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Formulation and Test of Physical Characteristics of Ethanol Extract Capsules of Red Atai Tuber (Angiopteris ferox Copel) Andi Nur Aisyah; Nur Khairi; Syamsu Nur; Amriani Amriani; Megawati Megawati; Lukman Lukman; Ikbal Ikbal; Marwati Marwati; Maulita Indrisari; Madinatul munawwarah
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 5, No. 1 (2023)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v0i0.46179

Abstract

Umbi paku atai merah (Angiopteris ferox Copel) merupakan tumbuhan paku yang berasal dari suku Dayak yang digunakan sebagai obat tradisional yang berpotensi sebagai antioksidan karena memiliki kandungan senyawa metabolit sekunder meliputii alkaloid, steroid, flavanoid, tanin serta saponin. Penggunaan umbi paku atai merah di masyarakat masih menggunakan cara tradisional yaitu diseduh dengan air panas, diminum air rebusannya dan meninggalkan rasa yang tidak enak, sehingga tujuan dari penelitian ini yaitu untuk memformulasi sediaan kapsul ekstrak etanol umbi paku atai merah yang memenuhi karakteristik fisik. Penelitian ini dilakukan pembuatan sediaan kapsul yang berisi granul dengan variasi konsentrasi aerosil FI 5%, FII 7% dan FIII 9%. Granul dibuat dengan metode granulasi basah, lalu dilakukan evaluasi karakteristik fisik granul dan kapsul. Hasil yang diperoleh dari ketiga granul tersebut memenuhi karakteristik fisik granul dengan parameter uji organoleptik, kandungan lembab, susut pengeringan, kecepatan alir, sudut istirahat, Bj sejati, Bj nyata, Bj mampat dan porositas. Sedangkan untuk kapsul FI dan FII merupakan sediaan yang memenuhi karakteristik fisik kapsul dengan parameter uji keseragaman bobot, waktu hancur dan higroskopis.
Efektivitas Ekstrak Daun Kelor (Moringa oleifera L.) Untuk Ulkus Peptikum Pada Tikus Putih (Rattus norvegicus) Yang Diinduksi Aspirin Indrisari, Maulita; Khairi, Nur; Muslimin, Lukman; Awaluddin, Akbar; Arisah, Arisah
Media Farmasi XXX Vol 19, No 1 (2023)
Publisher : Jurusan Farmasi Politeknik Kesehatan Makassar, Kementerian Kesehatan RI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v19i1.3292

Abstract

Effectiveness of Moringa Leaf Extract (Moringa oleifera L.) for Peptic Ulcuses In Aspirine-Induced White Rats (Rattus norvegicus)Moringa (Moringa oleifera L). is a plant that is known for its multipurpose, nutrient-dense, and medicinal properties. Moringa leaves contain flavonoid compounds, namely β-sitosterol which can reduce ulcers in the stomach. This research used 15 male white rats divided into 5 groups, namely the normal group, CMC Na (Negative), ranitidine (Positive), and treatment with extract doses of 100 and 300 mg/kg BW. Test animals were induced by aspirin at a dose of 500 mg/kg for 7 days, then given treatment for 7 days, except for the normal group. On the 15th day, all groups were sacrificed, then the gastric organs were visually observed, and the ulcer index was measured. the observations it was found that the administration of the extract at a dose of 300 mg/kgBB decreased the number of ulcers compared to the positive control group (p>0.05). The extract dose of 300 mg/kg BW reduces the number of aspirin-induced ulcer diameters. The results of statistics with Kruskall-Wallis, there was a significant difference after treatment (p<0.05), but there was no significant difference between groups (p>0.05). Ethanol extract of Moringa leaves at a dose of 300 mg/kgBB can be gastroprotective in aspirin-induced male white rats.Keyword: Moringa leaves, gastroprotective, gastric ulcer, aspirinKelor (Moringa oleifera L).merupakan tanaman yang dikenal multi guna, padat akan nutrisi dan bermanfaat sebagai obat. Daun kelor mengandung senyawa flavonoid, yakni β-sitosterol yang dapat mengurangi tukak pada lambung. Penelitian ini menggunakan tikus putih jantan sebanyak 15 ekor yang dibagi dalam 5 kelompok yaitu kelompok normal, Na CMC (Negatif), ranitidine (Positif), dan perlakuan dengan dosis  ekstrak 100 dan 300 mg/kgBB. Hewan uji di induksi aspirin dosis 500 mg/kgBB selama 7 hari, kemudian diberi pengobatan selama 7 hari, kecuali kelompok normal. Pada hari ke-15 semua kelompok dikorbankan kemudian diamati organ lambung secara visual diukur indeks tukak. Dari hasil pengamatan diketahui bahwa pemberian ekstrak dosis 300 mg/kgBB terjadi penurunan jumlah tukak dibandingkan dengan kelompok kontrol positif  (p>0,05). Dosis ekstrak 300 mg/kgBB memberikan efek penurunan jumlah diameter tukak akibat induksi aspirin. Berdasarkan hasil perhitungan dengan Kruskall-Wallis menunjukkan adanya perbedaan yang signifikan setelah perlakuan (p<0,05), namun tidak menunjukkan perbedaan signifikan antar kelompok (p>0,05). Ekstrak etanol daun kelor dengan dosis 300 mg/kgBB memiliki kemampuan sebagai gastroprotektif pada tikus putih  jantan yang diinduksi aspirin.Keyword : Daun kelor, gastroprotektif, tukak lambung, aspirin
Edukasi Pencegahan Penyakit Skabies Melalui Peer Educator Di Sekolah Enterpreneur Tahfidz Kekasih Al-Aqsha, Gowa, Sulawesi Selatan Muslimin, Lukman; Marwati, Marwati; Mus, Suwahyuni; Rosyid, Sujud Z; Irwana, Rina; Djamaluddin, Suci F; Khairi, Nur; Indrisari, Maulita; Nursamsiar, Nursamsiar; Megawati, Megawati; Imrawati, Imrawati; Nur, Syamsu; Sami, Fitriyanti; Amin, Astuti; Paluseri, Andi
Jurnal Pengabdian Kefarmasian Vol 4, No 2 (2023): JURNAL PENGABDIAN KEFARMASIAN
Publisher : Jurusan Farmasi Politeknik Kesehatan Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/jpk.v4i2.3421

Abstract

Scabies Prevention Through Peer Educators At The Entrepreneur School Of Tahfidz Kekasih Al-Aqsha, Gowa, South SulawesiBased on a survey that was carried out, it was found that there were incidents of head lice and scabies infections at the Tahfidz Kekasih Al-Aqsa Entrepreneurial School, in Pattallassang, Kab. Gowa, South Sulawesi. This shows that the student's knowledge of this disease is still low. So it is necessary to carry out outreach to increase students' knowledge of the dangers of scabies and its treatment. 45 students and 5 teachers attended this counseling. The methods used in this service are lecture, question and answer, and scabies examination. The presentation of material about scabies was carried out using PowerPoint media, after which the material continued with a question-and-answer session. At the end of the activity, a health examination was carried out to identify and provide treatment to students and teachers who suffered from scabies. The results of the counseling showed that 2 students were suffering from scabies. The counseling was considered successful because the students answered all the questions (100%).Keywords: Counseling, Peer Education, Scabies Berdasarkan survei yang telah dilakukan ditemukan adanya kejadian infeksi kutu rambut dan skabies (kudis) di Sekolah Enterpreneur Tahfidz Kekasih Al-Aqsha, di Pattallassang, Kab. Gowa, Sulawesi Selatan. Hal ini menunjukkan masih rendahnya pengetahuan para santri terhadap penyakit tersebut. Maka perlu dilakukan sosialisasi untuk meningkatkan pengetahuan santri terhadap bahaya penyakit skabies serta pengobatannya. Penyuluhan ini diikuti oleh 45 orang santri dan 5 orang guru. Metode yang digunakan dalam pengabdian ini adalah metode ceramah, tanya jawab, dan pemeriksaan skabies. Pemaparan materi tentang skabies dilakukan menggunakan media PowerPoint, setelah pemaparan materi dilanjutkan dengan sesi tanya jawab. Di akhir kegiatan, dilakukan pemeriksaan kesehatan untuk mengetahui dan memberikan pengobatan kepada santri maupun guru yang menderita skabies. Hasil penyuluhan menunjukkan bahwa ada 2 orang santri yang menderita skabies. Penyuluhan dinilai berhasil karena semua pertanyaan yang diberikan berhasil dijawab oleh santri (100%).Kata kunci : Penyuluhan, Peer Education, Skabies
Formulation of Body Odor Bacteria Inhibiting Deodorant Spray from Ethyl Acetate Extract of Klika Kesambi Jalil Genisa, Nur Khairi; Ismail; Maulita Indrisari; Andi Nur Aisyah, Andi Nur Aisyah; Syamsu Nur, Syamsu Nur
Window of Health : Jurnal Kesehatan Vol 7 No 1 (Januari 2024)
Publisher : Fakultas Kesehatan Masyarakat Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/woh.vi.919

Abstract

Acne is one of the skin damages caused by acne-causing bacteria. Flavonoids, saponins, and tannins in taro tubers can potentially have activity against acne-causing bacteria. This study aims to determine the formulation of extract transparent solid soap preparation that meets the characteristics and assess the activity of soap preparation as anti-acne against acne-causing bacteria. Taro tubers were extracted by maceration method. The extract was formulated as transparent solid soap preparations with variations in extract concentration, namely F0 0%, F1 2%, F2 4%, and F3 8%. The soap was evaluated for characteristics including organoleptic test, pH, moisture content, free fatty acids and alkali, mineral oil test, and foam stability test. Antibacterial activity testing of transparent soap extracts was carried out against acne-causing bacteria. The extraction results obtained an extract yield of 10.86%, the three extract formulas have transparent solid soap characteristics that meet the requirements. Soap preparation formula 1 has an inhibition zone of 21.66 ± 0.31 mm against P. acnes bacteria, 19.11±0.53 mm against S. epidermidis, 21.74±0.34 mm against S. aureus. Soap preparation formula 2 has an inhibition zone of 18.53±0.26 mm against P. acnes bacteria, 18.71±0.49 mm against S. epidermidis, 20.16±0.34 mm against S.aureus and soap preparation formula 3 has an inhibition zone of 19.03±0.68 mm against P. acnes bacteria, 19.93±0.86 mm against S. epidermidis, 22.75±0.59 mm against S.aureus. In conclusion, formula 2 with 2% extract concentration has the best soap characteristics and has the most optimal inhibition zone.
Aktivitas Antioksidan Ekstrak Etanol Batang, Daun, dan Akar Kopasanda (Chromolaena odorata L.) dengan Metode FRAP (Ferric Reducing Antioxidant Power): Antioxidant Activity of Ethanol Extract of Stems, Leaves, and Roots of Kopasanda (Chromolaena odorata L.) with FRAP (Ferric Reducing Antioxidant Power) Method Astuti Amin; Nur Khairi; Wahyu Hendrarti
Jurnal Sains dan Kesehatan Vol. 4 No. 5 (2022): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v4i5.1271

Abstract

Kopasanda (Chromolaena odorata L.) is a plant that contains flavonoid compounds that can act as antioxidants. This study aims to determine the antioxidant potential of the ethanol extract of the stems, leaves and roots of kopasanda by looking at the IC50 value. The stems, leaves and roots of Kopasanda were extracted by maceration using 70% ethanol as solvent. The results of the antioxidant activity test using the FRAP (Ferric Reducing Antioxidant Power) method showed very strong antioxidant activity with IC50 values ??of leaves 23.4 µg/ml, stems 37.556 g/ml and roots 36.860µg/ml with positive control of quarcetin, IC50 values ??were 2.724 g/ml . Based on these results, it can be said that the stems, leaves and roots have very strong antioxidant activity against the reduction of FRAP (Ferric Reducing Antioxidant Power).
PENGUKURAN PARAMETER SPESIFIK DAN NON SPESIFIK EKSTRAK ETANOL BERAS HITAM (Oryza sativa L. indica) ASAL TORAJA Nur Khairi; Saldi Hapiwaty; Sepriani Yusuf; Maulita Indrisari
JURNAL KATALISATOR Vol. 8 No. 2 (2023): Jurnal Katalisator Volume 8 No. 2, Oktober 2023
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62769/katalisator.v8i2.2452

Abstract

Beras hitam (Oryza sativa L. Indica) merupakan salah satu komoditas unggul lokal di Toraja Utara. Pengukuran parameter Standardisasi dilakukan sebagai upaya untuk memelihara mutu, keamanan serta khasiat sehingga dapat lebihmeningkatkan kepercayaan masyarakat terhadap manfaat bahan alam. Parameter spesifik adalah aspek kandungan kimiakualitatif dan kuantitatif kadar senyawa kimia yang bertanggung jawab langsung terhadap aktivitas farmakologi tertentu. Parameter non spesifik adalah penentuan aspek kimia, mikrobiologi, dan fisis yang akan mempengaruhi keamanankonsumen dan stabilitas. Ekstrak yang diperoleh dari hasil maserasi menggunakan etanol 70%-asam sitrat 3% selama 3 hari. Ekstrak yang dihasilkan memiliki persen rendamen sebesar 5,01%. Pengukuran parameter spesifik di peroleh ekstrak berwarna ungu kehitaman, kental, memiliki bau khas dan memilki rasa yang pahit. Ekstrak beras hitam mengandung senyawa flavonoid, saponin dan tanin, kadar senyawa larut dalam air 6,44% dan kadar senyawa larut dalam etanol 14,61%. Pengukuran parameter non spesifik diperoleh susut pengeringan 6,03%, kadar air sebesar 10%, bobot jenis 1,0090 g/mL, kadar abu total sebesar 9,8%, dan kadar abu tidak larut asam sebesar 1,80%, angka lempeng total tidak adanya cemaran, dan angka kapang khamir adanya cemaran 8,5x102 koloni/g.
Formulasi Kapsul Ekstrak Etanol Daun Sambung Nyawa (Gynurae procumbens (Lour) Merr) dengan Variasi konsentrasi Bahan Pengikat Polivinil Pirolidon (PVP) burhan, Asril; Ikbal; Zulham, Zulham; Aisyah , Andi Nur; Khairi, Nur; Ulfa, Maria
Media Farmasi Vol 20 No 2 (2024): Media Farmasi Edisi Oktober 2024
Publisher : Jurusan Farmasi Poltekkes kemenkes Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v20i2.522

Abstract

Formulation of Ethanol Extract Capsules of Sambung Nyawa Leaves (Gynurae procumbens (Lour) Merr) with Varying Concentrations of Polyvinyl Pyrrolidone (PVP) Sambungnyawa (Gynurae procumbens (Lour) Merr) is known to have several secondary metabolite compounds including alkaloids, flavonoids, anthraquinones, saponins, glycosides and essential oils. The aim of this research is to obtain a stable concentration of PVP binder if formulated in granule form for encapsulation in ethanol extract of sambungjiwa leaves. The variation in PVP concentration used was 0.5%; 1.5 %; 2.5 %; 3.5 %; and 4.5%. Granules are made using the wet granulation method then put into the capsule shell and continued with evaluation. Based on the evaluation results of the ethanol extract capsule formulations of sambungjiwa leaves, it can be concluded that variations in the concentration of PVP as a binder can affect the physical stability of the capsule preparation, where the five formulas with different concentration variations have different stability after hygroscopicity testing. The formula that has good physical stability is the FK4 formula with a PVP concentration of 3.5%. Sambung Nyawa (Gynurae procumbens (Lour) Merr) diketahui memiliki beberapa senyawa metabolit sekunder diantaranya alkaloid, flavonoid, antraquinon, saponin, glikosida dan minyak atsiri, Tujuan dari penelitian ini untuk mendapatkan konsentrasi bahan pengikat PVP yang stabil jika diformulasi dalam bentuk granul untuk dikapsulkan pada ekstrak etanol daun Sambung Nyawa. Variasi konsentrasi PVP yang digunakan adalah 0,5 %; 1,5 %; 2,5 %; 3,5 %; dan 4,5 %. Granul dibuat dengan metode granulasi basah kemudian dimasukkan ke dalam cangkang kapsul dan dilanjutkan dengan evaluasi. Berdasarkan hasil evaluasi dari formulasi kapsul ekstrak etanol daun Sambung Nyawa  dapat disimpulkan bahwa variasi konsentrasi PVP sebagai bahan pengikat dapat mempengaruhi kestabilan fisik sediaan kapsul, dimana kelima formula dengan variasi konsentrasi yang berbeda memiliki kestabilan yang berbeda-beda setelah pengujian higroskopisitas. Formula yang memiliki kestabilan fisik yang baik adalah formula FK4 dengan konsentrasi PVP 3.5%.
Anti-inflammatory Potential of Tithonia diversifolia Leaves in Carrageenan-Induced Edema Model in Mice (Mus Musculus) Indrisari, Maulita; Khairi, Nur; Muslimin, Lukman; Aksa, Rahmat; Amriani, Amriani; Rahimah, Sitti; Rahayu, Riska
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 8 No.1 (2025)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v8i1.57119

Abstract

Introduction: Edema is a common sign of inflammation characterized by increased tissue volume. Tithonia diversifolia leaves have traditionally been used as anti-inflammatory agents because they contain active compounds such as flavonoids, alkaloids, steroids, terpenoids, tannins, sesquiterpenoids, phenolic acids, and saponins. Aims: Determine the anti-inflammatory effects of ethanol extract of Tithonia diversifolia leaves on rats (Mus musculus) induced by carrageenan. Method: Extraction was carried out using maceration. The experimental design was pre- and post-test with five groups: healthy controls, positive controls (sodium diclofenac), and three treatment groups receiving 12.5 mg/30 gBW, 25 mg/30 gBW, and 37.5 mg/30 gBW of Tithonia diversifolia leaf extract. Edema was induced with carrageenan and measured using a plethysmometer at certain intervals. Result: The results showed that a dose of 37.5 mg/30 gBW significantly decreased edema volume, comparable to the diclofenac group (p>0.05). Conclusion: The ethanol extract of paitan leaves at this dose can function as an effective anti-inflammatory agent.
Diffusion Study of Cream Formula of Lyophilized Ethanol Extract of Moringa oleifera L. Leaves : Studi Difusi Formula Krim Ekstrak Etanol Terliofilisasi Daun Kelor (Moringa oleifera L.) Sapra, Amriani; Mus, Suwahyuni; Dwirandy, Dwirandy; Malluka, Rifka; Khairi, Nur
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 7 No. 2 (2021): (October 2021)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2021.v7.i2.15275

Abstract

Background: Moringa oleifera L. leaves have analgesic activity due to their flavonoids content. These polar antioxidants compounds usually have difficulty to diffuse through the skin. Objectives: The purpose of this study was to evaluate the diffusion parameters of cream contains the lyophilized of M. oleifera leaves ethanol extract. Material and Methods: The lyophilized of M.oleifera leaves ethanol extract (5%) formulated as an o/w cream with 2% of cetyl alcohol as a stiffening agent. The physical characteristics of the cream were determined for organoleptic, homogeneity, pH, viscosity, spreadability, and type of emulsion parameters. The diffusion parameters were determined with Franz cell diffusion using the skin's snake as a membrane with 0; 10; 30; 60 and 90 minutes sampling time. Results: Physical characteristics of the cream showed that o/w as the cream type with pH, viscosity, and spreadability value were 4.72±0.03; 14.000±225 cps; and 5.7±0.20 cm, respectively. The diffusion parameter showed total flavonoids penetrate through the membrane was 360.134±0.20 µg/cm2 with flux 239,875 µg/cm2hr. Conclusions: This study showed a cream formulation that fulfills the required physical characteristics standard and can deliver active compounds to penetrate through the membrane.
Pengaruh Emulgator Terhadap Stabilitas dan Aktivitas Tabir Surya Krim Ekstrak Mahkota Dewa dan Kencur Jalil, Nur Khairi; Maulita Indrisari; Ikbal; Nurul Hikma
Jurnal Tumbuhan Obat Indonesia Vol. 18 No. 1 (2025): July 2025
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v18i1.2633

Abstract

Paparan sinar ultraviolet (UV) yang berlebihan berpotensi menimbulkan kerusakan jaringan kulit, mempercepat penuaan, hingga meningkatkan risiko kanker kulit. Upaya pencegahan dilakukan melalui penggunaan tabir surya untuk membatasi penetrasi UV ke kulit. Dua sumber bahan aktif alami yang prospektif digunakan yaitu buah mahkota dewa dan rimpang kencur, buah mahkota dewa mengandung senyawa glukosida benzofenon yaitu phalerin dan rimpang kencur mengandung etil-parametoksisinamat yang merupakan senyawa turunan sinamat. Tujuan penelitian untuk menemukan konsentrasi emulgator yang optimal yang dapat meningkatkan stabilitas produk serta memperbaiki kinerja perlindungan terhadap sinar UV. Ekstrak diperoleh melalui proses maserasi menggunakan etanol96%, selanjutnya diformulasi dalam bentuk sediaan krim sebanyak 9 formula dengan variasi konsentrasi berbagai emulgator yaitu novemer, viscolam dan  tween 80-span 80 lalu dilakukan pengujian efektivitas tabir surya dari krim ekstrak dengan menghitung nilai %Te, %Tp, dan SPF. Hasil penelitian menunjukkan emulgator viscolam dengan konsentrasi 4% (formula VI) merupakan formula krim yang paling stabil berdasarkan parameter organoleptis, homogenitas, pH, tipe emulsi, viskositas, daya sebar serta daya lekat dan hasil pengujian tabir surya  dikategorikan sebagai proteksi ekstra dengan nilai %Te 3,83854 dan sunblock dengan nilai %Tp 2,703703 sedangkan nilai SPF 74,4323 yang memberikan efek proteksi ultra. Kata kunci: Ekstrak, Mahkota Dewa, Kencur, Emulgator, Tabir surya.