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All Journal Jurnal Kedokteran Brawijaya Majalah Kedokteran Bandung Biogenesis: Jurnal Ilmiah Biologi Global Medical and Health Communication Insisiva Dental Journal : Majalah Kedokteran Gigi Insisiva Berkala Kedokteran Universa Medicina Medical Laboratory Technology Journal Journal Of Vocational Health Studies JURNAL PENDIDIKAN JASMANI DAN OLAHRAGA Smart Medical Journal Jurnal Pengabdian Pada Masyarakat Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan Jurnal Kesehatan INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Indonesian Journal of Global Health research JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Mandala of Health : A Scientific Journal Jurnal Pengabdian Pada Masyarakat Medical and Health Journal Jurnal Tumbuhan Obat Indonesia Linggamas: Jurnal Pengabdian Masyarakat
Fitranto Arjadi
Universitas Jenderal Soedirman Purwokerto
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Journal : Jurnal Kedokteran Brawijaya

 1 
Endothelial Nitric Oxide Synthase 3 (eNOS3) Gene Polymorphisms and Essential Hypertension in Javanese Ethnic Group Arjadi, Fitranto; Aziz, Saefuddin; Muntafiah, Alfi
Jurnal Kedokteran Brawijaya Vol 28, No 3 (2015)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (466.205 KB) | DOI: 10.21776/ub.jkb.2015.028.03.4

Abstract

Hypertension is still a major public health problem in Indonesia and in several other countries. This disease is caused by multi factorial components involving both environmental and genetic factors. eNOS3 gene is one of the enzymes related to the high prevalence of hypertension. This gene expresses the NOS enzyme which regulates the synthesis of NO. NOS enzyme causes vasodilatation which decreases peripheral resistance and lowers blood pressure. This cross sectional study compared hypertension patients to those with normal blood pressure in the age group of 40-80 years old. The main purpose of this study is to evaluate the influence of eNOS3 gene Glu298Asp allele expression in Javanese ethnic group patients with hypertension. The samples consist of 50 respondents with hypertension and 50 respondents with normotension as control. Data of eNOS3 gene polymorphisms and NO plasma levels from the respondents were analyzed using t-test and chi-square test. Glu298Asp allele genotype variation in eNOS3 gene was detected by PCR-FRLP using primers G894TF and G894TR and the PCR products were cut using Mbol restriction enzymes. Sequencing result of each polymorphism band shows a typical nucleotide sequence compared to the nucleotide sequence of eNOS3 gene in Gen Bank. The results of this study showed no connection between Glu298Asp allele polymorphism in eNOS3 gene with hypertension in Javanese. There was also no relation between eNOS3 gene polymorphisms with high levels of respondents' NO plasma. Average NO plasma level of hypertension patients is 34,53 µmol/L, whereas average NO level of normal blood pressure is 32,5 µmol/L.Keywords: Allele Glu298Asp, eNOS3 gene, G894T, hypertension, Javanese ethnic, NO plasma level 
Combination of Vitamin C and E Improves Spermatogenesis of White Male Rat Model of Paradoxical Sleep Deprivation Stress Fitranto Arjadi; Mustofa Mustofa; Yudhi Wibowo; Nur Signa Aini Gumilas; Dzicky Rifqi Fuadi
Jurnal Kedokteran Brawijaya Vol. 32 No. 1 (2022)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2022.032.01.2

Abstract

Paradoxical Sleep Deprivation (PSD) elevates glucocorticoid and Reactive Oxygen Species (ROS) levels that cause oxidative stress, trigger spermatogenic cells damage, and reduce the number of sertoli cells. Vitamin C and E are antioxidants that could prevent spermatogenesis damage by preventing free radical formation. The study aimed to determine the effect of single and combined doses of vitamin C and E in improving spermatogenesis of white male rats (Rattus norvegicus) model of PSD. This is experimental research with post-test only and control group design on 28 white male rats distributed into four groups, i.e. group I (control, PSD), group II (PSD+vitamin C), group III (PSD+vitamin E), and group IV (PSD+a combination of vitamin C and E). Testicular preparations were stained using Hematoxylin-Eosin staining, quantitative scores of spermatogenic cells were measured using the Johnsen method, and the number of sertoli cells was counted in 10 seminiferous tubules in each of the three testicular sections. Group I has the lowest mean of Johnsen score (5.27±0.28), and group IV has the highest mean score (8.95±0.62), while the Mann-Whitney test showed a significant difference (p<0.05) between group II, III and IV compared to group I (control group). Mean sertoli cells number of group I is the lowest (10.66±1.04), and group IV has the highest sertoli cells number. The post-hoc LSD test showed a significant difference (p<0.05) between group IV and the other groups. Thus, the combination of vitamins C and E improves Johnsen score and sertoli cells number of male rats (Rattus norvegicus) experiencing PSD.
Co-Authors . HERNAYANTI Agatri, Norina Ahmad, Faiq Alaika Ailsa, Shafa Alfi Muntafiah Amilia Ramadhani Aminuyati Andromeda Andromeda Christiana Cahyani Prihastuti Denok Tri Hardiningsih Diah Krisnansari Dian Rosdiana, Dian Dinar Faiza Dita Ayu Dewi Laras Sati Diyah Woro Dwi Lestari Dody Novrial Dody Novrial, Dody Dzicky Rifqi Fuadi Edy Priyanto Edy Priyanto Fani Tuti Handayani, Fani Tuti Fidnillah, Diva Azka Fitri Diah Oktadewi Fuady, Dzicky Rifqi Ghazali, Muhammad Farid Ginus Partadireja Hajid Rahmadianto Harini, Ika Murti Haris Budi Widodo Hernayanti Hernayanti Hidi, Aulli Rahman Ika Murti Harini Joko Mulyanto, Joko Joko Setyono Kasum, Kasum Khusnul Muflikhah Kuncoro, Prasetyo Tri Lantip Rujito Lientje Setyawan Maurits Lientje Setyawati Maurits Mae Sri Hartati Wahyuningsih Mahardhika, Gembong Satria Mahindra Awwaludin Romdlon Mas'ud, Ahmad Fawzy Maulida, Adzkia Mubayinul Khoeroh Mulyono Pangestu Mulyono Pangestu Mulyoto Pangestu MULYOTO PANGESTU Mustofa Mustofa Mustofa Mustofa Mustofa Mustofa Naibaho, Debora Paramita Nenden Nursyamsi Agustina Nia Krisniawati Nitiprodjo, Abdul Hakim Nor Sri Inayati, Nor Sri Norina Agatri Norina Agatri Nur Signa Aini Gumilas Pauzi, Rizqi Yanuar Prasetyo Tri Kuncoro Pratama, Radya Putra Pugud Samodro Putri, Prima Maharani Qodri Santosa Rangga Wisnu Wardana Saad, Nursan Saefuddin Aziz Saefuddin Aziz Samodro, Pugud Setiawati Setiawati Setiawati Setiawati Setyanto, Muhamad Rifqi Sindhu Wisesa Sindhu Wisesa Sindhu Wisesa Sirajuddin, Mohammad Salman Slamet Riyanto Soegianto, Jap Yulius Billy Sri Kadarsih Soejono Sri Kadarsih Soejono Susiana Candrawati Thianti Sylviningrum Tuti Sri Suhesti Vitasari Indriani Vitasari Indriani Vitasari Indriani Wahyu Siswandari Wahyu Siswandari Wahyu Siswandari Wahyudin Wahyudin Wahyudin Wahyudin wardana, Tirta Widiartini, Catharina Widyaningsih, Pratiwi Nur Wisesa, Sindhu Yudatmo, Unggul Yudhi Wibowo Yulia Fauziyah Yusan, Rizak Tiara Zhafira, Adistya Hasna