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Dekokta Scurulla atropurpurea Terhadap Kelengkungan Tulang Belakang Embrio Ikan Zebra Nour Athiroh
Biota Vol 11 No 1 (2018)
Publisher : Universitas Islam Negeri Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (991.695 KB) | DOI: 10.20414/jb.v11i1.82

Abstract

Toxicity study on herb Scurulla atropurpurea has done by using Zebra fish (Danio rerio) embryo. The objective of this research is to study the effect of decocta of parasitic tea leaves on theraphy dosage, MATC, and LC50 to the backbones of Zebra fish embryo. This research is done by laboratory experiment method through in vitro by using research design post randomized control group only. The animal used in this research is Zebra fish embryo less than 3 hours post fertilization after fission process is finished and embryo is entering blastula stage. Total number of sample is 80 embryo and divided into 4 groups: control group without treatment, therapy dosage group (200ug/ml), LC50 group (2066ug/ml) and MATC group (237ug/ml) by decocta of parasitic tea leaves. Sample of Zebra fish embryo is putting in well-plate with 1 embryo per well. Treatment was given untill embryo at 72hpf at temperature 270 C. Data taken during study is analysed using one way ANOVA by SPSS version 16. Treatment with therapy dosage 200, MATC 237 and LC50 of decocta of parasitic tea leaves do not cause curvature of backbone in Zebra fish embrio. It is suspected that active compound in decocta of parasitic tea leaves at all above dosage do not able to disturb the structure and function of backbone.
The portrait of neem leaves-based high performance wound healing activity on zebrafish Nour Athiroh; Ari Hayati; Istirochah Pudjiwati; Ahmad Taufiq; Nurul Jadid Mubarakati
JURNAL PENELITIAN BIOLOGI BERKALA PENELITIAN HAYATI Vol 27 No 1 (2021): December 2021
Publisher : The East Java Biological Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23869/bphjbr.27.1.20214

Abstract

This study was designed to evaluate the role of sliced and dropping models of neem leaves (Azadirachta indica) and environmental factors on zebrafish wound shrinkage. This study employed two treatment models: neem leaf slices and drops model. The treatment in the neem leaf slice model was the control group (fish was injured without neem leaf slices treatment, and G1-G3 of each fish was injured at 0.3 cm + 0.5, 1, and 2 g. Treatment in the neem leaf drop model was control group (fish was injured without neem leaves drops, and G1-G3 of each fish was injured at 0.3 cm + 1, 2, 4 drops. Findings suggest that there is a significant difference between the control group by treating G1, G2, and G3 on the shrinkage of zebrafish wound area both in the neem leaf slice and drop models, but G1 was not significantly different from G2 and G3, as well as G2 and G3 both in the neem leaf slice and drop model. Neem leaves contain nutrients that play a vital role in the formation of collagen and the formation of new capillaries to help speed up the wound healing process. The healing process involves the dynamic interaction of physiological factors.
Gambaran Karakteristik Penderita HIV/AIDS di Kabupaten Sumenep Tahun 2018-2019 Luluk Rofiatul Mafluhah; Nour Athiroh Aboes Sjakoer; Ratna Djuniwati Lisminingsih
Jurnal Kesehatan Islam : Islamic Health Journal Vol 10, No 1 (2021): Jurnal Kesehatan Islam : Islamic Health Journal
Publisher : Publikasi oleh Fakultas Kedokteran Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jki.v10i1.9350

Abstract

HIV/AIDS cases have high rates in various countries. The reason is, HIV/AID cases are like an iceberg phenomenon, cases that are not seen and not recorded are more than cases that have been recorded. This study aims to describe the characteristics of HIV/AIDS sufferers in Sumenep District. This study used a descriptive qualitative method with a cross-sectional research design. There were 202 HIV/AIDS sufferers in Sumenep District, while the sample taken was 44 people from 3 Public Health Center. The results showed that based on gender the most were male (57.95%), while the age range was 25-49 years (75.25%), and the area with the most sufferers was Kalianget Sub-District (10.4%) of a total 202 sufferers. Referring to 44 patients who were sampled in this study, there were 39 patients (88.6%) who were married, the most transmission was sex (90.9%), most opportunistic infections were pulmonary tuberculosis (20.4%). Stage I (63.6%) is the most common clinical-stage suffered, and most HIV/AIDS sufferers have been infected for 1-2 years (93.2%). To break the chain of HIV/AIDS transmission, the public needs to be educated, from the mode of transmission to treatment, this also aims to eliminate the negative stigma against people with HIV/AIDS.
Pendampingan Inovasi Olahan Es Krim Jahe-Kencur pada Kelompok Wanita Tani di Mangliawan Malang Nour Athiroh; Nurul Jadid Mubarakati
Journal of Dedicators Community Vol 4, No 2 (2020)
Publisher : Universitas Islam Nahdlatul Ulama Jepara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34001/jdc.v4i2.1107

Abstract

Ginger and galangal powder are less attractive to people in Mangliawan village. The cooperative's ginger powder sales business experienced a setback. The aim is to provide creativity and innovation assistance to this ginger powder as a raw material for ice cream. The phenomenon of this decade appears in various variants of ice cream, but there is no ginger-galangal based ice cream business yet. The service method consists of: 1) program socialization, 2) training in making ice cream, 3) formation of non-governmental organizations as program partners, 4) program monitoring, 5) focus group discussion, f) evaluation. Measurement of the impact of the activity was carried out using a questionnaire technique which aims to obtain a direct picture of the community in Mangliawan village. The results of the service program are 1) the public's knowledge of the potential of kencur ginger and its processing has increased; 2) Partners know how to make kencur ginger ice cream; 3) public knowledge of the benefits of ginger ice cream increases; 4) There is a desire of the respondent to open a ginger-kencur ice cream business plan and increase the economic level.
Paparan benalu (teh dan mangga) terhadap kadar Superoksida Dismutase (SOD) serum tikus hipertensi model preventif Nur Mufida; Nour Athiroh Abdoes Sjakoer; Nurul Jadid Mubarakati
Jurnal Biologi Udayana Vol 26 No 1 (2022): JURNAL BIOLOGI UDAYANA
Publisher : Program Studi Biologi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JBIOUNUD.2022.v26.i01.p06

Abstract

Salah satu penyakit yang menjadi masalah kesehatan karena terjadi peningkatan prevalensi setiap tahunnya adalah penyakit hipertensi. Tingginya ROS (Reactive Oxygen Species) dalam tubuh akan meningkatkan pembentukan radikal bebas berlebih dan membuat antioksidan endogen SOD (Superoxide dismutase) terpakai secara berlebih sehingga menjadi penyebab munculnya penyakit hipertensi. Tanaman herbal benalu teh dan benalu mangga merupakan tumbuhan yang memiliki potensi sebagai pencegahan hipertensi dengan meningkatkan aktivitas SOD dalam tubuh. Tujuan penelitian ini untuk mengetahui pengaruh pemaparan ekstrak metanol kombinasi benalu teh dan benalu mangga (EMKBTBM) terhadap peningkatan kadar SOD serum pada tikus hipertensi yang diinduksi DOCA-Garam menggunakan model preventif. Pada penelitian ini menggunakan metode eksperimental dengan hewan uji berjumlah 25 ekor tikus wistar jantan yang terbagi menjadi 5 kelompok dan terdapat 5 ekor tikus pada setiap kelompok, yaitu kontrol negatif (K-), kontrol positif (K+), dan kelompok dengan perlakuan pemaparan EMKBTBM (P1) dosis 50 mg/kgBB, (P2) dosis 100 mg/kgBB, dan (P3) dosis 200 mg/kgBB. Didapatkan hasil penelitian yang menunjukkan bahwa pemaparan EMKBTBM berpengaruh terhadap peningkatan aktivitas SOD serum pada tikus hipertensi dengan perbedaan yang signifikan pada nilai reratanya antar semua kelompok dengan nilai p <0,05. Efektivitas pengaruh pemaparan benalu teh dan benalu mangga dikendalikan oleh EMKBTBM dosis 100 mg/KgBB yang merupakan dosis efektif dalam meningkatkan kadar SOD serum tikus model hipertensi DOCA-Garam.
Pengaruh ekstrak metanolik kombinasi benalu teh dan benalu mangga terhadap histopatologi hepar tikus model hipertensi (DOCA-Garam) Arina Roikhana; Nour Athiroh Axzbdoes Sjakoer; Nurul Jadid Mubarakati
Jurnal Biologi Udayana Vol 26 No 1 (2022): JURNAL BIOLOGI UDAYANA
Publisher : Program Studi Biologi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JBIOUNUD.2022.v26.i01.p13

Abstract

Hipertensi merupakan salah satu penyakit yang menyebabkan kematian utama pada manusia serta berhubungan dengan penyakit kardiovaskular. Hipertensi dapat merusak organ hepar yang berhubungan dengan Reactive Oxygen Species (ROS). Benalu mangga dan teh bermanfaat sebagai obat herbal untuk menjaga kesehatan tubuh manusia. Penelitian ini bertujuan untuk mengetahui pengaruh ekstrak metanol kombinasi benalu teh dan mangga terhadap histopatologi hepar tikus hipertensi (DOCA-Garam), desain eksperimen yang digunakan yaitu rancangan acak lengkap sebanyak 25 ekor tikus wistar jantan yang dikelompokkan menjadi 5 perlakuan yaitu kontrol (-) = 0 mg/KgBB EMKBTBM, kontrol (+) = 15 mg/KgBB DOCA-Garam, P1, P2, P3 masing- masing 50, 100, 200 mg/KgBB EMKBTBM. Analisis data yang digunakan adalah uji ANOVA two way yaitu JAMOVI dengan versi 1.1.9.0. Hasil penelitian ini menunjukkan bahwa terdapat perbedaan yang sangat nyata (p-value) <0.05 pada zona 1, 2, dan 3 jika dibandingkan dengan semua kelompok perlakuan, dan semua kelompok perlakuan yaitu antara kelompok kontrol (+) dengan kontrol (-), perlakuan 1, 2, dan 3 berbeda nyata terhadap rerata kerusakan sel (piknosis, karioreksis, kariolisis) hepatosit hepar. Dibuktikan dengan hasil analisis yang menyatakan p-value <0.05 yaitu <0.001, sehingga pemberian ekstrak metanol kombinasi benalu teh dan mangga dapat mengurangi nekrosis (piknosis, karioreksis, dan kariolisis) pada hepatosit organ hepar tikus hipertensi.
Gambaran Histopatologi Otak Pada Tikus Hipertensi (DOCA-Garam) yang Dipapar Ekstrak Metanolik Kombinasi Benalu Teh dan Benalu Mangga Model Preventif Dyan Aprillia Susanti; Nour Athiroh Abdoes Sjakoer; Nurul Jadid Mubarokati
Jurnal SAINS ALAMI (Known Nature) Vol 5, No 1 (2022)
Publisher : FMIPA UNISMA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/j.sa.v5i1.15541

Abstract

Hypertension is an increase in blood pressure that exceeds normal limits. In patients with hypertension, systolic blood pressure is 140 mmHg and diastolic blood pressure is 90 mmHg and comes from a complex and interconnected environment. Hypertension is a non-communicable disease that can cause death in humans and is closely related to cardiovascular disease. Hypertension is considered the main cause of 9.4 million deaths that occur in the world's population every year. Disorders of blood vessels around the brain due to hypertension can cause death. The purpose of this study was to determine the effectiveness of the methanolic extract of the combination of Mango Mistletoe and Mistletoe Tea (EMKBTBM) given to rats with hypertension model on the histopathological features of the brain in hypertensive rats (DOCA-salt) preventive model. The method used in this study was the true experimental method and the RAL research design on 25 male wistar rats with 3 treatments (PI, PII, PIII), (K-) group without any treatment (without administration of DOCA Salt and EMKBTBM) and (K+) using DOCA-Salt induction without giving EMKBTBM, and 5 times replication. The EMKBTBM was given with a ratio of mango mistletoe: tea mistletoe which was 3:1 and then given at a dose of 50, 100, 200 mg/KgBB in the treatment of PI, PII, PIII. Data analysis was carried out by using ANOVA statistical test using the JAMOVI application. Based on the results of the study, it was shown that giving EMKBTBM to rats had the effect of reducing the amount of damage (necrosis) in the white matter area of the brain. The administration of EMBTBM at a dose of 50 mg/KgBW was the most optimum dose in reducing the amount of white matter cell necrosis in the male wistar rat brain.Keywords:3 Brain Necrosis, Hypertension, Mango Mistletoe, Tea MistletoeABSTRAKHipertensi merupakan bertambahnya tekanan darah melebihi batas normal. Pada penderita hipertensi, tekanan darah sistolik 140 mmHg dan tekanan darah diastolik  90 mmHg serta berasal dari lingkungan yang kompleks dan saling berhubungan. Hipertensi ialah penyakit tidak menular yang dapat mengakibatkan kematian pada manusia dan berkaitan erat dengan penyakit kardiovaskular. Hipertensi dianggap sebagai sebab utama 9,4 juta kematian yang terjadi pada penduduk dunia pada setiap tahunnya. Gangguan pembuluh darah disekitar otak akibat hipertensi dapat menebabkan kematian. Tujuan dari penelitian ini adalah untuk mengetahui efektivitas Ekstrak Metanolik Kombinasi Benalu Mangga dan Benalu Teh (EMKBTBM) yang diberikan pada tikus model hipertensi terhadap gambaran histopatologi otak pada tikus hipertensi (DOCA-garam) model preventif. Metode yang digunakan dalam penelitian ini menggunakan metode true eksperimental serta desain penelitian RAL pada 25 ekor tikus wistar jantan dengan 3 perlakuan (PI, PII, PIII), (K-) kelompok tanpa perlakuan apapun (tanpa pemberian DOCA Garam dan EMKBTBM) dan (K+) menggunakan induksi DOCA-Garam tanpa pemberian EMKBTBM, serta 5x ulangan. Pemberian EMKBTBM dengan perbandingan benalu mangga : benalu teh yaitu 3:1 kemudian diberikan dengan dosis 50, 100, 200 mg/KgBB pada perlakuan PI, PII, PIII. Analisis data dilakukan dengan uji statistic ANOVA menggunakan aplikasi JAMOVI. Berdasarkan hasil penelitian menunjukkan pemberian EMKBTBM pada tikus mempunyai efek yaitu dapat mengurangi jumlah kerusakan (nekrosis) di area white matter otak. Pemberian EMBTBM dengan dosis 50 mg/KgBB merupakan dosis paling optimum dalam menurunkan jumlah nekrosis sel white matter otak tikus wistar jantan.Kata kunci: Benalu Teh, Benalu Mangga, Hipertensi, Nekrosis Otak
Uji Toksisitas Sub-Kronik 28 Hari Ekstrak Metanolik Daun Benalu Teh Dan Benalu Mangga Terhadap Fungsi Jantung Tikus Wistar Betina M. Abdul Qodir Jailani; Nour Athiroh Abdoes Sjakoer; Nurul Jadid Mubarakati
Jurnal Ilmiah Biosaintropis (Bioscience -Tropic) Vol 8 No 1 (2022): Agustus 2022
Publisher : Fakultas Matematika & Ilmu Pengetahuan Alam - Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (934.045 KB) | DOI: 10.33474/e-jbst.v8i1.364

Abstract

Benchmark damage to heart function lies in LDH, CPK, CK-MB as well as histopathology of heart organs. This study aims to determine the 28-day subchronic toxicity of methanolic extracts of tea parasites and mango parasites (EMBTBM) on the heart function of female Wistar rats by experimental methods. In analyzing the data, one way ANOVA test is used, namely SPSS with version 1.0 1.0. A total of 20 female Wistar rats were used as test animals. Then divided into 4 treatments, namely control, treatment 1 dose 250 mg/KgBW, treatment 2 dose 500 mg/KgBW and treatment 3 dose 1000 mg/KgBW, each containing 5 mice. From the results of the study, it was found that EMBTBM positively contained flavonoids in the form of quercetin and rutin to reduce LDH, CPK, and CK-MB levels in female Wistar rats, and be safe against the histopathology of the heart organs of female Wistar rats.
Histopathological Profile of Therapeutic Doses of Methanolic Extract Combination of Tea and Mango Mistletoes in Cardiac of Preventive Hypertensive Rats (DOCA-salt) Model Durrotul Hasanah; Nour Athiroh Abdoes Sjakoer; Nurul Jadid Mubarakati
JURNAL INDONESIA DARI ILMU LABORATORIUM MEDIS DAN TEKNOLOGI Vol 4 No 2 (2022): Enhanced knowledge of laboratory medicine's role in healthcare
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/ijmlst.v4i2.2693

Abstract

Tea and mango mistletoes have to lower blood pressure by improving oxidative stress and endothelial dysfunction. The flavonoid compounds found in these two mistletoes act as antihypertensives. Hypertension is a risk factors that influences the incidence of cardiac disease. This study examines the histopathological of the cardiac of hypertensive rats (preventive model) after treatment of methanolic extract combination of tea and mango mistletoes. This study used a completely randomized experimental design with 25 Wistar rats in total for five treatments, namely negative control (-), positive control (+), treatment 1 (dose of 50 mg/kg BW), treatment 2 (doses of 100 mg/kg BW), and treatment 3 (doses of 200 mg/kg BW). In this study, Deoxycorticosterone acetate (DOCA) were used to induce hyperttension in experimental animals. Data were analysed with one-way ANOVA test using JAMOVI (version 1.1.9.0) and posteriori. There was a significant difference between all groups (p<0.05). Administration of a methanolic extract combination of tea and mango mistletoes as the preventive model can significantly reduce hypertrophy of cardiac muscle cells. This effect occured with a dose of 50 mg/kg BW, the optimal dose to reduce hypertrophy of cardiac muscle cells in Wistar rats male.
Gambaran kesiapan UMKM menuju industri halal Jawa Timur: An Overview of Small and Medium Enterprise (SME) Readiness towards The East Java Halal Industry Nour Athiroh Abdoes Sjakoer; Eko Noerhayati; Siti Asmaniyah Mardiayani; M. Mas’ud Said
JURNAL AGROINDUSTRI HALAL Vol. 8 No. 2 (2022): Jurnal Agroindustri Halal 8(2)
Publisher : Lembaga Riset dan Pengabdian Kepada Masyarakat Universitas Djuanda Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30997/jah.v8i2.5094

Abstract

East Java has tremendous potential as a center for an integrated Halal industry based on superior products/products/services. East Java also has halal-certified MSMEs, dominated by the food and beverage sector (mamin). So the purpose of this study is to examine the profile of food MSMEs and describe the level of readiness of food MSMEs related to the halal industry in East Java. Methods This research uses a blended method, namely quantitative descriptive and qualitative methods. The exploration method is through the Rapid Rural Appraisal (RRA). Response selection using a purposive sampling technique. The results of the descriptive analysis of the profile of MSMEs who became respondents in this study were that most MSMEs already had NIB and PIRT. Most MSMEs that have NIB also have PIRT (48.72%). Ownership of NIB and PIRT is a commitment of MSMEs to comply with the government's business administration regulations. This shows the manager's administrative order, which is the key in developing the halal industry and culture. In conclusion, SMEs with PIRT also have a halal policy, have attended halal training, and are orderly in selecting and taking an inventory of a well-organized list of materials, products, and equipment, inventory management, procedures, and traceability. However, in terms of product handling, internal audit, and administrative review, many people still use PIRT, even though they already use it. Therefore, the focus of support is on these issues.
Co-Authors Abdur Rohman Wahid Ahmad Baidarus Ahmad Taufiq Aisyah Aisyah Aldina, Devana Rahma Andini, Saskia Ade Hutami Fery Anita Puspa Widiyana Anna Fathiah Annisatul Hakimah Ar Rahmah, Mumtazunnisa As Sufiyah Argus Argus Argus Mahyan Ari Hayati Ari Hayati Arina Roikhana Ariski Vevi Liswandari Ayu Pertiwi, Chintya Baidarus, Ahmad Dea Fatimatu Zahroh Devi Qurroti A'yun Dewi Qurrot &#039;Aini Dewi Qurrot 'Aini Doti Wahyuningsih Durrotul Hasanah Dwi Mareta Nur hidayati Dyan Aprillia Susanti Eka Kumalasari Eko Noerhayati Erna Sulistyowati Erna Susanti fahmiy, Rakhmawati Faisal Faisal Fajrin, Siti Awaliah Fatimah Abdul Sammad fatimah Fatimah Fatimah Fatimah Fatur rohman Rohman Forrela Zahwa Salamah Gatra Ervi Jayanti Gemilang, Satria Hari Santoso Hari Santoso hari santoso Hari Santoso Hari Santoso Hari Santoso Hasan Zayadi Hatif Khusnin Nida' Herlinda Rahayu Husain Latuconsina Husain Latucosina Husain, Muhammad Hafizh Istirochah Pujiwati Jadid Mubarakati, Nurul Jihan Farah Zakia Laili Mihmidati Lestari, Tengku Anggun Luluk Rofiatul Mafluhah M. Abdul Qodir Jailani M. Mas’ud Said Ma'ruf, Muhammad Mahanem Mat Noor, Mahanem Mat Mahyantika, Seftya Putri Maidhatul Rosidha Widyanti Majida Ramadhan Malia Anjani Mardhiyah, Mardhiyah Masyhuri Masyhuri Mihmidati, Laili Mohammad Mabrur Mubarokati, Nurul Jadid Muhammad Fahmi Hidayatullah Nafisa Nafisa Nafisa, Nafisa Nia Novita Nurrohmah Nirwana, Linggar Nur hidayati, Dwi Mareta Nur Mufida Nur Permatasari Nur Shofiyah Munawaroh Nur Shofiyah Munawaroh, Nur Shofiyah Nurrohmah, Nia Novita Nurul Jadid Mubarakati Nurul Jadid Mubarakati Nurul Jadid Mubarakati Nurul Jadid Mubarokati Oktaviana, Nimas Ajeng Rahayu Dwi Lestari Rahmawati, Rizka Dwi Rakhmawati fahmiy Ramadhan, Majida Ramadhani, Mieta Widya Ratna Djuniwati Lisminingsih Ratna Juniwati Lisminingsih Rizki Kusuma Hantika Saimul Laili Salamah, Forrela Zahwa Saputri, Syntia Diyah Hayu Ria Savana, Amartya Gesit Shinta mayangsari Sholikha alaiya Sholikha alaiya, Sholikha Silfi hamidatul lailiyah Silvia, Putri Azizatul Siti Asmaniyah Mardiayani Siti Awaliah Fajrin Siti Imama Khoiriyah Siti Qurrotul Aini Suroyya, Mariyam Susanti, Dyan Aprillia Tengku Anggun Lestari Umu Intan Kinasih Uyunul Hikmah Wahidah, Shinta Nuriyah Yudi Purnomo Zahroh, Dea Fatimatu Zakia, Jihan Farah