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Pendampingan Pembuatan Jamu Instan Tanaman sebagai Produk KB Alami pada Ibu Pkk Marwati, Marwati; Khairi, Nur; Alexandra, Francisca Diana; Fadillah, Nurul; Anggyasti, Anggyasti
Yumary: Jurnal Pengabdian kepada Masyarakat Vol. 6 No. 1 (2025): September
Publisher : Penerbit Goodwood

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35912/yumary.v6i1.3826

Purpose: The purpose of community service is to increase the knowledge of the PKK cadre women on the types of medicinal plants that are efficacious as natural birth control, increase their knowledge of traditional medicine processing that is efficacious as natural family planning, and increase their knowledge of reproductive health and types of family planning. Methodology: This study was conducted at the Moreira Farm in the Al Anshar East Timor Islamic Boarding School area. Hydroponics innovation has been applied by increasing the quantity and quality of hydroponics through technological tools and innovations to streamline and increase the yield of hydroponic plants to achieve higher quality than before. Results: The service method applied is the method of applying innovations by providing counselling assistance and practicing making instant herbal medicine Natural contraception of traditional medicine to increase understanding to cadres of PKK mothers in the development of natural materials. Conclusion: The conclusion of this activity is the increased knowledge of PKK women cadres and the community about the utilization of traditional medicine as instant herbal medicine for natural contraception to reduce the birth rate. Limitation: The knowledge of the PKK cadre and the community on the use of traditional medicine for natural family planning is still lacking. Contribution: This service is useful in the traditional medicine industry and the development of natural materials as products.

FORMULASI GRANUL INSTAN EKSTRAK BUAH BUNI (Antidesma bunius L.) SEBAGAI MINUMAN ANTIOKSIDAN Jalil Genisa, Nur Khairi; Amriani Sapra; Suryani Tawali; Maulita Indrisari
Jurnal Agroindustri Vol. 14 No. 1 (2024): May 2024
Publisher : BPFP Faperta UNIB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31186/jagroindustri.14.1.1-10

Buni is a plant that is widespread in Asia, especially Indonesia. Buni fruit has been reported to contain anthocyanins which have activity as flavonoids, antiocyanins, saponins, alkaloids and as high antioxidant agents, but because Buni fruit is seasonal so raw materials depend on the season, therefore to increase availability it needs to be extracted and formulated in a form preparations. The purpose of this study was to obtain an instant granule formula that meets the physical characteristics and to determine the IC50 value of the antioxidant activity of the instant granule preparation of buni fruit extract (Antidesma bunius L.). The extract was prepared by extraction method using 70% ethanol solvent with the addition of 3% citric acid for 3x24 hours. Instant granules were prepared using the wet granulation method using varying concentrations of PVP as a binder, namely 1%, 3% and 5%. Furthermore, the physical characteristics were evaluated including flow properties, moisture content, soluble time, then antioxidant activity was determined based on the IC50 value using the DPPH method. The results showed that F1 and F2 had good flow properties and F3 had very good flow properties, the moisture content was around 2-4% and the dissolution time was 2-3 minutes. Based on the test results obtained formula 3 with a PVP concentration of 5% is a formula that meets the physical requirements of granules and an IC50 value of 65.94 µg/mL is included in the strong antioxidant category.

Phytochemical profiling and enzyme inhibitory activity of Sterculia populifolia DC stem bark extract and fractions against elastase and tyrosinase Khairi, Nur; Nursamsiar, Nursamsiar; Utami, Novi F.; Marwati, Marwati; Nur, Syamsu; Indrisari, Maulita; Kursia, Sukriani
Narra J Vol. 5 No. 3 (2025): December 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i3.1778

The demand for natural ingredients in cosmetic and medical applications is steadily increasing, particularly for anti-aging and skin-lightening products. Sterculia populifolia DC, a member of the Sterculia genus, is known to contain diverse bioactive compounds such as flavonoids, phenolics, and terpenoids, which may offer pharmacological benefits. The aim of this study was to evaluate the anti-aging potential of S. populifolia stem bark extract and its solvent-partitioned fractions through enzyme inhibition assays coupled with phytochemical profiling. The stem bark was extracted using 96% ethanol via maceration, followed by sequential liquid-liquid partitioning with n-hexane, ethyl acetate, n-butanol, and water. Phytochemical constituents were characterized using liquid chromatography-tandem mass spectrometry (LC-MS/MS). The inhibitory activities of the extract and fractions against tyrosinase and elastase enzymes were evaluated using spectrophotometric assays, with kojic acid and quercetin as positive controls, respectively. IC₅₀ values were calculated to quantify enzyme inhibition potency. LC-MS/MS analysis revealed key bioactive compounds, including 4-[(E)-(3,5-diamino-1H-pyrazol-4-yl)diazenyl]phenol, isofraxidin, and (22E)-ergosta-4,6,8(14),22-tetraen-3-one. Among the tested samples, the ethanol extract exhibited the most potent activity, with an IC₅₀ of 93.35 µg/mL for elastase inhibition and 133.15 µg/mL for tyrosinase inhibition—classified as strong and moderate activity, respectively. Collectively, these findings demonstrate that S. populifolia stem bark extract possesses promising anti-aging and depigmenting properties, supporting its potential development as a natural bioactive ingredient in cosmetic and skincare formulations.

Activitas, Formulasi dan Efektivitas Gel Ekstrak Beras Hitam (Oryza sativa L) terhadap Bakteri Staphylococcus aureus dan Escherichia coli Khairi, Nur; Hapiwaty, Saldi; Indrisari, Maulita; Marwati, Marwati
Jurnal Penelitian Pendidikan IPA Vol 9 No 6 (2023): June
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v9i6.3914

Black rice (Oryza sativa L.) contains chemical compounds, namely ferulic acid, -oryzanol, amino acids, tannins, phenolics, and anthocyanins which have potential as antibacterial agents. This study aims to formulate an antibacterial gel preparation from black rice extract with an extract concentration of 10% and to test the antibacterial effectiveness of the gel preparation against Staphylococcus aureus and Escherichia coli bacteria. Black rice extract was obtained by maceration using 70% ethanol solvent: 3% citric acid. The extract obtained was then formulated in a gel dosage form. The results showed that black rice extract could be formulated as an antibacterial gel preparation that met the organoleptic, homogeneity, pH, spreadability, and adhesion requirements. In the results of the antibacterial effectiveness test, there is a clear zone which represents the ability to inhibit the growth of the tested bacteria by the gel. Black rice extract can be formulated in a gel dosage form with an extract concentration of 10% and a physically stable formula is obtained in formula III with a carbopol concentration of 2%. The average diameter of the antibacterial gel FIII preparation of black rice extract in inhibiting Staphylococcus aureus bacteria was classified as strong, namely 11.17 Â± 0.34 mm, while inhibition of Escherichia coli bacteria was also relatively strong, namely 12.20 Â± 0.46 mm

Effectiveness of breadfruit leaf extract in mouthwash formula to inhibit the bacteria of Streptococcus mutans that causes caries Khairi, Nur; Aisyah, Andi Nur; Indrisari, Maulita; Sukmawati, Sukmawati; Nisa, Michrun
Media Penelitian dan Pengembangan Kesehatan Vol. 36 No. 1 (2026): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v36i1.2722

Background: Dental caries is caused by Streptococcus mutans, which forms biofilms and produces acid that damages tooth enamel. Prevention is often achieved through mouthwashes containing antibacterial agents, but commercial products may have side effects due to chemical ingredients. Artocarpus altilis (breadfruit) leaves contain bioactive compounds like flavonoids and tannins, which have potential as natural antibacterial agents. Objective: This study aimed to evaluate the antibacterial activity of Artocarpus altilis leaf extract and formulate an effective mouthwash against Streptococcus mutans. Methods: The study used a true experimental design with a pretest-posttest control group. The extract was obtained by maceration with 96% ethanol. Three mouthwash formulations were prepared with varying glycerin concentrations (15%, 20%, and 25%). Antibacterial activity was assessed using the paper disk method, and data were analyzed using Kruskal-Wallis and Mann-Whitney tests. Results: The 2-4% extract had strong antibacterial activity, with inhibition zones ranging from 20.25–23.81 mm, significantly different from the negative control (p<0.05). The mouthwash formulations were liquid, yellow-green in color, with a characteristic breadfruit and mint scent, pH ranging from 5.5 to 7.9, and viscosity of 1 cPs. The mouthwash exhibited strong antibacterial activity, with inhibition zones between 18.81±1.5 mm and 18.94±0.5 mm, showing no significant differences across formulas (p>0.05). Conclusion: The 2% Artocarpus altilis extract and 15% glycerin formula was stable and effectively inhibited Streptococcus mutans

Pendampingan Pembuatan Jamu Instan Tanaman sebagai Produk KB Alami pada Ibu Pkk Marwati, Marwati; Khairi, Nur; Alexandra, Francisca Diana; Fadillah, Nurul; Anggyasti, Anggyasti
Yumary: Jurnal Pengabdian kepada Masyarakat Vol 6 No 1 (2025): September
Publisher : Penerbit Goodwood

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35912/yumary.v6i1.3826

Purpose: The purpose of community service is to increase the knowledge of the PKK cadre women on the types of medicinal plants that are efficacious as natural birth control, increase their knowledge of traditional medicine processing that is efficacious as natural family planning, and increase their knowledge of reproductive health and types of family planning. Methodology: This study was conducted at the Moreira Farm in the Al Anshar East Timor Islamic Boarding School area. Hydroponics innovation has been applied by increasing the quantity and quality of hydroponics through technological tools and innovations to streamline and increase the yield of hydroponic plants to achieve higher quality than before. Results: The service method applied is the method of applying innovations by providing counselling assistance and practicing making instant herbal medicine Natural contraception of traditional medicine to increase understanding to cadres of PKK mothers in the development of natural materials. Conclusion: The conclusion of this activity is the increased knowledge of PKK women cadres and the community about the utilization of traditional medicine as instant herbal medicine for natural contraception to reduce the birth rate. Limitation: The knowledge of the PKK cadre and the community on the use of traditional medicine for natural family planning is still lacking. Contribution: This service is useful in the traditional medicine industry and the development of natural materials as products.

Optimization of HPMC Concentration in Psidium guajava Leaf Extract Floating Tablets Achmad, Nurafni Annisa; Nasir, Ardiansyah Jumaedi; Sapra, Amriani; Khairi, Nur; Ali, Nurul Ulfah
Journal of Experimental and Clinical Pharmacy (JECP) Vol 6, No 1 (2026): February 2026
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v6i1.1639

Psidium guajava L. leaves have been empirically used in traditional medicine due to their flavonoid content, which exhibits antibacterial and anti-ulcer activities. A floating drug delivery system is intended to prolong gastric residence time and thereby enhance therapeutic effectiveness in the treatment of gastric ulcers. This study aimed to investigate the effect of varying concentrations of hydroxypropyl methylcellulose (HPMC) on the physical characteristics of floating tablets containing Psidium guajava leaf extract. The leaf extract, at a dose of 350 mg, was formulated into floating tablets using three HPMC concentrations: 10% (F1), 20% (F2), and 30% (F3). The tablets were evaluated for weight uniformity, hardness, friability, disintegration time, and floating properties. The results showed that all formulations complied with pharmacopeial requirements for weight uniformity, hardness (10-20 kg), friability (<1%), and disintegration time (<60 min). However, formulation F1 exhibited a longer floating lag time of 7200 s and failed to meet the floating ability criterion. Increasing HPMC concentration significantly affected tablet hardness, friability, and floating properties (p < 0.05). Formulation F2 demonstrated the most favorable characteristics, with hardness of 10.61 kg, friability of 0.69%, floating lag time of 60 s, and floating duration >12 h. In conclusion, HPMC concentration significantly influenced the physical and floating properties of Psidium guajava leaf extract floating tablets, with a 20% HPMC concentration providing the most optimal formulation characteristics.

PENGARUH PROPILENGLIKOL TERHADAP FORMULASI DAN KARAKTERISTIK FISIK SEDIAAN PATCH EKSTRAK ETANOL DAUN INGGU (Ruta angustifolia L. Pers) Hikma, Nurul; Yassir, Budiman; Khairi, Nur; Marwati, Marwati; Pattinggi, Patricia
Jurnal Riset Kefarmasian Indonesia Vol. 6 No. 2 (2024): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759//jrki.v6i2.507

Ruta angustifolia L.Pers contain essential oil, steroids, flavonoids, tannins, quinones, and saponins compounds which have the potential to act as analgesics. This research aimed to determine the effect of varying propylene glycol concentrations on the physical characteristics of patches using the solvent evaporation method. Patch preparations were made in 3 formulas with variations of propylene glycol, namely F1 (without propylene glycol), F2 (10%), F3 (20%), and F3 (30%), and the patch was evaluated. The results of the physical characteristics obtained were patches with a yellowish green color, typical extract smell, round shape, thin film, smooth, dry, and elastic with a folding resistance of >200 times, thickness ranging from 0.02-0.03 mm, weight uniformity meeting the requirements, namely CV value 5%, %drying loss <9.20%, humidity of each formula <9.79% with a pH of around 7. Thus, it can be concluded that the ethanol extract of inggu leaves influences the uniformity of the weight and thickness of the patch.

Phytochemical profiling and enzyme inhibitory activity of Sterculia populifolia DC stem bark extract and fractions against elastase and tyrosinase Khairi, Nur; Nursamsiar, Nursamsiar; Utami, Novi F.; Marwati, Marwati; Nur, Syamsu; Indrisari, Maulita; Kursia, Sukriani
Narra J Vol. 5 No. 3 (2025): December 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i3.1778

The demand for natural ingredients in cosmetic and medical applications is steadily increasing, particularly for anti-aging and skin-lightening products. Sterculia populifolia DC, a member of the Sterculia genus, is known to contain diverse bioactive compounds such as flavonoids, phenolics, and terpenoids, which may offer pharmacological benefits. The aim of this study was to evaluate the anti-aging potential of S. populifolia stem bark extract and its solvent-partitioned fractions through enzyme inhibition assays coupled with phytochemical profiling. The stem bark was extracted using 96% ethanol via maceration, followed by sequential liquid-liquid partitioning with n-hexane, ethyl acetate, n-butanol, and water. Phytochemical constituents were characterized using liquid chromatography-tandem mass spectrometry (LC-MS/MS). The inhibitory activities of the extract and fractions against tyrosinase and elastase enzymes were evaluated using spectrophotometric assays, with kojic acid and quercetin as positive controls, respectively. IC₅₀ values were calculated to quantify enzyme inhibition potency. LC-MS/MS analysis revealed key bioactive compounds, including 4-[(E)-(3,5-diamino-1H-pyrazol-4-yl)diazenyl]phenol, isofraxidin, and (22E)-ergosta-4,6,8(14),22-tetraen-3-one. Among the tested samples, the ethanol extract exhibited the most potent activity, with an IC₅₀ of 93.35 µg/mL for elastase inhibition and 133.15 µg/mL for tyrosinase inhibition—classified as strong and moderate activity, respectively. Collectively, these findings demonstrate that S. populifolia stem bark extract possesses promising anti-aging and depigmenting properties, supporting its potential development as a natural bioactive ingredient in cosmetic and skincare formulations.

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