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PENGARUH CURCUMA ZEDOARIA TERHADAP GAMBARAN HISTOPATOLOGI HEPAR TIKUS WISTAR DIABETIK Putri, Nabila dwi; Lina, Juliana; Wardhani, Fiska Maya; Hyachinta, Izdihar Putri; Hasibuan, Selly Rahmadiah
Jurnal Kesehatan Tambusai Vol. 5 No. 3 (2024): SEPTEMBER 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v5i3.32848

Abstract

Diabetes melitus merupakan penyakit yang menyerang banyak orang di seluruh dunia dan memerlukan pengobatan jangka panjang, bahkan seumur hidup, sehingga menimbulkan biaya pengobatan yang tinggi dan efek samping jangka panjang dari obat antidiabetes. Banyak orang yang memanfaatkan kunyit putih sebagai obat alternatif yang dinilai memiliki efek antidiabetes dan efek samping yang minim. Tujuan penelitian ini adalah untuk mengetahui pengaruh ekstrak kunyit putih terhadap kadar gula darah dan gambaran histopatologi hati. Penelitian ini merupakan penelitian eksperimental dengan metode the post only group design yang melibatkan 30 ekor Rattus norvegicus jantan meliputi berat badan 180-220 gram dan berusia 6-8 minggu. Tikus putih dibagi menjadi kelompok normal, kelompok negatif, dan kelompok perlakuan dengan dosis 250 mg/KgBB, 500 mg/KgBB, 750 mg/KgBB. Hasil yang diperoleh menunjukkan bahwa ekstrak kunyit putih (Curcuma zedoaria) dengan dosis 250 mg/KgBB , 500 mg/KgBB dan 750 mg/KgBB dapat menurunkan kadar gula darah tetapi pada gambaran histopatologi hati dengan dosis 250 mg/KgBB menunjukkan adanya degenerasi, ini dikarenakan sampel sudah memiliki riwayat penyakit dan efek pemberian aloksan. Namun pada dosis 500 mg/KgBB dan 750 mg/KgBB menunjukkan perbaikan sel yaitu berkurangnya degenerasi. Hal ini menunjukkan bahwa ekstrak kunyit putih tidak hanya mampu menurunkan kadar gula darah tetapi juga memperbaiki sel-sel yang rusak akibat dari diabetes.
The Effect of Physiotherapy on Pain Intensity in Patients with Low Back Pain (LBP) in Adults at Kabanjahe Hospital in 2025 Barus, Deo Jordy; Nasution, Masdalena; Lina, Juliana
Eduvest - Journal of Universal Studies Vol. 5 No. 10 (2025): Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v5i10.52298

Abstract

Low Back Pain (LBP) is one of the musculoskeletal disorders commonly experienced by adults due to unergonomic posture, excessive activity, and degenerative processes. This condition causes pain in the lower back which can hinder daily activities and reduce the quality of life. This study aims to determine the effect of physiotherapy on pain intensity in LBP patients at Kabanjahe General Hospital in 2025. The research method used was descriptive analytics with a cross-sectional design. The sample amounted to 100 adult respondents who were selected using purposive sampling techniques. Data was collected through questionnaires and Visual Analogue Scale (VAS) measurements, then analyzed using the Chi-Square test. The results showed a significant difference between pain intensity before and after physiotherapy (p = 0.001). There was a decrease in the proportion of severe pain from 30% to 10% and an increase in mild pain from 20% to 60% after physiotherapy. Of the three modalities used—InfraRed (IR), Transcutaneous Electrical Nerve Stimulation (TENS), and William Flexion Exercise—TENS provided the most effective results in reducing pain (75%), followed by IR (70%) and William Flexion Exercise (65%). Risk factors such as old age, long working hours, high body mass index, and poor posture also affect pain levels. In conclusion, physiotherapy has been shown to be effective in reducing pain intensity in LBP sufferers, particularly through a combination of electrotherapy modalities and regular physical exercise.
Pengaruh faktor risiko pekerja pemanen kelapa sawit terhadap terjadinya keluhan musculoskeletal disorders (MSDS) di PT. Perkebunan Nusantara IV unit Kebun Meranti Paham -, Hartono; Simatupang, Mega Riama Sawitri Br; Lina, Juliana; Bukit, Rosmeri br; Muharraran, Firdha
Jurnal Kesmas Prima Indonesia Vol. 7 No. 2 (2023): Edisi Juli
Publisher : Program Studi Sarjana Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jkpi.v7i2.4161

Abstract

Musculoskeletal Disorders (MSDs) are the most common occupational diseases that occur in the working population. The purpose of this study was to determine the effect of risk factors between age, workload, smoking habits and years of service of oil palm harvesters on the occurrence of musculoskeletal disorders. This study used an analytical survey method using a cross sectional design. The research sample is the entire population studied, namely 50 respondents at PT. Perkebunan Nusantara IV Meranti Paham Plantation Unit. The sampling technique used in this study is a total sampling technique where the number of samples is the same as the population. Data was collected using a Nordic Body Map (NBM) questionnaire. The analysis used was univariate, bivariate (Chi-square test) and multivariate analysis. The results of the bivariate analysis showed that there was a strong relationship between age and complaints of musculoskeletal disorders and the results also showed that there was a strong relationship between years of service and complaints of musculoskeletal disorders. The results of the multivariate analysis of the most dominant variable affecting musculoskeletal complaints were years of service after controlling for the age variable. So it was concluded that there was an influence between age and tenure with complaints of musculoskeletal disorders in oil palm harvesters. The most dominant factor for musculoskeletal complaints is years of service.
Hubungan Tingkat Penyesuaian Diri Terhadap Tuntutan Akademik Dengan Derajat Stress Pada Mahasiswa Baru Fakultas Kedokteran Universitas Prima Indonesia Aryana Angkat, Nazwa Nola; Lister, Clarissa; Lina, Juliana
Jurnal Impresi Indonesia Vol. 4 No. 11 (2025): Jurnal Impresi Indonesia
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/jii.v4i11.7137

Abstract

Stres akademik pada mahasiswa baru, khususnya di fakultas kedokteran, muncul akibat tekanan tuntutan belajar yang tinggi, materi kompleks, ujian intensif, dan persaingan ketat, yang berdampak pada kesehatan fisik, emosi, dan perilaku mahasiswa. Kondisi tersebut diduga karena mahasiswa kurang dapat menyesuaikan diri terhadap tuntutan akademik. Penelitian ini bertujuan menganalisis hubungan tingkat penyesuaian diri terhadap tuntutan akademik dengan derajat stress mahasiswa baru fakultas kedokteran. Penelitian ini menggunakan desain yaitu studi korelasi potong lintang (cross-sectional). Penelitian dilakukan di lingkungan kampus Fakultas Kedokteran Universitas Prima Indonesia. Populasi penelitian sebanyak 174 orang, dan sampel diperoleh 64 orang. Penarikan sampel secara purposif (purposive sampling). Analisis data dilakukan secara univariat dan bivariat menggunakan uji Rank Spearman Rho pada tingkat kepercayaan 95% (?=0,05). Hasil penelitian menunjukkan bahwa sebagian besar mahasiswa baru di Fakultas Kedokteran Universitas Prima Indonesia memiliki tingkat penyesuaian diri terhadap tuntutan akademik dalam kategori sedang (76,6%) dan mengalami stres pada derajat sedang (57,8%). Terdapat hubungan yang signifikan antara penyesuaian diri dengan tingkat stres mahasiswa baru, p = 0,003 dan koefisien korelasi -0,360, yang menunjukkan hubungan negatif dengan keeratan rendah. Ini berarti seiring dengan meningkatnya tingkat penyesuaian diri, derajat stres cenderung menurun, meskipun korelasinya tidak kuat. Korelasi tidak kuat karena disebabkan faktor-faktor lain di luar penyesuaian akademik juga berperan dalam memengaruhi tingkat stres mahasiswa. Peneliti selanjutnya disarankan mengeksplorasi faktor lain memengaruhi stres mahasiswa baru, seperti dukungan sosial yang kurang, motivasi belajar rendah, mekanisme koping rendah, beban studi tinggi, gaya kepemimpinan dosen, serta faktor kepribadian, dengan pendekatan kualitatif atau mixed methods untuk pemahaman yang lebih komprehensif.
Profil Klinis Tonsilitis Pada Anak di Rumah Sakit Royal Prima Tahun 2023-2025 Praysela, Praysela; Lister, Clarissa; Lina, Juliana
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v10i11.62412

Abstract

Tonsillitis is one of the most common ENT disorders in children and may affect growth and overall quality of life. This study aimed to describe the clinical profile of pediatric tonsillitis patients at Royal Prima Hospital during 2023–2025. A retrospective descriptive observational design was used, involving 60 medical records that met the inclusion criteria. The results showed that the highest proportion of patients was aged 13–18 years (63.3%), with males being slightly more dominant (51.7%). Most patients had a normal nutritional status (70%), and the most frequent chief complaint was painful swallowing (58.3%). Physical examination revealed tonsillar enlargement predominantly at grade T3-T3 (55%). Chronic tonsillitis was more prevalent (66.7%) than acute tonsillitis (33.3%). Operative treatment was more commonly performed (55%) compared to medical therapy (45%). In conclusion, chronic tonsillitis remains a significant health issue in children, emphasizing the need for appropriate management to prevent complications and improve patient well-being.
Effect of Pakkat Ethanol Extract (Calamus L. Blum) on Spermatogenesis and Testosterone Levels of Diabetes Mellitus Wistar Rats Lubis, Yolanda Eliza Putri; Aipin, Anggi Sri Ananda; Hanjaya; Lina, Juliana; Suhartomi
Jurnal Penelitian Pendidikan IPA Vol 11 No 12 (2025): December
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i12.13495

Abstract

Diabetes mellitus is a metabolic disorder marked by high blood glucose levels (hyperglycemia) that is caused by insulin deficiency. It also affects male infertility. Pakkat, young rattan, contains various phytochemicals, which can affect blood glucose levels, spermatogenesis, and testosterone production. Objective: To assess the effectiveness of Pakkat extract in regulating blood glucose levels, testosterone hormone, and spermatogenesis in alloxan-induced diabetic rats. This experimental study used 25 diabetic male Wistar rats and was grouped into five groups including negative control (distilled water), positive control (metformin), Treatment 1 (125 mg/KgBW Pakkat extract), 2 (250 mg/KgBW Pakkat extract), and 3 (500 mg/KgBW Pakkat extract) for 14 days. All data were analyzed by One-way ANOVA followed by a Post-Hoc Test. Pakkat extract at 125 mg/kgBW dose effectively reduced glucose levels (P-Value < 0.001) after 14 days. It also significantly increased spermatogenesis (P-Value < 0.001) and testosterone levels (P-Value < 0.001) in alloxan-induced diabetic rats. Thus, it can be concluded that any doses of Pakkat (Calamus L. Blume) extract significantly improve blood glucose levels after 14 days of administration. However, a higher dosage is required to increase spermatogenesis and testosterone hormone in diabetic conditions.
Hubungan Konsumsi Ultraprocessed Food Terhadap Emotional Intelligence Fritz, Regina; Lister, Clarissa; Lina, Juliana
Jurnal Pendidikan Indonesia Vol. 6 No. 12 (2025): Jurnal Pendidikan Indonesia
Publisher : Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/japendi.v6i12.8971

Abstract

Konsumsi ultraprocessed food (UPF) telah meningkat signifikan dalam beberapa dekade terakhir dan dikaitkan dengan berbagai dampak kesehatan. Penelitian ini bertujuan untuk menganalisis hubungan antara konsumsi UPF dengan emotional intelligence (EI) pada mahasiswa. Penelitian menggunakan desain cross-sectional analitik dengan sampel 156 mahasiswa yang dipilih melalui purposive sampling. Data konsumsi UPF dikumpulkan menggunakan Food Frequency Questionnaire (FFQ), sementara EI diukur menggunakan Trait Emotional Intelligence Questionnaire Short Form (TEIQue-SF). Analisis data menggunakan uji korelasi Spearman untuk menguji hubungan antara kedua variabel. Hasil penelitian menunjukkan bahwa mayoritas responden (65,4%) memiliki konsumsi UPF tinggi, dengan 54,5% responden memiliki tingkat EI sedang. Analisis korelasi Spearman menunjukkan adanya hubungan negatif yang signifikan antara konsumsi UPF dengan EI, dengan koefisien korelasi r=-0,402 dan nilai p<0,001, yang mengindikasikan bahwa semakin tinggi konsumsi UPF, maka semakin rendah tingkat EI. Mekanisme yang mendasari hubungan ini melibatkan dampak negatif UPF terhadap fungsi kognitif, regulasi emosi, dan kesehatan mental melalui jalur inflamasi, perubahan mikrobiota usus, dan gangguan neurotransmitter. Penelitian ini menyimpulkan bahwa terdapat hubungan negatif yang signifikan antara konsumsi UPF dengan EI pada mahasiswa. Temuan ini menekankan pentingnya edukasi gizi dan promosi pola makan sehat untuk meningkatkan kualitas kesehatan mental dan kemampuan regulasi emosi generasi muda. Temuan ini memiliki implikasi penting bagi pengembangan intervensi kesehatan berbasis nutrisi di kalangan mahasiswa. Program edukasi gizi dan promosi pola makan sehat perlu diintegrasikan dalam kebijakan kampus untuk meningkatkan kualitas kesehatan mental dan kemampuan regulasi emosi generasi muda, termasuk melalui penyediaan pilihan makanan sehat di kantin kampus dan kampanye kesadaran akan dampak jangka panjang konsumsi UPF.
Antidiabetic potential of andaliman: Histopathological and glycemic improvements in diabetic rats Simbolon, Boyke Marthin; Lina, Juliana; Saragih, Ayu Theresia
Buletin Kedokteran & Kesehatan Prima Vol. 5 No. 1 (2026): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v5i1.7891

Abstract

Background: Diabetes mellitus (DM) is a metabolic disorder characterized by chronic hyperglycemia and pancreatic dysfunction, particularly involving the Islets of Langerhans. Andaliman (Zanthoxylum acanthopodium) is a plant rich in flavonoids and antioxidants, which are believed to have antidiabetic effects. This study aimed to evaluate the effectiveness of the ethanol extract of Andaliman fruit on pancreatic histopathology in alloxan-induced diabetic rats. Methods: This study employed a true experimental design with a pre-test and post-test control group structure. Twenty-four male Wistar rats were randomly assigned to six groups: a normal control, a positive control (metformin 9 mg/kg), a diabetic control (alloxan 90 mg/kg), and three treatment groups induced with alloxan followed by administration of Andaliman extract at doses of 150, 250, and 350 mg/kg body weight, respectively. Treatments were administered for 14 days, after which blood glucose analysis (pre- and post-treatment) and pancreatic histopathological assessments were performed. Results: Statistical analysis revealed a significant reduction in blood glucose levels following treatment (p = 0.001). Histopathological examination showed that Andaliman extract ameliorated alloxan-induced damage to the Islets of Langerhans. The 350 mg/kg body weight dose resulted in the most pronounced tissue regeneration compared to the other treatment groups. Conclusion: The ethanol extract of Andaliman fruit effectively improves pancreatic histopathology and lowers blood glucose levels in diabetic rats.
Co-Authors Adek Amansyah Aipin, Anggi Sri Ananda Amanda, Carissa Anggraini, Sari Aryana Angkat, Nazwa Nola Ayub, Edwar Barus, Deo Jordy Br Manihuruk, Deselomita Hagarma Br Sembiring, Emelia Putri Bukit, Rosmeri Br Dewi, Tani Sindy Safira Dhillon, Siena Sanjana Dwi Putri, Nabila Edlin, Edlin Edy Fachrial Elmiam, Dwi Fadillah, Qori Fernando Fernando, Fernando Fibrini, Dewi Fiska Maya Wardhani Fitriani, Anche Pratiwi Fritz, Regina Hanjaya Harmileni Hartono Hasibuan, Ahmad Hasanuddin Hasibuan, Selly Rahmadiah Hutapea, Jhonson Hutapea, Risma Ronauli Hyachinta, Izdihar Putri irza Haicha Pratama Iskandar, Ari Rahman Ivonne, Ivonne Johnson Hutapea lister , Clarissa Lister, Clarissa Loren, Jeff Masdalena, Masdalena Muchtar, Muhammad Arafat Muharraran, Firdha Mukti, Ade Indra Mutia, Maya Sari Nadapdap, Marshall Jeremia Nasution, Masdalena Nasution, Prenan Dito Perdana Nasution, Tamimi Badzlina Nazara, Novita Mirna Sari Novita, Cut Elvira Pasaribu, Rigal Arizki Praysela, Praysela Purwoko, Heri Putri Hyachinta, Izdihar Putri, Nabila Dwi Rahmadiah Hasibuan, Selly Reh Malem br Karo Rosari, Carolina Yosita Cahya Saragih, Ayu Theresia Simatupang, Mega Riama Sawitri Br Simbolon, Boyke Marthin Sintya, Inda Dhea Sipayung, Yelvreza Rastiani Sitorus, Teresya Nova Stefenie, Stefenie Suhartomi Surbakti, Betharia Lorenza Br Theresia, Yohani Thirza, Repi Ivena Tiswan, Jiad Hanan Wardhani, Fiska Maya Widya Yanti Sihotang Wijaya, Johana Fransiska Yolanda Eliza Putri Lubis Yumardika, Deza Yunata, Kianie Engaline Zahira, Niza Zaluchu, Sarah Oculi