General Background: The integration of technology in elementary education remains uneven, particularly in fostering higher-order thinking skills. Specific Background: At SDN Cimahpar 1 in Bogor City, fifth-grade students exhibited low critical thinking performance, with learning media not fully leveraging digital interactivity. Knowledge Gap: While digital tools like Nearpod offer promising potential, empirical evidence on their efficacy in elementary science education, especially on topics like the human respiratory system, is limited. Aims: This study aimed to develop and validate an interactive multimedia product based on Nearpod to enhance critical thinking skills in science. Results: Employing the ADDIE model within a Research and Development (R&D) framework, the media was tested on 28 students through a one-group pretest-posttest design. Validation scores from media, content, and language experts ranged from 82.86% to 95.71% ("very suitable"). The N-gain score of 0.7115 indicated a high improvement in critical thinking. Student and teacher responses were also positive (89% and 95%, respectively). Novelty: This study is among the first to adapt Nearpod multimedia specifically for elementary-level science on human physiology in Indonesia. Implications: The findings affirm the practicality and effectiveness of Nearpod-based multimedia in enhancing critical thinking, suggesting scalable applications for broader elementary science curricula. Highlights: Enhances critical thinking through digital interactivity. Validated by experts with high suitability ratings. Proven effective with strong student and teacher responses. Keywords: Critical Thinking, Interactive Multimedia, Nearpod, Elementary Science, ADDIE Model