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All Journal Berkala Ilmu Kesehatan Kulit dan Kelamin Universa Medicina Syntax Literate: Jurnal Ilmiah Indonesia Jurnal Ners Jurnal Cahaya Mandalika JOURNAL LA MEDIHEALTICO MAHESA : Malahayati Health Student Journal Open Access Indonesian Journal of Medical Reviews Cermin Dunia Kedokteran Journal of Social Research COMSERVA: Jurnal Penelitian dan Pengabdian Masyarakat MEDICINUS Proceeding ISETH (International Summit on Science, Technology, and Humanity) Media Dermato-Venereologica Indonesiana Journal of General Procedural Dermatology and Venereology Indonesia Indonesian Basic and Experimental Health Sciences
Widhiati, Suci
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Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Efektivitas Terapi Minoksidil pada Alopesia Androgenetik: Studi in Vivo Monica, Pristia Widya; Kariosentono, Harijono; Widhiati, Suci
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v9i7.15878

Abstract

Alopesia androgenetik merupakan suatu kondisi genetik disebabkan oleh respons berlebih terhadap hormon androgen yang ditandai dengan berkurangnya ukuran folikel rambut terminal pada kulit kepala secara bertahap. Terapi yang tersedia saat ini untuk mencapai pengobatan yang efektif masih terbatas. Penelitian ini bertujuan untuk mengevaluasi efektivitas terapi minoksidil 5% melalui penilaian densitas folikel rambut pada mencit model alopesia androgenetik. Menggunakan metode mencit diinduksi menggunakan testosteron selama 10 hari, kemudian dibagi menjadi dua kelompok, kelompok pertama merupakan kelompok kontrol tanpa mendapakan perlakuan lanjutan. Kelompok kedua diberikan perlakuan aplikasi topikal minoksidil 5% sebanyak dua kali semprotan sekali sehari hingga hari ke-31. Pada hari ke-32, densitas folikel rambut dievaluasi melalui pemeriksaan histopatologi pewarnaan Hematoksilin & Eosin. Analisis statistik menggunakan uji Mann- Whitney dengan tingkat signifikansi p<0,05. Hasil penelitian menunjukan rerata densitas folikel rambut adalah 24,00 pada kelompok kontrol dan 40,14 pada kelompok perlakuan, dengan nilai p<0,05. Kelompok perlakuan aplikasi topikal minoksidil 5% secara signifikan meningkatkan densitas folikel rambut pada kulit mencit model AAG.
Allergic Contact Dermatitis Caused By Daily Soap Products: One Case Report Sambodo, Shelly Lavenia; Widhiati, Suci
Journal of Social Research Vol. 4 No. 12 (2025): Journal of Social Research
Publisher : International Journal Labs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55324/josr.v4i12.2896

Abstract

Allergic contact dermatitis (ACD) is a skin disorder resulting from contact with an allergenic substance. Most cases of ACD are caused by cosmetic ingredients and daily-use products. We report a case of ACD caused by sodium lauryl sulfate (SLS) and fragrance in soap, confirmed by positive patch test results. A 29-year-old woman with chronic persistent itching that did not improve with medication presented to the Dermatovenereology Outpatient Clinic of Dr. Moewardi Hospital. She had a history of using virgin coconut oil (VCO) and various handwashing soaps. Dermatological examination revealed multiple erythematous macules with overlying scales and xerotic skin, suggestive of ACD. The patient underwent a patch test with standard materials as well as personal products she brought to confirm the diagnosis. The patch test showed a positive allergic reaction to Sunlight® liquid soap, Biore® liquid soap, Cerianerss® lychee-flavored VCO, One Scrub Onemed® 4%, and Paquito® liquid soap. Patch testing is an important and useful tool for diagnosing ACD. Although the procedure is simple, it requires several days for evaluation. In this case, we identified the products responsible for ACD in our patient and advised her to avoid them. Several substances with allergenic potential were identified by comparing product compositions with patch test results. However, these findings could not determine which specific compounds were allergenic. Hence, further patch testing of individual compounds is necessary.
Retinoblastoma tumor suppressor protein is not a risk factor for the location of condyloma acuminatum among adults Primisawitri, Pratiwi Prasetya; Mulianto, ⁠Nurrachmat; Ellistasari, Endra Yustin; Poncorini, Eti; Kariosentono, ⁠⁠Harijono; Widhiati, Suci; Wasita, Brian; Setyawan, Novan Adi; Yudhistira, Muhammad Yurizar
Universa Medicina Vol. 44 No. 3 (2025): Ahead Of Print
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2025.v44.343-349

Abstract

BackgroundCondylomata acuminata (CA) are sexually transmitted infections primarily caused by low-risk HPV types 6 and 11. Retinoblastoma protein (pRb) interacts with HPV oncoproteins, leading to destabilization, genomic instability, and carcinogenesis. This study aimed to determine whether variations in pRb expression and sexual orientation are risk factors of the anatomical location of CA lesions and to compare differences in pRb expression by sexual orientation. MethodsA cross-sectional study was conducted among 33 patients aged >18 years with clinically and histopathologically confirmed CA. Demographic data, pRb expression assessed via excision biopsy and immunohistochemistry, and relevant risk factors were collected. Statistical analyses including Simple and multiple binary logistic regression were used to analyze the data, with model fit assessed using the Hosmer–Lemeshow test. ResultsWeak pRb expression predominated in anal lesions (92.3%; p=0.018) and among homosexual/bisexual individuals (57.9%; p=0.031), while moderate expression was more common in genital lesions (66.7%; p=0.018) and heterosexual individuals (57.1%; p=0.011). Simple logistic regression  analysis showed that HIV status (OR=11.88; p=0.025), sexual orientation (OR=13.33; p=0.001), and moderate-to-strong pRb expression (OR=24.00; p=0.008; OR=12.00; p=0.048) were associated with lesion location. In the multivariate model, pRb expression was excluded due to multicollinearity. Sexual orientation remained the only independent predictor of lesion location (Adj OR=8.89; p=0.023), with heterosexual individuals more likely to present with genital lesions. ConclusionThe expression of pRb was not a risk factor of the anatomical location of CA, and differed between genital and anal CA. However, sexual orientation emerged as the dominant independent factor associated with lesion location.   
Combined Immunosuppressive Therapy (Corticosteroid-Cyclosporine) on Hospital Stay in Patients with SevereCutaneous Adverse Reactions perspective of health worker: A Qualitative Study Widhiati, Suci; -, Hastika Dwi Oktiningrum; Tansil, Ivana; Arrosyid, Azhar
Indonesian Basic and Experimental Health Sciences Vol. 14 No. 1 (2025): November
Publisher : Rumah Sakit Umum Daerah Dr. Moewardi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/ibehs.vol14iss1pp98-102

Abstract

IntroductionSevere cutaneous adverse reactions (SCARs) such as Stevens-Johnson Syndrome (SJS), Toxic Epidermal Necrolysis (TEN), and DRESS are rare but life-threatening conditions requiring intensive inpatient care. Corticosteroids remain the main therapy but may prolong hospitalization and increase complications. Combining corticosteroids with cyclosporine has been considered to improve patient outcomes. This study explored healthcare professionals’ perspectives on the impact of this therapy combination on hospitalization duration for SCAR patients. MethodsA qualitative exploratory study was conducted at Dr. Moewardi General Hospital, Surakarta (August–October 2023). Purposive sampling recruited 12 healthcare professionals (3 consultants, 5 residents, 4 nurses) involved in SCAR management. Semi-structured interviews explored diagnostic confidence, treatment approaches, and hospitalization duration. Data were analyzed using thematic analysis. ResultPhysicians reported high diagnostic confidence, with typical hospital stays ranging from 14–30 days. Most favored corticosteroid–cyclosporine combination therapy, perceiving faster recovery and fewer complications. Barriers included limited drug availability, unfamiliarity with dosing, and safety concerns. Nurses emphasized wound care challenges, infection risks, and psychosocial needs. Both groups underlined the importance of multidisciplinary collaboration and family involvement in optimizing patient outcomes. ConclusionHealthcare professionals perceive corticosteroid–cyclosporine combination therapy as potentially effective in shortening hospitalization and reducing complications among SCAR patients. Institutional support, clinician training, and further clinical research are recommended to strengthen its implementation.
Co-Authors -, Hastika Dwi Oktiningrum Alia, Vrenda Aliwardani, Ambar Arrosyid, Azhar Aulia Yasmin, Aulia Brian Wasita Bunga, Gita Hening Dewi, Putti Fatiharani Dewi, Susanti Rosmala Dharmawan, Nugrohoaji Dita Eka Novriana Dwi Hidayah Ellistari, Endra Yustin Ellistasari, Endra Yustin Endraputra, Pristiawan Febriani, Dina Fiqnasyani, Siti Efrida Hapsari, Jasmine Rahmi Harahap, Irene Jessica Pinarsinta Indah Julianto, Indah Irawanto, Muhammad Eko Jalasena Mysea, Marsyanda Kamilah, Lian Kariosentono, Harijono Kariosentono, ⁠⁠Harijono Kusumawardani, Arie Lidjaja, Lifesia Natali Marcella, Benazier Mochtar, Moerbono Monica, Pristia Widya Mulianto, Nurachmat Mulianto, ⁠Nurrachmat Murasmita, Alamanda Nareswari, Adniana Novan Adi Setyawan Noviani, Laura Nurrachmat Mulianto Nurul Hidayati Octarica, Stella Gracia Paramitasari, Anggana Rafika Poncorini, Eti Prasetyadi Mawardi Primisawitri, Pratiwi Prasetya Purnomo, Frederick Johan Purwoko, Agus Putri, Osdatilla Esa Rahma, Alfina Rosita, Fiska Rosmarwati, Ervina Sari, Endra Yustin Ellista Shelly Lavenia Sambodo Tansil, Ivana Triasari Oktavriana Widyastuti, Zilpa Yudhistira, Muhammad Yurizar