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In Vivo Test of Combined Leaf Extracts of Tea Mistletoe and Mango Mistletoe on Hepatic TNF-alpha Levels in Wistar Rats Nur Aziza; Nour Athiroh Abdoes Sjakoer; Ari Hayati
Biology, Medicine, & Natural Product Chemistry Vol 15, No 1 (2026)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2026.151.1677-1682

Abstract

Tea mistletoe (Scurrula atropurpurea) and mango mistletoe (Dendrophthoe pentandra) are known to contain bioactive compounds with potential anti-inflammatory activity. Tumor Necrosis Factor Alpha (TNF-alpha) is a key proinflammatory cytokine whose hepatic expression can be elevated by a high-fat diet. This study aimed to investigate the effect of combined extracts of tea mistletoe and mango mistletoe and determine the most effective dose in reducing hepatic TNF-alpha levels in Wistar rats induced by a high-fat diet. An in vivo experimental design was employed using 35 male Wistar rats, randomly divided into five groups: negative control, positive control (high-fat diet), and three treatment groups receiving combined extracts at doses of 50, 100, and 200 mg/kg body weight for 37 days. Hepatic TNF-alpha levels were quantified using ELISA. The results showed that the combination of tea mistletoe and mango mistletoe extracts significantly reduced TNF-alpha levels in the liver of Wistar rats fed a high-fat diet. Among the tested doses, 200 mg/kg body weight demonstrated the greatest reduction compared to lower doses. In conclusion, the combined extracts exhibit promising anti-inflammatory effects by lowering hepatic TNF-alpha levels, with 200 mg/kg body weight identified as the most effective dose under the conditions of this study.
Co-Authors Abdur Rohman Wahid Ahmad Baidarus Ahmad Taufiq Aisyah Aisyah Aldina, Devana Rahma Andini, Saskia Ade Hutami Fery Anita Puspa Widiyana Anna Fathiah Annisatul Hakimah Ar Rahmah, Mumtazunnisa As Sufiyah Argus Argus Argus Mahyan Ari Hayati Ari Hayati Arina Roikhana Ariski Vevi Liswandari Ayu Pertiwi, Chintya Baidarus, Ahmad Dea Fatimatu Zahroh Devi Qurroti A'yun Dewi Qurrot 'Aini Dewi Qurrot 'Aini Doti Wahyuningsih Durrotul Hasanah Dwi Kartika Wati Dwi Mareta Nur hidayati Dyan Aprillia Susanti Eka Kumalasari Eko Noerhayati Erna Sulistyowati Erna Susanti fahmiy, Rakhmawati Faisal Faisal Faisal Faisal Fajrin, Siti Awaliah Fatimah Abdul Sammad Fatimah Fatimah fatimah Fatimah Fatur rohman Rohman Forrela Zahwa Salamah Gatra Ervi Jayanti Gemilang, Satria Hari Santoso Hari Santoso Hari Santoso hari santoso Hari Santoso Hari Santoso Hasan Zayadi Hatif Khusnin Nida' Herlinda Rahayu Husain Latuconsina Husain Latucosina Husain, Muhammad Hafizh Istirochah Pujiwati Jadid Mubarakati, Nurul Jihan Farah Zakia Kammal Nizam Amrullah Laili Mihmidati Lestari, Tengku Anggun Luluk Rofiatul Mafluhah M. Abdul Qodir Jailani M. Mas’ud Said Ma'ruf, Muhammad Mahanem Mat Noor, Mahanem Mat Mahyantika, Seftya Putri Maidhatul Rosidha Widyanti Malia Anjani Mardhiyah, Mardhiyah Masyhuri Masyhuri Mihmidati, Laili Mohammad Mabrur Mubarokati, Nurul Jadid Muhammad Fahmi Hidayatullah Nafisa Nafisa Nafisa, Nafisa Nia Novita Nurrohmah Nirwana, Linggar Nur Aziza Nur hidayati, Dwi Mareta Nur Mufida Nur Permatasari Nur Shofiyah Munawaroh Nur Shofiyah Munawaroh, Nur Shofiyah Nurrohmah, Nia Novita Nurul Jadid Mubarakati Nurul Jadid Mubarakati Nurul Jadid Mubarakati Nurul Jadid Mubarokati Oktaviana, Nimas Ajeng Putri Maharani Aulia Rakhman Rahayu Dwi Lestari Rahmawati, Rizka Dwi Rakhmawati fahmiy Ramadhan, Majida Ramadhani, Mieta Widya Ratna Djuniwati Lisminingsih Ratna Juniwati Lisminingsih Rianda Siwi Cholida Rizki Kusuma Hantika Saimul Laili Salamah, Forrela Zahwa Salsabilatul Mukarommah Saputri, Syntia Diyah Hayu Ria Savana, Amartya Gesit Shinta mayangsari Sholikha alaiya Sholikha alaiya, Sholikha Silfi hamidatul lailiyah Silvia, Putri Azizatul Siti Asmaniyah Mardiayani Siti Awaliah Fajrin Siti Imama Khoiriyah Siti Qurrotul Aini Suroyya, Mariyam Susanti, Dyan Aprillia Tania Putri Nur Yasinta Tengku Anggun Lestari Umu Intan Kinasih Uyunul Hikmah Wahidah, Shinta Nuriyah Yudi Purnomo Zahroh, Dea Fatimatu Zakia, Jihan Farah