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All Journal Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Penelitian Pendidikan IPA (JPPIPA) Window of Health : Jurnal Kesehatan Media Farmasi PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Journal of Pharmaceutical and Medicinal Sciences Fullerene Journal of Chemistry Jurnal Ilmiah Farmasi Farmasyifa ad-Dawaa : Journal of Pharmaceutical Sciences Jurnal farmasi UIN Alauddin Makassar Jurnal Mandala Pengabdian Masyarakat Yumary: Jurnal Pengabdian kepada Masyarakat Narra J Journal of Experimental and Clinical Pharmacy (JECP) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Pengabdian Kefarmasian jpki Jurnal Katalisator Media Farmasi Jurnal Tumbuhan Obat Indonesia Media Penelitian dan Pengembangan Kesehatan Jurnal Sains dan Kesehatan
Khairi, Nur
Fakultas Ilmu Kesehatan Universitas Almarisah Madani
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Pendampingan Pembuatan Jamu Instan Tanaman sebagai Produk KB Alami pada Ibu Pkk Marwati, Marwati; Khairi, Nur; Alexandra, Francisca Diana; Fadillah, Nurul; Anggyasti, Anggyasti
Yumary: Jurnal Pengabdian kepada Masyarakat Vol. 6 No. 1 (2025): September
Publisher : Penerbit Goodwood

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35912/yumary.v6i1.3826

Abstract

Purpose: The purpose of community service is to increase the knowledge of the PKK cadre women on the types of medicinal plants that are efficacious as natural birth control, increase their knowledge of traditional medicine processing that is efficacious as natural family planning, and increase their knowledge of reproductive health and types of family planning. Methodology: This study was conducted at the Moreira Farm in the Al Anshar East Timor Islamic Boarding School area. Hydroponics innovation has been applied by increasing the quantity and quality of hydroponics through technological tools and innovations to streamline and increase the yield of hydroponic plants to achieve higher quality than before. Results: The service method applied is the method of applying innovations by providing counselling assistance and practicing making instant herbal medicine Natural contraception of traditional medicine to increase understanding to cadres of PKK mothers in the development of natural materials. Conclusion: The conclusion of this activity is the increased knowledge of PKK women cadres and the community about the utilization of traditional medicine as instant herbal medicine for natural contraception to reduce the birth rate. Limitation: The knowledge of the PKK cadre and the community on the use of traditional medicine for natural family planning is still lacking. Contribution: This service is useful in the traditional medicine industry and the development of natural materials as products.
Phytochemical profiling and enzyme inhibitory activity of Sterculia populifolia DC stem bark extract and fractions against elastase and tyrosinase Khairi, Nur; Nursamsiar, Nursamsiar; Utami, Novi F.; Marwati, Marwati; Nur, Syamsu; Indrisari, Maulita; Kursia, Sukriani
Narra J Vol. 5 No. 3 (2025): December 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i3.1778

Abstract

The demand for natural ingredients in cosmetic and medical applications is steadily increasing, particularly for anti-aging and skin-lightening products. Sterculia populifolia DC, a member of the Sterculia genus, is known to contain diverse bioactive compounds such as flavonoids, phenolics, and terpenoids, which may offer pharmacological benefits. The aim of this study was to evaluate the anti-aging potential of S. populifolia stem bark extract and its solvent-partitioned fractions through enzyme inhibition assays coupled with phytochemical profiling. The stem bark was extracted using 96% ethanol via maceration, followed by sequential liquid-liquid partitioning with n-hexane, ethyl acetate, n-butanol, and water. Phytochemical constituents were characterized using liquid chromatography-tandem mass spectrometry (LC-MS/MS). The inhibitory activities of the extract and fractions against tyrosinase and elastase enzymes were evaluated using spectrophotometric assays, with kojic acid and quercetin as positive controls, respectively. IC₅₀ values were calculated to quantify enzyme inhibition potency. LC-MS/MS analysis revealed key bioactive compounds, including 4-[(E)-(3,5-diamino-1H-pyrazol-4-yl)diazenyl]phenol, isofraxidin, and (22E)-ergosta-4,6,8(14),22-tetraen-3-one. Among the tested samples, the ethanol extract exhibited the most potent activity, with an IC₅₀ of 93.35 µg/mL for elastase inhibition and 133.15 µg/mL for tyrosinase inhibition—classified as strong and moderate activity, respectively. Collectively, these findings demonstrate that S. populifolia stem bark extract possesses promising anti-aging and depigmenting properties, supporting its potential development as a natural bioactive ingredient in cosmetic and skincare formulations.
Effectiveness of breadfruit leaf extract in mouthwash formula to inhibit the bacteria of Streptococcus mutans that causes caries Khairi, Nur; Aisyah, Andi Nur; Indrisari, Maulita; Sukmawati, Sukmawati; Nisa, Michrun
Media Penelitian dan Pengembangan Kesehatan Vol. 36 No. 1 (2026): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v36i1.2722

Abstract

Background: Dental caries is caused by Streptococcus mutans, which forms biofilms and produces acid that damages tooth enamel. Prevention is often achieved through mouthwashes containing antibacterial agents, but commercial products may have side effects due to chemical ingredients. Artocarpus altilis (breadfruit) leaves contain bioactive compounds like flavonoids and tannins, which have potential as natural antibacterial agents. Objective: This study aimed to evaluate the antibacterial activity of Artocarpus altilis leaf extract and formulate an effective mouthwash against Streptococcus mutans. Methods: The study used a true experimental design with a pretest-posttest control group. The extract was obtained by maceration with 96% ethanol. Three mouthwash formulations were prepared with varying glycerin concentrations (15%, 20%, and 25%). Antibacterial activity was assessed using the paper disk method, and data were analyzed using Kruskal-Wallis and Mann-Whitney tests. Results: The 2-4% extract had strong antibacterial activity, with inhibition zones ranging from 20.25–23.81 mm, significantly different from the negative control (p<0.05). The mouthwash formulations were liquid, yellow-green in color, with a characteristic breadfruit and mint scent, pH ranging from 5.5 to 7.9, and viscosity of 1 cPs. The mouthwash exhibited strong antibacterial activity, with inhibition zones between 18.81±1.5 mm and 18.94±0.5 mm, showing no significant differences across formulas (p>0.05). Conclusion: The 2% Artocarpus altilis extract and 15% glycerin formula was stable and effectively inhibited Streptococcus mutans
Pendampingan Pembuatan Jamu Instan Tanaman sebagai Produk KB Alami pada Ibu Pkk Marwati, Marwati; Khairi, Nur; Alexandra, Francisca Diana; Fadillah, Nurul; Anggyasti, Anggyasti
Yumary: Jurnal Pengabdian kepada Masyarakat Vol 6 No 1 (2025): September
Publisher : Penerbit Goodwood

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35912/yumary.v6i1.3826

Abstract

Purpose: The purpose of community service is to increase the knowledge of the PKK cadre women on the types of medicinal plants that are efficacious as natural birth control, increase their knowledge of traditional medicine processing that is efficacious as natural family planning, and increase their knowledge of reproductive health and types of family planning. Methodology: This study was conducted at the Moreira Farm in the Al Anshar East Timor Islamic Boarding School area. Hydroponics innovation has been applied by increasing the quantity and quality of hydroponics through technological tools and innovations to streamline and increase the yield of hydroponic plants to achieve higher quality than before. Results: The service method applied is the method of applying innovations by providing counselling assistance and practicing making instant herbal medicine Natural contraception of traditional medicine to increase understanding to cadres of PKK mothers in the development of natural materials. Conclusion: The conclusion of this activity is the increased knowledge of PKK women cadres and the community about the utilization of traditional medicine as instant herbal medicine for natural contraception to reduce the birth rate. Limitation: The knowledge of the PKK cadre and the community on the use of traditional medicine for natural family planning is still lacking. Contribution: This service is useful in the traditional medicine industry and the development of natural materials as products.
Activitas, Formulasi dan Efektivitas Gel Ekstrak Beras Hitam (Oryza sativa L) terhadap Bakteri Staphylococcus aureus dan Escherichia coli Nur Khairi; Saldi Hapiwaty; Maulita Indrisari; Marwati Marwati
Jurnal Penelitian Pendidikan IPA Vol 9 No 6 (2023): June
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v9i6.3914

Abstract

Black rice (Oryza sativa L.) contains chemical compounds, namely ferulic acid, -oryzanol, amino acids, tannins, phenolics, and anthocyanins which have potential as antibacterial agents. This study aims to formulate an antibacterial gel preparation from black rice extract with an extract concentration of 10% and to test the antibacterial effectiveness of the gel preparation against Staphylococcus aureus and Escherichia coli bacteria. Black rice extract was obtained by maceration using 70% ethanol solvent: 3% citric acid. The extract obtained was then formulated in a gel dosage form. The results showed that black rice extract could be formulated as an antibacterial gel preparation that met the organoleptic, homogeneity, pH, spreadability, and adhesion requirements. In the results of the antibacterial effectiveness test, there is a clear zone which represents the ability to inhibit the growth of the tested bacteria by the gel. Black rice extract can be formulated in a gel dosage form with an extract concentration of 10% and a physically stable formula is obtained in formula III with a carbopol concentration of 2%. The average diameter of the antibacterial gel FIII preparation of black rice extract in inhibiting Staphylococcus aureus bacteria was classified as strong, namely 11.17 ± 0.34 mm, while inhibition of Escherichia coli bacteria was also relatively strong, namely 12.20 ± 0.46 mm
Antibacterial Activity of Hand Sanitizer Spray Containing Green Betel Leaf (Piper betle L.) Extract against Staphylococcus aureus and Pseudomonas aeruginosa Marwati Marwati; Siti Mujayana; Zahwa Adiyanti; Siti Nur Afni; Muhammad Sholeh; Ildah Amaliah; Muh Erwin; Nur Khairi
Journal of Experimental and Clinical Pharmacy (JECP) Vol 6, No 2 (2026): August 2026
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v6i2.1672

Abstract

Green betel (Piper betle L.) leaf has traditionally been used as a medicinal plant and is known to contain various bioactive compounds with antioxidant, anticancer, and antibacterial properties, including flavonoids, phenolics, tannins, essential oils, and terpenoids. This study aimed to formulate and evaluate the antibacterial effectiveness of a hand sanitizer spray containing active isolates of P. betle leaves against Pseudomonas aeruginosa and Staphylococcus aureus. P. betle leaves were extracted using the sonication method with 96% ethanol as solvent. The compounds were separated using conventional chromatography and characterized by Fourier Transform Infrared (FTIR) spectroscopy. Antibacterial activity was evaluated at concentrations of 1%, 1.5%, and 2% using the inhibition zone method. The most active isolate was subsequently formulated into a hand sanitizer sprays. The results showed that a yellow isolate (10 mg) was obtained from P. betle leaves. FTIR characterization indicated the presence of OH, CH, C=O, and sp² CH functional groups. The antibacterial activity test demonstrated that the 1% isolate concentration produced the largest inhibition zone, measuring 9.97 mm against P. aeruginosa and 10.6 mm against S. aureus. The formulated hand sanitizer spray exhibited significantly higher inhibition zones of 19.37 mm against P. aeruginosa and 20.9 mm against S. aureus, while also meeting acceptable physical stability parameters. These findings suggest that green betel leaf isolate has potential as a natural antibacterial agent in hand sanitizer sprays.
Pengaruh Jenis Cairan Penyari terhadap Aktivitas Antioksidan Daun Kembang Bulan (Tithonia diversifolia (Hemsi.) A.Grey) dengan Metode ABTS Nursamsiar Nursamsiar; Khairuddin Khairuddin; Jumarni Jumarni; Marwati Marwati; Nurkhairi Nurkhairi
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia), Vol. 18 No. 02 Desember 20
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v18i2.10615

Abstract

Radikal bebas berkontribusi pada beberapa gangguan pada manusia termasuk ateroklerosis, radang sendi, iskemia, gastritis, kanker dan inflamasi. Kembang bulan (Tithonia diversifolia (Hemsi.) A.Grey) merupakan spesies tumbuhan yang mempunyai potensi untuk dikembangkan sebagai antioksidan. Penelitian ini dilakukan untuk mengamati pengaruh jenis cairan penyari terhadap bioaktivitas kembang bulan sebagai antioksidan dalam meredam radikal 2,2'-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS). Sampel dimaserasi menggunakan tiga cairan penyari yaitu etanol 70%, etil asetat, dan n-heksan. Sedangkan potensinya sebagai antioksidan diuji dengan metode ABTS. Hasil penelitian menunjukan aktivitas antioksidan ekstrak etanol 70%, etil asetat dan n-heksan berturut-turut memberikan nilai IC50sebesar 56,71 µg/ml (kuat), 106,47 µg/ml (sedang) dan 191,57 µg/ml (lemah) dan vitamin C sebagai pembanding 10,46 µg/ml (sangat kuat). Semakin polar cairan penyari semakin kuat aktivitas antioksidan daun kembang bulan dalam meredam radikal ABTS.
Co-Authors Abdul Halim Umar Agustina Ma'tang Parinding Aisyah , Andi Nur Aisyah, Andi Nur Akbar Awaluddin Aksa, Rahmat Alexandra, Francisca Diana Ali Djamhuri Amriani Amriani Amriani Sapra Andi Nur Aisyah Andi Nur Aisyah Andi Nur Aisyah, Andi Nur Aisyah Andi Paluseri Andi Paluseri Anggyasti, Anggyasti Arisah, Arisah Astuti Amin Awaluddin, Akbar Burhan, Asril Dali Djamaluddin, Suci F Dwirandy, Dwirandy Eko Allo Fadillah Maryam Fajriansyah Fajriansyah Fitriyanti Jumaetri Hapiwaty, Saldi Harlyanti Muthma'innah Mashar Ikbal Ikbal Ikbal Ildah Amaliah Indradewa, Rhian Irwana, Rina Ismail Ismail Ismail Jumarni Jumarni Khairuddin Khairuddin Khairuddin Khairuddin Lukman Lukman Madinatul munawwarah Malluka, Rifka Margaretha Margaretha Maria Ulfa Maria Ulfa Maria Ulfa Marwati Marwati Marwati Marwati Marwati Marwati Marwati Marwati Marwati Marwati Mar’atun Jannah, Imrawati, Muzakkir Baitz, Maulita Indrisari Maulita Indrisari, Maulita Megawati - Megawati Megawati Michrun Nisa Mirnawati Salampe Muh Erwin Muhammad Sholeh Mus, Suwahyuni Muslimin, Lukman Noer Fauziah Nursamsiar Nursamsiar Nurul fadillah, Nurul Nurul Hikma Nurwijayanti Nurzadrina Wahyuddin paluseri, Andi Reny Syahruni Riska Rahayu Rosyid, Sujud Z Sami, Fitriyanti Sapra, Amriani Sepriani Yusuf Siti Mujayana Siti Nur Afni Sitti Rahimah Sukmawati Sukmawati Sukriani Kursia, Sukriani Suwahyuni Suwahyuni Syamsu Nur Syamsu Nur Syamsu Nur, Syamsu Syamsu Nur, Syamsu Nur Utami, Novi F. Wahyu Hendrarti Wahyu Hendrarti Yuri Pratiwi Utami Zahwa Adiyanti