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All Journal Journal of Food and Pharmaceutical Science Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Cancer Chemoprevention Indonesian Journal of Pharmaceutical Science and Technology Majalah Obat Tradisional Jurnal Farmasi Sains dan Komunitas Jurnal Pengabdian UntukMu NegeRI Smart Medical Journal ALCHEMY Jurnal Penelitian Kimia Jurnal Pengabdian Pada Masyarakat Majalah Farmaseutik JCES (Journal of Character Education Society) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Ilmu Kefarmasian Indonesia JKPK (Jurnal Kimia dan Pendidikan Kimia) Bubungan Tinggi: Jurnal Pengabdian Masyarakat Madaniya Jurnal Farmasi Klinik dan Sains Jurnal Pengabdian Pada Masyarakat Jurnal Pengabdian Kepada Masyarakat Itekes Bali Journal of Food and Pharmaceutical Sciences Journal of Applied Agriculture, Health and Technology Jurnal Kefarmasian Indonesia Jurnal Abdimas Indonesia

ERMAWATI, DIAN EKA

Sekolah Vokasi, Universitas Sebelas Maret, Surakarta

Author-ID : 1304732

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The Effect of Combination of Polyvinyl alcohol and Alfa-cellulose on Physical and Chemical Properties Salam Leaves Ethanolic Extract Patch (Syzygium polyanthum (wight) walp.) Dian Eka Ermawati; Novi Andriani
Majalah Farmaseutik Vol 18, No 4 (2022): in press
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v18i4.73257

Salam leaves contain the flavonoid as an anti-inflammatory at a dose of 2.1% w/w. Topical anti-inflammatory was chosen because it is easier to apply. A patch can release the active substance continuously for a long time, compared to gels and creams. Polymers are the main component of patch to control the speed of drug release. Polyvinyl alcohol and alpha-cellulose are polymers that can increase the rate of drug diffusion and form a strong film layer. This study aims to determine the effect of the combination of PVA and Alpha-cellulose on the physicochemical properties of the salam leaves ethanolic extract patch. This research was carried out by maceration of salam leaves using ethanol 96% then dispersed in a patch that was made with variations ratio of PVA and alpha-cellulose, namely 1:1; 3:1; 1:3. The patches were tested for physicochemical properties including organoleptic, pH, thickness, weight, folding endurance, and humidity. Statistical analysis of the test data used One Way ANOVA and Paired Samples T-Test with a confidence level of 95%. The results showed that the combination of PVA and alpha-cellulose polymer in the patch preparation had a significant effect on the weight, thickness, and moisture test, but did not affect an organoleptic, folding endurance, and pH test. Based on the parameters of the physicochemical properties test, the chosen formula was a patch with a ratio of PVA and alpha-cellulose 7:3 because it met the requirements for the patch preparation including the weight of 1.96-2.06 grams, thickness 1.15-1.18 mm, folding endurance >300 times, humidity 25.75 – 30.17% and pH 6.3 – 7.1. The selected formula contains flavonoids based on qualitative analysis using the TLC method.

Peningkatan Pengetahuan Masyarakat dengan Pendampingan Formulasi Handsanitizer Standar WHO di Kelurahan Mojosongo, Surakarta Dian Eka Ermawati; Anif Nur Artanti; Sholichah Rohmani; Wisnu Kundarto
Jurnal Pengabdian Pada Masyarakat Vol 7 No 3 (2022): Jurnal Pengabdian Pada Masyarakat
Publisher : Universitas Mathla'ul Anwar Banten

INCREASING PUBLIC KNOWLEDGE WITH ASSISTANCE IN WHO STANDARD HANDSANITIZER FORMULATION IN MOJOSONGO VILLAGE, SURAKARTA. The Applied Pharmacy Research Group has a service roadmap that examines medicinal products, supplements, cosmetic and traditional medicines that can contribute and be adopted by society. One of the issues is liquid dosage form formulation. Alcohol is the one of choice after washing hands with soap. The use of hand sanitizer can deactivate microorganisms that stick to hand. This increase in use because pandemic covid-19 that made many people take preventive action. One way to prevent the spread of the Corona virus is maintain cleanliness such as diligently washing hands with soap and water. In the other hand the use of handsanitizer is also recommended when you cannot reach water and soap. Activity community service in Mojosongo Village, focuses on increasing public knowledge in formulate liquid Handsanitizer that is practical and simple according to the standards requirment by WHO (World Health Organization). The results of the questionnaire conducted before and after assistance in making hand sanitizers stated that most of the respondents had showed an increase in knowledge related to components in the manufacture of handsanitizers

Pengembangan Produk Permen Jelly Jamu Kunyit Asam Industri Rumah Tangga Jamu di Sleman Yogyakarta Dian Eka Ermawati; Wisnu Kundarto; Yeni Farida
Jurnal Pengabdian Pada Masyarakat Vol 7 No 2 (2022): Jurnal Pengabdian Pada Masyarakat
Publisher : Universitas Mathla'ul Anwar Banten

PRODUCT DEVELOPMENT OF GUMMY OF TURMERIC ACID JAMU PRODUCTION BY HERBAL HOMINDUSTRY IN SLEMAN YOGYAKARTA. Jamu of turmeric acid is an Indonesian herbal drink made from turmeric and tamarind. The home industry in Sleman Yogyakarta produces turmeric acid jamu and promising to develop as gummy. The Consumers of turmeric acid Jamu are limited, Children who want to consume jamu are rarely, whereas curcumin in turmeric can increase appetite, especially for school-age children. Product innovation is needed to process jamu become more desirable, durable, and still efficacious, for example, jelly candy or gummy. Gummy is made with the addition of gelling agent that made texture is chewy. Carrageenan is a gelling agent made from seaweed and safe for food products. The aims of product development are to develop micro businesses and to improve the economy and public confidence in the quality of herbal medicine especially jamu. Gummy formulation with carrageenan and turmeric acid jamu as the main ingredient. Formula with 8.0% carrageenan is the optimum formula because it meets the quality requirements for gummy and is most preferred by respondents.

Diversifikasi Produk Handsanitizer dengan Bahan Aktif Minyak Atsiri Produksi Pabrik Atsiri UMKM Surya Wulan Kabupaten Kulonprogo Dian Eka Ermawati; M. Fiqri Zulphadly
Jurnal Pengabdian Pada Masyarakat Vol 8 No 1 (2023): Jurnal Pengabdian Pada Masyarakat
Publisher : Universitas Mathla'ul Anwar Banten

Pandemi COVID-19 menurunkan proses produksi minyak atsiri (MA), dan harga jual minyak anjlok, terutama di Samigaluh. Bahan baku dari petani dibeli dengan harga yang lebih murah, sehingga banyak petani yang menolak pesanan dan mengubah lahannya untuk menanam produk pangan. Stok bahan baku daun kering terutama sereh dan daun cengkeh saat ini menumpuk di gudang penyimpanan yang seharusnya bisa segera dimurnikan. Selain itu minyak cengkeh kaya akan eugenol sebagai antiseptik, analgesik, dan efektif melawan infeksi bakteri. Serai mengandung citronellol dan geraniol, juga memiliki aktivitas antibakteri dan jamur. Tujuan penelitian ini dapat menjadi alternatif pengembangan produk Handsanitizer (Hz) dengan bahan aktif MA untuk membantu UMKM mengembangkan usaha baru dibidang PKRT. Peluang bisnis Hz saat ini sangat terbuka lebar karena dianjurkan setiap fasilitas umum menyediakannya untuk mencegah penularan virus Covid-19. Oleh karena itu, melalui program pengabdian kepada masyarakat, kami mentransfer ilmu dalam mengolah EO menjadi bahan aktif dalam formula Hz. Diversifikasi EO ke dalam bahan aktif formula Hz menghasilkan produk yang baik dan stabil serta memiliki aktivitas antibakteri yang optimal. Mitra dapat merumuskan produk dengan baik dan dapat dikembangkan bersama kelompok UMKM lokal. Prosedur pengajuan izin sudah disusun, dan produknya sudah bisa ditemukan di media sosial yaitu Instagram dan e-commerce. The COVID-19 has decreased the destilated process for essential oils (EO), and the selling price of oil has plummeted, especially in the Samigaluh. Raw materials from farmers are purchased at lower prices, so many farmers refuse orders and convert their land to growing food products. Stocks of dry leaf raw materials, especially lemongrass and clove leaves, are currently piling up in storage warehouses that should be able to be refined immediately. In addition clove oil is rich in eugenol as an antiseptic, analgesic, and effective against bacterial infections. Lemongrass consists citronellol and geraniol, also has antibacterial and fungal activity. The aim of this research can be an alternative for developing Handsanitizer (Hz) products using active ingredients of EO to help UMKMs develope new businesses in the field of PKRT. The business opportunity for Hz is currently very wide open. It is highly recommended that every public facility provide it to prevent the transmission of the Covid-19 virus. Therefore, through community service programs, we transfer knowledge in processing EO into active ingredients in Hz formulas. The diversification of EO into the active ingredients of the Hz formula produces good and stable products and has optimal antibacterial activity. Partners can formulate products well and can be developed with local UMKM groups. The permit application procedure has been compiled, and the product can be found on social media, namely Instagram and e-commerce.

The effect of temperature solubility on particle size and antibacterial activity of nanosilver of gembili’s inulin Dian Eka Ermawati; Hayunda I'zaaz Fajrin; Sholichah Rohmani; M. Nur Dewi Kartikasari
Pharmaciana Vol 13, No 1 (2023): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Gembili Tuber (Dioscorea esculenta L.) is an Indonesia local tuber that reported to have potential as a source of inulin. Inulin is one of fiber types and carbohydrates sources derived from plants and has prebiotic and antibacterial activity. However, inulin long chain has low solubility in water, so it is necessary to modify the solubility in the biosynthetic process. In this study, the biosynthetic process was carried out using inulin as bioreducer of silver ions to help increase the absorption of gembili inulin. Gembili inulin was mixed with silver nitrat solution at variation temperature at 25 â„ƒ and 60 â„ƒ of biosynthetic process, in order to produce the expected particle size and antibacterial activity against bacteria Staphylococcus aureus and Eshcerichia coli. The results of this study indicate that variations in solubility temperature of inulin in nanosilver biosynthetic produce particle size of 12-49 nm with round shape. Whereas the temperature of inulin solubility did not show any significant difference towards AgNO3 control in the antibacterial activity test against S.aureus and E.coli bacteria. FTIR spectra showed that interaction between functional groups of silver nitrate and gembili inulin. Inulin only acts as a capping agent of nanosilver biosynthetic and does not induce antibacterial activity of nanosilver.

The Effect of Surfactant Concentration to Particle Size and Loading Dose of Immunity Jamuâ€™s Ethanolic Extract SNEDDS (Self-Nano Emulsifying Drugs Delivery System) Dian Eka Ermawati; Samrotul Jannah
Majalah Obat Tradisional Vol 28, No 2 (2023)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.83321

Immunity jamu consists of ginger, turmeric, Centella, and cinnamon, that act as immunostimulant agents. However, the infusion is impractical and used a limited dose of the extract, so it is necessary to develop drug delivery to resolve that problem. The SNEDDS technique is expected to increase the solubility, drug release, and absorption of active substances in the body, especially for low solubility of an active substance. SNEDDS consists of oil, surfactant, and co-surfactant. A surfactant is a substance that can reduce surface tension so that emulsion globules form in nanoparticle size. Tween 80 can produce a more transparent solution for oil-in-water emulsions than surfactants with low HLB values. This study aimed to determine the effect of surfactant concentration on the physical properties of SNEDDS to obtain the most loading dose but the smallest particle size. The formula consists of tamanu oil tween 80-propylene glycol of 1:7:1; 1:8:1; and 1:9:1 that incorporated extracts were 75, 150, and 375 mg. The physical tests included transmittance percentage, emulsification time on AGF media, phase separation, and stability test using the cycling test method. SNEDDS, then followed by the Particle Size Analyzer test. The results showed that the greater surfactant concentration produced a better transmittance value, a faster emulsification time, and stability. Formula with oil: surfactant: co-surfactant of 1:8:1 is a system that meets the requirement for immunity jamu with an optimal loading dose and small particle size compared to another formula. The extractâ€™s loading dose of 375 mg has a particle size of 27.17 nm and a polydispersity index of 0.25.

Transport Test of Total Flavonoid Model of Strawberry Emulgel (Fragaria vesca L.) Through Shed Snakeskin Membrane Dian Eka Ermawati; Suwaldi Martodiharjo; T.N Saifullah Sulaiman
Majalah Farmaseutik Vol 19, No 2 (2023)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v19i2.78129

Strawberries contain antioxidants, including quercetin-3-β-D-glucoside, coenzyme Q10, anthocyanins pelargonidin-3-O-glucoside, and cyanidin-3-glucoside. The amount of anthocyanins and flavonoids in fruit tends to decrease by 40-50% after the formulation process, so it is necessary to develop a formula to be applied as a topical preparation. The combination of emulsifiers can stabilize the active substance and increase the permeation of the preparation. This study aims to determine the total flavonoid permeation profile of strawberry fruit emulgel preparations with a combination of emulsifiers. This study used a total flavonoid model from strawberry emulgel. Emulgel was prepared with a combination of emulsifier span 80: croduret 50: propylene glycol at a ratio of 2: 4: 2. The permeation test was carried out using a modified vertical Franz diffusion cell equipped with Shed Snakeskin membrane. The permeation test results showed that the cumulative amount of total flavonoids transported across the shed snakeskin membrane was 117.14 g/cm2 out of a total of 2.24 mg of strawberries in the emulgel formula for 5 hours. The permeability of the snakeskin shed membrane was 2.84x10-5 g/cm2, and the flux value was 6.6x10-5 g/sec. The release kinetics follow the Higuchi kinetic model with the diffusion mechanism.

Formulation of Anti-Acne Gel of Moringa oleifera L Ethanolic Extract and Antibacterial Test on Staphylococcus epidermidis Dian Eka Ermawati; Cahyarani Intan Ramadhani
Journal of Food and Pharmaceutical Sciences Vol 7, No 1 (2019): J. Food Pharm. Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.707

Moringa oleifera L. leaves contain flavonoid, alkaloid, and phenolic compounds which haveantibacterial activity. Staphylococcus epidermidis is one of the bacteria that causes acne. The purpose of this studyis to compare bacteriostatic ability of the extracts and gel for S. epidermidis bacteria and to get gel formula thatcan fulfills the physical properties of a good gel. Moringa leaves were extracted with maceration method usingethanol 70% in three days. HPMC 4000 was used as the polymer. Extract was added with variationconcentrations of 5, 10, and 15%. Physical evaluation of gel was organoleptic, homogeneity, pH, viscosity,adhesion, and spread tests for 4 weeks. In vitro bacteriostatic activity test with 1% clindamycin gel as positivecontrol and polymer gel as negative control. The result showed that variations concentrations of ethanolicextract of Moringa leaves affected the physical properties of gel including viscosity, pH, adhesion andspreadability. Bacteriostatic activity test of ethanolic extract of Moringa leaf was classified as strong activity,while 15% Moringa leaf ethanol extract gel was classified as moderate activity with average diameter was 9.14mm.

Inovasi Masker Beraromaterapi sebagai Alternatif Solusi Diversifikasi Usaha Apotek di Masa Pandemi Covid-19 Sasongko, Heru; Farida, Yeni; Noveri, Priscilla; Rahmat S, Anang Kuncoro; Zulpadly, M.Fiqri; Ermawati, Dian Eka; Sutarno, Sutarno
Jurnal Abdimas ITEKES Vol 2 No 1 (2022)
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat Institute Teknologi dan Kesehatan (ITEKES) Bali

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37294/jai.v2i1.440

Penggunaan masker merupakan salah satu upaya dalam pencegahan penyebaran Covid-19 yang direkomendasikan oleh WHO. Beberapa essential oils telah terbukti memiliki efek antivirus dan antibakteri, sehingga potensial untuk dikembangkan masker beraromaterapi. Kegiatan pengabdian masyarakat ini ditujukan untuk memberikan alternatif solusi diversifikasi usaha apotek dengan pembuatan masker beraromaterapi. Mitra utama pengabdian adalah Apotek Jamsaren yang berlokasi di Laweyan Surakarta, serta melibatkan mitra UMKM Graha Karya dan Rumah Atsiri Indonesia. Tahapan kegiatan yang dilakukan adalah membuat desain masker, membuat prototype masker, membuat formulasi essential oils dan melakukan uji ketahanan aroma masker diakhiri dengan transfer produk teknologi tepat guna (TTG) kepada mitra. Kegiatan dilakukan pada bulan April hingga Agustus 2021. Luaran kegiatan adalah dihasilkannya masker beraromaterapi dengan merk â€œAromaskâ€ yang mengandung campuran dari essential oils lemongrass, peppermint dan citrus. Ketahanan aroma masker saat dipakai adalah 6 jam 24 detik dan masih tercium samar hingga 9 jam. Pada keadaan masker tidak digunakan dan disimpan pada suhu ruangan, aroma dapat bertahan hingga 7 hari. Produk diserahkan kepada pihak Apotek Jamsaren untuk dapat dikembangkan sebagai salah satu komoditas usaha dan didistribusikan kepada masyarakat. Kata kunci : Apotek, essential oils, masker beraromaterapi, pandemi Covid-19

The Characteristic and Antibacterial Activity of Nanosilver Biosynthetic using Sweet Orange Ermawati, Dian Eka; Putro, David Sarono; Amaris Susanto, Nindita Clourisa
Journal of Food and Pharmaceutical Sciences Vol 11, No 1 (2023): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.5760

Sweet orange contains citric acid and ascorbic acid that act as a silver ion bioreducer to form nanosilver (AgNPs). Silver ion green synthesis using sweet orange peel resulted in smaller particle sizes than C. lemon and C. limeta. Therofore, this study aims to determine the characteristic of nanosilver biosynthetic using sweet orange bioreductor and antibacterial activity. Silver nitrate solution of 1.0 mM was mixed with sweet orange juice - peel infusion in ratio of 3.0: 0.0; 1.5: 1.5; and 0.0: 3.0 mL. The process was conducted using a water bath at 60 ˚C for 45 minutes. The formation of AgNPs is indicated by a color change from colorless to yellowish-brown using UV/Vis spectrophotometer and PSA. The stability test of AgNPs is determined for 30 days storage at room temprature and their antibacterial activity against S. aureus and S. epidermidis. The results showed that sweet orange juice accelerated the color change at the SPR range of AgNPs at 438-459 nm, but it is less stable. The mix solution of sweet orange juice and sweet orange peel infusion of 1.5: 1.5 mL are stable and promising as an antibacterial agent. Futhermore, the AgNPs produced had a particle size of 41±10 nm and a spherical shape.

Co-Authors Adi, Lutfan Prastyo Aditya, Shafira Nur Agung P. Surya Agung Putu S.P.Kristyawan Aini S., Aini Alfia Andhika Putri Amaris Susanto, Nindita Clourisa Andini, Bimar Putri Anggraini Febriyanty Anif Nur Artanti Anif Nur Artanti Anif Nur Artanti Anif Nur Artanti, Anif Nur Aprilia Saefanan Shofa Aratanti, Anif Nur Cahyarani Intan Ramadhani Cahyarani Intan Ramadhani Damayanti, Avina Kusuma Darojati, Ulfa Afrinurfadhilah Daswati Daswati Dita Yuli Budiasih Diyah Tri Utami Dyah Ayu Ambarwati Ediati Sasmito Esha ND., Pramitha Farida, Yeni Fitria, Krismona Rizky Nur Fridha Angelina Pamuji Galuh Kartikasari H., Muchammad Hanuriansyah, Yavi Hayunda I'zaaz Fajrin Heni Utami Prilantari Heru Sasongko Heru Sasongko Heru Sasongko Heru Sasongko Hidayati, Astri Husna, Hanna Miftahul Indah Purwantini Indrajati, Dyah Yekti KD, Anggi Kundarto, Wisnu Kuntari, Tabita Putri M Fiqri Zulpadly M. Fiqri Zulpadly M. Fiqri Zulphadly M. Nur Dewi Kartikasari M. Nur Dewi Kartikasari Meitasari, Annisa Diyah Meitasari, Annisa Diyan Muchammad H., Muchammad mufrod mufrod Nailul Maghfiroh ND., Pramitha Esha Niken Rosyana Dewi Septini Nindita Clourisa Amaris Susanto Nining Sugihartini Noveri, Priscilla Novi Andriani Novi Andriani, Novi Nugraha Mas'ud Nurul Rochmawati Parwatiningsih, Sri Anggarini Prihapsara, Fea Putri, Hapsari Duanda Putriana, Susanti Putro, David Sarono Putu UA., Ni Qutratu'ain, Syahla Rahmat S, Anang Kuncoro Raka Sukmabayu W.S Ramadhani, Cahyarani Intan Rochmani, Sholichah S., Aini Saifullah Sulaiman Salsabila, Fitri Samrotul Jannah Setyowati, Tri Sholichah Rohmani Sholichah Rohmani Sholichah Rohmani Sholichah Rohmani Sholichah Rohmani, Sholichah Sulaiman, TeukuNanda Saifullah Susanti, Indhun Dyah Susanto, Nindita Claurisa Amaris Susanto, Nindita Clourisa Amaris Sutarno Sutarno Suwaldi . Suwaldi Martodiharjo T.N Saifullah Sulaiman Tambunan, Rido Rohana UA., Ni Putu Ul Millah, Nida untari, meta kartika Utami, Diyah Tri Villian Septiana Waliyyin Razan Qanit Wisnu Kundarto Wisnu Kundarto Wisnu Kundarto Wisnu Kundarto Wulandari, Wening Yeni Farida Zulpadly, M. Fiqri Zulpadly, M.Fiqri Zulpadly, Muhammad Fiqri Zulphadly, M.Fiqri

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