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All Journal Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Indonesian Journal of Chemistry JCRS (Journal of Community Research and Service) Jurnal Mandala Pharmacon Indonesia Jurnal Pengabdian Masyarakat (ABDIRA) ANDIL Mulawarman Journal of Community Engagement Journal of Pharmaceuticals and Natural Sciences al Kimiya : Jurnal Ilmu Kimia dan Terapan Jurnal Sains dan Kesehatan Jurnal Abdita Naturafarm Jurnal Riseta Naturafarm Jurnal Riseta Soshum
Islamudin Ahmad
Universitas Mulawarman
Religion Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Green Extraction of Eurycomanone from Eurycoma longifolia Using Imidazolium-Based Ionic Liquids Combined with Microwave-Assisted Method Puspita, Esmeralda Dwi; Iswahyudi, Iswahyudi; Ayu, Welinda Dyah; Ahmad, Islamudin
Journal of Pharmaceuticals and Natural Sciences Vol. 2 No. 3 (2025): J. Pharm. Nat. Sci.
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/jpns.v2i3.38

Abstract

Background: Pasak Bumi (Eurycoma longifolia Jack) is an endemic plant that has been utilized as a medicinal agent by communities in Kalimantan and Sumatra for an extended period. The entirety of E. longifolia, inclusive of its leaves, stems, and roots, has been utilized as a medicinal agent. The primary compound present in E. longifolia is eurycomanone, which is commonly found in the roots of the plant. Objective: This study aims to optimize the extraction of eurycomanone from E. longifolia roots using imidazolium-based ionic liquids (1-butyl-3-methylimidazolium chloride [BMIM][Cl]) through microwave-assisted extraction (MAE), applying response surface methodology (RSM) for statistical meodeling. Methods: A Box-Behnken design was employed to evaluate the effects of three independent variable including [BMIM][Cl]concentration, extraction time, and solid-liquid ratio on eurycomanone content. Quantification was performed using a validated HPLC method, and model performance was assessed via analysis of variance (ANOVA). Results: The concentration of [BMIM][Cl] significantly influenced eurycomanone content (p<0.001), while extraction time and solid-liquid ratio showed no significant individual effects. The optimized condition yielded 0.4061 µg/mg of eurycomanone, closely matching the predicted value (0.3835 µg/mg). The model demonestreated good fit (R2 = 0.8135) and non-significant Lack of Fit (p = 0.6566), indicating reliable predictive capability. Conclusion: MAE using [BMIM][Cl] is an effective and environmentally friendly approach for extracting eurycomanone. The developed model provides a robust framework for process optimization and potential scale-up in phytopharmaceutical applications.
Alkaloid Profiling of Kadamba (Mitragyna speciosa Korth. Havil.) Leaves through Chromatographic Separation and UV-Vis Spectrophotometery Analysis Arifuddin, M.; Azmi, Fatur Rahman; Iswahyudi, Iswahyudi; Bone, Mahfuzun; Farrah, Harra Ismi; Arifian, Hanggara; Almeida, Maria; Rusman, Arman; Samsul, Erwin; Riki, Riki; Rija'i, Hifdzur Rashif; Hikmawan, Baso Didik; Junaidin, Junaidin; Febrina, Lizma; Rusli, Rolan; Ibrahim, Arsyik; Ahmad, Islamudin; Herman, Herman
Journal of Pharmaceuticals and Natural Sciences Vol. 2 No. 3 (2025): J. Pharm. Nat. Sci.
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/jpns.v2i3.44

Abstract

Mitragyna speciosa Korth. berasal dari famili Rubiaceae yang banyak tumbuh di daratan negara-negara Asia Tenggara. Tumbuhan ini selain disebut Kratom, khususnya di daerah Kalimantan Timur dikenal juga dengan nama "Kadamba". Mitragyna speciosa Korth. belongs to the Rubiaceae family and is widely found in the mainland of Southeast Asian countries. This plant, known as Kratom, is also referred to as "Kadamba" in East Kalimantan. Kadamba has been used for generations as a traditional medicine and contains predominantly alkaloid compounds, which generally function as analgesics, antitussives, antidiarrheals, adrenergic agents, antimalarials, antibacterials, and antinociceptives. The aim of this research is to determine the isolation and identification methods for alkaloid compounds in Kadamba leaves. In this study, extraction was performed using methanol solvent, followed by fractionation using Vacuum Liquid Chromatography (VLC) and Column Chromatography (CC) with gradient eluents: 100% hexane, n-hexane : Ethyl Acetate (5:1, 1:1, 1:5), 100% Ethyl Acetate, Ethyl Acetate : Methanol (1:1, 1:5), and 100% Methanol. The compounds were then identified using Thin Layer Chromatography (TLC). The isolation process used preparative Thin Layer Chromatography (PTLC) with eluent n-hexane: ethyl acetate: 25% ammonia (6.5:3:0.5 v/v/v), and the spots were observed under UV light at 245 nm and 366 nm. The visible spots were sprayed with Dragendorff's reagent to identify the alkaloid compounds. The results showed that the UV-Vis spectrophotometric characterization of isolate B6-b had two peaks at wavelengths of 288 nm and 294 nm.
Gerakan Masyarakat Bijak Konsumsi Obat (GMBKO) pada Masyarakat Desa Liang Ulu Kecamatan Kota Bangun Kabupaten Kutai Kartanegara Ahmad, Islamudin; Arifuddin, M.; Samsul, Erwin; Maulidha, Faizatun; Mus, Nurul Muhlisa
Jurnal Pengabdian Masyarakat (ABDIRA) Vol 3, No 4 (2023): Abdira, Oktober
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/abdira.v3i4.382

Abstract

Medicine is an inseparable part of society because of its usefulness in reducing symptoms or curing a disease. In order for medicines to provide maximum results, a correct understanding of the rules for consuming medicines, whether in the form of synthetic drugs or those of natural origin from plants, is required. One area that is rich in medicinal plants, including endemic Kalimantan medicinal plants such as kratom and has attention to the use of medicinal plants to improve health status, is Liang Ulu Village. To provide understanding and increase the knowledge of the people of Liang Ulu Village, Kota Bangun District, Kutai Kartanegara Regency regarding the proper and correct use of medicines and medicinal plants, community service activities were carried out in the form of the Community Wisely Consuming Medicines (MBKO) movement. The service methods used include delivering material, discussions, and distributing posters and leaflets. Success parameters are seen based on pre and post-test data to measure the increase in public understanding. The results of community service activities show an increase in knowledge from 62.56% to 82%.
Co-Authors Afpriana, Mia Agus Setiawaty Ahmad Jailani, Ahmad Al Farisy, Hanif Almeida, Maria Alza, Muhammad Gibran Andi Tenri Kawareng Andika, Arya Bhima Apriliana, Lika Arifian, Hanggara Arifuddin, M Arifuddin, Muhammad Arsya, Dinara Eza Syahadati Ashari, Zahra Nabila Putri Asia, Nazha Delmora Asriani Aulia, Alda Rizki Ayu, Welinda Dyah Azizah, Wilda Azmi, Fatur Rahman Badawi, Satriani Baso Didik Hikmawan Bone, Mahfuzun Brigita, Vista Candrakanti, Bratandari Hana Damayanti, Nina Emilia, Rina Erwin Samsul Farah, Harra Ismi Farrah, Harra Ismi Fatimah, Sindi Febrina, Lizma Filicia, Harfenas Althea Galih Rahmadana, Adly Hairunnisa Harianti, Chita Herman Herman Ibrahim, Arsyik Idris, Viviana Ilmi, Muhammad Fachrul Iswahyudi ISWAHYUDI ISWAHYUDI Jofachri, Muhammad Joshevine, Imelda Junaidin, Junaidin Laksono, Ailsa Purwabhagawanta Saskirana Laode Rijai Lestari, Seftya Ayu M. Arifuddin M. Arifuddin, M. Malindo, Andi Muhammad Alfian MASRUHIM, MUHAMMAD AMIR Maulana, Abdul Razak Maulidha, Faizatun Mohd Azlan Nafiah, Mohd Azlan Muhammad Faisal Mulyana Mulyana Mus, Nurul Muhlisa Nabila, Nur Qurratul Nadirah Nayaputri, Devina Yasintha Novarossi, Gusti Dimas Novermawati Nur, Yuspian Nurul Hasanah Prabowo, Wisnu Cahyo Pramana, Muhammad Yoga Adhi Pratiwi Putri, Bella Prayogi, Wahyu Tri Puspita, Esmeralda Dwi Puspitawati, Ni Komang Anika Putri Sulistian, Salwah Rabbani, Najwa Jembar Aulya Rahmadani, Dessi Rahman, Dela Juliarsih Ridhotulloh, Yusuf Isro Rija'i, Hifdzur Rashif Rijai, Hifdzur Rashif Rija’i, Hifdzur Rashif Riki RIKI RIKI, RIKI Rolan Rusli Rusman, Arman Sabila, Arina Hasya Salam, Supriatno Sari, Karin Sopiya Simatupang, Devona Valerie Sulistyarini, Riski Supriatno Syamsiar, Syamsiar Tinambungan, Wirawati Wardhana, Nicko WISNU PRABOWO Yani, Naufal Vigar Yanti, Resti Safitri Yazid, Muhammad Ilfan Yusniah, Andi Zahra, Khansa Aprillia Zahrah, Nabila