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All Journal Journal of Food and Pharmaceutical Science Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Cancer Chemoprevention Indonesian Journal of Pharmaceutical Science and Technology Majalah Obat Tradisional Jurnal Farmasi Sains dan Komunitas Jurnal Pengabdian UntukMu NegeRI Smart Medical Journal ALCHEMY Jurnal Penelitian Kimia Jurnal Pengabdian Pada Masyarakat Majalah Farmaseutik JCES (Journal of Character Education Society) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Ilmu Kefarmasian Indonesia JKPK (Jurnal Kimia dan Pendidikan Kimia) Bubungan Tinggi: Jurnal Pengabdian Masyarakat Madaniya Jurnal Farmasi Klinik dan Sains Jurnal Pengabdian Pada Masyarakat Jurnal Pengabdian Kepada Masyarakat Itekes Bali Journal of Food and Pharmaceutical Sciences Journal of Applied Agriculture, Health and Technology Jurnal Kefarmasian Indonesia Jurnal Abdimas Indonesia
ERMAWATI, DIAN EKA
Sekolah Vokasi, Universitas Sebelas Maret, Surakarta
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Evaluation of Virgin Coconut Oil Concentration Variations in Emulgel Formulations of Garlic (Allium sativum L.) Extract as an Antibacterial Hand Sanitizer Rohmani, Sholichah; Fitria, Krismona Rizky Nur; Utami, Diyah Tri; Susanto, Nindita Clourisa Amaris; Ermawati, Dian Eka; Sasongko, Heru; Zulpadly, M. Fiqri; Darojati, Ulfa Afrinurfadhilah; Meitasari, Annisa Diyan; Aratanti, Anif Nur; Untari, Meta Kartika
Jurnal Kefarmasian Indonesia VOLUME 15, NUMBER 2, JULY-DECEMBER 2025
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

One of the effective ways to stay healthy is maintaining cleanliness, including hand hygiene. Various diseases can be easily transmitted through the hands. However, modern developments have changed the habit of handwashing with water to using hand antiseptics. Hand sanitizer is an alternative to overcome this problem. Unfortunately, some hand sanitizer gels on the market still contain alcohol as an antibacterial ingredient. It is necessary to innovate in making hand sanitizers using non-alcoholic ingredients as antibacterials, for example, natural ingredients like garlic. Garlic contains allicin that functions as an antibacterial. Meanwhile, VCO contains high lauric acid with antibiotic properties that function as antiviral, antibacterial, and antiprotozoal. It also contains capric acid, with antiviral and antibacterial functions. This study aims to examine the effect of concentration variation of VCO on the physical stability of garlic extract emulgel preparation and antibacterial effectiveness against the growth of Staphylococcus aureus. The concentration variation of VCO in this study was 3%, 5%, and 7% for 3 types of formulas. The results showed that the concentration variation of VCO in emulgel preparations gave differences in the physical properties of the gel, including pH, viscosity, adhesive strength, and spreadability. It can be concluded that the higher the VCO concentration, the higher the pH, viscosity, and adhesive power, and the lower the spreadability and antibacterial inhibition power against Staphylococcus aureus. The best result from the evaluation of physicochemical properties and antibacterial tests was Formula 1, although it was still in the weak inhibitory power category.
Medication Adherence among Acute Coronary Syndrome Outpatients at Sardjito Hospital in 2019 M Fiqri Zulpadly; Dian Eka Ermawati; Heru Sasongko
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 21 No. 01 Juli 2024
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v21i1.17807

Abstract

Worldwide, heart disease accounts for the majority of deaths. One of the indications of coronary illness is Acute Coronary Syndrom (ACS) STEMI. With a prevalence rate of 7.2%, Indonesia still has the highest ACS incidence, and it continues to rise annually. Several factors are involved in reducing the mortality rate of ACS, namely by controlling several risk factors that can reduce the incidence and improve treatment. This study aims to determine the level of adherence to drug use in patients who are registered with new STEMI and outpatients at Sardjito Hospital Yogyakarta. The research method used in this study was non-experimental analytic observational with a retrospective cohort design. Measurement using the Medication Possession Ratio (MPR) method. The study population was patients who were registered for the first ACS diagnosis since January 2017 and followed the course of their treatment until the patient stopped using the drug or the end of observation (31 December 2018). The number of samples obtained according to the inclusion criteria was 495 patients. Adherence to the use of antithrombotic drugs was greater in female patients (82.4%), age < 60 years (88.4%), and patients using combination antithrombotic therapy regimens (81.4%). Statistical significance was shown in the category of gender (Log Rank = 0.046) and treatment regimen (Log Rank = 0.005). However, the age category did not show statistical significance (Log Rank = 0.289). The conclusion of this study is that adherence to the use of antithrombotic drugs in STEMI patients is influenced by gender and therapeutic regimen.
Optimization of Span 80-Croduret 50-Propylene Glycol as Emulsifier of Dried Strawberry Juice (Fragaria vesca L.) Emulgel and Permeation Test Through Shed Snakeskin Membrane Ermawati, Dian Eka; Martodihardjo, Suwaldi; Sulaiman, TeukuNanda Saifullah
Majalah Obat Tradisional Vol 31, No 1 (2026)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.98265

Abstract

Strawberry is a natural source of antioxidants with potential to inhibit melanin production in the skin. However, its application in topical formulations is limited by factors such as stability, skin permeability, and effective delivery, necessitating the development of an appropriate delivery system. This has led to the selection of double emulsion due to the water solubility of the active ingredient. To produce a stable emulsion, it is required to combine emulsifier with different hydrophilic-lipophilic balance values. This study aimed to obtain the optimal proportion of emulsifier combinations for formulating an emulgel containing dried strawberry. Antioxidant activity was evaluated using the DPPH assay, while the content of active compounds was quantified using the UV-Vis spectrophotometric method. The optimization of emulsifier proportions was carried out using the simplex lattice design (SLD), with globule size, viscosity, and separation ratio as response parameters. The optimized emulsion system was then incorporated into a hydrogel. Physicochemical stability of the emulgel was assessed based on organoleptic properties, pH, viscosity, spreadability, and phase separation. Permeation studies were conducted using Franz diffusion cells with shed snakeskin membrane as the diffusion barrier. The study successfully demonstrated that dried strawberry juice possesses antioxidant activity, with an IC₅₀ value of 0.331 mg/mL. The levels of key active compounds, namely quercetin (23.3% w/w) and anthocyanins (13.23% w/w), supporting its potential use in topical antioxidant applications. The most effective emulsifier system was determined to be a Span 80:Croduret 50:Propylene Glycol ratio of 1:2:1. This emulsifier composition yielded an emulsion with favorable droplet size, viscosity, and stability characteristics. Incorporation into a 1.5% Polygel CA hydrogel resulted in an emulgel formulation with excellent physicochemical stability, as indicated by consistent pH, spreadability, viscosity, and absence of phase separation during storage. Permeation studies using Franz diffusion cells showed that the optimized emulgel was capable of delivering 117.14 μg/cm² of flavonoids across shed snakeskin membrane within 5 hours, with a permeability coefficient of 2.84×10⁻⁵ μg/cm² and a flux rate of 6.6×10⁻⁵ μg/sec, indicating good skin permeation potential.
PENDAMPINGAN DIVERSIFIKASI PRODUK JAHE LATTE PADA UMKM UMZA SEBAGAI UPAYA PENINGKATAN DAYA SAING PRODUK HERBAL LOKAL Kartikasari, M. Nur Dewi; Susanti, Indhun Dyah; Ermawati, Dian Eka; Parwatiningsih, Sri Anggarini
Jurnal Abdimas Indonesia Vol 8, No 1 (2026): JURNAL ABDIMAS INDONESIA
Publisher : Universitas Muhammadiyah Kudus

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26751/jai.v8i1.3182

Abstract

This community service activity was motivated by the still low level of innovation and business legality in the herbal-based food Micro, Small, and Medium Enterprises (MSMEs) sector in the former Surakarta Residency area. The objectives of the activity were to enhance product innovation capabilities, strengthen food safety aspects through the implementation of good production practices, and support the processing of distribution permits and digital marketing strategies for UmZa MSMEs. The activity was conducted over three months in the Sukoharjo area, involving a single main partner that met the criteria for a ginger-based microenterprise. The implementation method employed a participatory approach, comprising stages of observation, focus group discussions, product diversification training, Good Manufacturing Practices training, licensing assistance, packaging innovation, and digital marketing training. The variables evaluated included increasing partner knowledge and skills, product quality, and business legality readiness. Data were collected through questionnaires, observations, and interviews, then analyzed descriptively. The results showed a 40% increase in partner knowledge, the implementation of hygienic production practices, the development of two new Jahe Latte product variants, and the preparation of distribution permit documents in accordance with regulations. This activity was concluded to have successfully increased the competitiveness and sustainability of MSMEs through the integration of product innovation, legality, and digitalization. Further mentoring is recommended to expand market reach and support halal certification for local herbal products.
The Effect of Citronella oil Concentration on Physicochemical Properties of Laponite Hydrogel and Antimicrobial Activity Test to Streptococcus aureus ATCC 25923 and Candida albicans ATCC 14053 Ermawati, Dian Eka; Putriana, Susanti; Susanto, Nindita Claurisa Amaris
Smart Medical Journal Vol 7, No 2 (2024): August
Publisher : Faculty of Medicine Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/smj.v7i2.92213

Abstract

Introduction: The Citronella plant produces 78 -85% citral oil. This oil has antimicrobial activity. The oil was developed as an antimicrobial topical and incorporated into laponite hydrogel for optimal use. Laponite hydrogel has a cooling sensation and is compatible with polar and non-polar active substances. This study aims to evaluate the effect of citronella oil concentration on physicochemical properties and examine its antimicrobial activity.Methods: The Citronella plant was distilled using the steam distillation method and analyzed using the GC-MS. The laponite hydrogel was prepared with three concentrations: 6%, 8%, and 10%. Physicochemical properties included pH value, viscosity, stickiness, spreadability, and organoleptics, and the chosen formula was tested for antimicrobial activity. The research data were compared with relevant literature, and ANOVA statistics were analyzed with a confidence level of 95%.Results: Based on the research results, increasing the concentration of citronella oil caused the laponite hydrogel to become increasingly cloudy, viscosity, and sickness but decreased the pH and spreadability. Citronella oil concentration of 8% is the chosen formula that fulfills the best hydrogel preparation with evaluation results of pH value of 7.24 ± 0.064, spreadability of 5.68 ± 0.320 cm, thickness of 1.25 ± 0.012 seconds, and viscosity of 23596.3 ± 227.55 mPa. s. The citronella oil hydrogel has antibacterial and antifungal properties and moderate strong inhibitory.Conclution: As a delivery system for citronella oil, Laponite can be developed as a pharmaceutical preparation to treat mouth ulcers as an alternative synthetic product with good antimicrobial potential.
Optimization of the Proportion of Surfactant, Co-Surfactant, and Candlenut Oil for Self-Nanoemulsifying Drug Delivery System (SNEDDS) of Secang Heartwood (Caesalpinia sappan L.) Methanolic Extract Anif Nur Artanti; Fea Prihapsara; Nugraha Mas&#039;ud; Dian Eka Ermawati
ALCHEMY Jurnal Penelitian Kimia Vol 17, No 1 (2021): March
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.17.1.39054.124-131

Abstract

This study aimed to determine the optimum proportion of hazelnut oil, surfactants, and cosurfactants for SNEDDS of Secang Heartwood using the simplex lattice design (SLD) method using the Design-Expert software. The SNEDDS formula was prepared using Tween 80 and Croduret 50 ss as surfactants, propylene glycol as cosurfactant, and candlenut oil based on physical stability parameters: formula transmittance (%), separation phase, and emulsification time. The optimum SNEDDS formula was compared with the predictive value [p> 0.05] provided by the SLD; then extract the loading dose, accelerated stability test, analysis of particle size, and zeta potential. The optimum proportion of Tween 80-Croduret 50 ss, propylene glycol, and hazelnut oil, based on the SLD, was 62.43%; 22.57%; and 15.0%. The results showed that the transmittance was 93.2%; emulsification time was 74.67 seconds, and; separation phase was 0.89. The SLD's predictive values of the transmittance percentage, emulsification time, and separation phase were 94.98%, 78.97 seconds, 0.84, respectively. The results of the one-sample t-test statistical analysis showed no significant difference between the observative and predictive results. SNEDDS was found capable of loading 25.0 mg of secang heartwood methanolic extract in each system, with a particle size of 23.2 nm, a polydispersity index of 0.142, and zeta potential of +20.8 mV.
The Effect of Variation Concentration of Simplex Syrup on the Physicochemical Stability of Nanosilver Syrup Ermawati, Dian Eka; Hanuriansyah, Yavi; Susanto, Nindita Clourisa Amaris; Rochmani, Sholichah; Utami, Diyah Tri; Zulpadly, M. Fiqri; Sasongko, Heru; Darojati, Ulfa Afrinurfadhilah; Meitasari, Annisa Diyan; Untari, Meta Kartika
JKPK (Jurnal Kimia dan Pendidikan Kimia) Vol 9, No 2 (2024): JKPK (Jurnal Kimia dan Pendidikan Kimia)
Publisher : Program Studi Pendidikan Kimia FKIP Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jkpk.v9i2.84012

Abstract

Inulin from Gembili has been identified as an effective bioreductor for forming nanosilver with a size of 481.4 nm, stable for 30 days when stored at 4°C. Inulin nanosilver exhibits immunomodulatory properties and has been proven safe through acute toxicity evaluation at a dose of 4 mg/kgBB. A drug delivery system needs to be developed for its use as a supplement. Syrup was chosen due to its alcohol-free nature, better taste, and ease of measuring the active substance compared to elixirs, solutions, and suspensions. Simplex syrupus, used as a syrup base, influences stability by potentially forming crystals during storage. This research aims to determine how varying concentrations of simplex syrupus affect the physicochemical properties of inulin nanosilver syrup. The study involved the biosynthesis process using Gembili's inulin, nanosilver characterization, formulation, and stability testing. Inulin nanosilver syrup was prepared with simplex syrupus concentrations of 20%, 40%, and 60%. The physicochemical stability of the syrup, including organoleptic properties, pH, and viscosity, was tested before and after storage at 4°C and 40°C over six cycles. The selected formula was evaluated for sugar reduction content and FT-IR profile. Data analysis was performed using SPSS 21.0 for Windows with One-way ANOVA and Paired T-Test. Results indicated that higher concentrations of simplex syrupus led to increased consistency, pH, and viscosity. A 60% concentration of simplex syrupus met the physicochemical stability requirements, with a medium-thick consistency, pH of 5.25±0.03, and viscosity of 92±2.6 cps. The reducing sugar content was 20.59% ±0.002, and the FT-IR profile confirmed the presence of inulin nanosilver, indicated by Ag-N groups compared to silver nitrate solution. This product has the potential to be developed as a health supplement.
Co-Authors Adi, Lutfan Prastyo Aditya, Shafira Nur Agung P. Surya Agung Putu S.P.Kristyawan Aini S., Aini Alfia Andhika Putri Amaris Susanto, Nindita Clourisa Andini, Bimar Putri Anggraini Febriyanty Anif Nur Artanti Anif Nur Artanti Anif Nur Artanti Anif Nur Artanti, Anif Nur Aprilia Saefanan Shofa Aratanti, Anif Nur Cahyarani Intan Ramadhani Cahyarani Intan Ramadhani Damayanti, Avina Kusuma Darojati, Ulfa Afrinurfadhilah Daswati Daswati Dita Yuli Budiasih Diyah Tri Utami Dyah Ayu Ambarwati Ediati Sasmito Esha ND., Pramitha Farida, Yeni Fitria, Krismona Rizky Nur Fridha Angelina Pamuji Galuh Kartikasari H., Muchammad Hanuriansyah, Yavi Hayunda I&#039;zaaz Fajrin Heni Utami Prilantari Heru Sasongko Heru Sasongko Heru Sasongko Heru Sasongko Hidayati, Astri Husna, Hanna Miftahul Indah Purwantini Indrajati, Dyah Yekti KD, Anggi Kundarto, Wisnu Kuntari, Tabita Putri M Fiqri Zulpadly M. Fiqri Zulpadly M. Fiqri Zulphadly M. Nur Dewi Kartikasari M. Nur Dewi Kartikasari Meitasari, Annisa Diyah Meitasari, Annisa Diyan Muchammad H., Muchammad mufrod mufrod Nailul Maghfiroh ND., Pramitha Esha Niken Rosyana Dewi Septini Nindita Clourisa Amaris Susanto Nining Sugihartini Noveri, Priscilla Novi Andriani Novi Andriani, Novi Nugraha Mas&#039;ud Nurul Rochmawati Parwatiningsih, Sri Anggarini Prihapsara, Fea Putri, Hapsari Duanda Putriana, Susanti Putro, David Sarono Putu UA., Ni Qutratu'ain, Syahla Rahmat S, Anang Kuncoro Raka Sukmabayu W.S Ramadhani, Cahyarani Intan Rochmani, Sholichah S., Aini Saifullah Sulaiman Salsabila, Fitri Samrotul Jannah Setyowati, Tri Sholichah Rohmani Sholichah Rohmani Sholichah Rohmani Sholichah Rohmani Sholichah Rohmani, Sholichah Sulaiman, TeukuNanda Saifullah Susanti, Indhun Dyah Susanto, Nindita Claurisa Amaris Susanto, Nindita Clourisa Amaris Sutarno Sutarno Suwaldi . Suwaldi Martodiharjo T.N Saifullah Sulaiman Tambunan, Rido Rohana UA., Ni Putu Ul Millah, Nida untari, meta kartika Utami, Diyah Tri Villian Septiana Waliyyin Razan Qanit Wisnu Kundarto Wisnu Kundarto Wulandari, Wening Yeni Farida Zulpadly, M. Fiqri Zulpadly, M.Fiqri Zulpadly, Muhammad Fiqri Zulphadly, M.Fiqri