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All Journal Indonesian Journal of Pharmaceutical Science and Technology Jurnal Agroindustri Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Penelitian Pendidikan IPA (JPPIPA) Window of Health : Jurnal Kesehatan Media Farmasi PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Journal of Pharmaceutical and Medicinal Sciences Fullerene Journal of Chemistry Jurnal Ilmiah Farmasi Farmasyifa ad-Dawaa : Journal of Pharmaceutical Sciences Jurnal Riset Kefarmasian Indonesia Jurnal farmasi UIN Alauddin Makassar Jurnal Mandala Pengabdian Masyarakat Yumary: Jurnal Pengabdian kepada Masyarakat Narra J Journal of Experimental and Clinical Pharmacy (JECP) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Pengabdian Kefarmasian jpki Jurnal Katalisator Media Farmasi Jurnal Tumbuhan Obat Indonesia Media Penelitian dan Pengembangan Kesehatan Jurnal Sains dan Kesehatan
Khairi, Nur
Fakultas Ilmu Kesehatan Universitas Almarisah Madani
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Journal : Media Farmasi

 1 
Formulasi Kapsul Ekstrak Etanol Daun Sambung Nyawa (Gynurae procumbens (Lour) Merr) dengan Variasi konsentrasi Bahan Pengikat Polivinil Pirolidon (PVP) burhan, Asril; Ikbal; Zulham, Zulham; Aisyah , Andi Nur; Khairi, Nur; Ulfa, Maria
Media Farmasi Vol 20 No 2 (2024): Media Farmasi Edisi Oktober 2024
Publisher : Jurusan Farmasi Poltekkes kemenkes Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v20i2.522

Abstract

Formulation of Ethanol Extract Capsules of Sambung Nyawa Leaves (Gynurae procumbens (Lour) Merr) with Varying Concentrations of Polyvinyl Pyrrolidone (PVP) Sambungnyawa (Gynurae procumbens (Lour) Merr) is known to have several secondary metabolite compounds including alkaloids, flavonoids, anthraquinones, saponins, glycosides and essential oils. The aim of this research is to obtain a stable concentration of PVP binder if formulated in granule form for encapsulation in ethanol extract of sambungjiwa leaves. The variation in PVP concentration used was 0.5%; 1.5 %; 2.5 %; 3.5 %; and 4.5%. Granules are made using the wet granulation method then put into the capsule shell and continued with evaluation. Based on the evaluation results of the ethanol extract capsule formulations of sambungjiwa leaves, it can be concluded that variations in the concentration of PVP as a binder can affect the physical stability of the capsule preparation, where the five formulas with different concentration variations have different stability after hygroscopicity testing. The formula that has good physical stability is the FK4 formula with a PVP concentration of 3.5%. Sambung Nyawa (Gynurae procumbens (Lour) Merr) diketahui memiliki beberapa senyawa metabolit sekunder diantaranya alkaloid, flavonoid, antraquinon, saponin, glikosida dan minyak atsiri, Tujuan dari penelitian ini untuk mendapatkan konsentrasi bahan pengikat PVP yang stabil jika diformulasi dalam bentuk granul untuk dikapsulkan pada ekstrak etanol daun Sambung Nyawa. Variasi konsentrasi PVP yang digunakan adalah 0,5 %; 1,5 %; 2,5 %; 3,5 %; dan 4,5 %. Granul dibuat dengan metode granulasi basah kemudian dimasukkan ke dalam cangkang kapsul dan dilanjutkan dengan evaluasi. Berdasarkan hasil evaluasi dari formulasi kapsul ekstrak etanol daun Sambung Nyawa  dapat disimpulkan bahwa variasi konsentrasi PVP sebagai bahan pengikat dapat mempengaruhi kestabilan fisik sediaan kapsul, dimana kelima formula dengan variasi konsentrasi yang berbeda memiliki kestabilan yang berbeda-beda setelah pengujian higroskopisitas. Formula yang memiliki kestabilan fisik yang baik adalah formula FK4 dengan konsentrasi PVP 3.5%.
Formulasi Sampo Antiketombe Liofilisat Buah Mengkudu (Morinda citrifolia): Aktivitas Antijamur, Uji Stabilitas Dan Keamanan Melalui HET-CAM Khairi, Nur; Yasir, Budiman; Indrisari, Maulita
Media Farmasi Vol 22 No 1 (2026): Media Farmasi Edisi April 2026
Publisher : Jurusan Farmasi Poltekkes kemenkes Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v22i1.1898

Abstract

Dandruff is a common issue caused by the overgrowth of Malassezia furfur on the scalp. This study aims to develop a safe antidandruff shampoo formulation based on lyophilized noni fruit (Morinda citrifolia L.) and evaluate its effectiveness in combating dandruff. The lyophilized noni fruit was tested for its antifungal activity at five concentrations: 2%, 4%, 6%, 8%, and 10%, and then formulated into shampoo in three concentrations: F1 (6%), F2 (8%), and F3 (10%). The effectiveness of the shampoo formulations was tested against Malassezia furfur using the agar diffusion method. The safety of the formulations was also evaluated using the HET-CAM method to ensure their non-irritating properties. The results indicated that lyophilized noni fruit exhibited significant antifungal activity, with the largest inhibition zone observed at 10% concentration (23.16 ± 5.36 mm), which was not significantly different from the positive control (ketoconazole). Additionally, the HET-CAM test showed no irritation for all formulations, with an irritation score of 0. This study concludes that lyophilized noni fruit shampoo can serve as an effective and safe natural alternative for dandruff treatment.
Co-Authors Abdul Halim Umar Achmad, Nurafni Annisa Agustina Ma'tang Parinding Aisyah , Andi Nur Aisyah, Andi Nur Akbar Awaluddin Aksa, Rahmat Alexandra, Francisca Diana Ali Djamhuri Ali, Nurul Ulfah Amriani Amriani Amriani Sapra Amriani Sapra Andi Nur Aisyah Andi Nur Aisyah Andi Nur Aisyah, Andi Nur Aisyah Andi Paluseri Andi Paluseri Anggyasti, Anggyasti Arisah, Arisah Astuti Amin Awaluddin, Akbar Burhan, Asril Dali Djamaluddin, Suci F Dwirandy, Dwirandy Eko Allo Fadillah Maryam Fajriansyah Fajriansyah Fitriyanti Jumaetri Hapiwaty, Saldi Harlyanti Muthma'innah Mashar Hikma, Nurul Ikbal Ikbal Ikbal Indradewa, Rhian Irwana, Rina Ismail Ismail Ismail Jumarni Jumarni Khairuddin Khairuddin Lukman Lukman Lukman Muslimin Madinatul munawwarah Malluka, Rifka Margaretha Margaretha Maria Ulfa Maria Ulfa Maria Ulfa Marwati Marwati Marwati Marwati Marwati Marwati Mar’atun Jannah, Imrawati, Muzakkir Baitz, Maulita Indrisari Maulita Indrisari, Maulita Megawati - Megawati Megawati Michrun Nisa Mirnawati Salampe Mus, Suwahyuni Muslimin, Lukman Nasir, Ardiansyah Jumaedi Noer Fauziah Nursamsiar Nursamsiar Nurul fadillah, Nurul Nurul Hikma Nurwijayanti Nurzadrina Wahyuddin paluseri, Andi Pattinggi, Patricia Reny Syahruni Riska Rahayu Rosyid, Sujud Z Sami, Fitriyanti Sapra, Amriani Sepriani Yusuf Sitti Rahimah, Sitti Solly Aryza Sukmawati Sukmawati Sukriani Kursia, Sukriani Suryani Tawali Suwahyuni Suwahyuni Syamsu Nur Syamsu Nur Syamsu Nur, Syamsu Syamsu Nur, Syamsu Nur Utami, Novi F. Wahyu Hendrarti Wahyu Hendrarti Yasir, Budiman Yassir, Budiman Yuri Pratiwi Utami Zulham Zulham