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All Journal Journal of Food and Pharmaceutical Science Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Cancer Chemoprevention Indonesian Journal of Pharmaceutical Science and Technology Majalah Obat Tradisional CHEMPUBLISH JOURNAL Jurnal Farmasi Sains dan Komunitas Jurnal Pengabdian UntukMu NegeRI Smart Medical Journal ALCHEMY Jurnal Penelitian Kimia Jurnal Pengabdian Pada Masyarakat Majalah Farmaseutik JCES (Journal of Character Education Society) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Ilmu Kefarmasian Indonesia Bubungan Tinggi: Jurnal Pengabdian Masyarakat Madaniya Jurnal Farmasi Klinik dan Sains Jurnal Pengabdian Pada Masyarakat Jurnal Pengabdian Kepada Masyarakat Itekes Bali Journal of Food and Pharmaceutical Sciences Journal of Applied Agriculture, Health and Technology Jurnal Kefarmasian Indonesia
ERMAWATI, DIAN EKA
Sekolah Vokasi, Universitas Sebelas Maret, Surakarta
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The Effect of Citronella oil Concentration on Physicochemical Properties of Laponite Hydrogel and Antimicrobial Activity Test to Streptococcus aureus ATCC 25923 and Candida albicans ATCC 14053 Ermawati, Dian Eka; Putriana, Susanti; Susanto, Nindita Claurisa Amaris
Smart Medical Journal Vol 7, No 2 (2024): August
Publisher : Faculty of Medicine Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/smj.v7i2.92213

Abstract

Introduction: The Citronella plant produces 78 -85% citral oil. This oil has antimicrobial activity. The oil was developed as an antimicrobial topical and incorporated into laponite hydrogel for optimal use. Laponite hydrogel has a cooling sensation and is compatible with polar and non-polar active substances. This study aims to evaluate the effect of citronella oil concentration on physicochemical properties and examine its antimicrobial activity.Methods: The Citronella plant was distilled using the steam distillation method and analyzed using the GC-MS. The laponite hydrogel was prepared with three concentrations: 6%, 8%, and 10%. Physicochemical properties included pH value, viscosity, stickiness, spreadability, and organoleptics, and the chosen formula was tested for antimicrobial activity. The research data were compared with relevant literature, and ANOVA statistics were analyzed with a confidence level of 95%.Results: Based on the research results, increasing the concentration of citronella oil caused the laponite hydrogel to become increasingly cloudy, viscosity, and sickness but decreased the pH and spreadability. Citronella oil concentration of 8% is the chosen formula that fulfills the best hydrogel preparation with evaluation results of pH value of 7.24 ± 0.064, spreadability of 5.68 ± 0.320 cm, thickness of 1.25 ± 0.012 seconds, and viscosity of 23596.3 ± 227.55 mPa. s. The citronella oil hydrogel has antibacterial and antifungal properties and moderate strong inhibitory.Conclution: As a delivery system for citronella oil, Laponite can be developed as a pharmaceutical preparation to treat mouth ulcers as an alternative synthetic product with good antimicrobial potential.
Optimization of the Proportion of Surfactant, Co-Surfactant, and Candlenut Oil for Self-Nanoemulsifying Drug Delivery System (SNEDDS) of Secang Heartwood (Caesalpinia sappan L.) Methanolic Extract Anif Nur Artanti; Fea Prihapsara; Nugraha Mas'ud; Dian Eka Ermawati
ALCHEMY Jurnal Penelitian Kimia Vol 17, No 1 (2021): March
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.17.1.39054.124-131

Abstract

This study aimed to determine the optimum proportion of hazelnut oil, surfactants, and cosurfactants for SNEDDS of Secang Heartwood using the simplex lattice design (SLD) method using the Design-Expert software. The SNEDDS formula was prepared using Tween 80 and Croduret 50 ss as surfactants, propylene glycol as cosurfactant, and candlenut oil based on physical stability parameters: formula transmittance (%), separation phase, and emulsification time. The optimum SNEDDS formula was compared with the predictive value [p> 0.05] provided by the SLD; then extract the loading dose, accelerated stability test, analysis of particle size, and zeta potential. The optimum proportion of Tween 80-Croduret 50 ss, propylene glycol, and hazelnut oil, based on the SLD, was 62.43%; 22.57%; and 15.0%. The results showed that the transmittance was 93.2%; emulsification time was 74.67 seconds, and; separation phase was 0.89. The SLD's predictive values of the transmittance percentage, emulsification time, and separation phase were 94.98%, 78.97 seconds, 0.84, respectively. The results of the one-sample t-test statistical analysis showed no significant difference between the observative and predictive results. SNEDDS was found capable of loading 25.0 mg of secang heartwood methanolic extract in each system, with a particle size of 23.2 nm, a polydispersity index of 0.142, and zeta potential of +20.8 mV.
Pengaruh Konsentrasi Polivinil Alkohol terhadap Sifat Fisik dan Kimia Sediaan Peel-off Mask Ekstrak Etanol Kayu Secang (Caesalpinia sappan L.) Dian Eka Ermawati; Lutfan Prastyo Adi
Journal of Applied Agriculture, Health, and Technology Vol. 2 No. 1 (2023): June
Publisher : Sekolah Vokasi, Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jaht.v2i1.638

Abstract

Free radicals can be prevented with antioxidant agents. Secang wood contains anthocyanin and flavonoid which have the potential as an antioxidant. Peel-off Mask is a gel cosmetic preparation that is practical because it does not require water. Secang wood extract can be developed as an active ingredient in peel-off mask preparations for the treatment of skin problems caused by exposure to free radicals. The formation of the plastic film on the peel-off mask depends on the concentration of polyvinyl alcohol (PVA) as a polymer. The purpose of this study was to examine the effect of PVA concentration on the physicaochemical properties of the peel-off mask preparation of sappan wood ethanolic extract. This research is a laboratory experimental study, the sappan wood was macerated with 96% ethanol solvent for three days with a ratio of 1:5. Peel-off mask formula with variations in PVA concentration of 12%, 13%, and 14%. Evaluation of the physical properties of the preparations carried out were organoleptic test, homogeneity test, dry time test, viscosity test, dispersion test and evaluation of chemical properties, namely pH test for four weeks. The data obtained were analyzed theoretically and statistically using the One-Way ANOVA method with SPSS 21. The results showed that variations in concentration had a significant effect on the consistency, viscosity, dispersion, and drying time of the peel-off mask of sappan wood ethanolic extract. The concentration of PVA that had the best evaluation was PVA 14% with a thick consistency; drying time 19,77±1,86 minutes; pH 6,33±0,21; viscosity 80,0±12,06 dPa.s; and spreadibility 5,76±0,41cm.
Characterization and In Vivo Evaluation of Durian Peel Extract Nanoliposome Transdermal Patch on Wound Healing Susanto, Nindita Clourisa Amaris; Putri, Milkazia Elda; Utami, Dayinta Tyas; Ermawati, Dian Eka; Sasongko , Heru; Rohmani , Sholichah; Artanti, Anif Nur; Utami, Dyah Tri; Zulpadly Mh, M. Fiqri; Darojati, Ulfa Afrinurfadhilah; Meitasari , Annisa Diyan; Untari, Meta Kartika; Izza, Alfina
Chempublish Journal Vol. 10 No. 1 (2026): Chempublish Journal (January - June)
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v10i1.48779

Abstract

Wounds are a form of continuity damage due to loss of tissue, structure and anatomical function of the skin caused by heat trauma or sharp object scratches. The prevalence of wound injury patients in Indonesia is 9.2%. One of the natural ingredients that is effective in inhibiting the growth of infectious organisms is durian, especially in its skin. In this study, durian peel was formulated in liposome dosage form and applied to patch preparations. The purpose of this study was to assess the effectiveness of durian skin extract liposomes (Durio zibethinus Murr.) on wound healing in white rats. The results of this study are that the patches produced can provide a therapeutic effect on the healing of incision wounds in wistar strain male white rats (Rattus norvegicus L.) with a healing percentage on day 7 of 72.5% which is characterized by the absence of edema, bleeding, growth of fur in mice, the appearance of scabs and wound closure.
Co-Authors Aditya, Shafira Nur Agung P. Surya Agung Putu S.P.Kristyawan Aini S., Aini Alfia Andhika Putri Amaris Susanto, Nindita Clourisa Andini, Bimar Putri Anggraini Febriyanty Anif Nur Artanti Anif Nur Artanti Anif Nur Artanti Anif Nur Artanti, Anif Nur Aprilia Saefanan Shofa Aratanti, Anif Nur Cahyarani Intan Ramadhani Cahyarani Intan Ramadhani Damayanti, Avina Kusuma Darojati, Ulfa Afrinurfadhilah Daswati Daswati Dita Yuli Budiasih Diyah Tri Utami Dyah Ayu Ambarwati Ediati Sasmito Esha ND., Pramitha Farida, Yeni Fitria, Krismona Rizky Nur Fridha Angelina Pamuji Galuh Kartikasari H., Muchammad Hanuriansyah, Yavi Hayunda I'zaaz Fajrin Heni Utami Prilantari Heru Sasongko Heru Sasongko Hidayati, Astri Husna, Hanna Miftahul Indah Purwantini Indrajati, Dyah Yekti Izza, Alfina KD, Anggi Kundarto, Wisnu Kuntari, Tabita Putri Lutfan Prastyo Adi M Fiqri Zulpadly M. Fiqri Zulpadly M. Fiqri Zulphadly M. Nur Dewi Kartikasari M. Nur Dewi Kartikasari Meitasari , Annisa Diyan Meitasari, Annisa Diyah Meitasari, Annisa Diyan Muchammad H., Muchammad mufrod mufrod Nailul Maghfiroh ND., Pramitha Esha Niken Rosyana Dewi Septini Nindita Clourisa Amaris Susanto Nining Sugihartini Noveri, Priscilla Novi Andriani Novi Andriani, Novi Nugraha Mas'ud Nurul Rochmawati Prihapsara, Fea Putri, Hapsari Duanda Putri, Milkazia Elda Putriana, Susanti Putro, David Sarono Putu UA., Ni Qutratu'ain, Syahla Rahmat S, Anang Kuncoro Raka Sukmabayu W.S Ramadhani, Cahyarani Intan Rohmani , Sholichah S., Aini Saifullah Sulaiman Salsabila, Fitri Samrotul Jannah Sasongko , Heru Setyowati, Tri Sholichah Rohmani Sholichah Rohmani Sholichah Rohmani Sholichah Rohmani Sholichah Rohmani, Sholichah Susanto, Nindita Claurisa Amaris Susanto, Nindita Clourisa Amaris Sutarno Sutarno Suwaldi Martodiharjo T.N Saifullah Sulaiman Tambunan, Rido Rohana UA., Ni Putu untari, meta kartika Utami, Dayinta Tyas Utami, Diyah Tri Utami, Dyah Tri Villian Septiana Waliyyin Razan Qanit Wisnu Kundarto Wisnu Kundarto Wulandari, Wening Yeni Farida Zulpadly Mh, M. Fiqri Zulpadly, M. Fiqri Zulpadly, M.Fiqri Zulpadly, Muhammad Fiqri Zulphadly, M.Fiqri