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All Journal VALENSI Nexus Kedokteran Komunitas WARTA The Indonesian Journal of Public Health Jurnal Gizi dan Kesehatan GIZI INDONESIA INDONESIAN JOURNAL OF APPLIED PHYSICS AcTion: Aceh Nutrition Journal Jurnal Gizi Klinik Indonesia Sebatik Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Jurnal Aisyah : Jurnal Ilmu Kesehatan Nusantara Science and Technology Proceedings Jurnal Dharma Bhakti Ekuitas Narra J Jurnal Jaminan Kesehatan Nasional JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Smart Society Empowerment Journal Gema Lingkungan Kesehatan Plexus Medical Journal FISIO MU: Physiotherapy Evidences Media Penelitian dan Pengembangan Kesehatan
Tonang Dwi Ardyanto
Departement Of Clinical Pathology, Faculty Of Medicine, Sebelas Maret University, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Search for SARS-CoV-2 Inhibitors. Is it still needed?Molecular Docking Study of Teicoplanin Derivatives and Vancomycin against SARS-CoV-2 Mpro Mulyani, Sri; Lestari, Nova Dwi; Samodra, Imam; Wibowo, Fajar Rakhman; VH, Elfi Susanti; Ardyanto, Tonang Dwi
Jurnal Kimia Valensi Jurnal Kimia VALENSI, Volume 11, No. 1, May 2025
Publisher : Department of Chemistry, Faculty of Science and Technology Syarif Hidayatullah Jakarta State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v11i1.44709

Abstract

Coronaviruses have been known since 2002 in the case of SARS (Severe Acute Respiratory Syndrome). SARS-CoV-2, the cause of the COVID-19 pandemic, is believed to be an evolution of the SARS-causing coronavirus (SARS-CoV). This evolution shows the complex interaction dynamics between the virus and the host, which have characterized the emergence of new SARS-CoV-2 strain variations until now. Therefore, the search for these antiviral drugs is still critical. MPro is one of the important proteins for the life cycle of pathogenic coronaviruses, so it is an attractive target for developing drugs that inhibit this virus. This study examined the interaction of teicoplanin derivatives and vancomycin as SARS-CoV-2 MPro (6LU7) inhibitors through molecular docking with Autodock Vina. The smallest RMSD value was selected and stored to calculate the energy value. The image of atoms in the ligand and receptor was processed with Autodock Tools, LigPlus, and PyMOL. The study showed that teicoplanin derivatives such as teicoplanin aglycone, teicoplanin-A3-1, and vancomycin had the potential as SARS-CoV-2 Mpro inhibitors. Based on the interaction at the active site and the obtained ΔG values, even the teicoplanin aglycon had a more significant inhibitory potential than other potent inhibitors such as N3.
THE BENEFICIAL EFFECT OF Moringa Oleifera LEAVES ON HEMOGLOBIN LEVELS IN PREGNANT WOMEN WITH ANEMIA: A SYSTEMATIC REVIEW Badri, Baarizah Febriana; Indarto, Dono; Ardyanto, Tonang Dwi; Avelia, Annisa
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 9, No 1 (2024): March 2024
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30604/jika.v9i1.2650

Abstract

Anemia is a serious maternal health problem that can result in long-term negative impacts such as preeclampsia, hemorrhage before and after delivery, stunting, reduced baby immunity, fetal retardation growth, and fetal death. Moringa oleifera is a miracle plant that has been used for anemia treatment. This study aimed to analyze systematically the effect of M. oleifera leaves on hemoglobin levels and dietary intake of iron and zinc in pregnant women with anemia. Our study used the Cochrane tool to select all randomized control trial (RCT) articles and met the requirements of the PRISMA diagram, filtered using some keywords: pregnant women, anemia, M.oleifera powder, and Fe supplements. The selected articles were further screened using the Population, Intervention, Comparator, Outcomes, and Study Type (PICOS) protocol and assessed for their quality using the Cochrane tool bias risks. Five full-text articles used M.oleifera leaves for anemia treatment in women with their first and or third trimester pregnancies. However, increased Hb levels in pregnant women who consumed 100g of fresh M.oleifera leaves with iron supplementation were higher than that of pregnant women who consumed M oleifera powder and extract. In addition, only one full-text article reported dietary intake of Fe and Zn as secondary outcomes after treating M. oleifera leaves. In conclusion, the administration of M. oleifera leaves has a minor effect on Hb levels and no effect on dietary intake of Fe and Zn in pregnant women with anemia.
Hubungan Status Gizi dengan Kebugaran Jasmani Atlet Taekwondo Remaja Istiqomah, Isnanda Putri Nur; Kristiyanto, Agus; Ardyanto, Tonang Dwi
FISIO MU: Physiotherapy Evidences Vol.3,No.1 Januari 2022
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/fisiomu.v3i2.4996

Abstract

Penelitian ini bertujuan untuk menganalisis hubungan antara status gizi dengan kebugaran jasmani atlet taekwondo remaja. Metode penelitian ini menggunakan desain cross sectional dengan jumlah sampel sebanyak 30 atlet taekwondo remaja, sampel diambil menggunakan metode secara acak sederhana yaitu simple random sampling. Pengumpulan data meliputi status gizi dengan cara pengambilan data antropometri berat badan dan tinggi badan, kebugaran jasmani dengan menggunakan tes lari MFT (multistage fitness). Analisis yang digunakan adalah analisis univariat dan bivariat menggunakan uji korelasi pearson product moment. Hasil penelitian menunjukkan terdapat hubungan antara status gizi dengan kebugaran jasmani (p= 0,028). Nilai R sebesar -0,401 menunjukkan kekuatan hubungan yang sedang, nilai negatif menunjukkan hubungan yang terbalik pada variabel. Status gizi lebih maka kebugaran jasmani menurun. status gizi berhubungan dengan kebugaran jasmani. Atlet yang memiliki status gizi yang baik cenderung memiliki kebugaran jasmani yang baik pula. Perlu dilakukan penambahan informasi terkait gizi pada atlet sehingga terciptanya status gizi baik serta kebugaran jasmani yang baik pada atlet.
DURIAN SEED EXTRACT AMELIORATES LIPID PROFILES IN METABOLIC SYNDROME MODEL RATS Rusliana, Eka; Nurwati, Ida; Ardyanto, Tonang Dwi
Media Penelitian dan Pengembangan Kesehatan Vol. 35 No. 1 (2025): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v35i1.2393

Abstract

Sindrom metabolik merupakan sekumpulan kelainan metabolik yang kompleks dan berkaitan dengan terjadinya dislipidemia yang ditandai dengan adanya perubahan profil lipid yang abnormal meliputi peningkatan kadar trigliserida, kadar low-density lipoprotein (LDL) dan rendahnya kadar high-density lipoprotein (HDL). Ekstrak biji durian mengandung senyawa flavonoid, alkaloid, fenolik dan triterpenoid yang berpotensi dalam memperbaiki profil lipid. Penelitian ini bertujuan untuk mengamati ekstrak biji durian dalam perbaikan profil lipid. Penelitian ini merupakan eksperimental laboratorium desain pretest-posttest dengan kelompok kontrol. Sebanyak 30 ekor tikus jantan galur Wistar usia 8 minggu, berat 150-200 g dibagi menjadi 6 kelompok. Kelompok kontrol normal (NG) yaitu tikus yang diberi pakan standar, sedangkan 5 kelompok ainnya dibuat model sindrom metabolik dengan diberi diet High Fat High Fructose (HFHFr) 14 hari dan induksi  Streptozotocin (STZ)-Nicotinamide (NA), meliputi kelompok kontrol negatif (NC), yang diberi aquades, dan kelompok kontrol positif (PC), yang diberi simvastatin 0,9 mg/kgBB. Kelompok perlakuan yaitu kelompok perlakuan 1 (TG1), kelompok perlakuan 2 (TG2), dan kelompo perlakuan 3 (TG3), diberikan ekstrak biji durian dosis 100, 200, dan 300 mg/kgBB selama 21 hari. Data dianalisis menggunakan Paired T-test dan One-way ANOVA, dengan signifikansi p<0,05. Hasil menunjukkan setelah 21 hari pemberian ekstrak biji durian terjadi penurunan kadar trigliserida dan LDL serta peningkatan kadar HDL yang signifikan (p<0,05), yang mana perubahan terbesar terjadi pada kelompok dosis 300 mg/kgBB dengan trigliserida sebesar -38,24 ± 6,45 mg/dl, LDL -45,67 ± 2,71 mg/dl dan HDL 54,22 ± 2,72 mg/dl. Pemberian ekstrak biji durian dapat memperbaiki profil lipid pada sindrom metabolik dengan dosis terbaik yaitu 300 mg/kgBB.
Co-Authors Adang Muhammad Gugun, Adang Muhammad Adji Suwandono Adji Suwandono Agung Susanto Agus Kristiyanto Agus Kristiyanto Agus Sholikin Agus Sholikin Agus, Telly P. Ambar Mudigdo Amilia Yuni Damayanti Amin Subandrio, Amin Andikashwari, Sekarnira Andri Haryanto Anik Lestari Anwar, Fuad Aprilningsih, Hendrastutik Apriningsih, Apriningsih Apriningsih Apriningsih, Hendrastutik Ari Natalia Probandari Ari Probandari Artika Ramadhani Astri Tantri Indriani Astri Tantri Indriani Astri Tantri Indriani Avelia, Annisa Ayunda Oktavia Badri, Baarizah Febriana Benyamin Saut Berty Denny Hermawati Betty Suryawati Bismantara, Haryo Brian Wasita Brian Wasita Cari Cari Citra Jaya Dedy Revelino Delta Nur Septianingsih Deviro Deviro Dewi, Herlina K. Dian Ariningrum Donald Pardede Dono Indarto Dono Indarto Dyanneza, Frieska Elfi Susanti V. H. Ema Nur Fitriana Endang Suparniati Erzan Dhanalvin Eti Poncorini Pamungkasari Fajar Rakhman Wibowo Firdaus Hafidz As Shidieq Firdaus, Nais Volum Florentinus Nurtitus Frieska Dyanneza Frieska Dyanneza Frieska Dyanneza Gautama, Coana S. Gilbert Renardi Kusila Hendrastutik Apriningsih Hendrastutik Apriningsih Hendrastutik Apriningsih Hendrastutik Apriningsih Hermawati, Berty D. Hidayat, Syamsu Ida Nurwati Ika Mukti Virgiyanti Ika Mukti Virgiyanti Indriani, Astri Tantri Iskandar, Kasir Isnanda Putri Nur Istiqomah Istiqomah, Isnanda Putri Nur Khariri Khariri Kuncorowati, Niken Dwi Aryani Kuncorowati, Niken Dyah Aryani Kurniawati, Golda Laily Shofiyah Laily Shofiyah Lestari, Nova Dwi Maria Galuh Kamenyangan Maria Galuh Kamenyangan Sari, Maria Galuh Kamenyangan Maria Sekar Cahyaningrum Moh Fanani Mohtar Yunianto Muchtar Hanafi Muttaqien Muttaqien, Muttaqien Myrtha, Risalina Niken Dwi Aryani Kuncorowati Niken Dyah Aryani Kuncorowati Niken Dyah Aryani Kuncorowati Nisri Ina Zahrah Novianto Adi Nugroho Nugroho, Novianto Adi Nur Hafidha Hikmayani Nurhasan Agung Prabowo Prabowo, Nurhasan A. Prabowo, Nurhasan Agung Putranto, Wachid Putri, Desy P. Qadrijati, Isna Ragil Rahma Nafila Ratih Tri Amelia Resta Farits Pradana Reviono Rini Astuti Risalina Myrtha Risalina Myrtha Rizky Amalia Puspitaningrum Rusliana, Eka Samodra, Imam Shofiyah, Laily Soeparmi Soeparmi Soetrisno Soetrisno Sri Indratni Sri Indratni Sri Mulyani Sugiarto S Tahono Tahono Tsalatshita, Risky Wan Aisyiah Baros Widana Primaningtyas Wulandari, Evi L. Yeni Farida Yulia Sari Yulita Hendrartini