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Erlin Yustin Tatontos
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary Other

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Journal : Jaringan Laboratorium Medis

 1 
Fluktuasi Aktivitas Enzim SGOT dan SGPT pada Pasien Kanker Payudara yang Menjalani Kemoterapi di RSUD Provinsi NTB Ananda, Fadila Rizki; Tatontos, Erlin Yustin; Fihiruddin, Fihiruddin
Jaringan Laboratorium Medis Vol. 7 No. 2 (2025): November 2025
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jlm.v7i2.13322

Abstract

Chemotherapy is one of the primary treatment for breast cancer. Despite its effectiveness, chemotherapy has the potential to cause hepatotoxicity due to drug metabolism in the liver. This condition is generally indicated by elevated levels of SGOT and SGPT enzymes. Liver enzyme monitoring is essential to assess hepatocellular function throughout the course of therapy. This research aims to determine fluctuations in SGOT and SGPT enzyme activity in breast cancer patient undergoing chemotherapy at the NTB Provincial Hospital, and describe the pattern of changes in enzyme values based on the frequency of chemotherapy cycles. An analytical observational study with a cross-sectional approach was employed. Samples were selected purposively based on the medical records of breast cancer patients who underwent 1 to 6 cycles of chemotherapy between January and December 2024. Data were analyzed descriptively based on the distribution and the average of SGOT and SGPT enzyme levels. The results showed fluctuating SGOT and SGPT levels across different chemotherapy cycles. There was no consistent pattern of increase in enzyme activity based on chemotherapy frequency.  The average SGOT levels from cycle 1 to 6 were 24, 28, 27, 30, 33, and 24 IU/L, while the average SGPT levels were 35, 27, 29, 25, 29, and 29 IU/L, with a range of SGOT values of 13-404 IU/L and SGPT with a range of 5-304 IU/L. most enzyme values remained within normal range. It was concluded that chemotherapy frequency did not show a consistent association with increased SGOT and SGPT activity. These research emphasize the importance of routine monitoring of liver function during each chemotherapy cycle, so that potential hepatotoxicity can be adjusted according to the patient condition.  
Co-Authors . Kholik Aden Turmuji Aeni Halawiya Agrijanti, Agrijanti Aini, Aini Ananda, Fadila Rizki Anggun Sari Mianti Anky Frasatya Aolani, Almira Zaida Ari Khusuma Aurira Thrisna Dwi Aprianti Ayu Rosita Dendi Arisandi Dera Suci Elmaria Dewi, Lale Budi Kusuma Dramawan, Awan Eliza, Ida Eliza, Ida Erna Kristinawati Ersandhi Reshnleksmana Ershandi Resnhaleksmana Feni Wahyuni Fihiruddin, Fihiruddin Getas, I Wayan Gunarti Gunarti Gunarti Gunarti Gunarti, Gunarti Hana Fatinah I Gede Arya Santika Arya I Gusti Ayu Ambarawati Iswara Sesa I Nyoman Purna I Wayan Getas I Wayan Sali Ida Eliza IGAN Danuyanti Iswari Pauzi Iswari Pauzi Khairunnisa Kholik, Kholik Kristinawati, Erna Kurnia Rizki Lalu Sri Gede Lalu Sri Gede Lu’lu’il Adawiyah Maruni wiwin Danuarti Maruni Wiwin Diarti Maruni Wiwin Diarti Maruni Wiwin Diarti Maruni Wiwin Diarti Maruni Wiwin Diarti Maruni Wiwin Diarti Maswan, Moch Miftahul Aini, Miftahul Mutiara Rachmawati Suseno Nanda Yuniza Pratiwi Ni Nengah Yunita Nurul Inayati Nurul Inayati Nurul Inayati Nurul Inayati Nurul Inayati Nurul Inayati Nurul Inayati Pauzi, Iswari Putu Dita Septiani Putu Femila Rahmani, Putri Ziddanur RAI WIADNYA, IDA BAGUS Riska Novitasari Rizki, Kurnia Rohmi Rohmi Rohmi, Rohmi Salleh, Mohd Nazil Septiani, Erna Septiawan, Dandi Siti zaetun Siti Zaetun, Siti sofiatummina Sri Hartuti Thomas Tandi Manu Titin Emilia Nirmala Sari Urip Urip Urip Urip Urip Urip Urip Urip Urip Urip Urip Urip Urip Urip Urip Urip Urip Urip Urip Urip Urip Urip Urip, Urip Yuliana Wardani Yunan Jiwintarum Yunan Jiwintarum Yunan Jiwintarum Yunan Jiwintarum Zainal Fikri