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All Journal ILMU KELAUTAN: Indonesian Journal of Marine Sciences Medula Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan The Indonesian Biomedical Journal AKSIOLOGIYA : Jurnal Pengabdian Kepada Masyarakat Journal Syifa Sciences and Clinical Research (JSSCR) Majalah Farmasetika Borneo Journal Of Pharmascientech Mattawang: Jurnal Pengabdian Masyarakat Jurnal Farmasi Sains dan Praktis Jurnal Pengabdian Nusantara (JPN) MOSIRAHA : Jurnal Pengabdian Farmasi Lansau: Jurnal Ilmu Kefarmasian Jurnal Pengabdian Kepada Masyarakat Meambo Jurnal Pengabdian Masyarakat Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Kefarmasian Indonesia Jurnal Farmasi Galenika Indonesian Journal of Jamu Journal of Community Engagement in Health MEDULA Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo
Parawansah, P
Department Of Pharmacology And Clinical Pharmacy, Faculty Of Pharmacy, Universitas Halu Oleo
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Aktivitas Antidiare Seduhan Kayu Secang (Caesalpinia sappan L.) Pada Mencit (Mus musculus) Parawansah P
JURNAL FARMASI GALENIKA Vol 2 No 02 (2015): JURNAL FARMASI GALENIKA
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v2i02.38

Abstract

Sappan (Caesalpinia sappan L.) is one of the plants that has efficacy in treating some diseases. One of them is as an antidiarrheal. The nature of the Caesalpinia sappan are adstringens which can relieve diarrhea with intestinal mucous membrane collapse. The purpose of this study was to determine the effect of antidiarrheal of C.sappan steeped and to know how much concentration that has an effect as an antidiarrheal in mice. The type of this research was experimental study consisting of five treatments with three repetitions. Research carried out by observing the frequency of diarrhea to change to be normal feces after oral administration with C.sappan steeped with a concentration of 1%, 2%, 3%, Loperamideas a positive control, Na CMC as a negative control and the time of observation for 10 hours.The results showed that C.sappan steeped showed the most good antidiarrheal effect that was at a concentration of 2% b/v with an average frequency of bowel movements as much as 1.6 times. Anova statistical analysis results showed that the data hypothesis was accepted or there were significant differences between treatment groups. This research concluded that C. sappan steeped could give antidiarrheal effects that accelerated the changes of feces consistency to be normal.
The Activity of Notika Leaves (Archboldiodendron calosericeum Kobuski) Against Tumors Necrosis Factor Alpha (TNF-α) Levels in Rats Nuralifah Nuralifah; Parawansah Parawansah; Fadhliyah Malik; Nining Yulianti
MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo Vol. 10 No. 1 (2022): Oktober
Publisher : MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo

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Abstract

Background: Inflammation is a response process to tissue injury and infection. The inflammatory response causes the release of pro-inflammatory mediators such as IL-1, IL-6 and TNF-α which are the main cytokines in the acute inflammatory response. Plants that have the potential to be anti-inflammatory are notika leaves (Archboldiodendron calosericeum Kobuski). Purpose: This research was conducted to evaluate the anti-inflammatory activity of the ethanol extract of notika leaves against the levels of Tumor Necrosis Factor Alpha (TNF-α) in Wistar rats. Methods: The study used a post test only control group design. Rats were divided into five groups consisting of a positive control (diclofenac sodium), three extracts (100, 200 and 300 mg/kg BW) and Teeee carragenantrol gopre roups that are inlaporkan dari tanaman ketapang dalam spewa yang dilaporkan pada besar, dll --lar.negative control (NaCMC 0.5%). In vivo tests were carried out by induction of inflammatory using carragenan, administering preparations and measuring TNF-α levels using the ELISA method. Data were analyzed using the One Way ANOVA test. Results: The results showed that the mean levels of TNF-α in the positive control group (0.475 ng/L), negative control (0.816 ng/L), extract dose 100 mg/kgBW (0.67 ng/L), extract dose 200 mg/kgBW (0.7285 ng/L) and extract dosage of 300 mg/kgBW (0.7785 ng/L). Conclusion: The study concludes that the ethanol extract of notika leaves has anti-inflammatory activity against the levels of Tumor Necrosis Factor Alpha (TNF-α) in Wistar rats based on the reduction in levels with negative control and optimum dose was 100 mg/kgBW.
Ethanol Extract Activity of Teak Leaves (Tectona grandis L) Against Histopotological Appearance of Pancreatic Organs in Rats (Rattus norvegicus) Model Type II DM Nuralifah; Parawansah; Ruslin; Rachma Malina; Emma Haerunnita
MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo Vol. 10 No. 2 (2023): April
Publisher : MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo

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Abstract

Background: Diabetes mellitus is a disease characterized by increased blood glucose levels and changes in the histopathological structure of the islets of Langerhans of the pancreas. One of the plants used empirically as an antidiabetic is the teak plant (Tectona grandis Linn). The content compounds that are thought to act as antidiabetics are flavonoids. Purpose: The purposes of this study is to determine the activity of the ethanol extract of Tectona grandis L leaves which has antihyperglycemic activity as seen from the histopathology of the pancreas of white rats (Rattus norvegicus). Methods: Modeling diabetes mellitus in test animals was carried out by inducing 40 mg/kg BW streptozotocin intraperitoneally. There were 6 treatment groups, namely the normal control group, the positive control group, the negative control group, and the teak leaf ethanol extract group at doses of 100, 200, and 300 mg/kg. Results: The ethanol extract of Tectona grandis leaves has repair activity for regenerating endocrine cells in the islets of Langerhans with an average number of endocrine cells in the normal control group of 483 cells, positive control group 474 cells, negative control 318 cells, dose 100 mg/kg body weight 450 cells, a dose of 200 mg/KBB 462 cells and a dose of 300 mg/KBB 469 cells and it can regenerate endocrine cells. Conclusion: the ethanol extract of Tectona grandis L leaves at a dose of 300 mg/kg BW has activity in repairing endocrine cells with cell morphology almost resembling normal cells.
Correlation Of Age And BMI With The Incident Of Nausea And Vomiting In Patients Post Sectio Caesarian Operation With Spinal Anesthesia In Aliyah Hospital 2 Agussalim Ali; Parawansah; Sulastrianah
MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo Vol. 10 No. 3 (2023): Suplemen
Publisher : MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo

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Abstract

Background. Postoperative nausea and vomiting are one of the complications experienced by patients with anesthesia and surgery. There are many factors that influence this occurrence, including age and BMI, where young age and obese BMI tend to experience postoperative nausea and vomiting. This is based on the fact that older age is easier to control nausea and vomiting than young people and obese BMI has more fat tissue to store anesthetic drugs so that the side effects of drugs can last longer. Method. This study used an observational analytic method with a cross sectional approach carried out at Aliyah Hospital 2. The number of samples in this study were 38 people who were taken using total sampling technique. Data collection was obtained from filling in the observation sheet and then the data was analyzed using the Fisher's Exact Test statistical test. The dependent variable in this study was postoperative nausea and vomiting and the independent variables were age and BMI. Results. The results of this study found that age did not have a significant relationship with the incidence of postoperative nausea and vomiting at Aliyah Hospital 2 (p = 0.298) and BMI had a significant relationship with the incidence of postoperative nausea and vomiting at Aliyah Hospital 2 (p = 0.019). Conclusion. From this study it can be concluded that the incidence of postoperative nausea and vomiting after spinal anesthesia is higher in patients with older age and excessive BMI.
The Impact of the Ethyl Acetate Fraction of Bitter Melon Fruit (Momordica charantia l.) on Insulin Hormone Levels of Diabetic Rats (Rattus norvegicus) Using the Enzyme-Linked Immunosorbent Assay Method Parawansah; Tien; Amiruddin Eso; Muhammad Junaid Azis; Nuralifah
MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo Vol. 10 No. 3 (2023): Suplemen
Publisher : MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo

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Abstract

Background: The World Health Organization (WHO) has forecast a rise in the prevalence of diabetes mellitus from 2.8% in 2000 to 4.4% in 2030. Numerous investigations have been undertaken to identify alternate avenues for antidiabetic treatment. Momordica charantia, sometimes referred to as bitter melon, is recognized for its possession of mimic insulin components. The ethanol extracts derived from Momordica charantia have been found to exhibit favorable outcomes in the reduction of blood glucose levels and the stimulation of pancreatic beta cells for the secretion of insulin hormone. Purpose: The purpose of this research is to investigate the impact of bitter melon extract on insulin levels in rats induced with streptozotosin. Method: The present study employed various methodologies to investigate the research question. The present investigation comprised three distinct sets of tests, specifically streptozotosin-induced rats, streptozotosin-induced rats administered with an ethyl acetate fraction of Momordica charantia extract, and non-induced streptozotosin rats. The measurement of insulin levels is conducted using the enzyme-linked immunosorbent assay (ELISA) technique. If the p-value was more than 0.05, an unpaired T-test was employed for data analysis. Result: The research findings indicate that there is no statistically significant distinction in the insulin levels between streptozotosin-induced rats and streptozotosin-induced rats administered with the ethyl acetate fraction of the Momordica charantia extract group (p = 0.081). The insulin levels of streptozotosin-induced rats administered with an ethyl acetate fraction of Momordica charantia extract were found to be statistically similar to those of non-induced streptozotosin rats (p = 0.505). Conclusion: There is no discernible distinction in the insulin levels among streptozotosin-induced rats, streptozotosin-induced rats administered with an ethyl acetate fraction of Momordica charantia extract, and non-induced streptozotosin rats.
Immunostimulatory Effect of Cayratia trifolia L. Domin on Granulocytes and Natural Killer Cells in Tuberculosis-Induced Rats Muhammad Ilyas Y; Wa Ode Salma; Mubarak Mubarak; Nasrudin Nasrudin; Parawansah Parawansah; Fadhliyah Malik; Asriullah Jabbar; Asniar Pascayantri; Esti Badia; Sernita Sernita; Nirwati Rusli; Lukman La Basy
Jurnal Jamu Indonesia Vol. 11 No. 3 (2026): May–June 2026
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v11i3.433

Abstract

Pulmonary tuberculosis (TB) remains a major public health problem in Indonesia and a leading cause of death from infectious diseases, partly because of impaired host immunity. Galing (Cayratia trifolia L. Domin) has been reported to exert immunomodulatory effects in bacterial infections. This study evaluated the immunostimulatory effect of galing leaf and stem extracts on granulocytes and natural killer (NK) cells in a TB-induced rat model. Leaf and stem extracts were administered orally to 28 Wistar rats at doses of 400 and 500 mg/kg body weight for seven days, followed by induction with TB ESAT-6 antigen. Granulocyte counts were measured using a hematology analyzer, whereas NK cells were quantified by ELISA. Galing extract significantly increased granulocyte and NK cell expression compared with the negative control (p<0.05). These findings indicate that galing extract has potential as an immunostimulatory agent in pulmonary TB by enhancing granulocyte and NK cell responses.
PENINGKATAN PENGETAHUAN SISWA SMP NEGERI 10 KENDARI TENTANG PENGELOLAAN OBAT MELAUI EDUKASI DAGUSIBU Parawansah Parawansah; Hasnawati Hasnawati; Aulia Sakinah Diah; Indah Latif; Nidya Aftira; Suchi Febriani; Yuliani Uzuni
BESIRU : Jurnal Pengabdian Masyarakat Vol. 3 No. 7 (2026): BESIRU : Jurnal Pengabdian Masyarakat, Juli 2026
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/besiru.v3i7.2718

Abstract

DAGUSIBU merupakan program edukasi yang memberikan panduan mengenai cara pengelolaan obat yang benar. Kegiatan pengabdian ini bertujuan meningkatkan pengetahuan siswa SMP Negeri 10 Kendari tentang pengelolaan obat yang benar. Metode yang digunakan berupa penyuluhan melalui ceramah, media presentasi, leaflet, diskusi, dan tanya jawab kepada 30 siswa anggota OSIS. Kegiatan diawali dengan pretest untuk mengetahui pengetahuan awal peserta, kemudian dilanjutkan dengan penyampaian materi dan evaluasi melalui sesi tanya jawab. Hasil menunjukkan adanya peningkatan pemahaman yang ditandai oleh antusiasme, keaktifan dalam diskusi, serta kemampuan siswa menjawab pertanyaan  dengan  benar.  Edukasi  DAGUSIBU  efektif  meningkatkan pengetahuan siswa mengenai penggunaan obat yang rasional dan diharapkan mendorong perilaku pengelolaan obat yang benar dalam kehidupan sehari-hari.
PENGUATAN PERAN KELUARGA DALAM PENCEGAHAN STUNTING PADA ANAK MELALUI PENDEKATAN PROMOTIF DAN PREVENTIF Wa Ode Sitti Zubaydah; Parawansah Parawansah; Fatimardiyach Rahmi; Selvi Selvi; Waode Shima Indisia; Molifa Dalis; Anisa Fauzia Asri
BESIRU : Jurnal Pengabdian Masyarakat Vol. 3 No. 7 (2026): BESIRU : Jurnal Pengabdian Masyarakat, Juli 2026
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/besiru.v3i7.2743

Abstract

Stunting is a chronic nutritional issue resulting from prolonged malnutrition during a child's growth and development, leading to impaired physical growth and brain development. The initiative employed an outreach approach conducted as part of a community service program. The objective was to provide the community with direct information regarding stunting, health education, and the family's role in early prevention. The activity took place at the Benu-Benua Community Health Center in Puunggaloba Village, Kendari City, Southeast Sulawesi. The target audience consisted of local mothers with children under the age of five. The program involved presentations covering the definition of stunting, its causes, and prevention strategies. Results indicated active participant engagement and increased awareness regarding the importance of proper child nutrition. However, the findings also revealed that the community's level of knowledge concerning stunting remains low. Therefore, sustained health and nutrition education programs are necessary.
Anti-inflammatory Activity of Tectona grandis Linn. F. Extract Against TNF-α using In Vivo and Silico Methods Parawansah Parawansah; Nuralifah Nuralifah; Arfan Arfan; Sulastrianah Sulastrianah; Radja Al Fath Widya Iswara; Kiki Murni; Sitti Humairah
Jurnal Kefarmasian Indonesia VOLUME 15, NUMBER 1, FEBRUARY 2025
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

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Abstract

Tumor necrosis factor-alpha (TNF-α), a cytokine involved in inflammation, plays a critical role in inflammatory processes, particularly in synovial cells. Therefore, TNF-α represents a promising target for anti-inflammatory interventions. This study investigates the anti-inflammatory potential of Tectona grandis leaf extract by evaluating its ability to inhibit TNF-α activity. To identify bioactive compounds from the extract that may interact with the TNF-α receptor, molecular docking simulations were employed. In vivo experiments were conducted using different doses of the extract (100, 200, and 300 mg/kg body weight), and TNF-α levels were quantified to assess the anti-inflammatory effect. At a dose of 300 mg/kg, TNF-α levels were significantly reduced to 0.358 μg/L, indicating superior anti-inflammatory activity compared to the lower doses (0.539 μg/L at 100 mg/kg and 0.433 μg/L at 200 mg/kg). Molecular docking simulations revealed two bioactive compounds, Phaeophorbid A and (132S, 17S, 18S)-132-Hydroxy-20-Chloro-Ethylpheophorbide A, which demonstrated strong binding affinities (-5.4 kcal/mol and -5.2 kcal/mol, respectively) and interacted with the TNF-α receptor through hydrogen bonds and hydrophobic interactions. These results underscore the potential of Tectona grandis as a source of novel anti-inflammatory agents, suggesting its value in the development of therapeutic strategies targeting TNF-α in inflammation-related disorders.
PENINGKATAN PENGETAHUAN MASYARAKAT MELALUI SOSIALISASI DAGUSIBU DI DESA WAWATU BERSAMA PUSKESMAS LALOWARU Elhamayasari Elhamayasari; Rachma Malina; Parawansah Parawansah; Suryani Suryani; Ayi Tri Hapsari; Dewi Rahmawati Rufia; Ance Triana; Asna Ramadani; Alda Rizma; Indar Prasti; Dita Rizqyah
BESIRU : Jurnal Pengabdian Masyarakat Vol. 3 No. 1 (2026): BESIRU : Jurnal Pengabdian Masyarakat, Januari 2026
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/besiru.v3i1.2149

Abstract

DAGUSIBU (Dapatkan, Gunakan, Simpan, dan Buang) merupakan program edukasi kepada masyarakat mengenai pengelolaan obat yang benar dan aman, yang dilaksanakan oleh tenaga kefarmasian khususnya apoteker. Kegiatan pengabdian masyarakat ini bertujuan meningkatkan pengetahuan masyarakat tentang penggunaan obat yang rasional berdasarkan konsep DAGUSIBU. Kegiatan dilaksanakan di Posyandu Delima Desa Wawatu, Kecamatan Moramo Utara, Kabupaten Konawe Selatan, Provinsi Sulawesi Tenggara pada 27 November 2025. Metode yang digunakan meliputi penyampaian materi melalui ceramah, pembagian leaflet, serta diskusi interaktif berupa tanya jawab. Sasaran kegiatan adalah masyarakat umum, terutama lansia dan ibu hamil. Hasil kegiatan diharapkan dapat meningkatkan pemahaman masyarakat mengenai penggunaan obat yang benar, meningkatkan kepatuhan terhadap terapi, serta menurunkan risiko efek samping obat. Secara keseluruhan, kegiatan sosialisasi DAGUSIBU terbukti berkontribusi dalam meningkatkan pengetahuan masyarakat.
Co-Authors ,, Suryani Abd Rafid Adryan Fristiohady Agung Wibawa Mahatva Yodha Alda Rizma Ali, Agussalim Alifariki, La Ode Alya Zuhriyah Amaliah Amaliah Amirudin Eso Amirudin Esso Ance Triana Andi Noor Kholidah Anisa Fauzia Asri Anwar, Irvan Arfan Arfan Arfan Arfan Arimaswti Arimaswati Armadany, Fery Indradewi Ashaeryanto Asna Ramadani Asniar Pascayantri Aspadiah, Vica Asriullah Jabbar Asriullah Jabbar Aulia Sakinah Diah Ayi Tri Hapsari Badia, Esti Dewi Rahmawati Rufia Dian Munasari Solo Dias Tama Diasty Nuraisya Dita Rizqyah Djusiana Eka Cessaria Elhamayasari Elhamayasari Elvantri Yani Emma Haerunnita Eso, Amiruddin Fadhliyah Malik Fadhliyah Malik Fadilah Fadilah Fatimardiyach Rahmi Feri Indradewi Ferry Sandra Fitrawan, La Ode Muhammad Gemini Alam Ghina Salsabila Awandhaputri Hasnawati Hasnawati Hutamy Viranda Rahman I Putu Sudayasa I Putu Sudayasa I Putu Sudayasa I Putu Sudayasa Indah Latif Indar Prasti Indriyati Indriyati Irmawati Irmawati Jamaluddin Jamaluddin Juminten Saimin Kasmawati, Henny Kiki Murni La Ode Alifariki La Ode Muhammad Fitrawan La Ode Muhammad Julian Purnama La Rangki Lidya Agriningsih Haruna Loly Subhiaty Idrus Lukman La Basy Mesrawati Trisetya Molifa Dalis Mubarak Mubarak Muh Aidil Adha Muhammad Fathur Rahman Muhammad Fathur Rahman Muhammad Hajrul Malaka Muhammad Ilyas Y Muhammad Junaid Azis Mulyawati, Sufiah Asri Nada Shofa Nadiya Mutmainnah Nasrudin Nasrudin Nidya Aftira Nining Yulianti Nining Yulianti Nirwati Rusli Nita Trinovitasari Nita Trinovitasari Nur Illiyyin Akib Nur Misa Nuralifah Nuralifah, Nuralifah Nurramadhani A. Sida Nurramadhani Asida Nurul Afifah Yusran Nurul Febrina Rahmawati Nuzul Aulia Fajarwati B Pratiwi, Aulif Puteri Febriyanthi Rachman Rachma Malina Radja Al Fath Widya Iswara Rahimah Nurfadilah Dahlan Rahmawati Rahmawati Rahmawati Rahmawati Rahmawati Rathapon Asasutjarit Rifa’atul Mahmudah Risma Ritha Hastria Rosdiana Natzir Ruslin S. Sukurni Sabarudin Sabarudin Sahidin Sahidin Saida Saida Satriana Nasrun Selvi Selvi Selvy Aulia Sernita Sherly Intan Ardani Sitti Humairah Suchi Febriani Sulastrianah Sulastrianah, Sulastrianah Syarifin, Andi Noor Kholidha Tien Tien Tomy Nurtamin Tridamayanti Fataraing Ulan Dwi Shintia Wa Ode Arlina Misnaeni Wa Ode Chesaria F.A Wa Ode Salma Wa Ode Siti Rahayu Fathanah Wa Ode Sitti Zubaydah Wa Ode Yentri Putia Ningtiyas Darmin Wahyuni Wahyuni Wandarsih Juniarti Akbar Waode Shima Indisia Yamin Yamin, Y Yulfa Yulfa Yuliani Uzuni