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All Journal Padjadjaran Journal of Dentistry Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Indonesian Journal of Chemistry JCRS (Journal of Community Research and Service) Jurnal Mandala Pharmacon Indonesia Jurnal Pengabdian Masyarakat (ABDIRA) Indonesian Journal of Biological Pharmacy Sevanam: Jurnal Pengabdian Masyarakat ANDIL Mulawarman Journal of Community Engagement Journal of Pharmaceuticals and Natural Sciences al Kimiya : Jurnal Ilmu Kimia dan Terapan Jurnal Sains dan Kesehatan Jurnal Abdita Naturafarm Jurnal Riseta Naturafarm Jurnal Riseta Soshum
Islamudin Ahmad
Universitas Mulawarman
Religion Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Green Extraction of Eurycomanone from Eurycoma longifolia Using Imidazolium-Based Ionic Liquids Combined with Microwave-Assisted Method Puspita, Esmeralda Dwi; Iswahyudi, Iswahyudi; Ayu, Welinda Dyah; Ahmad, Islamudin
Journal of Pharmaceuticals and Natural Sciences Vol. 2 No. 3 (2025): J. Pharm. Nat. Sci.
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/jpns.v2i3.38

Abstract

Background: Pasak Bumi (Eurycoma longifolia Jack) is an endemic plant that has been utilized as a medicinal agent by communities in Kalimantan and Sumatra for an extended period. The entirety of E. longifolia, inclusive of its leaves, stems, and roots, has been utilized as a medicinal agent. The primary compound present in E. longifolia is eurycomanone, which is commonly found in the roots of the plant. Objective: This study aims to optimize the extraction of eurycomanone from E. longifolia roots using imidazolium-based ionic liquids (1-butyl-3-methylimidazolium chloride [BMIM][Cl]) through microwave-assisted extraction (MAE), applying response surface methodology (RSM) for statistical meodeling. Methods: A Box-Behnken design was employed to evaluate the effects of three independent variable including [BMIM][Cl]concentration, extraction time, and solid-liquid ratio on eurycomanone content. Quantification was performed using a validated HPLC method, and model performance was assessed via analysis of variance (ANOVA). Results: The concentration of [BMIM][Cl] significantly influenced eurycomanone content (p<0.001), while extraction time and solid-liquid ratio showed no significant individual effects. The optimized condition yielded 0.4061 µg/mg of eurycomanone, closely matching the predicted value (0.3835 µg/mg). The model demonestreated good fit (R2 = 0.8135) and non-significant Lack of Fit (p = 0.6566), indicating reliable predictive capability. Conclusion: MAE using [BMIM][Cl] is an effective and environmentally friendly approach for extracting eurycomanone. The developed model provides a robust framework for process optimization and potential scale-up in phytopharmaceutical applications.
Alkaloid Profiling of Kadamba (Mitragyna speciosa Korth. Havil.) Leaves through Chromatographic Separation and UV-Vis Spectrophotometery Analysis Arifuddin, M.; Azmi, Fatur Rahman; Iswahyudi, Iswahyudi; Bone, Mahfuzun; Farrah, Harra Ismi; Arifian, Hanggara; Almeida, Maria; Rusman, Arman; Samsul, Erwin; Riki, Riki; Rija'i, Hifdzur Rashif; Hikmawan, Baso Didik; Junaidin, Junaidin; Febrina, Lizma; Rusli, Rolan; Ibrahim, Arsyik; Ahmad, Islamudin; Herman, Herman
Journal of Pharmaceuticals and Natural Sciences Vol. 2 No. 3 (2025): J. Pharm. Nat. Sci.
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/jpns.v2i3.44

Abstract

Mitragyna speciosa Korth. berasal dari famili Rubiaceae yang banyak tumbuh di daratan negara-negara Asia Tenggara. Tumbuhan ini selain disebut Kratom, khususnya di daerah Kalimantan Timur dikenal juga dengan nama "Kadamba". Mitragyna speciosa Korth. belongs to the Rubiaceae family and is widely found in the mainland of Southeast Asian countries. This plant, known as Kratom, is also referred to as "Kadamba" in East Kalimantan. Kadamba has been used for generations as a traditional medicine and contains predominantly alkaloid compounds, which generally function as analgesics, antitussives, antidiarrheals, adrenergic agents, antimalarials, antibacterials, and antinociceptives. The aim of this research is to determine the isolation and identification methods for alkaloid compounds in Kadamba leaves. In this study, extraction was performed using methanol solvent, followed by fractionation using Vacuum Liquid Chromatography (VLC) and Column Chromatography (CC) with gradient eluents: 100% hexane, n-hexane : Ethyl Acetate (5:1, 1:1, 1:5), 100% Ethyl Acetate, Ethyl Acetate : Methanol (1:1, 1:5), and 100% Methanol. The compounds were then identified using Thin Layer Chromatography (TLC). The isolation process used preparative Thin Layer Chromatography (PTLC) with eluent n-hexane: ethyl acetate: 25% ammonia (6.5:3:0.5 v/v/v), and the spots were observed under UV light at 245 nm and 366 nm. The visible spots were sprayed with Dragendorff's reagent to identify the alkaloid compounds. The results showed that the UV-Vis spectrophotometric characterization of isolate B6-b had two peaks at wavelengths of 288 nm and 294 nm.
Gerakan Masyarakat Bijak Konsumsi Obat (GMBKO) pada Masyarakat Desa Liang Ulu Kecamatan Kota Bangun Kabupaten Kutai Kartanegara Ahmad, Islamudin; Arifuddin, M.; Samsul, Erwin; Maulidha, Faizatun; Mus, Nurul Muhlisa
Jurnal Pengabdian Masyarakat (ABDIRA) Vol 3, No 4 (2023): Abdira, Oktober
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/abdira.v3i4.382

Abstract

Medicine is an inseparable part of society because of its usefulness in reducing symptoms or curing a disease. In order for medicines to provide maximum results, a correct understanding of the rules for consuming medicines, whether in the form of synthetic drugs or those of natural origin from plants, is required. One area that is rich in medicinal plants, including endemic Kalimantan medicinal plants such as kratom and has attention to the use of medicinal plants to improve health status, is Liang Ulu Village. To provide understanding and increase the knowledge of the people of Liang Ulu Village, Kota Bangun District, Kutai Kartanegara Regency regarding the proper and correct use of medicines and medicinal plants, community service activities were carried out in the form of the Community Wisely Consuming Medicines (MBKO) movement. The service methods used include delivering material, discussions, and distributing posters and leaflets. Success parameters are seen based on pre and post-test data to measure the increase in public understanding. The results of community service activities show an increase in knowledge from 62.56% to 82%.
Edukasi Beyond Use Date (BUD) kepada Masyarakat di Puskesmas Lempake Samarinda Samsul, Erwin; Sari, Indah Dewi; Pasaribu, Handayani; Mus, Nurul Muhlisa; Hikmawan, Baso Didik; Arifuddin, M.; Rusman, Arman; Riki, Riki; Bone, Mahfuzun; Herman, Herman; Junaidin, Junaidin; Febrina, Lizma; Ibrahim, Arsyik; Rijai, Hifdzur Rashif; Ahmad, Islamudin; Almeida, Maria; Rijai, Laode; Arifian, Hanggara
Sevanam: Jurnal Pengabdian Masyarakat Vol 5 No 1 (2026): Maret
Publisher : Universitas Hindu Negeri I Gusti Bagus Sugriwa Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25078/sevanam.v5i3.5684

Abstract

ABSTRACT There are still some people who do not understand the difference between the expiration date (Expired Date/ED) and the drug usage limit (Beyond Use Date/BUD). BUD is the time limit for drug use after compounding or after the primary packaging is opened. This activity aims to increase public knowledge, understanding, and awareness regarding the importance of paying attention to the safe limit for drug use or Beyond Use Date (BUD), so that people can use drugs wisely, safely, and responsibly. The activity implementation method includes counseling, material presentation, distribution of leaflets or brochures, and filling out pre-tests and post-tests. The number of participants who took part in this activity was 26 people. The results of the health promotion activity at the Lempake Community Health Center, Samarinda City showed that the average knowledge of participants about Beyond Use Date before providing education was 31.92%, and increased to 88.08% after being given information. Thus, it can be concluded that this activity was successful in increasing public knowledge regarding Beyond Use Date in the Lempake Community Health Center area, Samarinda City.. Key words: Beyond Use date (BUD), Expired date (ED), Lempake Health Center Samarinda City
NMR-Based Metabolic Profiling and Anticancer Activity of Nephelium ramboutan-ake and Nephelium lappaceum Flesh Febrina, Lizma; Rusli, Rolan; Samsul, Erwin; Rijai, Laode; Ahmad, Islamudin; Rusman, Arman; Hikmawan, Baso Didik; Rija'i, Hifdzur Rashif; Almeida, Maria
Indonesian Journal of Chemistry Vol 26, No 2 (2026)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.104162

Abstract

In this research, 1H-NMR-based metabolomics assessed the metabolite profiles of two Nephelium species flesh, specifically Nephelium ramboutan-ake and Nephelium lappaceum. Our research findings indicate that the metabolite profile of N. ramboutan-ake is qualitatively identical, although numerically distinct from that of N. lappaceum. The PLSDA data indicate that N. ramboutan-ake possesses elevated concentrations of acetic acid, malic acid, GABA, and succinic acid compared to N. lappaceum. In N. lappaceum, alanine and glucose serve as the distinguishing metabolites. Additionally, the anticancer efficacy of two Nephelium samples was assessed. As a result, the anticancer properties of N. ramboutan-ake were superior to those of N. lappaceum. PLS analysis indicated that GABA exhibited the most positive connection with the anticancer activity of Nephelium samples. These results indicate that the higher GABA concentrations of N. ramboutan-ake have a beneficial effect on its anticancer activity.
Interactive Learning to Foster Nationalism Among Junior High School Students: Penguatan Wawasan Kebangsaan Melalui Pembelajaran Interaktif di SMPN 2 Kota Bangun Saputra, Rio Rizky; Ahmad, Andi; Aurelia, Aisha; Nirmala, Amanda; Hasanah, Auliatul; Nikmah, Nur Rahmi Niatun; Rahman, Rifka Arnita; Rinaldy, Tyara Annisa; Safitri, Hersa; Al Pajar, M. Martin; Ahmad, Islamudin
ANDIL Mulawarman Journal of Community Engagement Vol. 3 No. 2 (2026): ANDIL Mulawarman J Comm Engag
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LP2M), Universitas Mulawarman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30872/andil.v3i2.3799

Abstract

The “Love Your Country from an Early Age!” program was implemented at SMPN 2 Kota Bangun as a strategic effort to strengthen students’ national awareness in the face of globalization, which often threatens national identity. This community service activity targeted ninth-grade students and student council members, aiming to instill fundamental national values through interactive learning approaches. The methods applied included thematic lectures supported by multimedia presentations, small group discussions, and educational quizzes designed to foster active participation and collaborative learning. Evaluation was conducted using pre-tests, post-tests, and direct observation of student engagement throughout the program. The results demonstrated a significant improvement in students’ understanding of national values. The average pre-test score of 62.5 increased to 84.3 in the post-test, with more than 80% of participants correctly answering basic questions related to Pancasila, the 1945 Constitution, Bhinneka Tunggal Ika, and the Unitary State of the Republic of Indonesia (NKRI). In addition to cognitive gains, students exhibited positive attitudes such as enthusiasm, collaboration, and the ability to connect the material with everyday practices, including respecting diversity and maintaining the school environment. These findings confirm that interactive learning is an effective approach to instilling national values and fostering concrete expressions of patriotism among junior high school students. The program provides a practical model for character education that can be replicated in other schools, thereby contributing to the preservation of Indonesia’s national identity and values in the era of globalization.
Green Extraction of Kleinhovia hospita Saponins: Superiority of Microwave Irradiation over Maceration and the Critical Role of Solvent Polarity Hikmawan, Baso Didik; Khotimah, Khusnul; Permana, Mutia Ramadhani Rose; Ahmad, Islamudin; Febrina, Lizma; Arifuddin, Muhammad; Ibrahim, Arsyik; Salam, Supriatno
Indonesian Journal of Biological Pharmacy Vol 5, No 3 (2025): IJBP (Desember)
Publisher : Department of Biological Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijbp.v5i3.69627

Abstract

Kleinhovia hospita is a hepatoprotective plant rich in bioactive saponins, yet conventional extraction methods remain inefficient. This study aimed to optimize saponin recovery by comparing Microwave-Assisted Extraction (MAE) against conventional maceration and assessing the effect of solvent polarity. Saponins were extracted using MAE (15 minutes) and maceration (72 h) with various ethanol concentrations ranging from 0 to 96%. Total Saponin Content (TSC) was quantified colorimetrically using the vanillin-sulfuric acid method. MAE significantly outperformed maceration, attaining a two-fold increase in saponin purity (106.67 and 52.92 mg Diosgenin Equivalent (DE)/g extract, respectively) in a fraction of the time. Solvent analysis revealed a trade-off: whereas 96% ethanol yielded the highest specific purity (133.89 mg DE/g), it resulted in low mass recovery. In contrast, 50% ethanol extracted the highest Total Saponin Yield (TSY) (18.84 mg/g powder), effectively balancing matrix swelling with solubility. MAE utilizing 50% ethanol is identified as the optimal, rapid, and green strategy for the industrial production of standardized K. hospita extracts.
Correlation between demographic and environmental factors and dental caries prevalence in a remote Indonesian coastal community: a cross-sectional study Masyhudi, Masyhudi; Candra, Krishna Purnawan; Handayani, Esti; Ahmad, Islamudin; Bujang, Kopli
Padjadjaran Journal of Dentistry Vol 38, No 1 (2026): March 2026
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol38no1.68102

Abstract

Introduction: Dental caries is a significant global health concern. Factors such as socioeconomic status, diet, oral hygiene, and access to dental care influence its prevalence. Limited information exists on dental health in remote sea-floating villages. This study aimed to analyze the correlation between demographic and environmental factors and dental caries prevalence in a sea-floating community. Methods: This cross-sectional study was conducted in Malahing Village, a sea-floating village located adjacent to the Makassar Strait, 4 km east of Bontang city. Seventy-two respondents aged 5–59 years were examined for the DMFT index, while intrinsic factors (demographic and dental health behaviors) and extrinsic factors (environmental and dental health services) were collected via questionnaires. Data were analyzed using descriptive univariate analysis to determine variable characteristics and Spearman’s correlation analysis. Results: Dental caries prevalence was 98.61%, with a DMFT index of 10.01. Age (r=0.564, p=0.001), education (r=0.370, p=0.002), and occupation (r=0.273, p=0.020) showed strong, moderate, and weak positive correlations, respectively. Rainwater exposure (r=-0.353, p=0.003) showed a moderate negative correlation. Sex, dental health behaviors, water source, and dental visits were not significantly correlated with caries prevalence. Adults showed highest prevalence (66.67%) but low DMFT index (1.00). Government employees had high DMFT scores (4.61). Twice-daily brushing was uncommon (66.67%) among individuals with high DMFT scores (6.15). Patients who never visited a dentist (44.44%) showed high DMFT scores (8.33). Conclusions: In this underserved coastal community, demographic disadvantages and environmental exposures, particularly water sources, combined with limited dental care contribute to an elevated caries burden compared to the national and international levels. Despite complex associations with environmental factors, rainwater exposure showed negative correlation with caries prevalence, highlighting measurement challenges. The high proportion of patients never visited a dentist, low oral health awareness, and nonstandard water management highlight critical service gaps.
Assessment of Sub-Chronic Toxicity of a Polyherbal Infusion of Peperomia pellucida, Moringa oleifera, and Biancaea sappan in Male Mice (Mus musculus) Akbar, Heldi Fadillah; Mahmudah, Febrina; Ahmad, Islamudin
Journal of Pharmaceuticals and Natural Sciences Vol. 3 No. 1 (2026): J. Pharm. Nat. Sci.
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/jpns.v3i1.46

Abstract

This study evaluated the sub-chronic toxicity of a polyherbal infusion composed of Peperomia pellucida, Moringa oleifera, and Biancaea sappan in male mice. Thirty healthy male mice aged 6–8 weeks, weighing 20–30 g, were orally administered doses of 560, 650, and 1300 mg/kg body weight daily for 28 days, with satellite groups observed for up to 42 days. Clinical monitoring and body weight measurements revealed no signs of toxicity or growth impairment. However, organ index analysis demonstrated dose-dependent increases in liver and kidney weights, and histopathological examination confirmed hepatocellular degeneration and tubular damage at the highest dose. These findings indicate that the infusion is generally safe at low to moderate doses, but prolonged high-dose consumption may compromise hepatic and renal integrity. The study provides important toxicological evidence supporting the establishment of safe dosage ranges for polyherbal formulations and contributes to the scientific validation of traditional medicine practices.
The Local Wisdom of the Acehnese People in Utilizing for Malaria and Asthma Treatment: Kearifan Lokal Masyarakat Suku Aceh dalam Pemanfaatan Tumbuhan Obat Untuk Malaria dan Asma Rahmah, Eka Nur; Pratama, Al Sira Salsa Madia; Ananda, Aulia; Sholelah, Annisa Mar'atus; Natasyah, Nanda Edlan Putri; Ahmad, Islamudin
Jurnal Riseta Soshum Vol. 3 No. 1 (2026): J Riseta Soshum
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/jrs.v3i1.23

Abstract

Background: Malaria and asthma remain significant health challenges in Aceh, particularly in rural areas with limited access to modern healthcare. Objective: This study aims to identify and analyze traditional medicinal plants used by the Acehnese people in the treatment of malaria and asthma, focusing on plant parts, preparation methods, and ethnopharmacological relevance. Methods: A narrative review was conducted using primary literature published between 2017 and 2025, retrieved from Google Scholar. Sources were selected based on relevance, completeness, and credibility, and analyzed to identify usage patterns and cultural practices. Results: The findings indicate that Zingiber officinale (ginger) is the most frequently used plant (25%), followed by Piper betle (betel leaf), Acorus calamus (sweet flag), and Psidium guajava (guava). Rhizomes and leaves are the dominant plant parts utilized (40% each), with boiling as the most common preparation method (50%). These practices reflect the community’s local wisdom and empirical knowledge of bioactive compounds. Conclusion: The Acehnese people’s ethnomedicinal practices demonstrate strong potential for the development of standardized herbal medicines. Preserving and documenting local knowledge, while integrating it with modern pharmaceutical approaches, is essential to strengthen culturally rooted and sustainable healthcare systems.
Co-Authors Afpriana, Mia Agus Setiawaty Ahmad Jailani, Ahmad Ahmad, Andi Akbar, Heldi Fadillah Al Farisy, Hanif Al Pajar, M. Martin Almeida, Maria Alza, Muhammad Gibran Ananda, Aulia Andi Tenri Kawareng Andika, Arya Bhima Apriliana, Lika Arifian, Hanggara Arifuddin, M Arifuddin, Muhammad Arsya, Dinara Eza Syahadati Ashari, Zahra Nabila Putri Asia, Nazha Delmora Asriani Aurelia, Aisha Ayu, Welinda Dyah Azizah, Wilda Azmi, Fatur Rahman Badawi, Satriani Baso Didik Hikmawan Bone, Mahfuzun Brigita, Vista Bujang, Kopli Candrakanti, Bratandari Hana Damayanti, Nina Emilia, Rina Erwin Samsul Esti Handayani Farah, Harra Ismi Farrah, Harra Ismi Fatimah, Sindi Febrina, Lizma Filicia, Harfenas Althea Galih Rahmadana, Adly Hairunnisa Harianti, Chita Hasanah, Auliatul Herman Herman Ibrahim, Arsyik Idris, Viviana Ilmi, Muhammad Fachrul Iswahyudi ISWAHYUDI ISWAHYUDI Jofachri, Muhammad Joshevine, Imelda Junaidin, Junaidin khusnul khotimah Krishna Purnawan Candra Laksono, Ailsa Purwabhagawanta Saskirana Laode Rijai Lestari, Seftya Ayu Lizma Febrina M. Arifuddin M. Arifuddin, M. Mahmudah, Febrina Malindo, Andi Muhammad Alfian MASRUHIM, MUHAMMAD AMIR Masyhudi Masyhudi, Masyhudi Maulana, Abdul Razak Maulidha, Faizatun Mohd Azlan Nafiah, Mohd Azlan Muhammad Faisal Mulyana Mulyana Mus, Nurul Muhlisa Nabila, Nur Qurratul Nadirah Natasyah, Nanda Edlan Putri Nayaputri, Devina Yasintha Nikmah, Nur Rahmi Niatun Nirmala, Amanda Novarossi, Gusti Dimas Novermawati Nur, Yuspian Nurul Hasanah Pasaribu, Handayani Permana, Mutia Ramadhani Rose Prabowo, Wisnu Cahyo Pramana, Muhammad Yoga Adhi Pratama, Al Sira Salsa Madia Pratiwi Putri, Bella Prayogi, Wahyu Tri Puspita, Esmeralda Dwi Puspitawati, Ni Komang Anika Putri Sulistian, Salwah Rabbani, Najwa Jembar Aulya Rahmadani, Dessi Rahmah, Eka Nur Rahman, Dela Juliarsih Rahman, Rifka Arnita Ridhotulloh, Yusuf Isro Rija'i, Hifdzur Rashif Rijai, Hifdzur Rashif Rija’i, Hifdzur Rashif Riki RIKI RIKI, RIKI Rinaldy, Tyara Annisa Rolan Rusli Rusman, Arman Sabila, Arina Hasya Safitri, Hersa Salam, Supriatno Saputra, Rio Rizky Sari, Indah Dewi Sari, Karin Sopiya Sholelah, Annisa Mar'atus Simatupang, Devona Valerie Siswahyudianto Sulistyarini, Riski Supriatno Syamsiar, Syamsiar Tinambungan, Wirawati Wardhana, Nicko WISNU PRABOWO Yani, Naufal Vigar Yanti, Resti Safitri Yazid, Muhammad Ilfan Yusniah, Andi Zahra, Khansa Aprillia Zahrah, Nabila