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ERMAWATI, DIAN EKA
Sekolah Vokasi, Universitas Sebelas Maret, Surakarta
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The Diversifikasi Minyak Sereh UMKM Surya Wulan Kulonprogo DI Yogyakarta sebagai Bahan Aktif Sabun Cuci Tangan Halal Ermawati, Dian Eka; Zulpadly, M. Fiqri; Kartikasari, M. Nur Dewi; Indrajati, Dyah Yekti
Jurnal Pengabdian Pada Masyarakat Vol 9 No 3 (2024): Jurnal Pengabdian Pada Masyarakat
Publisher : Universitas Mathla'ul Anwar Banten

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30653/jppm.v9i3.844

Abstract

Pandemi Covid-19 pada tahun 2020-2022 berdampak signifikan terhadap penyulingan minyak atsiri khususnya di UMKM Surya Wulan Samigaluh Kulonprogo, DI Yogyakarta. Proses penyulingan yang terhenti mengakibatkan harga jual minyak atsiri anjlok karena permintaan menurun. Stok bahan baku daun sereh menumpuk di Gudang yang seharusnya dapat segera dilakukan penyulingan. Keterbatasan penjualan produk minyak atsiri curah maka perlu adanya diversifikasi produk yang bernilai ekonomi tinggi. Kandungan eugenol, citronelol dan geraniol minyak sereh antara 5-20% memiliki aktifitas analgesik dan efektif melawan infeksi bakteri Staphylococcus aureus, juga efektif sebagai antijamur Candida albicans. Dasar riset ini dapat menjadikan alternatif bahan aktif alami produk sabun cuci tangan, disamping bahan aktif sintetik yang memiliki efek samping membuat kulit menjadi kering. Proses pengabdian dengan menstandsrkan kandungan aktif minyak atsiei kemudian diolah menjadi produk dan dibantu mendapatkan sertifikasi halal. Produk sabun cuci tangan minyak sereh dapat membantu UMKM dalam mengembangkan usaha baru dibidang PKRT (Produk Kebersihan Rumah Tangga). Dalam meningkatkan kepercayaan konsumen sabun cuci tangan perlu dilakukan sertifikasi halal karena bersentuhan langsung dengan kulit sehingga harus terbebas dari najis. Oleh karena itu kami melakukan transfer knowlage dalam mengolah bahan baku minyak atsiri menjadi bahan aktif dalam formula produk sabun cuci tangan dan pendaftaran sertifikasi halal melalui program pengabdian masyarakat. The COVID-19 pandemic in 2020-2022 has significantly impacted essential oil refining, especially in the UMKM Surya Wulan Samigaluh Kulonprogo, DI Yogyakarta. The halted refining process caused the selling price of essential oils to plummet due to decreased demand. Stocks of raw materials for lemongrass leaves are piling up in warehouses, which should be refined immediately. Due to the limited sales of bulk essential oil products, it is necessary to diversify products with high economic value. The eugenol, citronellol, and geraniol content of lemongrass oil is between 5-20%, which has analgesic activity and is effective as an antibacterial agent against Staphylococcus aureus and as an antifungal Candida albicans. The basis of this research can be an alternative to natural active ingredients for hand washing soap products, besides synthetic active ingredients, which have the side effect of making the skin dry. Lemongrass oil hand soap products can help UMKMs develop new businesses in PKRT (Household Hygiene Products). To increase consumer confidence, hand soap needs to be halal certified because it comes in direct contact with the skin, so it must be free from uncleanness. Therefore, we transfer knowledge in processing essential oil raw materials into active ingredients in handsoap product formulas and register for halal certification through community service programs.
The effect of syrup simplex concentration on the physicochemical stability of Gembili’s inulin (Dioscorea esculenta (Lour.) Burkill) nanosilver colloid Ermawati, Dian Eka; Hanuriansyah, Yavi
Pharmaciana Vol. 14 No. 2 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i2.26569

Abstract

Gembili tuber's inulin is a successful bioreductor agent that forms a nanosilver with a size of 481.4 nm and is stable for 30 days at 4 °C storage. That nanosilver has immunomodulatory activity and is proven safe from the results of acute toxicity tests at a dose of 4 mg/kgBB. However, a drug delivery system is needed to be developed as a supplement product. The syrup was chosen because it is free of alcohol, has a better taste, measured dose, and stability of the active substance compared to elixir, solution, and suspension. Simplex syrup as a syrup base affects stability because it has the potential to form crystals during storage. This research aims to determine the effect of simplex syrup concentration on the stability of nanosilver syrup. The research was conducted with the biosynthesis process using gembili's inulin, nanosilver characteristic, modified syrup formula, and stability test. Nanosilver syrup was prepared by modifying the simplex syrup concentration of 20%, 40%, and 60%. Nanosilver was added at 4 mg/KB b.w, then tested the physicochemical; stability, including organoleptic, pH, and viscosity, before and after storage with temperature variations of 4 °C and 40 °C for six cycles. The best formula then analysis of sugar reduction content and FT-IR. Data analysis using SPSS 21.0 Windows with One-way ANOVA test, Post Hoc, and Paired T-Test. The results showed that the concentration of simplex syrup affected consistency, pH, and viscosity. The simplex syrup concentration of 60% met the requirement with a medium thick consistency, pH 5.25±0.03, a viscosity of 92±2.6 cps, reducing sugar content was 20.59% ±0.002, and the FTIR profile showed that it still contained nanosilver which was indicated by the presence of Ag-N groups compared to silver nitrate solution.
Efektivitas Technode Hydrogel 0,02% Sebagai Penyembuhan Luka Post Operasi Ovariohisterectomi dan Orchhiectomi Pada Kucing Domestik (Felis silvestris Catus) Dibandingkan Iodine 10% Ul Millah, Nida; Eka Ermawati, Dian
Journal of Applied Agriculture, Health, and Technology Vol. 1 No. 1 (2022): June
Publisher : Sekolah Vokasi, Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jaht.v1i1.334

Abstract

Antibiotics have been reduced to support Anti-Microbial Resistance (AMR) campaigns worldwide due to widespread bacterial resistance to commonly used antibiotics, the emergence of new superbugs or diseases, and the impact of antibiotic waste on the environment and soil. Iodine is generally used as an alternative because it has antibacterial and antifungal potential, suitable for preventing wound infections. However, iodine can cause a serous exudative effect and quickly become inactive when mixed with serous fluids. The study aims to find alternative therapeutic preparations to replace antibiotics when treating open wounds. Experimental research in which domestic cats were divided into two groups. Group A was given 10% iodine therapy twice a day, while Group B was given Technode Hydrogel 0,02% therapy twice a day for seven days. The wound score was calculated based on three points with the following criteria: discharge, swelling, erythema, and dehiscence. The scoring system was adopted as suggested by Sylvestre. The results showed that Technode Hydrogel 0,02% had an average wound score of 0,457 compared to 10% iodine which was 0,714. Hydrogel Technode is expected to be the best alternative for wound care, both in terms of efficacy and efficiency, to help the healing process of open wounds.
The Effect of Temperature on Physicochemical Properties of Moringa Leaf Ethanolic Extract (Moringa oleifera L.) Patch and Anti-Inflamatory Test Ermawati, Dian Eka; Hidayati, Astri; Untari, Meta Kartika
Journal of Food and Pharmaceutical Sciences Vol 12, No 2 (2024): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.13527

Abstract

Moringa leaf extract contains flavonoids confirmed as anti-inflammatory at 200 mg/Kg b.w. The patch was chosen for topical anti-inflammatory preparation because it is continuous for an extended treatment period. Previous research has developed a patch formula using a polymer combination of polyvinyl alcohol (PVA) and alpha-cellulose (1: 2) that meets the requirements for good patch preparation. However, the effect of temperature resistance on physicochemical properties and anti-inflammatory activity needs to be confirmed. Moringa leaves were macerated in 96% ethanol and dispersed into a patch matrix of PVA and alpha-cellulose. Patches were treated at various storage temperatures, namely 4°C, 25°C, and 40°C each for 8 hours for six cycles. Mice were divided into three groups: blank patch, brand patch product, and moringa leaf patch. Mice were given 0.05 mL of carrageenan suspension intraplanar on the sole of the left foot, and the edema volume was measured using a plethysmometer. Statistical analysis uses One-Way ANOVA and T-test. The results showed that temperature affected the pH, thickness, and weight properties but did not affect the moisture, folding endurance, and organoleptic properties. The average edema volume of mice in the brand product group was not significantly different from the moringa leaf patch group, with a significance value of 0.066 (p > 0.05). The Moringa leaf ethanolic extract patch confirmed it can reduce the volume of mouse foot edema by 5 hours.
The Effect of Variation Concentration of Simplex Syrup on the Physicochemical Stability of Nanosilver Syrup Ermawati, Dian Eka; Hanuriansyah, Yavi; Susanto, Nindita Clourisa Amaris; Rochmani, Sholichah; Utami, Diyah Tri; Zulpadly, M. Fiqri; Sasongko, Heru; Darojati, Ulfa Afrinurfadhilah; Meitasari, Annisa Diyan; Untari, Meta Kartika
JKPK (Jurnal Kimia dan Pendidikan Kimia) Vol 9, No 2 (2024): JKPK (Jurnal Kimia dan Pendidikan Kimia)
Publisher : Program Studi Pendidikan Kimia FKIP Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jkpk.v9i2.84012

Abstract

Inulin from Gembili has been identified as an effective bioreductor for forming nanosilver with a size of 481.4 nm, stable for 30 days when stored at 4°C. Inulin nanosilver exhibits immunomodulatory properties and has been proven safe through acute toxicity evaluation at a dose of 4 mg/kgBB. A drug delivery system needs to be developed for its use as a supplement. Syrup was chosen due to its alcohol-free nature, better taste, and ease of measuring the active substance compared to elixirs, solutions, and suspensions. Simplex syrupus, used as a syrup base, influences stability by potentially forming crystals during storage. This research aims to determine how varying concentrations of simplex syrupus affect the physicochemical properties of inulin nanosilver syrup. The study involved the biosynthesis process using Gembili's inulin, nanosilver characterization, formulation, and stability testing. Inulin nanosilver syrup was prepared with simplex syrupus concentrations of 20%, 40%, and 60%. The physicochemical stability of the syrup, including organoleptic properties, pH, and viscosity, was tested before and after storage at 4°C and 40°C over six cycles. The selected formula was evaluated for sugar reduction content and FT-IR profile. Data analysis was performed using SPSS 21.0 for Windows with One-way ANOVA and Paired T-Test. Results indicated that higher concentrations of simplex syrupus led to increased consistency, pH, and viscosity. A 60% concentration of simplex syrupus met the physicochemical stability requirements, with a medium-thick consistency, pH of 5.25±0.03, and viscosity of 92±2.6 cps. The reducing sugar content was 20.59% ±0.002, and the FT-IR profile confirmed the presence of inulin nanosilver, indicated by Ag-N groups compared to silver nitrate solution. This product has the potential to be developed as a health supplement.
The Evaluation of Clove oil Concentration on Physicochemical and Antimicrobial Activity in the Laponite Gel Delivery System Ermawati, Dian Eka; Putriana, Susanti; Setyowati, Tri; Kuntari, Tabita Putri; Salsabila, Fitri; Kartikasari, M. Nur Dewi
Journal of Food and Pharmaceutical Sciences Vol 12, No 3 (2024): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.15875

Abstract

Recurrent Aphthous Stomatitis (SAR) is inflammation in the oral mucosa. One of the factors that can cause SAR is bacterial and fungal infections of the oral mucosa. Clove oil is an essential oil that contains eugenol and has antimicrobial, analgesic, anti-inflammatory, and antioxidant activities. Clove oil in this study resulted from steam distillation with an eugenol content of 71.06%. Clove oil as an antimicrobial topical requires a drug delivery system that is easy and comfortable to apply. Laponite is a synthetic hydrophilic layered silicate that can hydrate and expand when water is added, is compatible with the properties of active ingredients, and is without an emulsifier. Please state the objective of this research. This research aims to determine the effect of variations in the concentration of clove oil incorporated in laponite on the gel's physicochemical properties and antimicrobial activity. Laponite with a concentration of 2.5% was developed in water and then added to clove oil with a concentration of 2%, 4% and 6%. Physicochemical properties test of oral gel preparations includes organoleptic tests, homogeneity, pH, adhesion, and spreadability tests. Antimicrobial activity test to Streptococcus mutans bacteria and Candida albicans fungi. The research showed that a gel preparation using laponite with a concentration of 2.5% was semi-solid with a clove oil odor. Clove oil, with an eugenol content of 71.06%, has potent antimicrobial activity. The higher concentration of clove oil increases the viscosity and sticky time but decreases the pH and spreadability. The adhesive time and pH of the gel are suitable for application to the oral mucosa with mouth ulcers, and 2.5% laponite can form a gel preparation that meets the gel's physicochemical properties and antimicrobial activity.
The Evaluation of Clove oil Concentration on Physicochemical and Antimicrobial Activity in the Laponite Gel Delivery System Ermawati, Dian Eka; Putriana, Susanti; Setyowati, Tri; Kuntari, Tabita Putri; Salsabila, Fitri; Kartikasari, M. Nur Dewi
Journal of Food and Pharmaceutical Sciences Vol 12, No 3 (2024): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.15875

Abstract

Recurrent Aphthous Stomatitis (SAR) is inflammation in the oral mucosa. One of the factors that can cause SAR is bacterial and fungal infections of the oral mucosa. Clove oil is an essential oil that contains eugenol and has antimicrobial, analgesic, anti-inflammatory, and antioxidant activities. Clove oil in this study resulted from steam distillation with an eugenol content of 71.06%. Clove oil as an antimicrobial topical requires a drug delivery system that is easy and comfortable to apply. Laponite is a synthetic hydrophilic layered silicate that can hydrate and expand when water is added, is compatible with the properties of active ingredients, and is without an emulsifier. Please state the objective of this research. This research aims to determine the effect of variations in the concentration of clove oil incorporated in laponite on the gel's physicochemical properties and antimicrobial activity. Laponite with a concentration of 2.5% was developed in water and then added to clove oil with a concentration of 2%, 4% and 6%. Physicochemical properties test of oral gel preparations includes organoleptic tests, homogeneity, pH, adhesion, and spreadability tests. Antimicrobial activity test to Streptococcus mutans bacteria and Candida albicans fungi. The research showed that a gel preparation using laponite with a concentration of 2.5% was semi-solid with a clove oil odor. Clove oil, with an eugenol content of 71.06%, has potent antimicrobial activity. The higher concentration of clove oil increases the viscosity and sticky time but decreases the pH and spreadability. The adhesive time and pH of the gel are suitable for application to the oral mucosa with mouth ulcers, and 2.5% laponite can form a gel preparation that meets the gel's physicochemical properties and antimicrobial activity.
The Optimization of Porang starch-lactose as a co-processed excipient of Bajakah (Spatholobus littoralis Hassk) root dried extract's effervescent tablet Ermawati, Dian Eka; Andini, Bimar Putri; Damayanti, Avina Kusuma
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 1 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i1.46521

Abstract

Bajakah root has stronger antioxidant activity than vitamin C. The Dayak people use it to maintain health. Bajakah root infusion has an unpleasant taste and aroma, also unstable, so effervescent tablets are developed to resolve that problem. Effervescent tablets are prepared by direct compression method. The starch of porang tuber is a food that can act as fillers and tablet binders. The co-processed excipient can produce tablet fillers for the directly compressed method. Co-processed excipients of lactose-porang starch have excellent flow properties, improve tablet hardness, have good compatibility, and are cheaper. In this study, the proportions of porang starch and lactose as co-processed excipients were determined using the Simplex Lattice Design method, and then tested the flow properties and granule repose angle. The physical properties of the tablets include weight uniformity, hardness, brittleness, dissolution time, and antioxidant activity test. Test data were analyzed using the One Sample T-test. The results showed that effervescent tablets with co-processed excipient porang starch-lactose 64: 36% provide good physical stability, granule flow time of 10.45 ± 0.29 gram/second, granule repose angle of 27.52 ± 0.95°; tablet weight uniformity with a CV value of 1.021%; tablet hardness 5.74 ± 0.07 Kg, tablet friability of 0.549 ± 0.03%; tablet disintegration time 86 ± 4 seconds. The bajakah root has antioxidant activity of 0.155 mg/mL.
Hydrating serum made of potassium azeloyl diglycinate with CMC-Na variations as a gelling agent on physical-chemical and safety tests Rohmani, Sholichah; Aditya, Shafira Nur; Husna, Hanna Miftahul; Ermawati, Dian Eka; Utami, Diyah Tri
JURNAL ILMU KEFARMASIAN INDONESIA Vol 22 No 1 (2024): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v22i1.1257

Abstract

Potassium azeloyl diglycinate is an ingredient for moisturizing the skin. In this research, potassium-azeloyl-diglycinate was formulated into a gel-based hydrating serum. A good serum gel can be identified by its physicochemical properties and stability, which are determined by the composition of the ingredients used, one of which is CMC-Na, which is used as a gelling agent. The aim of this research was to test the effect of CMC-Na concentrations (1%, 1.25%, and 1.5%) on the physicochemical stability of serum and to find a formulation with the best stability by testing the water content and safety. The evaluation results show that increasing the concentration of CMC-Na has an impact on increasing viscosity, pH, and adhesion, thereby providing a different gel consistency in each formula and reducing its spreadability. The best formulation is Formula-2, which is then tested for water content on respondents. The research results show that this formula has the ability to hydrate the skin, as seen from an increase in oil content of 8.39% and an increase in water content of 8.86%. Initial acute dermal toxicity test results show that the serum is safe to use on the skin and does not cause side effects or toxicity reactions.
The Immunomodulator Effects of Biosynthetic Nanosilver Based on Immunoglobulin G Level of Mice Induced by Measles Vaccine Compared with Immunostimulant Agent Ermawati, Dian Eka; Nuraini, Putri Indah; Anjani, Niki Putri
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 21, No 2 (2024)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.005834

Abstract

Inulin is a carbohydrate class contained in gembili tuber (Dioscorea esculenta (Lour.) Burkill) as a source of prebiotics to maintain immunity. Inulin can be used as a nanosilver bioreductor and increase the solubility of gembili's inulin. This study aims to determine the effectiveness of gembili's inulin nanosilver as an immunomodulator based on IgG levels of vaccine-induced Mice. Nanosilver at doses of 2 mg/KgBW, 4 mg/KgBW, 8 mg/KgBW, and 12 mg/KgBW was compared with synthetic immunostimulants to observe the type of immunomodulatory activity. This research was conducted in several stages, including the biosynthesis process, characterization, determination of nanosilver dose, animal conditioning, animal treatments, taking blood from retro-orbital sinuses, and ELISA reader. Blood serum obtained from the animals was analyzed for IgG levels using Mice IgG ELISA Kit and Spectrophotometer UV-VIS. The pH variation test was also conducted in this study which aims to determine the stability of the nanosilver solution at pH 8, 10, and 12. The results of the ELISA reader showed that the dose of 4 mg/KgBW. had the highest Optical Density value compared to other doses. Then, the comparison with synthetic immunostimulants produces p values of 0.13 0.05, which is not significantly different. Nanosilver inulin at 4 mg/KgBW. is the chosen dose as an immunomodulator with immunostimulant activity. The stability results showed that increasing pH changes do not affect the pH change of gembili's inulin nanosilver solution. It is because nanosilver's pH control and adjustment are still in the alkaline range.
Co-Authors Adi, Lutfan Prastyo Aditya, Shafira Nur Agung P. Surya Agung Putu S.P.Kristyawan Aini S., Aini Alfia Andhika Putri Amaris Susanto, Nindita Clourisa Andini, Bimar Putri Anggraini Febriyanty Anif Nur Artanti Anif Nur Artanti Anif Nur Artanti Anif Nur Artanti, Anif Nur Anjani, Niki Putri Aprilia Saefanan Shofa Aptika Oktaviana Trisna Dewi Cahyarani Intan Ramadhani Cahyarani Intan Ramadhani Damayanti, Avina Kusuma Darojati, Ulfa Afrinurfadhilah Daswati Daswati Dita Yuli Budiasih Diyah Tri Utami Dyah Ayu Ambarwati Ediati Sasmito Esha ND., Pramitha Farida, Yeni Fea Prihapsara Fea Prihapsara Fea Prihapsara Fea Prihapsara, Fea Fridha Angelina Pamuji Galuh Kartikasari H., Muchammad Hanifah, Fitria Lidini Hanuriansyah, Yavi Hayunda I'zaaz Fajrin Heni Utami Prilantari Heru Sasongko Heru Sasongko Heru Sasongko Heru Sasongko Hidayati, Astri Husna, Hanna Miftahul Indah Purwantini Indrajati, Dyah Yekti KD, Anggi Kundarto, Wisnu Kuntari, Tabita Putri M Fiqri Zulpadly M. Fiqri Zulpadly M. Fiqri Zulphadly M. Nur Dewi Kartikasari M. Nur Dewi Kartikasari Megasari, Anis Laela Meitasari, Annisa Diyah Meitasari, Annisa Diyan Muchammad H., Muchammad mufrod mufrod Nafisa, Fadhila Dian Nailul Maghfiroh ND., Pramitha Esha Niken Rosyana Dewi Septini Nindita Clourisa Amaris Susanto Nining Sugihartini Noveri, Priscilla Novi Andriani Novi Andriani, Novi Nugraha Mas'ud Nuraini, Putri Indah Nurul Rochmawati Prastia, Echa Hana Putri, Hapsari Duanda Putriana, Susanti Putro, David Sarono Putu UA., Ni Qutratu'ain, Syahla Rahmat S, Anang Kuncoro Raka Sukmabayu W.S Ramadhani, Cahyarani Intan Rochmani, Sholichah Rohmani, Sholicha S., Aini Saifullah Sulaiman Salsabila, Fitri Samrotul Jannah Setyowati, Tri Sholichah Rohmani Sholichah Rohmani Sholichah Rohmani Sholichah Rohmani Sholichah Rohmani, Sholichah siti nurkhasanah Susanto, Nindita Clourisa Amaris Sutarno Sutarno Suwaldi Martodiharjo T.N Saifullah Sulaiman Tambunan, Rido Rohana UA., Ni Putu Ul Millah, Nida untari, meta kartika Utami, Diyah Tri Villian Septiana Waliyyin Razan Qanit Wisnu Kundarto Wisnu Kundarto Wisnu Kundarto Wisnu Kundarto Wulandari, Wening Yeni Farida Zulpadly, M. Fiqri Zulpadly, M.Fiqri Zulpadly, Muhammad Fiqri Zulphadly, M.Fiqri