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In Silico and In Vitro Study Selaginella doederleinii Herb Extract as An Antineoplastic on MCF-7 Cells and Formulation Development of Nano Effervescent Granule Anggraini, Chaessy Yori; Kusumaningtyas, Triana Arum; Juniananda, Melisa; Ningrum, Dhecella Winy Cintya; Febriansah, Rifki; Hermawansyah, Adi
Indonesian Journal of Cancer Chemoprevention Vol 14, No 2 (2023)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev14iss2pp128-138

Abstract

Breast cancer, the leading cause of cancer-related deaths in women with 685,000 deaths in 2020. Exploring natural compounds with minimal side effects has emerged as a potential treatment. However, utilizing natural substances faces challenges, such as poor bioavailability, requiring technologies like nanotechnology to enhance absorption. This study focuses on evaluating Ethanol Extract of Selaginella doederleinii (EESD) as an anticancer against MCF-7, both in silico, in vitro methode and develop a formulation of EESD nanoparticle effervescent granules. This study commenced with extraction, Gas Chromatography-Mass Spectrometry (GC-MS) identification, in silico studies, namely bioinformatics and molecular docking, 3-(4,-5-dimethylthiazo-2-yl)-2,5-diphenyltetrazolium bromide (MTT) Assay tests on MCF-7, and the formulation of nanoparticle preparations. EESD was extracted using the maceration method, resulting in an extract weighing 103.5 grams with a 6.9% yield. GC-MS identified three major compounds—cyclopentadecanoic, 2-hydroxy; hexadecanoic acid; and 9-octadecanoid, methyl ester. Bioinformatics revealed interactions with specific protein targets, and molecular docking indicated hexadecanoic acid's superior binding to TP53, surpassing paclitaxel at -8.7 kcal/mol. This suggests its potential to modulate TP53, impacting P53's role in impeding cancer cell growth. EESD exhibited an IC50 of 215μg/mL, signifying moderate cytotoxicity. In formulating nanoparticle effervescent granules, five formulas were transformed into nanoparticles and underwent organoleptic, pH, granule dissolution, and water content evaluations. Formula I is the formula that best meets the criteria with a pH of 6.55, granule dissolution <5 minutes, and water content <4%. The research results indicate that EESD shows anticancer activity against MCF-7 and this study has successfully developed a formula of nanoparticle from EESD in effervescent granule form.Keywords: Selaginella doederleinii, breast cancer, co-Cemotheraphy, MCF-7 Cell, in silico.
SOCIALIZATION OF ENTREPRENEURSHIP THE REGARDING OF SELLING PRICES IN THE OFFERING MSME PRODUCT TO VOCATIONAL HIGH SCHOOL STUDENTS Hermawansyah, Adi; Cipto, Rahajeng Cahyaning Putri; Artikasari, Devi; Triana, Alvina Alda; Sasih Kirani, Amanda Retno; Bunga, Ardiyanto Fernando; Darmawan, Darmawan; Zuhra, Faza Muraya; Ferdinand, Gregorius Ergi; Ardiana, Ira Maya; Sari, Junita Dewi Indah; Akmal, Muhammad Firja
Abdi Dosen : Jurnal Pengabdian Pada Masyarakat Vol. 8 No. 1 (2024): MARET
Publisher : LPPM Univ. Ibn Khaldun Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32832/abdidos.v8i1.2277

Abstract

Micro, Small and Medium Enterprises (MSME) is an important part of the economy of a country or region, especially in Indonesia. The development of micro, small and medium enterprises has an important meaning in encouraging national economic growth and reducing is poverty. The development of MSME sector is often described as one of the factor for successful development, especially for those with low per capita income. One of the key factors in the success of MSME is their ability to determine the right product selling price. The right selling price can help MSME achieve several goals, such as: Increasing sales, achieving profit targets, competing in the market, attracting consumers and increasin profitability. Determining the selling price of MSME products is a complex process and requires careful consideration and marketing strategies to maximize prices and promotion for the product sales.
MICRO, SMALL, AND MEDIUM ENTERPRISES (MSME) CART-MAKING Hermawansyah, Adi; Norhidayah, Siti; Zamzam, Muhammad; Jelina, Sherly; Saputri, Maulidya Fathimah; Prastistha, Erica Agni; Amelia, Riska; Rifka, Rosmida; Ferry, Christian; Malik, Syahrul; Imelba, Wianda Faza; Chuarajab Ms., Tawakkal
Abdi Dosen : Jurnal Pengabdian Pada Masyarakat Vol. 8 No. 1 (2024): MARET
Publisher : LPPM Univ. Ibn Khaldun Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32832/abdidos.v8i1.2284

Abstract

The development of micro, small and medium enterprises (MSME) play a vital role in improving the local economy and expanding economic opportunities for the community. One effective strategy in supporting the growth of MSME is through creating business carts that can function as a mobile platform for selling products or services. This research aims to examine the process of making MSME carts with a focus on design innovation, materials used, and efficient and environmentally friendly production methods. Research methods involve literature analysis, field surveys, and interviews with relevant stakeholders. The research results show that the use of appropriate technology and materials can increase the durability, safety and aesthetics of MSME carts, while the use of efficient production methods can reduce production costs and speed up processing time. The practical implications of this research are to provide practical guidance for MSME in choosing designs, materials and production methods that suit their needs and to encourage the government and related institutions to provide adequate support and facilities for the development of MSMEs through the manufacture of business carts. Thus, this research has the potential to make a significant contribution to increasing the competitiveness of MSME and strengthening the local economy in a sustainable manner.
Penguatan Literasi Ilmu Kewirausahaan Terhadap Generasi Z Wahyuni, Nuorma; Setyaningsih, Erlin; Canta, Dila Seltika; Hermawansyah, Adi; Hasrullah, Hasrullah
Jompa Abdi: Jurnal Pengabdian Masyarakat Vol. 3 No. 2 (2024): Jompa Abdi: Jurnal Pengabdian Masyarakat
Publisher : Yayasan Jompa Research and Development

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57218/jompaabdi.v3i2.1077

Abstract

Ilmu tentang kewirausahaan menjadi sebuah kewajiban yang harus dipahami oleh generasi Z saat ini dalam menghadapi dinamika pendidikan dan ekonomi. Literasi tentang ilmu kewirausahaan tentang memamahi konsep dasar bisnis, pengembangan ketrampilan, sikap dan pengetahuan yang diperlukan untuk berhasil dalam dunia bisnis dan kompetitif. Melalui pelaksanaan metode perngabdian kepada masyarakat yang menggabungkan teori, diskusi dan evaluasi memungkinkan para peserta dapat menambah literasi, mengasah kreativitas, inovasi yang diperlukan untuk merintis usaha secara efektif dimasa depan. Penguatan literasi kewirausahaan dalam berbagai tahap pendidikan diharapkan dapat menjadi acuan para peserta. Dengan kegiatan sosialisasi penguatan literasi ilmu kewirusahaan ini, tim penulis mengharapkan dapat memberikan manfaat bagi peserta secara personal dan dapat membawa dampak positif bagi pertumbuhan pendidikan dari segi literasi, ekonomi, dan pembangunan masyarakat secara utuh di masa depan.
The Influence of Marketing Mix on Aice Ice Cream Purchase Decision in Balikpapan: Marketing mix Erlimisnawati, Erlimisnawati; Prihandoyo, C.; Hermawansyah, Adi
Jurnal Ekonomi Vol. 13 No. 01 (2024): Jurnal Ekonomi, Edition January - March 2024
Publisher : SEAN Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

This research is aims to determine the impact of the marketing mix on the purchasing decisions of Aice ice cream in Balikpapan. The study was conducted at PT. Shunli Aneka Food and Aice outlets in Balikpapan with 385 respondents. This research utilized a quantitative method. Data collection was carried out by distributing questionnaires directly. The data analysis technique in this study was multiple linear regression analysis, including testing the instrument, classical assumption tests, and hypothesis testing partially (t-test). The results of the multiple linear regression analysis indicate that the product, price, promotion, and location have a positive and significant influence on purchasing decisions, both partially and simultaneously.
SOSIALISASI GERAKAN MELESTARIKAN BUDAYA LOKAL TERHADAP GENERASI Z DAN ALPHA DALAM MENJAGA BAHASA DAERAH DAN MAKANAN TRADISIONAL Wahyuni, Nuorma; Canta, Dila Seltika; Setyaningsih, Erlin; Hermawansyah, Adi
MAJU : Indonesian Journal of Community Empowerment Vol. 2 No. 6 (2025): MAJU : Indonesian Journal of Community Empowerment, November 2025
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/maju.v2i6.1921

Abstract

The language ​​and traditional foods are an important part of Indonesia's identity and cultural heritage, reflecting the diversity and richness of the archipelago. However, the globalization and technological advances have led to a decline in interest in local culture among the younger generation. This community service activity aims to foster the interest, awareness, and active involvement of Generation Z and Generation Alpha in preserving regional languages ​​and foods through an educational, creative, and digital-based approach. The method is used the outreach and interactive discussion at the  vocational high school in Balikpapan, involving participants in the creation of the digital content about regional languages ​​and foods. The results of the activity is demonstrating of increasing the insight and positive attitudes among participants in efforts to preserve and maintain local culture, particularly regional languages ​​and foods. The digital approach has proven effective in attracting the interest of the younger generation and making cultural preservation a form of self-expression that is relevant to current developments, while simultaneously strengthening patriotism and nationalism.
PENGEMBANGAN MEDIA PEMBELAJARAN ANIMASI 3D UNTUK PENGENALAN ANGGOTA TUBUH MENGGUNAKAN TIGA BAHASASTUDI KASUS DI RA BAITUS SYAKUR Canta, Dila Seltika; Setyaningsih, Erlin; Wahyuni, Nuorma; Hermawansyah, Adi; Sudarman, Sudarman
SINERGI : Jurnal Riset Ilmiah Vol. 2 No. 11 (2025): SINERGI : Jurnal Riset Ilmiah, November 2025
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/sinergi.v2i11.1922

Abstract

The Process of developing a multilingual (Indonesian, Arabic, and English) three-dimensional (3D) animated learning media to introduce the  body parts to early childhood at RA Baitus Syakur ( Kinder Garten ). The Media development was motivated by the lack of innovation in conventional two-dimensional learning media, which has resulted in the inability to optimally foster children's motivation and attention to learning. This study used a Research and Development (R&D) method with a simplified Borg and Gall model, encompassing the stages of needs analysis, product design, media creation, expert validation, revision, and limited and field trials. The field trial with 32 students showed significant improvements in body part recognition (20%), Indonesian vocabulary mastery (15%), and Arabic and English mastery (25%). Teacher and student responses also indicated a high level of satisfaction and enthusiasm for the developed media. This trilingual 3D animated learning media has proven feasible and effective in increasing learning of motivation, language skills  and The understanding of human body concept interactively and enjoyable way for early childhood
The developing of Marketing Mix Strategy & Using of QRIS As Supporting Purchasing Intention: A Systematic Literature Review Adi Hermawansyah; Sudarmiatin Sudarmiatin; Agus Hermawan
International Journal of Economics and Management Sciences Vol. 2 No. 4 (2025): November : International Journal of Economics and Management Sciences
Publisher : Asosiasi Riset Ekonomi dan Akuntansi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/ijems.v2i4.1073

Abstract

The Marketing Mix strategy is a combination of various marketing elements that include product, price, distribution place, and promotion. The Marketing Mix strategy, also known as the marketing mix is a concept in marketing that explains four main elements that must be managed in an integrated manner to achieve marketing objectives. In general practice, the using of QRIS is a payment standard using a QR code developed by Bank Indonesia and the Indonesian Payment System Association to simplify and accelerate digital transactions. Through VOSviewer analysis, the implementation of QRIS can have a positive impact on the operations and business performance of MSMEs, and the marketing mix strategy in the context of business digitalization becomes an important approach to maintaining MSME competitiveness. The results of the VOSviewer visual map analysis and the review of previous State of the Art research indicate that most existing studies still focus on aspects of QRIS adoption and transaction efficiency alone. These studies generally highlight how digital payment system is able to improve the speed, security, and convenience of transactions but have not yet widely linked them directly to marketing mix strategies and consumer purchasing decisions. This indicates a research gap in understanding the role of QRIS is not only as a transaction tool but also as part of the marketing strategy that influences consumer behaviour.
Usability Web Pada Website D2mart.Id Ayu Sulistiawati; Adi Hermawansyah; Erlin Setyaningsih
Jurnal Indonesia Sosial Teknologi Vol. 3 No. 01 (2022): Jurnal Indonesia Sosial Teknologi
Publisher : Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (4529.622 KB) | DOI: 10.59141/jist.v3i01.322

Abstract

Website d2mart.id adalah sebuah website yang digunakan sebagai wadah penjualan online di Desa Bangun Mulya Kecamatan Waru Kabupaten Penajam Paser Utara. Pada penelitian ini bertujuan untuk mengetahui tingkat penggunaan dan kepuasan pengguna pada aplikasi website D2mart.id di Desa Bangun Mulya Kecamatan Waru. adapun metode yang digunakan adalah kualitatif deskriftif dengan responden sebanyak 100 orang yang berasal dari peserta sosialisasi website D2mart.id dengan menggunakan instrument penelitian yaitu usability testing, wawancara dan kuesioner, yang mana kuesioner tersebut merupakan kuesioner pilihan untuk mengukur usability yakni menggunakan kuesioner PSSUQ (Post- Study System Quesionnaire). Berdasarkan hasil penelitian diperoleh antaralain bahwa fitur iklan tidak dapat langsung terhubung ke facebook atau instagram dan verifikasi data terasa rumit serta hasil evaluasi dari usability testing dengan 5 partisipan yang telah mengerjakan 4 tugas skenario didapatkan hasil komponen efficiency sebesar 0,023 goalsatausec, komponen error 7,7% per tugas, komponen satification menggunakan kuesioner PSSUQ dengan nilai rata-rata 5. Serta hasil wawancara terdapat 5 partisipan yang mengalami 6 masalah yang berbeda mereka alami. Maka dapat diambil kesimpulan dari unsur satisfaction dan wawancara bahwa website d2mart.id dengan hasil agak setuju namun perlu perbaikan dan pengembangan lebih lanjut.
Analisis Pengelolaan Aplikasi E-Yankel dengan Itil V3 Domain Service Operation (Studi Kasus Kelurahan di Balikpapan) Sutri Deriyanti; Adi Hermawansyah; Nuorma Wahyuni
Jurnal Indonesia Sosial Teknologi Vol. 3 No. 01 (2022): Jurnal Indonesia Sosial Teknologi
Publisher : Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (4233.527 KB) | DOI: 10.59141/jist.v3i01.327

Abstract

Sistem Informasi Pelayanan Kelurahan (Yankel) dengan adanya sistem informasi ini masyarakat dapat melakukan atau mengajukan pelayanan secara online dari rumah dalam rangka percepatan penanganan pembatasan penyebaran penularan Covid-19 di wilayah kota Balikpapan. Aplikasi Yankel ini adalah memberikan layanan kepada masyarakat untuk meminta layanan secara online dan drop berkas yang diinginkan dan dilaksanakan oleh Kelurahan. Terdapat beberapa alasan untuk mengevaluasi layanan TI pada Yankel karena Kelurahan tersebut sudah pernah menggunakan layanan TI yang sebelumnya yang ada di Kecamatan Balikpapan yang sudah lama digunakan beberapa tahun terakhir. Layanan tersebut lebih lengkap, untuk menjangkau masyarakat kota yang memerlukan akses online untuk pembuatan keperluan adminstrasi yang diperlukan warga masyarakat dan dapat diakses dengan cepat sesuai dengan kebutuhan masyarakat. Selain itu, jarak antara kantor satu dengan kantor lainya dengan jalan-jalan kota di Balikpapan berputar-putar cukup menyulitkan sebagai pendatang baru untuk mencari lokasi yang ada di 34 Kelurahan tersebut, jadi membuat operasional Kelurahan menjadi lebih menarik untuk di evaluasi. Dan yang terakhir faktor aplikasi Yankel ini masih tergolong baru dan belum populer di warga kota Balikpapan, hingga program ini sudah ada masih terdapat kendala untuk memperkenalkannya kepada masyarakat kota yang ada di Balikpapan. Penelitian ini menggunakan framework Information Technology Infrastructure Library (ITIL) V3 domain service operation untuk menganalisis kesenjangan dan merumuskan rekomendasi untuk perbaikan ke depannya. Kuesioner yang digunakan adalah berbasis online menggunakan google from yang kemudian di analisis menggunakan SPSS.
Co-Authors Abdul Rahmadan Haeradi Aden Zakaria Aditya Pratama Agus Hermawan Akmal, Muhammad Firja Anggraini, Chaessy Yori Ardiana, Ira Maya Artikasari, Devi Ayu Nuriyana Ayu Sulistiawati Azizah, Bilqis Rahil Azzam Marwan Bruce Anzward Budi Eko Soetjipto Bunga, Ardiyanto Fernando Bunga, Cut Dewi C. Prihandoyo Chlara Novita Chuarajab Ms., Tawakkal Cipto, Rahajeng Cahyaning Putri Darmah Tullah Darmawan Darmawan Dedy Deomedes, Stepanus Dila Seltika Canta Dila Seltika Canta Dila Seltika Canta Dila Seltika Canta Dila Seltika Canta Dilla Putri Kinanti Dina Evitria Dina Rosalina Mariska Putri Dinda Selfiawati Erlimisnawati, Erlimisnawati Erlin Setyaningsih Erlin Setyaningsih Erlin Setyaningsih ERLIN SETYANINGSIH Ferdinand, Gregorius Ergi Ferry, Christian Fikri Rahmanda Zidane Parapat Hasrullah Hasrullah Hasrullah, Hasrullah Heri Pratikto Imelba, Wianda Faza Indra Rahayu Ivan Widjaja Jelina, Sherly Joy Nashar Utama Jaya Joy Nashar Utamajaya Juniananda, Melisa Kusumaningtyas, Triana Arum Ludi Wishnu Wardana Malik, Syahrul Meta Ermila Sari Nely Tangke Rante Nico Gerry Ningrum, Dhecella Winy Cintya Nisa Fitriyani, Nisa Norhidayah, Siti Nuorma Wahyuni Nuorma Wahyuni Nuorma Wahyuni Nur Bintang Ayu May Riska Putri Nurkhayati, Nurkhayati Nurul Saqa Aqmarina Perdana Priya Haresmita, Perdana Priya Pradani, Missya Putri Kurnia Prastistha, Erica Agni Prihandoyo, C. Prisca Cisca Pongtiko Putri Melinda Putri wahyu Kholifah Putri, Davila Zalianti Rianawati, Luluc Rifka, Rosmida Rifki Febriansah Riska Amelia Saiful Malik Saputri, Maulidya Fathimah Sari, Junita Dewi Indah Sasih Kirani, Amanda Retno Seltika Canta, Dila Setyaningsih, Erlin Sri Wahyuni Sudarman Sudarman Sudarman Sudarman Sudarman Sudarmiatin Sukimin Surmiati Surmiati Sutri Deriyanti Syifa Nirmala Triana, Alvina Alda Wahyuni, Nourma Wahyuni, Nuorma Yanzil Azizil Yudaruddin Zamzam, Muhammad Zuhra, Faza Muraya