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All Journal Berkala Ilmu Kesehatan Kulit dan Kelamin Universa Medicina Syntax Literate: Jurnal Ilmiah Indonesia Jurnal Cahaya Mandalika JOURNAL LA MEDIHEALTICO MAHESA : Malahayati Health Student Journal Open Access Indonesian Journal of Medical Reviews Cermin Dunia Kedokteran COMSERVA: Jurnal Penelitian dan Pengabdian Masyarakat MEDICINUS Proceeding ISETH (International Summit on Science, Technology, and Humanity) Media Dermato-Venereologica Indonesiana Journal of General Procedural Dermatology and Venereology Indonesia Indonesian Basic and Experimental Health Sciences
Widhiati, Suci
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Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Combined Immunosuppressive Therapy (Corticosteroid-Cyclosporine) on Hospital Stay in Patients with SevereCutaneous Adverse Reactions perspective of health worker: A Qualitative Study Widhiati, Suci; -, Hastika Dwi Oktiningrum; Tansil, Ivana; Arrosyid, Azhar
Indonesian Basic and Experimental Health Sciences Vol. 14 No. 1 (2025): November
Publisher : Rumah Sakit Umum Daerah Dr. Moewardi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/ibehs.vol14iss1pp98-102

Abstract

IntroductionSevere cutaneous adverse reactions (SCARs) such as Stevens-Johnson Syndrome (SJS), Toxic Epidermal Necrolysis (TEN), and DRESS are rare but life-threatening conditions requiring intensive inpatient care. Corticosteroids remain the main therapy but may prolong hospitalization and increase complications. Combining corticosteroids with cyclosporine has been considered to improve patient outcomes. This study explored healthcare professionals’ perspectives on the impact of this therapy combination on hospitalization duration for SCAR patients. MethodsA qualitative exploratory study was conducted at Dr. Moewardi General Hospital, Surakarta (August–October 2023). Purposive sampling recruited 12 healthcare professionals (3 consultants, 5 residents, 4 nurses) involved in SCAR management. Semi-structured interviews explored diagnostic confidence, treatment approaches, and hospitalization duration. Data were analyzed using thematic analysis. ResultPhysicians reported high diagnostic confidence, with typical hospital stays ranging from 14–30 days. Most favored corticosteroid–cyclosporine combination therapy, perceiving faster recovery and fewer complications. Barriers included limited drug availability, unfamiliarity with dosing, and safety concerns. Nurses emphasized wound care challenges, infection risks, and psychosocial needs. Both groups underlined the importance of multidisciplinary collaboration and family involvement in optimizing patient outcomes. ConclusionHealthcare professionals perceive corticosteroid–cyclosporine combination therapy as potentially effective in shortening hospitalization and reducing complications among SCAR patients. Institutional support, clinician training, and further clinical research are recommended to strengthen its implementation.
Nail Abnormalities In Genodermatose Widhiati, Suci; Danarti, Retno; Budi Rustiawati, Cyntia Arum
Indonesian Basic and Experimental Health Sciences Vol. 14 No. 2 (2026): April
Publisher : Rumah Sakit Umum Daerah Dr. Moewardi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/ibehs.vol14iss2pp128-134

Abstract

Introduction Nail abnormalities may serve as early indicators of various genodermatoses, either presenting in isolation or alongside systemic features. These abnormalities, though sometimes cosmetic, often hold significant diagnostic value, especially in inherited ectodermal disorders. Understanding the anatomy and embryology of the nail unit is crucial for identifying the origin and nature of such defects. Method This literature review was conducted by analyzing selected journal articles, case reports, and textbooks focusing on genodermatoses with distinct nail involvement. The analysis centered on the classification of nail abnormalities based on their anatomical origin: nail matrix, nail bed, or combined mesodermal-ectodermal defects. Results Findings revealed that nail abnormalities are prominent in several genodermatoses. Nail matrix defects are observed in congenital dyskeratosis, marked by nail dystrophy, leukoplakia, and mucocutaneous pigmentation. Nail bed defects, as seen in congenital pachyonychia and hydrotic ectodermal dysplasia, lead to thickened, dystrophic nails and associated skin changes. Combined mesodermal-ectodermal disorders, such as nail-patella syndrome, present with absent or hypoplastic nails alongside skeletal, renal, and ocular abnormalities. Each condition displayed specific nail manifestations that can aid early diagnosis. Discussion: The review emphasizes the importance of integrating knowledge of nail anatomy and development to differentiate between types of nail abnormalities. Identifying the anatomical origin aids in narrowing the differential diagnosis and can provide early clues to systemic genodermatoses, even before other clinical signs emerge. Conclusion: Nail abnormalities are important diagnostic markers in genodermatoses. Routine nail examination should be an integral part of dermatological assessments to facilitate early recognition and diagnosis of underlying genetic disorders.
Co-Authors -, Hastika Dwi Oktiningrum Alia, Vrenda Aliwardani, Ambar Arrosyid, Azhar Aulia Yasmin, Aulia Brian Wasita Budi Rustiawati, Cyntia Arum Bunga, Gita Hening Dewi, Putti Fatiharani Dewi, Susanti Rosmala Dharmawan, Nugrohoaji Dita Eka Novriana Ellistari, Endra Yustin Ellistasari, Endra Yustin Febriani, Dina Fiqnasyani, Siti Efrida Hapsari, Jasmine Rahmi Harahap, Irene Jessica Pinarsinta Indah Julianto, Indah Irawanto, Muhammad Eko Jalasena Mysea, Marsyanda Kamilah, Lian Kariosentono, Harijono Kariosentono, ⁠⁠Harijono Kusumawardani, Arie Lidjaja, Lifesia Natali Marcella, Benazier Mochtar, Moerbono Monica, Pristia Widya Mulianto, Nurachmat Mulianto, ⁠Nurrachmat Murasmita, Alamanda Nareswari, Adniana Novan Adi Setyawan Noviani, Laura Nurul Hidayati Paramitasari, Anggana Rafika Poncorini, Eti Primisawitri, Pratiwi Prasetya Purnomo, Frederick Johan Purwoko, Agus Rahma, Alfina Rosita, Fiska Rosmarwati, Ervina Sari, Endra Yustin Ellista Tansil, Ivana Triasari Oktavriana Widyastuti, Zilpa Yudhistira, Muhammad Yurizar