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All Journal EKSAKTA: Journal of Sciences and Data Analysis Dinamisia: Jurnal Pengabdian Kepada Masyarakat JURNAL KESEHATAN PERINTIS Jurnal Ilmu Kefarmasian Indonesia Pharmacoscript Jurnal Farmamedika (Pharmamedica Journal) Jurnal Farmagazine Journal of Pharmaceutical and Health Research Journal of Holistic and Health Sciences (Jurnal Ilmu Holistik dan Kesehatan) Journal of Experimental and Clinical Pharmacy (JECP) Jurnal IPTEK Bagi Masyarakat Jurnal Pengabdian Masyarakat Aufa (JPMA) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan International Journal Mathla'ul Anwar of Halal Issues Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Abdi Masyarakat Kita Sciences of Pharmacy Ibnu Sina: Jurnal Kedokteran dan Kesehatan - Fakultas Kedokteran Universitas Islam Sumatera Utara Journal of Global Pharma Technology Jurnal Pengabdian Pada Masyarakat Jurnal Ilmiah Kesehatan Delima Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Farmasi Galenika Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Stiani, Sofi Nurmay
Sekolah Tinggi Ilmu Kesehatan Salsabila Serang
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Journal : Journal of Global Pharma Technology

 1 
Enhancing Dissolution and Bioavaibility of Purely Water Insoluble Natural Compounds by Solid Dispersion with Hot Melt Extrusion Technique Sofi Nurmay Stiani; Taofik Rusdiana; Anas Subarnas
Journal of Global Pharma Technology Volume 10 Issue 07: (2018) July 2018
Publisher : Journal of Global Pharma Technology

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Abstract

The use of herbal remedies is still a trend in the world, especially Indonesia as the second largest country after Brazil is rich in medicinal plants, in addition to having many pharmacological properties also have low side effects. The most common problems with biopharmaceutically related natural substances are low drug solubility, low biopharmaceutics, stability problems and active substance absorption. Bioavailability is an important factor in achieving the effects of drug therapy. Low bioavailability may occur due to low water solubility, instability in the digestion, and difficulty passing through the membrane. To overcome the problem of bioavaibility of natural material compounds should be made efforts to improve it, one of them with solid dispersion method. The solid dispersion is the dispersion of one or more active ingredients in an inert solid carrier. Technique of Dispersion in the carrier can be by way of hot spin mixing, co-evaporation, co-precipttion, freeze-drying, spray drying and HME. Techniques that are still rarely used in Indonesia is hot melt extrusion (HME). This study aims to explore characteristics of the chemical properties of natural materials, efforts to increase the bioavailability of natural compounds, and solid dispersion techniques.Keywords: Bioavailability, Natural compounds, solid dispersion, hot melt extrusion
The Use of Various Polymers with Solid Dispersion Application of Hot Melt Extrusion (HME) Preparing New Delivery Drug System Sofi Nurmay Stiani
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
Publisher : Journal of Global Pharma Technology

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Abstract

Hot Melt Extrusion (HME) at the beginning appeared widely used in the plastic industry and food industry, but in the last few decades, many researchers have succeeded in applying the HME method as a drug delivery system and determining various dosage forms in the pharmaceutical industry. The challenges that arise in the pharmaceutical are related to the solubility, dissolution rate, and bioavailability of drugs, especially for drugs that have low solubility in water. The low solubility and bioavailability will reduce the pharmacological effect of a drug. Solid dispersion using HME method succeeded in answering this challenge by distributing the drug evenly in the hydrophilic polymer during the extrusion process and changing the crystalline form to the amorphous form while maintaining drug stability. This review will examine the polymers are suitable for the HME method, Mechanism for solid dispersion using HME method, Steps must be taken to prepare solid dispersions using HME and characterization of solid dispersion resulting from HME and determinants of success of solid dispersions Keywords: Polymer, Solid Dispersion, hot-melt extrusion, Mechanism of solid dispersion, Step HME.
Co-Authors Achmad Fudholi Ade Anwar Ade Apriliani Adini, Syilvi Aditia Saeffurrohman Afifah Nur Shobah Afifah Nur Shobah Afifah Nur Shobah Agnes Syafera Agus Sulaeman Anas Subarnas Andri Harpan Anjani, Shabrina Talitha Apriliani, Ade Ashari, Elva Febri Audy Nursifa'atun Aufalya Wibirezkina Aulia, Ayu Ayuni, Eka Sirly Baha Udin Cahya, Wulan Candra Junaedi Chairani, Farahdina Dewi Intan Sri Rahayu Deya Adiby Nabillah Dharojatul Khasfah Effendi, Erwin Elfrida Ratnawati Endah Endah endah, endah Endi Muchyar Eneng Elda Ernawati Eneng Elda Ernawati Fajrin Noviyanto Fajrin Noviyanto Fajrin Noviyanto, Fajrin Farahdina, Chairani Fathiyati Fathiyati Fauzi, Andrian Maulana Fauzy, Adrian Maulana Ferdiyansyah, Ferdiyansyah Fifih Lutfiyah Ghina Annufus Hanifah Dwi Safitri Harpan, Andri Hasanah, Indah Ayu Nur Hayati, Farida Herawati, Fera Indriatmoko, Dimas Danang Ismiyati, Renditya Kelutur, Faruk Jayanto Kholifah, Eva Kuncoro, Banu Kurnia, Nia Marlina Latifah Nur, Rizki Leni Halimatusyadiah Lidiah, Mae Lutfiyah, Fifih Maharani, Sylvianti Maharani, Zahra Citra Marlina, Nia Masfuah, Imas Megawati, Sefi Meila Pertiwi Mohammad Rizal Mohammad Rizal, Mohammad Muhamad Ichsan Fahlevy Nabillah, Deya Adiby Nasiti, Febriane Dwi Neneng Nasliah Nia Marlina Nita Rusdiana S.Farm., M.Sc, Apt Nur Shobah, Afifah Nurani, Agnes Wieanita Nurhayati, Ghina Siti Nurhikmah, Ihda Nurul Fitri, Nabila Ofsah, Olin Najilah Oktaviana Hadi, Agriyaningsih Perdi, Perdi Pratiwi, Linda Rani Pratiwi, Rossi Putri, Nabila Septiani Rahmawida Putri Renditya Ismiyati Renditya Ismiyati Renditya Ismiyati Rini Rumantir Ristiani, Yuanisa Rizkiana, Muhammad Dinta Rustiyani, Risa Sabilla, Aliffia Nur Saeffurrohman, Aditia Salsabillah, Audy Nursifa'atun Satibi . Seira, Trisya Selviani, Astri Septina Sumantri, Aulia Shabrina Talitha Anjani Shirly Kumala Shobah, Afifah Nur Siska Purnama Sari Siswa Setyahadi Siti Lailatu Zahroh Siti Marina Subchan, Mohamad Suci Nurainun Sumarlin US Sumarlin US Syifa Maulidia Rizqi Syilvi Adini Sylvi Addini Sylvianti Maharani Taofik Rusdiana US, Sumarlin Wibirezkina, Aufalya Yulistina, Isti Yusransyah, Yusransyah Zahroh, Siti Lailatu