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Journal : Duta Pharma Journal

AKTIVITAS ANTIHIPERGLIKEMI DAN REGENERASI SEL β PANKREAS DARI FRAKSI ETIL ASETAT DAUN KERSEN (Muntingia calabura) PADA TIKUS YANG DIINDUKSI STREPTOZOTOSIN PRATAMA, KHARISMA; Wicahyo , Septian Maulid; Hidayat, Rahmad
Duta Pharma Journal Vol. 4 No. 1 (2024): DUTA PHARMA JOURNAL
Publisher : Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47701/djp.v4i1.3818

Abstract

Normal blood glucose levels and antioxidant activity are the keys to preventing Diabetes Mellitus and its complications. Some herbal plants have this activity. Cherry leaves (Muntingia calabura) are plants around us that have empirical uses, one of which is lowering blood glucose. The aim of the research was to determine the activity of the ethyl acetate fraction of cherry leaves in reducing blood glucose and improving pancreatic beta cells. Forty-two 8-week-old male Wistar rats weighing 180-200 g were induced with diabetes using streptozotocin and divided randomly. Group I was normal control, group II was negative control, control III was positive control using glibenclamide, groups IV and V tested ethyl acetate fractions 250 and 350 mg/kg BW. Treatment is carried out orally once a day for 18 days. Glucose levels were measured on days 1, 4, 11 and 18. The results showed that the extract and fractions could reduce blood glucose levels with the 350 mg/kg BW ethyl acetate fraction reducing the highest (not significantly different from the positive control) and both could increase the activity of the SOD, GPx enzymes and reduce MDA levels and improve pancreatic Langerhans islets. In conclusion, cherry leaf extract and fractions have antihyperglycemic activity and pancreatic islet regeneration.
Co-Authors Almumtahanah, Almumtahanah Amelia, Lince Amelyadi, Amelyadi Amrullah, Syahid Ananda Maulidia Ananda Putri, Efrina Annisa Rahmawati Ari Saputra, Ari Astuti Purnamawati, Ditha Bhakti, Wida Kuswida Bramadi Arya Cau Kim Jiu Cau Kim Jiu Cau Kim Jiu Cau Kim Jiu Cau Kim Jiu Cau Kim Jiu Cau Kim Jiu Cau Kim Jiu Cau Kim Jiu Ditha Astuti Ditha Astuti Purnamawati Dwi Ariani, Desti Dyah Aryani Perwitasari Emaus Zulkarnain, Albert Fathul Khair Fitriagustiani, Fitriagustiani Gmeliana Adha Sari Gusmiah, Tisa Gusti Jhoni Putra Gusti Jhoni Putra, Gusti Jhoni Haafizah Dania Hadian Pat Usmayanti Hanafi Hanafi Hardyanti, Meri Hartono Hartono Hartono Hartono Hartono Hartono Hartono Hartono Hartono Hartono Hartono Hartono Hartono tono Haryanto Haryanto Haryanto Haryanto Hasria Alang Imron Prasojo, Dudy Indri Erwhani Indri Erwhani Indri Erwhani Indri Erwhani Irwana, Irwana Jagad, Nur Jati Jaka Pradika Jaka pradika Kardiatun, Tutur Karimatunnisa, Evisa Kawuryan, Uji Khair, Fathul Khairillah, Yuyun Nisaul Khoirillah, Fanni Kurniawati, Riska Lalu Muhammad Irham Latipah Lestari Makmuriana Lukita, Yenni Maliza, Rita Mardiyani, Ridha Maria Ulfa Maulidia, Ananda Mimiyati Miranti Miranti Nichapatr Phuttikhamin Nita Zulfia Nur Safitri, Anita Nuril Lutvi Azizah Pameria, Anita Paramitha, Nurul Parliani Parliani Pasmawati, Pasmawati Paudilah Phuttikhamin, Nichapatr Pitri Pitri Pitri, Pitri Pradika, Jaka Pratama, Sandi Fransisco Puspita, Dinarwulan Rahayu Setianingsih Rahmad Kurniawan Ramadhan, Rizki Akbar Ramadhaniyati, Ramadhaniyati Ramanda, Galih Dwiki Ranita, Adia Ridlo Ronas, Mahin Satria Dewi, Hellen Siswanto, Muhammad Ikhwan Sri Arianti Sri Ariyanti Sukarni Sukartina Supriono Suriadi Jais SURTIKANTI SURTIKANTI Sutrisno, Sutrisno Syahid Amrullah Syahid Amrullah Syahid Syahid, Syahid Amrullah Tisa Gusmiah Tri Andari tri wahyuni Tri Wahyuni Tri Wahyuni Usman Usman Usman Usman Usman Usman Usman Usman Usman Usman Usman Usman Usmayanti, Hadian Pat Uti Rusdian Hidayat Wahyudi, Ardi Wicahyo , Septian Maulid Wuriani Wuriani Wuriani Wuriani Wuriani Wuriani Wuriani Wuriani Wuriani Wuriani Wuriani Wuriani Wuriani Wuriani Wuriani Wuriani Wuriani Wuriani, Wuriani Yenni Lukita Yuli Hidayati Zakiah Zakiah Zakiah Zakiah