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All Journal E-Jurnal Medika Udayana Bulletin of Electrical Engineering and Informatics Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Urology Jurnal Berkala Epidemiologi Jurnal Biosains Pascasarjana Jurnal NERS Indonesian Journal of Tropical and Infectious Disease Journal of Information Systems Engineering and Business Intelligence Journal of Tropical Biodiversity and Biotechnology Jurnal Kimia Riset The Indonesian Biomedical Journal Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Jurnal Manajemen Kesehatan Yayasan RS.Dr. Soetomo Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Jurnal Samudra Ekonomi dan Bisnis INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Narra J Berkala Ilmiah Kimia Farmasi Hang Tuah Medical Journal International Journal of Economics (IJEC) Jurnal Balireso: Jurnal Pengabdian pada Masyarakat
Aryati Aryati
Dengue Study Group, Institute Of Tropical Disease, Universitas Airlangga, Mulyorejo Street, Mulyorejo 60115, Surabaya, East Java, Indonesia Clinical Pathology Department, Faculty Of Medicine, Universitas Airlangga, Prof.Dr.Moestopo Street, Tambaksari
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Electrical & Electronics Engineering Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Journal : Jurnal NERS

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The Relationship of Ns1 Antigen Profi Le and Days of Illness in Children with Dengue Virus Infection Dwiyanti Puspitasari; Saraswati Dewi; Aryati Aryati
Jurnal Ners Vol. 8 No. 1 (2013): April 2013
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (275.654 KB) | DOI: 10.20473/jn.v8i1.3867

Abstract

Introduction: Dengue NS1 Antigen (NS1 Ag) detection or quantification has become a specific diagnostic tool for dengue virus infection, but has variable sensitivity. Previous research reported NS1 Ag level can be detected up to the 7th–10th day of fever, others stated the sensitivity was decreased after four days of fever. We performed this research to analyze the NS1 Ag profile and its relationship with the day of illness.Methods: This study was a prospective cohort study on 39 children hospitalized at Dr. Soetomo Hospital Surabaya since November 2009 to May 2010. Inclusion criteria were acute fever less than 72 hours, bleeding tendency denoted at least by positive tourniquet test, age between 1–14 years, and confirmed by positive dengue IgM/IgG on the 5th day of fever. We performed daily quantitative dengue NS1 Ag tests until defervescence day, and its relationship with the day of illness were analyzed.Results: NS1 Ag was positive in 19/39 samples. Secondary infection occurred in 14/19 of Dengue Fever and 17/20 of Dengue Hemorrhagic Fever cases. Positivity of NS1Ag was higher in primary (6/8 cases) than secondary infection (12/31 cases). Mean level of NS1 Ag was highest on the 2nd day, decreased afterwards and undetected on the 5th day of fever. There was significant relationship between NS1 Ag positivity (P=0.037, rs=-0.9) and level (P<0.001, rs=-1) with the day of illness.Conclusion: Dengue NS1 Ag positivity and level were highest during the acute phase of fever and decreased afterwards.The Relationship of Ns1 Antigen Profi Le and Days of Illness in Children with Dengue Virus Infection
Co-Authors Agus Santosa Agus Sulistyono Agustin Iskandar Aksono HP., Eduardus Bimo Alida Roswita Harahap Anak Agung Wiradewi Lestari Andina Putri Aulia Andyanita Hanif Hermawati Anniwati, Leonita Aprilia, Andrea AR, M. Yazid Ariani, Grace Arifoel Hajat Bastiana Bastiana Budi Utomo Cavalier, Etienne Darto Saharso Desak Gde Ushadi Bulan Dewata Dewi Wulandari Djoko Santoso Doddy M. Soebadi Dominicus Husada Dwiyanti Puspitasari, Dwiyanti Eko Sulistijono Erawati Erawati Erni Juwita Nelwan, Erni Juwita Erwin Astha Triyono Fahimah Martak Ferdy Royland Marpaung Gondo Mastutik Handayani, Cut Fitri Harianto Notopuro Harsasi Setyawati Haryanto, Isnaeni Yudi Hebert Adrianto Heny Arwati Herdiman Theodorus Pohan Hermawati, Andayanita Hanif Hermina Novida, Hermina I A Putri Wirawati I Dewa Gede Ugrasena Ilham Harlan Amarullah Indah Susanti Iris Rengganis Isnaeni Isnaeni Yudi Haryanto Isnin Anang Marhana Jusak Nugraha Kris Cahyo Mulyatno, Kris Cahyo Kuntaman Kuntaman Kusmiati, Tutik Kusumastuti, Etty H. Laksita, Tetuka B. Lulut Kusumawati Lumban Toruan, Anggia Augustasia M. Andriady S. Nasution Maharani, Anisa Mardiyah, Nikmatul Margalin, Brilliant Marpaung, Ferdy Royland Masanori Kameoka, Masanori Masyeni, Sri Ma`ruf, Anwar Merylin Ranoko Mohammad Guritno Suryokusumo Mufasirin Muhammad Nazarudin Muhammad Rivai Mustika Amri Nabil Salim Ambar Nia Saurina Niluh Suwasanti Norwahyuni, Yuyun Nunki, Nastasya Nur Chamidah Nurdianto, Arif Rahman Patria Dewi, Pande Putu Ayu Perbowo, Primandono Pranidya, Nada Putri Purnomo, Windu Puspa Wardhani R Raharjo, Paulus R. Tedjo Sasmono Rahmawati, Lita Diah Retno Palupi Riries Rulaningtyas Rizaliansyah, Ferdian Rizqidhana Juliana Putri Rony, Zahara Tussoleha Royland Marpaung, Ferdy Rusli, Musofa Saptawati Bardosono Saraswati Dewi Sari, Arabella Vonia Sasmono, R. Tedjo Serlin serang Setianingsih, Yennie A. Shifa Fauziyah Shuhai Ueda Siti Churrotin, Siti Soegeng Soegijanto Sofro, Muchlis AU Sri Subekti Sri Sumarsih Suci Andriani Suhendro Suhendro SUKACITA TEHUPURING Sunari, I Gusti Agung Ayu Eka Putri Sunaryo Hardjowijoto Suprapto Maat Syamsu Nujum Teguh Hari Sucipto, Teguh Hari Theresia Indah Budhy Sulisetyawati Thomas Tandi Manu Tjokroprawiro, Brahmana A. Tomohiro Kotaki, Tomohiro Trieva Verawaty Butarbutar Ueda, Shuhai Usman Hadi wahjoe djatisoesanto Wardhani, Puspa Wibrianto, Aswandi Widajati, Rahma Widodo J Pujiraharjo Yetti Hernaningsih Yohan, Benediktus Yovilianda Maulitiva Untoro Yulia Iriani, Yulia Yulia Nadar Indrasari Yuliasih