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All Journal International Journal of Public Health Science (IJPHS) Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Kedokteran Brawijaya Pharmaciana: Jurnal Kefarmasian Jurnal Kesehatan Masyarakat Indonesian Journal of Tropical and Infectious Disease JURNAL KESEHATAN LINGKUNGAN (Journal of Environmental Health) Berkala Kedokteran Medical Laboratory Technology Journal Molecular and Cellular Biomedical Sciences (MCBS) Journal Of Vocational Health Studies Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Jurnal Kreativitas PKM WICAKSANA: Jurnal Lingkungan dan Pembangunan Biomolecular and Health Science Journal JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Jurnal Kedokteran: Media Informasi Ilmu Kedokteran dan Kesehatan Jurnal Layanan Masyarakat (Journal of Public Service) Indian Journal of Forensic Medicine & Toxicology Hang Tuah Medical Journal Folia Medica Indonesiana
Heny Arwati
DEPARTMENT OF MEDICAL PARASITOLOGY, FACULTY OF MEDICINE, UNIVERSITAS AIRLANGGA
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Journal : Medical Laboratory Technology Journal

 1 
Pengaruh Ekstrak Kelakai (Stenochlaena palustris (Burm.f) Bedd) terhadap Kadar Interleukin-10 (IL-10) Mencit Denny Margono; Eko Suhartono; Heny Arwati
Medical Laboratory Technology Journal Vol. 2 No. 1 (2016): June
Publisher : Poltekkes Kemenkes Banjarmasin Jurusan Analis Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (725.006 KB) | DOI: 10.31964/mltj.v2i1.43

Abstract

Abstract : Interleukin-10 as pro-inflammatory cytokines have a role to protect the damage of severe malaria. Kelakai contain bioactive compounds that have anti-inflammatory activity. The purpose of this study was to determine the potential of the extract kelakai on levels of IL-10 in mice BALB / s infected by P. berghei ANKA. This study is true experimental studies with posttest-only with Control Group Design. The treatment group was divided into 8 groups. Two groups received kelakai extract per oral 10 mg/kgBW and 100 mg/kgBW. Four groups received kelakai extract per oral 10 mg/kgBW and 100 mg/kgBW 3 hours after infection and when the parasitaemia reaches 15-20%. Negative controls do not receive the extract kelakai and parasitic infections. Positive controls get a parasitic infection. Treatment was given for 4 days. Blood samples were taken 24 hours after the last treatment. Levels of IL-10 were measured by sandwich ELISA method. Data were analyzed with Games Howell test, with a confidence level of 95%. There were no significant differences between treatment groups. Extract kelakai Giving oral dose of 10 mg/KgBW and 100 mg/KgBW not significantly increase the levels of interleukin-10. Keywords: Stenochlaena palustris (Burm.f) bedd; Interleukin-10 Abstrak : Interleukin-10 sebagai Sitokin pro-inflamasi memiliki peran melindungi kerusakan pada malaria berat. Kelakai mengandung senyawa bioaktif yang mempunyai aktifitas anti-inflamasi. Tujuan penelitian ini adalah untuk mengetahui potensi ekstrak kelakai terhadap kadar IL-10 pada mencit BALB/s yang diinfeksi P. berghei ANKA. Penelitian ini merupakan studi eksperimental murni dengan Posttest-only with Control Group Design. Kelompok perlakuan dibagi menjadi 8 kelompok. Dua kelompok mendapat ekstrak kelakai per oral 10 mg/kg berat badan dan 100 mg/kg berat badan. Empat kelompok mendapat ekstrak kelakai per oral 10 mg/kg berat badan dan 100 mg/kg berat badan 3 jam setelah infeksi dan pada saat parasitemia mencapai 15-20%. Kontrol negatif tidak mendapat ekstrak kelakai dan infeksi parasit. Kontrol positif mendapat infeksi parasit. Perlakuan diberikan selama 4 hari. Sampel darah diambil 24 jam setelah perlakuan terakhir. Kadar Il-10 diukur dengan ELISA metode sandwich. Data dianalisa dengan tes Games Howell, dengan tingkat kepercayaan 95%. Tidak didapatkan perbedaan bermakna antar kelompok perlakuan. Pemberian Ekstrak kelakai secara oral dosis 10 mg/Kg berat badan dan 100 mg/Kg berat badan tidak signifikan meningkatkan kadar Interleukin-10. Kata-kata Kunci : Stenochlaena palustris (Burm.f) Bedd; Interleukin-10
Correlation of Parasitaemia and Anemia in Mice Infected with Plasmodium berghei ANKA Inas Hasna Azizah; Stevani Florentia Bahi; Heny Arwati; Mufassirin Mufassirin
Medical Laboratory Technology Journal Vol. 9 No. 1 (2023): June
Publisher : Poltekkes Kemenkes Banjarmasin Jurusan Analis Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31964/mltj.v8i2.494

Abstract

Malaria is an infectious disease caused by protozoa of the genus Plasmodium and transmitted through the bite of a female Anopheles mosquito. Plasmodium berghei ANKA is a species of rodent malaria parasite that is commonly used to study malaria pathology and the immune system against infections. Parasitaemia in malaria is the figure of malaria pathology due to some numbers of parasite-infected erythrocytes present in the peripheral blood. Hemoglobin (HGB) and hematocrit (HCT) levels are the parameters of anemia and some hematological changes caused by malaria infection. This study aimed to determine the correlation between parasitemia and anemia in BABL/c mice infected with Plasmodium berghei ANKA. Two uninfected and infected mice groups were compared for parasitemia, HGB, and HCT levels. Analysis statistics showed a significant difference in HGB and HCT between uninfected and infected groups. Pearson correlation analysis showed no significant correlation between parasitemia and HGB and HCT levels in infected mice. Anemia in mice infected with Plasmodium berghei ANKA can occur when parasitemia is even low; the higher parasitemia worsens the hamatological condition. Parasitemia plays a role independently in the severity of anemia. Plasmodium berghei infection in mice is useful for studying malaria anemia.
Co-Authors Alpha Fardah Athiyyah Amadeus Michel Goein Anak Agung Istri Sri Wiadnyani Apsari, Putu Indah Budi Apsari, Putu Indah Budi Aryati Aryati atika Awwaliyah Azmi Izzati Bagus Dwi Nugraha Budi Utomo Budi Utomo Cyuzuzo Callixte Cyuzuzo Callixte Cyuzuzo Callixte Cyuzuzo, Callixte Denny Margono Denny P.N.H. Margono Denny P.N.H. Margono, Denny P.N.H. Dewi Hariyani Dinda Eka Putri Dusabimana Jean Damascene Dwi Susanti Dyah Ayu Febiyanti Eko Suhartono Fathmawati Fathmawati Florentina Sustini Frista Amalia Fuzianingsih, Eka Noviya Gabriel Zean Gunawan, Inggil Mukti Hartono Kahar, Hartono Hebert Adrianto Hidayat, Poppy Inas Hasna Azizah Indah S Tantular Indah Setyawati Tantular, Indah Setyawati INDAH TANTULAR Irene, Tuyishimire Jelita Aprisano Putri Jelita Aprisano Putri Juniastuti Juniastuti Kartika Arum Wardani KARTIKASARI, DWI PENI Khairul Bariyah, Khairul Kholida Nur Aini Kris Cahyo Mulyatno, Kris Cahyo Kusmartisnawati Kusmartisnawati Kusmartisnawati Kusmartisnawati, Kusmartisnawati Laily Nur Azizah Lelyana Sih Afgriyuspita Linda Dewanti Lindarto, Wira Widjaya Lucia Tri Suwanti, Lucia Tri M. Yasin Fitri Nugroho Majematang Mading Mardliyana Shalihah Marselaonety La’lang Meliance Bria Moses Tende Stephens Mufassirin Mufassirin Muhammad Kazwaini Muhammad Zulkifly Tasman Nabilla Feirizky Chairunnisa Nabilla Feirizky Chairunnisa Nathania Disa Ariesta Andriani Navisa, Claudia Clary Ni Wayan Winianti Nindya Tresiana Putri Nsanzimana Jean Baptiste Nurdianto, Arif Rahman Nurina Hasanatuludhhiyah Poppy Hidayat Priangga Adi Wiratama Puspa Wardhani Puspa Wardhani Puspa Wardhani Putri Rahayu putu indah budi apsari R. Heru Prasetyo Rahmatullah, Ivan Raudatul Jannah Rosalia Friska Ananda Rossyanti, Lynda Selviana Selviana Shoukat, Shahzad Sillehu, Sahrir Siti Munawaroh SRI HIDAJATI Sri Subekti Sriwijayanti Sulistyawati Stevani Florentia Bahi Subagyo Yotopranoto Subagyo Yotopranoto Subagyo Yotopranoto SUBAGYO YOTOPRANOTO Sudjajadi Keman Suhintam Pusarawati Sukmawati Basuki Suprapto Maat Supriyanto Supriyanto SUSANTI, DWI Syafarinah Nur Hidayah Akil Tantular, Indah Tanzilia, May Fanny Thomas Tandi Manu Willy Sandhika Windya Tri Hapsari Wiwied Ekasari Yetti Hernaningsih Yoes Prijatna Dachlan Yuniawan, Farah Shabrina Amazida Yuwono Marta Dinata