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All Journal Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Indonesian Journal of Chemistry JCRS (Journal of Community Research and Service) Jurnal Mandala Pharmacon Indonesia Jurnal Pengabdian Masyarakat (ABDIRA) Sevanam: Jurnal Pengabdian Masyarakat ANDIL Mulawarman Journal of Community Engagement Journal of Pharmaceuticals and Natural Sciences al Kimiya : Jurnal Ilmu Kimia dan Terapan Jurnal Sains dan Kesehatan Jurnal Abdita Naturafarm Jurnal Riseta Naturafarm Jurnal Riseta Soshum
Islamudin Ahmad
Universitas Mulawarman
Religion Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Green Extraction of Eurycomanone from Eurycoma longifolia Using Imidazolium-Based Ionic Liquids Combined with Microwave-Assisted Method Puspita, Esmeralda Dwi; Iswahyudi, Iswahyudi; Ayu, Welinda Dyah; Ahmad, Islamudin
Journal of Pharmaceuticals and Natural Sciences Vol. 2 No. 3 (2025): J. Pharm. Nat. Sci.
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/jpns.v2i3.38

Abstract

Background: Pasak Bumi (Eurycoma longifolia Jack) is an endemic plant that has been utilized as a medicinal agent by communities in Kalimantan and Sumatra for an extended period. The entirety of E. longifolia, inclusive of its leaves, stems, and roots, has been utilized as a medicinal agent. The primary compound present in E. longifolia is eurycomanone, which is commonly found in the roots of the plant. Objective: This study aims to optimize the extraction of eurycomanone from E. longifolia roots using imidazolium-based ionic liquids (1-butyl-3-methylimidazolium chloride [BMIM][Cl]) through microwave-assisted extraction (MAE), applying response surface methodology (RSM) for statistical meodeling. Methods: A Box-Behnken design was employed to evaluate the effects of three independent variable including [BMIM][Cl]concentration, extraction time, and solid-liquid ratio on eurycomanone content. Quantification was performed using a validated HPLC method, and model performance was assessed via analysis of variance (ANOVA). Results: The concentration of [BMIM][Cl] significantly influenced eurycomanone content (p<0.001), while extraction time and solid-liquid ratio showed no significant individual effects. The optimized condition yielded 0.4061 µg/mg of eurycomanone, closely matching the predicted value (0.3835 µg/mg). The model demonestreated good fit (R2 = 0.8135) and non-significant Lack of Fit (p = 0.6566), indicating reliable predictive capability. Conclusion: MAE using [BMIM][Cl] is an effective and environmentally friendly approach for extracting eurycomanone. The developed model provides a robust framework for process optimization and potential scale-up in phytopharmaceutical applications.
Alkaloid Profiling of Kadamba (Mitragyna speciosa Korth. Havil.) Leaves through Chromatographic Separation and UV-Vis Spectrophotometery Analysis Arifuddin, M.; Azmi, Fatur Rahman; Iswahyudi, Iswahyudi; Bone, Mahfuzun; Farrah, Harra Ismi; Arifian, Hanggara; Almeida, Maria; Rusman, Arman; Samsul, Erwin; Riki, Riki; Rija'i, Hifdzur Rashif; Hikmawan, Baso Didik; Junaidin, Junaidin; Febrina, Lizma; Rusli, Rolan; Ibrahim, Arsyik; Ahmad, Islamudin; Herman, Herman
Journal of Pharmaceuticals and Natural Sciences Vol. 2 No. 3 (2025): J. Pharm. Nat. Sci.
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/jpns.v2i3.44

Abstract

Mitragyna speciosa Korth. berasal dari famili Rubiaceae yang banyak tumbuh di daratan negara-negara Asia Tenggara. Tumbuhan ini selain disebut Kratom, khususnya di daerah Kalimantan Timur dikenal juga dengan nama "Kadamba". Mitragyna speciosa Korth. belongs to the Rubiaceae family and is widely found in the mainland of Southeast Asian countries. This plant, known as Kratom, is also referred to as "Kadamba" in East Kalimantan. Kadamba has been used for generations as a traditional medicine and contains predominantly alkaloid compounds, which generally function as analgesics, antitussives, antidiarrheals, adrenergic agents, antimalarials, antibacterials, and antinociceptives. The aim of this research is to determine the isolation and identification methods for alkaloid compounds in Kadamba leaves. In this study, extraction was performed using methanol solvent, followed by fractionation using Vacuum Liquid Chromatography (VLC) and Column Chromatography (CC) with gradient eluents: 100% hexane, n-hexane : Ethyl Acetate (5:1, 1:1, 1:5), 100% Ethyl Acetate, Ethyl Acetate : Methanol (1:1, 1:5), and 100% Methanol. The compounds were then identified using Thin Layer Chromatography (TLC). The isolation process used preparative Thin Layer Chromatography (PTLC) with eluent n-hexane: ethyl acetate: 25% ammonia (6.5:3:0.5 v/v/v), and the spots were observed under UV light at 245 nm and 366 nm. The visible spots were sprayed with Dragendorff's reagent to identify the alkaloid compounds. The results showed that the UV-Vis spectrophotometric characterization of isolate B6-b had two peaks at wavelengths of 288 nm and 294 nm.
Gerakan Masyarakat Bijak Konsumsi Obat (GMBKO) pada Masyarakat Desa Liang Ulu Kecamatan Kota Bangun Kabupaten Kutai Kartanegara Ahmad, Islamudin; Arifuddin, M.; Samsul, Erwin; Maulidha, Faizatun; Mus, Nurul Muhlisa
Jurnal Pengabdian Masyarakat (ABDIRA) Vol 3, No 4 (2023): Abdira, Oktober
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/abdira.v3i4.382

Abstract

Medicine is an inseparable part of society because of its usefulness in reducing symptoms or curing a disease. In order for medicines to provide maximum results, a correct understanding of the rules for consuming medicines, whether in the form of synthetic drugs or those of natural origin from plants, is required. One area that is rich in medicinal plants, including endemic Kalimantan medicinal plants such as kratom and has attention to the use of medicinal plants to improve health status, is Liang Ulu Village. To provide understanding and increase the knowledge of the people of Liang Ulu Village, Kota Bangun District, Kutai Kartanegara Regency regarding the proper and correct use of medicines and medicinal plants, community service activities were carried out in the form of the Community Wisely Consuming Medicines (MBKO) movement. The service methods used include delivering material, discussions, and distributing posters and leaflets. Success parameters are seen based on pre and post-test data to measure the increase in public understanding. The results of community service activities show an increase in knowledge from 62.56% to 82%.
Edukasi Beyond Use Date (BUD) kepada Masyarakat di Puskesmas Lempake Samarinda Samsul, Erwin; Sari, Indah Dewi; Pasaribu, Handayani; Mus, Nurul Muhlisa; Hikmawan, Baso Didik; Arifuddin, M.; Rusman, Arman; Riki, Riki; Bone, Mahfuzun; Herman, Herman; Junaidin, Junaidin; Febrina, Lizma; Ibrahim, Arsyik; Rijai, Hifdzur Rashif; Ahmad, Islamudin; Almeida, Maria; Rijai, Laode; Arifian, Hanggara
Sevanam: Jurnal Pengabdian Masyarakat Vol 5 No 3 (2026): Maret
Publisher : Universitas Hindu Negeri I Gusti Bagus Sugriwa Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25078/sevanam.v5i3.5684

Abstract

ABSTRACT There are still some people who do not understand the difference between the expiration date (Expired Date/ED) and the drug usage limit (Beyond Use Date/BUD). BUD is the time limit for drug use after compounding or after the primary packaging is opened. This activity aims to increase public knowledge, understanding, and awareness regarding the importance of paying attention to the safe limit for drug use or Beyond Use Date (BUD), so that people can use drugs wisely, safely, and responsibly. The activity implementation method includes counseling, material presentation, distribution of leaflets or brochures, and filling out pre-tests and post-tests. The number of participants who took part in this activity was 26 people. The results of the health promotion activity at the Lempake Community Health Center, Samarinda City showed that the average knowledge of participants about Beyond Use Date before providing education was 31.92%, and increased to 88.08% after being given information. Thus, it can be concluded that this activity was successful in increasing public knowledge regarding Beyond Use Date in the Lempake Community Health Center area, Samarinda City.. Key words: Beyond Use date (BUD), Expired date (ED), Lempake Health Center Samarinda City
NMR-Based Metabolic Profiling and Anticancer Activity of Nephelium ramboutan-ake and Nephelium lappaceum Flesh Febrina, Lizma; Rusli, Rolan; Samsul, Erwin; Rijai, Laode; Ahmad, Islamudin; Rusman, Arman; Hikmawan, Baso Didik; Rija'i, Hifdzur Rashif; Almeida, Maria
Indonesian Journal of Chemistry Vol 26, No 2 (2026)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.104162

Abstract

In this research, 1H-NMR-based metabolomics assessed the metabolite profiles of two Nephelium species flesh, specifically Nephelium ramboutan-ake and Nephelium lappaceum. Our research findings indicate that the metabolite profile of N. ramboutan-ake is qualitatively identical, although numerically distinct from that of N. lappaceum. The PLSDA data indicate that N. ramboutan-ake possesses elevated concentrations of acetic acid, malic acid, GABA, and succinic acid compared to N. lappaceum. In N. lappaceum, alanine and glucose serve as the distinguishing metabolites. Additionally, the anticancer efficacy of two Nephelium samples was assessed. As a result, the anticancer properties of N. ramboutan-ake were superior to those of N. lappaceum. PLS analysis indicated that GABA exhibited the most positive connection with the anticancer activity of Nephelium samples. These results indicate that the higher GABA concentrations of N. ramboutan-ake have a beneficial effect on its anticancer activity.
Interactive Learning to Foster Nationalism Among Junior High School Students: Penguatan Wawasan Kebangsaan Melalui Pembelajaran Interaktif di SMPN 2 Kota Bangun Saputra, Rio Rizky; Ahmad, Andi; Aurelia, Aisha; Nirmala, Amanda; Hasanah, Auliatul; Nikmah, Nur Rahmi Niatun; Rahman, Rifka Arnita; Rinaldy, Tyara Annisa; Safitri, Hersa; Al Pajar, M. Martin; Ahmad, Islamudin
ANDIL Mulawarman Journal of Community Engagement Vol. 3 No. 2 (2026): ANDIL Mulawarman J Comm Engag
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LP2M), Universitas Mulawarman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30872/andil.v3i2.3799

Abstract

The “Love Your Country from an Early Age!” program was implemented at SMPN 2 Kota Bangun as a strategic effort to strengthen students’ national awareness in the face of globalization, which often threatens national identity. This community service activity targeted ninth-grade students and student council members, aiming to instill fundamental national values through interactive learning approaches. The methods applied included thematic lectures supported by multimedia presentations, small group discussions, and educational quizzes designed to foster active participation and collaborative learning. Evaluation was conducted using pre-tests, post-tests, and direct observation of student engagement throughout the program. The results demonstrated a significant improvement in students’ understanding of national values. The average pre-test score of 62.5 increased to 84.3 in the post-test, with more than 80% of participants correctly answering basic questions related to Pancasila, the 1945 Constitution, Bhinneka Tunggal Ika, and the Unitary State of the Republic of Indonesia (NKRI). In addition to cognitive gains, students exhibited positive attitudes such as enthusiasm, collaboration, and the ability to connect the material with everyday practices, including respecting diversity and maintaining the school environment. These findings confirm that interactive learning is an effective approach to instilling national values and fostering concrete expressions of patriotism among junior high school students. The program provides a practical model for character education that can be replicated in other schools, thereby contributing to the preservation of Indonesia’s national identity and values in the era of globalization.
Co-Authors Afpriana, Mia Agus Setiawaty Ahmad Jailani, Ahmad Ahmad, Andi Al Farisy, Hanif Al Pajar, M. Martin Almeida, Maria Alza, Muhammad Gibran Andi Tenri Kawareng Andika, Arya Bhima Apriliana, Lika Arifian, Hanggara Arifuddin, M Arifuddin, Muhammad Arsya, Dinara Eza Syahadati Ashari, Zahra Nabila Putri Asia, Nazha Delmora Asriani Aurelia, Aisha Ayu, Welinda Dyah Azizah, Wilda Azmi, Fatur Rahman Badawi, Satriani Baso Didik Hikmawan Bone, Mahfuzun Brigita, Vista Candrakanti, Bratandari Hana Damayanti, Nina Emilia, Rina Erwin Samsul Farah, Harra Ismi Farrah, Harra Ismi Fatimah, Sindi Febrina, Lizma Filicia, Harfenas Althea Galih Rahmadana, Adly Hairunnisa Harianti, Chita Hasanah, Auliatul Herman Herman Ibrahim, Arsyik Idris, Viviana Ilmi, Muhammad Fachrul Iswahyudi ISWAHYUDI ISWAHYUDI Jofachri, Muhammad Joshevine, Imelda Junaidin, Junaidin Laksono, Ailsa Purwabhagawanta Saskirana Laode Rijai Lestari, Seftya Ayu M. Arifuddin M. Arifuddin, M. Malindo, Andi Muhammad Alfian MASRUHIM, MUHAMMAD AMIR Maulana, Abdul Razak Maulidha, Faizatun Mohd Azlan Nafiah, Mohd Azlan Muhammad Faisal Mulyana Mulyana Mus, Nurul Muhlisa Nabila, Nur Qurratul Nadirah Nayaputri, Devina Yasintha Nikmah, Nur Rahmi Niatun Nirmala, Amanda Novarossi, Gusti Dimas Novermawati Nur, Yuspian Nurul Hasanah Pasaribu, Handayani Prabowo, Wisnu Cahyo Pramana, Muhammad Yoga Adhi Pratiwi Putri, Bella Prayogi, Wahyu Tri Puspita, Esmeralda Dwi Puspitawati, Ni Komang Anika Putri Sulistian, Salwah Rabbani, Najwa Jembar Aulya Rahmadani, Dessi Rahman, Dela Juliarsih Rahman, Rifka Arnita Ridhotulloh, Yusuf Isro Rija'i, Hifdzur Rashif Rijai, Hifdzur Rashif Rija’i, Hifdzur Rashif Riki RIKI RIKI, RIKI Rinaldy, Tyara Annisa Rolan Rusli Rusli, Rolan Rusman, Arman Sabila, Arina Hasya Safitri, Hersa Salam, Supriatno Saputra, Rio Rizky Sari, Indah Dewi Sari, Karin Sopiya Simatupang, Devona Valerie Sulistyarini, Riski Supriatno Syamsiar, Syamsiar Tinambungan, Wirawati Wardhana, Nicko WISNU PRABOWO Yani, Naufal Vigar Yanti, Resti Safitri Yazid, Muhammad Ilfan Yusniah, Andi Zahra, Khansa Aprillia Zahrah, Nabila