mengetahui hubungan komunikasi interpersonal apoteker dengan kepatuhan minum obat pasien DM Tipe 2 rawat jalan, mengetahui faktor komunikasi interpersonal paling dominan dan faktor eksternal yang mempengaruhi kepatuhan minum obat. Sampel adalah pasien yang memenuhi kriteria inklusi. Data diperoleh dari pengisian kuesioner oleh pasien, observasi dan rekam medik. Kuesioner sebelum digunakan untuk pengambilan data di uji validitas dan reliabilitas. Data yang diperoleh dari kuesioner kemudian dianalisis univariat, bivariat menggunakan chi square dan  multivariat menggunakan regresi logistik berganda. Hasil penelitian menujukkan karakteristik yang mempengaruhi kepatuhan minum obat yaitu obat DM yang digunakan dan jumlah item obat yang diterima. Hasil menganalisis bivariat angka p kurang dari 0,05 maknanya ada relasi diantara komunikasi interpersonal apoteker (keterbukaan, empati, tingkah laku suportif, tingkah laku positif serta kesetaraan) dengan ketaatan minum obat pasien DM Tipe 2 rawat jalan pada RSUD Jaraga Sasameh. Hasil analisis multivariat faktor komunikasi interpersonal paling dominan adalah perilaku positif dengan nilai exp (B) sebesar 16,013. Faktor eksternal yang mempengaruhi adalah sarana penunjang, dan waktu.
AKTIVITAS ANTIINFLAMASI EKSTRAK ETANOL DAUN INGGU (Ruta angustifolia [L.] Pers) PADA TIKUS PUTIH JANTAN DENGAN METODE INDUKSI KARAGENAN DAN RADIASI UV Kusniawati, Mega Ayu; Ningsih, Dwi; Herowati, Rina
JURNAL ETNOFARMASI Vol 1 No 01 (2023): JURNAL ETNOFARMASI
Publisher : Universitas Pendidikan Muhammadiyah Sorong

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Inflamasi merupakan suatu respon tubuh terhadap cedera. Salah satu tanda inflamasi adalah edema. Penelitian ini bertujuan untuk mengetahui aktivitas antiinflamasi ekstrak etanol daun inggu dan mengetahui dosis ekstrak etanol daun inggu yang memiliki aktivitas antiinflamasi paling optimal dengan metode induksi karagenan dan radiasi UV. Daun inggu diekstraksi dengan metode maserasi dengan etanol 96%. Pengujian dilakukan pada 25 ekor tikus dibagi dalam 5 kelompok yaitu kontrol negatif (CMC Na), kontrol positif (Natrium Diklofenak 4,5 mg/kg BB), ekstrak etanol daun inggu dengan dosis 25 mg, 50 mg dan 100 mg/kg BB. Pada metode induksi karagenan pengukuran aktivitas antiinflamasi dilakukan dengan mengukur volume edema pada telapak kaki tikus yang diinduksi dengan lambda karagenan 0,8%. Pada metode radiasi UV pengukuran aktivitas antiinflamasi berdasarkan skor eritema akibat induksi radiasi UVB. Data yang diperoleh dilakukan analisa ANOVA dan LSD untuk mengetahui perbedaan antar kelompok perlakuan. Hasil penelitian menunjukkan ekstrak etanol daun inggu dosis 25 mg, 50 mg dan 100 mg/kg BB mempunyai aktivitas antiinflamasi dengan metode induksi karagenan sedangkan dosis 50 mg dan 100 mg/kg BB mempunyai aktivitas antiinflamasi dengan metode radiasi UV. Ekstrak etanol daun inggu dosis 100 mg/kg BB mempunyai aktivitas antiinflamasi paling optimal dan sebanding dengan kontrol positif pada kedua metode. Kandungan yang diduga berefek sebagai antiinflamasi yaitu flavonoid dan steroid
Differences in drug availability levels before and during the covid19 pandemic in the pharmaceutical installation of NTB provincial hospital Wisnu, M. Ari; Herowati, Rina; Harsono, Samuel Budi
Journal of Health Management and Pharmacy Exploration Vol. 2 No. 1 (2024): February 2024
Publisher : Surya Hijau Manfaat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52465/johmpe.v2i1.192

Abstract

Health services are now increasingly needed during the COVID-19 pandemic which threatens public health. The need for public medicines that must be available such as flu, cough, vitamin c, antibiotics and antimalarials and antivirals for health services makes hospitals must try to fulfil and currently the COVID-19 pandemic situation is still continuing so hospitals must be ready to provide health services to patients.This study aims to determine the differences in drugs in the Pharmacy Installation of the NTB Provincial Hospital before the COVID-19 pandemic in 2019 and during the COVID-19 pandemic in 2020. This study is a descriptive-evaluative study with retrospective data collection in 2019 which represents the period before the COVID-19 pandemic and 2020 which represents the COVID-19 pandemic. The samples used in the study consisted of drug data from the Pharmacy Installation of the NTB Province Regional General Hospital (RSUD) and were analyzed using the Wilcoxon test. The results obtained are the level of drug availability in the pharmaceutical installation of the NTB Provincial Hospital obtained based on the results of observing data in 2019 and 2020, namely 19 and 37 months. There is a significant difference (Asymp. Sig (2-tailed) 0.000) the level of drug availability in the Pharmacy Installation of the NTB Provincial Hospital before and during the COVID-19 pandemic in 2020 with a difference of 18 months.
Molecular Docking and Pharmacokinetic Studies of Moringa oleifera As Angiotensin-Converting Enzyme Inhibitors Hasan, Rahmawaty; Herowati, Rina
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 11 No. 1 (2024): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v11i12024.80-88

Abstract

Background: Hypertension in pregnancy is a vascular disorder that occurs before pregnancy or arises during pregnancy that there were 30% of cases of maternal death. Moringa oleifera's potential to lower blood pressure can be utilized as an alternative antihypertensive during pregnancy, minimizing the risk of preeclampsia. Objective: The purpose of this study was to determine the molecular target of Moringa oleifera is intended to optimize pharmacodynamic activity based on the interaction pattern of the compounds with the ACE inhibitor (PDB ID: 1O86). Methods: Molecular docking is carried out using Autodock 4.0 program (AutoDock Tools). Results: According to the binding energy value and ACE inhibitory interaction, a-Rhamnopyranosyl, b-Sitosterol, and Sinalbin are prospective Moringa oleifera compounds as alternative antihypertensive. These potential compounds can inhibit ACE with binding energy -8.23; -9.27; -9.14 kcal/mol. Pharmacokinetic predictions reported that the potential compounds are absorbed in the intestine and indicates as molecules are tightly bound to plasma proteins and, as well as CYP3A4 and CYP2C9 inhibitors. The prediction of toxicity indicates that the potential compounds are classified as drug-induced acute liver failure with low carcinogens. Conclusion: a-Rhamnopyranosyl, b-Sitosterol and Sinalbin can be suitable lead compounds for synthetic drugs for antihypertensive agents.
Aktivitas Gastroprotektif Kombinasi Madu Dan Virgin Coconut Oil (Cocos nucifera) Pada Model Tikus Tukak Lambung Widyastuti, Lita; Herowati, Rina; Ariawan, M Wahyu; Purwidyaningrum, Ika
Jurnal Fitofarmaka Indonesia Vol 11, No 1 (2024): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v11i1.1064

Abstract

Gastric ulcers are damage that occurs to the mucosal tissue, submucosa and the muscle layer of the stomach, this condition is caused by hypersecretion of stomach acid. The substance content of VCO has a gastroprotective effect because it includes flavonoid compounds, phenols, catalase, ascorbic acid, and vitamin E, while VCO includes octanoic acid, δ-Octalactone, dodecanoic acid, δ-Decalactone, acetic acid. The aim of this research is to understand the gastroprotective activity resulting from giving a combination of honey and VCO to aspirin-induced rats. Honey and VCO in single administration include one dose, namely 14 ml/kgBW honey and 10 ml/kgBW VCO, while in combination treatment three doses are given, namely 10.5; 7; 3.5 ml/kgBB honey and 7.5; 5; 2.5 ml/kgBB VCO. Then in the combined treatment, 5 variations of doses were given, namely honey and VCO (7:7.5); (7:5); (7:2.5); (10.5:5); (3.5:5) ml/kgBB. TNFα levels before being induced by aspirin, after being induced by aspirin, after honey and VCO therapy, and macroscopic observations on a single treatment showed that administration of honey and VCO at doses of 10.5 ml/kgBW and 5 ml/kgBW showed a gastroprotective effect compared to other doses. Then, in histopathological testing, doses with gastroprotective effects can restore mucosal cell cohesion which has been previously damaged due to erosion. The combination of honey and VCO showed gastroprotective results at a dose of 10.5 ml/kgBB honey and 5 ml/kgBB VCO.
Network Pharmacology Approach to Acalypha indica L. and Plumbago zeylanica L. As Anti-Rheumatoid Arthritis Candidates Dini Afriliza; Rina Herowati; Ana Indrayati
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 11 No. 2 (2024): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v11i22024.204-218

Abstract

Background: Rheumatoid arthritis (RA) is a chronic autoimmune disease that can reduce quality of life. Currently, the goal of therapy is to achieve remission and prevent joint damage and disability. Acalypha indica L. and Plumbago zeylanica L. are known to be involved in rheumatoid pathogenesis. Objective: This study aimed to determine the compounds in Acalypha indica L. and Plumbago zeylanica L. that correlate with target proteins and anti-rheumatoid arthritis mechanisms. Methods: Plant compound data were collected from the KNApSAcK and IMPPAT databases, target protein data were collected using the KEGG pathway, validated using UniProt, and protein-protein interactions were analyzed using STRING. Target protein prediction using SwissTarget Prediction and SEA. Visualization of network pharmacology profiles using Cytoscape software based on the correlation between plant compounds and target proteins. Results: Acalypha indica L., which correlates with target proteins, contained quinine, gallotannin, 1,4 benzoquinone, chrysin, and kaempferol. For Plumbago zeylanica L., the compounds were vanillic acid, cinnamic acid, plumbagin, isoaffinetin, isoorientin, isovitexin, methylnaphthazarin, l-tryptophan, beta-sitosterol, stigmasterol, ficusin, suberosin, and quercetin 3-ol-rhamnoside. Conclusion: Network pharmacology visualization results showed that both Acalypha indica L. and Plumbago zeylanica L. correlated with disease target proteins in their respective rheumatoid arthritis signaling pathways.
Analisis Biaya Medik Langsung dan Utilitas Pasien Asma Rawat Jalan di Rumah Sakit Umum Daerah Dr. Agoesdjam Hospital Ketapang Widiastuti Widiastuti; Tri Murti Andayani; Rina Herowati
Jurnal Penelitian Kesehatan SUARA FORIKES 2023
Publisher : FORIKES

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/sf14nk212

Abstract

Asthma is a chronic disease that imposes a heavy burden on patients, is responsible for high costs in health care and can reduce quality of life. The aim of this study was to determine the direct medical costs of outpatient asthma patients at RSUD Dr. Agoesdjam Ketapang and what cost components are dominant, utility value, as well as factors that can influence utility value and direct medical costs for asthma patients. This research was an observational study with a cross-sectional design. Data collection was carried out concurrently and retrospectively. The materials used were medical records, a list of financial and pharmaceutical costs to see direct medical costs, the EQ-5D-5L questionnaire used to see the utility value of asthma patients, and the Asthma Control Test (ACT) questionnaire. The research subjects consisted of 80 patients. Data processing includes patient demographic data, ACT scores, comorbidities, therapy patterns, direct medical costs and utilities which are analyzed using non-parametric tests. The results of the study showed that the direct medical costs for outpatient asthma patients were IDR. 19,493,603.00 with the average direct medical costs for asthma patients being IDR 243,670.00. The highest cost component was pharmaceutical costs Rp. 16,493,603.00 (84.61%). The average utility value was 0.65, while the significant p values for each factor were gender = 0.028, education = 0.010, level of asthma control based on ACT score = 0.000 and therapy pattern = 0.000. It was concluded that factors influencing patient utility were gender, education and level of asthma control; while the factor for medical costs is the therapy pattern.Keywords: direct medical costs; asthma; utility ABSTRAK Asma merupakan penyakit kronis yang memberikan beban berat terhadap pasien, bertanggung jawab atas pengeluaran biaya yang tinggi dalam perawatan kesehatan dan dapat menurunkan kualitas hidup. Tujuan penelitian ini adalah untuk mengetahui biaya medik langsung pasien asma rawat jalan di RSUD Dr. Agoesdjam Ketapang dan komponen biaya apa yang dominan, nilai utilitas, serta faktor-faktor yang dapat memengaruhi nilai utilitas dan biaya medik langsung pasien asma. Penelitian ini merupakan penelitian observasional dengan rancangan cross-sectional. Pengambilan data dilakukan dengan cara concurent dan retrospektif. Bahan yang digunakan yaitu catatan rekam medik, daftar biaya keuangan dan farmasi untuk melihat biaya medik langsung, kuesioner EQ-5D-5L digunakan untuk melihat nilai utilitas pasien asma, dan kuesioner Asthma Control Test (ACT). Subyek penelitian berjumlah 80 pasien. Pengolahan data meliputi data demografi pasien, skor ACT, komorbid, pola terapi, biaya medik langsung dan utilitas yang dianalisis menggunakan uji non parametrik. Hasil penelitian menunjukkan bahwa besar biaya medik langsung pasien asma rawat jalan sebesar Rp. 19.493.603,00 dengan rata-rata besar biaya medik langsung pasien asma adalah Rp.243.670,00. Komponen biaya tertinggi adalah biaya farmasi Rp 16.493.603,00 (84,61%). Nilai rata-rata utilitas adalah 0,65, sedangkan nilai p yang signifikan untuk masing-masing faktor adalah jenis kelamin = 0,028, pendidikan = 0,010, tingkat kontrol asma yang bedasarkan skor ACT = 0,000 dan pola terapi =0,000. Disimpulkan bahwa faktor yang memengaruhi utilitas pasien adalah jenis kelamin, pendidikan dan tingkat kontrol asma; sedangkan faktor bagi biaya medik adalah pola terapi.Kata kunci: biaya medik langsung; asma; utilitas