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All Journal Indonesian Journal of Pharmaceutical Science and Technology Jurnal Agroindustri Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Penelitian Pendidikan IPA (JPPIPA) Window of Health : Jurnal Kesehatan Media Farmasi PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Journal of Pharmaceutical and Medicinal Sciences Fullerene Journal of Chemistry Jurnal Ilmiah Farmasi Farmasyifa ad-Dawaa : Journal of Pharmaceutical Sciences Jurnal Riset Kefarmasian Indonesia Jurnal farmasi UIN Alauddin Makassar Jurnal Mandala Pengabdian Masyarakat Yumary: Jurnal Pengabdian kepada Masyarakat Narra J Journal of Experimental and Clinical Pharmacy (JECP) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Pengabdian Kefarmasian jpki Jurnal Katalisator Media Farmasi Jurnal Tumbuhan Obat Indonesia Media Penelitian dan Pengembangan Kesehatan Jurnal Sains dan Kesehatan
Khairi, Nur
Fakultas Ilmu Kesehatan Universitas Almarisah Madani
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Journal : Media Farmasi

 1 
Efektivitas Ekstrak Daun Kelor (Moringa oleifera L.) Untuk Ulkus Peptikum Pada Tikus Putih (Rattus norvegicus) Yang Diinduksi Aspirin Indrisari, Maulita; Khairi, Nur; Muslimin, Lukman; Awaluddin, Akbar; Arisah, Arisah
Media Farmasi XXX Vol 19, No 1 (2023)
Publisher : Jurusan Farmasi Politeknik Kesehatan Makassar, Kementerian Kesehatan RI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v19i1.3292

Abstract

Effectiveness of Moringa Leaf Extract (Moringa oleifera L.) for Peptic Ulcuses In Aspirine-Induced White Rats (Rattus norvegicus)Moringa (Moringa oleifera L). is a plant that is known for its multipurpose, nutrient-dense, and medicinal properties. Moringa leaves contain flavonoid compounds, namely β-sitosterol which can reduce ulcers in the stomach. This research used 15 male white rats divided into 5 groups, namely the normal group, CMC Na (Negative), ranitidine (Positive), and treatment with extract doses of 100 and 300 mg/kg BW. Test animals were induced by aspirin at a dose of 500 mg/kg for 7 days, then given treatment for 7 days, except for the normal group. On the 15th day, all groups were sacrificed, then the gastric organs were visually observed, and the ulcer index was measured. the observations it was found that the administration of the extract at a dose of 300 mg/kgBB decreased the number of ulcers compared to the positive control group (p>0.05). The extract dose of 300 mg/kg BW reduces the number of aspirin-induced ulcer diameters. The results of statistics with Kruskall-Wallis, there was a significant difference after treatment (p<0.05), but there was no significant difference between groups (p>0.05). Ethanol extract of Moringa leaves at a dose of 300 mg/kgBB can be gastroprotective in aspirin-induced male white rats.Keyword: Moringa leaves, gastroprotective, gastric ulcer, aspirinKelor (Moringa oleifera L).merupakan tanaman yang dikenal multi guna, padat akan nutrisi dan bermanfaat sebagai obat. Daun kelor mengandung senyawa flavonoid, yakni β-sitosterol yang dapat mengurangi tukak pada lambung. Penelitian ini menggunakan tikus putih jantan sebanyak 15 ekor yang dibagi dalam 5 kelompok yaitu kelompok normal, Na CMC (Negatif), ranitidine (Positif), dan perlakuan dengan dosis  ekstrak 100 dan 300 mg/kgBB. Hewan uji di induksi aspirin dosis 500 mg/kgBB selama 7 hari, kemudian diberi pengobatan selama 7 hari, kecuali kelompok normal. Pada hari ke-15 semua kelompok dikorbankan kemudian diamati organ lambung secara visual diukur indeks tukak. Dari hasil pengamatan diketahui bahwa pemberian ekstrak dosis 300 mg/kgBB terjadi penurunan jumlah tukak dibandingkan dengan kelompok kontrol positif  (p>0,05). Dosis ekstrak 300 mg/kgBB memberikan efek penurunan jumlah diameter tukak akibat induksi aspirin. Berdasarkan hasil perhitungan dengan Kruskall-Wallis menunjukkan adanya perbedaan yang signifikan setelah perlakuan (p<0,05), namun tidak menunjukkan perbedaan signifikan antar kelompok (p>0,05). Ekstrak etanol daun kelor dengan dosis 300 mg/kgBB memiliki kemampuan sebagai gastroprotektif pada tikus putih  jantan yang diinduksi aspirin.Keyword : Daun kelor, gastroprotektif, tukak lambung, aspirin
Co-Authors Abdul Halim Umar Achmad, Nurafni Annisa Agustina Ma'tang Parinding Aisyah , Andi Nur Aisyah, Andi Nur Akbar Awaluddin Aksa, Rahmat Alexandra, Francisca Diana Ali Djamhuri Ali, Nurul Ulfah Amriani Amriani Amriani Sapra Amriani Sapra Andi Nur Aisyah Andi Nur Aisyah Andi Nur Aisyah, Andi Nur Aisyah Andi Paluseri Andi Paluseri Anggyasti, Anggyasti Arisah, Arisah Astuti Amin Awaluddin, Akbar Burhan, Asril Dali Djamaluddin, Suci F Dwirandy, Dwirandy Eko Allo Fadillah Maryam Fajriansyah Fajriansyah Fitriyanti Jumaetri Hapiwaty, Saldi Harlyanti Muthma'innah Mashar Hikma, Nurul Ikbal Ikbal Ikbal Indradewa, Rhian Irwana, Rina Ismail Ismail Ismail Jumarni Jumarni Khairuddin Khairuddin Lukman Lukman Lukman Muslimin Madinatul munawwarah Malluka, Rifka Margaretha Margaretha Maria Ulfa Maria Ulfa Maria Ulfa Marwati Marwati Marwati Marwati Marwati Marwati Mar’atun Jannah, Imrawati, Muzakkir Baitz, Maulita Indrisari Maulita Indrisari, Maulita Megawati - Megawati Megawati Michrun Nisa Mirnawati Salampe Mus, Suwahyuni Muslimin, Lukman Nasir, Ardiansyah Jumaedi Noer Fauziah Nursamsiar Nursamsiar Nurul fadillah, Nurul Nurul Hikma Nurwijayanti Nurzadrina Wahyuddin paluseri, Andi Pattinggi, Patricia Reny Syahruni Riska Rahayu Rosyid, Sujud Z Sami, Fitriyanti Sapra, Amriani Sepriani Yusuf Sitti Rahimah, Sitti Solly Aryza Sukmawati Sukmawati Sukriani Kursia, Sukriani Suryani Tawali Suwahyuni Suwahyuni Syamsu Nur Syamsu Nur Syamsu Nur, Syamsu Syamsu Nur, Syamsu Nur Utami, Novi F. Wahyu Hendrarti Wahyu Hendrarti Yasir, Budiman Yassir, Budiman Yuri Pratiwi Utami Zulham Zulham