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All Journal Saintika Medika: Jurnal Ilmu Kesehatan dan Kedokteran Keluarga. Jurnal Berkala Epidemiologi Folia Medica Indonesiana Indonesian Journal of Cancer The Indonesian Biomedical Journal Health Notions Syntax Literate: Jurnal Ilmiah Indonesia MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan Majalah Patologi Indonesia Biomolecular and Health Science Journal JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Majalah Biomorfologi (Biomorphology Journal) Jurnal Layanan Masyarakat (Journal of Public Service) Jurnal Pengabdian Masyarakat dalam Kesehatan Narra J Indonesian Journal of Cancer Jurnal Pengabdian Masyarakat Bhinneka Jurnal Pengabdian Masyarakat Bangsa

DYAH FAUZIAH, DYAH

Departemen Patologi Anatomi RS Dr. Soetomo Fakultas Kedokteran Universitas Airlangga Surabaya

Author-ID : 2392253

Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Analisis Ekspresi p21 dan CDK6 pada Karsinoma Payudara Invasif Tipe Luminal A, Luminal B dan HER2/neu Nasrun Bakri; Nila Kurniasari; Dyah Fauziah
Majalah Patologi Indonesia Vol 28 No 1 (2019): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (584.169 KB)

Latar belakangKarsinoma payudara adalah keganasan paling sering ditemukan pada wanita. Berbagai literatur menunjukkanbahwa p21 dan CDK6 mempunyai peranan pada proliferasi sel tumor di berbagai keganasan. Korelasi danperbedaan ekspresi p21 dan CDK6 pada klasifikasi subtipe molekular karsinoma payudara invasif belumbanyak diteliti. Tujuan penelitian ini untuk mengetahui ekspresi p21 dan CDK6 pada karsinoma payudarainvasif tipe luminal A, luminal B dan HER/neu.MetodePenelitian ini dilakukan secara retrsospektif dengan desain observasional analitik cross sectional blok parafinkarsinoma payudara invasif subtipe luminal A, luminal B dan HER2/neu di Laboratorium Patologi AnatomikRSUD Dr. Soetomo Surabaya. Hasil penelitian dilakukan dengan uji statistik Kruskal-Wallis untuk uji beda danuji statistik Spearman untuk uji korelasi.HasilPenelitian ini menunjukkan tidak ada perbedaan bermakna ekspresi p21 (p=0,402) dan CDK6 (p=0,238) padasubtipe luminal A, luminal B dan HER2/neu. Tidak terdapat korelasi bermakna antara ekspresi p21 dan CDK6pada luminal A (p=0,211), luminal B (p=0,286) dan HER2/neu (p=0,192).KesimpulanEkspresi p21 dan CDK6 tidak mempunyai perbedaan bermakna pada karsinoma payudara invasif subtipeluminal A, luminal B dan HER2/neu

Characteristics of Renal Cell Carcinoma Patients in RSUD Dr Soetomo Surabaya in 2014-2017 Ferdiansyah Rusdhy; Wahjoe Djatisoesanto; Dyah Erawati; Dyah Fauziah
Health Notions Vol 3, No 12 (2019): December
Publisher : Humanistic Network for Science and Technology (HNST)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/hn31206

Renal Cell Carcinoma is a type of malignant renal tumour. According to GLOBOCAN 2012 data, it ranked 17th on the most common malignancy in Indonesia with an incidence rate of 1.5 per 100000 citizens. Mortality rates for men is 1.6 per 100000, while it is 0.8 per 100000 case for women. The clinical symptoms of flank pain, flank mass, and hematuria, are usually only found in patients with later stages of cancer development. This descriptive study aims to present data on characteristics of Renal Cell Carcinoma patients. Data were collected from histopathological medical records of RSUD Dr. Soetomo Surabaya. We found that 25 of 40 patients are male, with most patients aged between 50 to 59 at time of diagnosis. Majority of patients worked as a private sector worker, and had high school level education. They presented with stage 2 tumour, with Clear Cell Renal Cell Carcinoma subtype. All 40 patients were treated by Radical Nephroctomy. Keywords: renal cell carcinoma; characteristics

A CASE SERIES OF MYOEPITHELIAL CARCINOMA SPINDLE CELL TYPE, CLEAR CELL TYPE, AND PLASMACYTOID TYPE Dian Yuliartha Lestari; Dyah Fauziah
Saintika Medika Vol. 13 No. 2 (2017): DESEMBER 2017
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/sm.v13i2.5524

Myoepithelial Carcinoma adalah salah satu keganasan kelenjar liur yang sangat jarang terjadi, dimana terdiri dari komponen sel-sel myoepithelial yang berdifferensiasi sebagai sel spindle, sel jernih (clear), sel epitheloid, sel stelate, maupun sel plasmacytoid. Kami melaporkan 3 kasus myoepithelial carcinoma yang didiagnosis di Rumah Sakit Dr. Soetomo Surabaya dalam kurun waktu 4 tahun terakhir dengan tiga tipe yang berbeda, yaitu; spindle cell type, clear cell type, dan plasmacytoid type. Dua kasus terjadi pada kelenjar parotis, lainnya pada kelenjar submandibula, dimana ketiganya terjadi pada wanita dengan rentang usia 45-76 tahun. Keluhan saat datang berobat adalah timbul benjolan semakin membesar secara perlahan dan tidak menimbulkan nyeri. Hasil pemeriksaan histopatologis menyatakan suatu carcinoma mengesankan myoepithelial carcinoma. Hasil pemeriksaan immunohistokimia smooth muscle actin (SMA) dan S100 mayoritas menunjukkan hasil yang positif, dimana menyokong diagnosis suatu myoepithelial carcinoma Kata kunci: myoepithelial carcinoma, spindle cell type, clear cell type plasmacytoid type

CLINICAL PROFILES OF VITILIGO WITH NARROWBAND UVB AND TOPICAL CORTICOSTEROID THERAPY AT DR. SOETOMO HOSPITAL Sarah Fauzia; Rahmadewi Rahmadewi; Dyah Fauziah
Jurnal Berkala Epidemiologi Vol. 8 No. 1 (2020): Jurnal Berkala Epidemiologi (Periodic Epidemiology Journal)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbe.V8I12020.8-15

Background: Vitiligo is a depigmenting disorder that causes a loss of melanocytes in the epidermis. Treatment preferences are based on the characteristics of the vitiligo lesions. Purpose: This study evaluates the clinical profiles of vitiligo treated with narrowband UVB (NB-UVB) radiation and topical corticosteroid therapy in Dr. Soetomo Hospital in 2017. Methods: This study is a retrospective study that uses data from the medical records of vitiligo patients who were treated with NB-UVB radiation and topical corticosteroids in Dr. Soetomo Hospital in 2017. The dependent variable was vitiligo treated with NB-UVB radiation or topical corticosteroids, while the independent variables were disease onset, precipitating factor, duration, stability, amount, affected area, location, and type of vitiligo. Results: Thirty-seven patients (19 females) were included, four of whom had been treated with NB-UVB radiation and 33 with topical corticosteroids. In the NB-UVB radiation group, 75% had stable lesions, 50% had a single lesion, 50% had multiple lesions, 75% had an affected area <10cm2, 40% had lesions around their face, 40% had lesions on their extremities, and 75% had focal vitiligo. In the topical corticosteroids group, 75.76% had active lesions, 81.82% had multiple lesions, 81.82% had an affected area <10 cm2, 28.21% had lesions around their upper extremities, 28.21% had lesions around their lower extremities, and 45.45% had segmental vitiligo. Conclusion: Treatment preference in Dr. Soetomo Hospital 2017 was indicated by the patients’ clinical profiles.

Analysis of Maspin Expression in Invasive Ductal Carcinoma of the Breast on Stages IIA and IIIB Arif Satria Hardika; Dyah Fauziah
Folia Medica Indonesiana Vol. 54 No. 1 (2018): March
Publisher : Faculty of Medicine, Universitas Airlangga

Mammary Serine Protease Inhibitor (maspin) is a tumor suppressor gene, a member of the serine protease inhibitor (serpin) family that works by inhibiting motility of cell movement, invasion and metastasis. Maspin expression is expected to be a prognostic factor as well as a predictive factor in mammary tumors. However, in some recent studies, maspin has a variety of expressions. Although it is known that no maspine appears as an indicator of tumor progression and metastasis, recent study has shown that maspine expression is associated with an aggressive phenotype of breast cancer and with a poor prognosis. Correlations between maspine expression and poor prognosis have also been reported in pancreatic, ovarian, thyroid, bladder and lung cancers. Knowledge of the expression and role of this maspin as well as its relationship with the pathogenesis of breast invasive ductal carcinoma is still small. The aim of this study was to look at differences in maspin expression in breast-invasive ductal carcinoma of stage IIA and stage IIIB groups. This research method used analytic observational research with cross sectional approach. The samples were invasive carcinoma of NST paraffin at the Department of Anatomic Pathology of Dr Soetomo Hospital, Surabaya, from January to December 2015. Thirty samples were divided into two groups, namely stage IIA and stage IIIB groups and immunohistochemical examination with maspin antibody was carried out. The difference of maspin expression in stage IIA and stage IIIB was analyzed using Mann-Whitney statistic test. There were significant differences in maspin expression between stage IIA and stage IIIB groups, where stage IIA has a high maspin expression rather than stage IIIB.

Analysis of Minichromosome Maintenance-2 (MCM-2) and Cyclin D1 Expression in Meningioma Yuliana Kurniawati; Dyah Fauziah
Folia Medica Indonesiana Vol. 54 No. 3 (2018): September
Publisher : Faculty of Medicine, Universitas Airlangga

World Health Organization histopathological grading of meningioma is associated with recurrence and clinical outcome. Grade II meningioma can be difficult to distinguish with grade I especially in case in which mitosis is not easily identified. MCM-2 and Cyclin D1 play crucial role in cell cycle and have been reported overexpressed in many malignant tumors. The aim of this observational analytic study was to analyze the differences and correlation between MCM-2 and Cyclin D1 in various meningioma grading. Immunohistochemystry with MCM-2 and Cyclin D1 was performed on 25 paraffin blocks of grade I, II and III meningiomas at the Laboratory of Anatomical Pathology, Dr. Soetomo Hospital. The immunoexpression are evaluated using Labelling Index, then analyzed statistically. The results showed significant difference in expression of MCM-2 within various meningioma grading (p=0.000) and significant difference in expression of Cyclin D1 within grade I and II also within grade I and III (p<0.050), but not in grade II and III (p>0.050). There was also positive correlation between MCM-2 and Cyclin D1 expression in various meningioma grading (rs=0.683, p=0.000). MCM-2 may play role in distinguishing various meningioma grading. Cyclin D1 can distinguish grade I and II also grade I and III, but not grade II and III. Overexpression MCM-2 was along with Cyclin D1 in various meningioma gradings.

Levels of Hemoglobin, Leukocytes, and Platelets of Chronic Kidney Disease Patients Undergoing Hemodialysis in Surabaya Mega Kahdina; Nunuk Mardiana; Dyah Fauziah
Biomolecular and Health Science Journal Vol. 1 No. 1 (2018): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Background: Chronic kidney disease (CKD) is increasing in Indonesia, furthermore, it requires high treatment cost such as conservative therapy and kidney transplantation or dialysis. There are two types of dialysis; hemodialysis (HD) and peritoneal dialysis. The patient who undergoes HD needs periodical laboratories evaluation due to its impact on hemoglobin (Hb), leukocyte and platelets. The purpose of this study was to obtain the levels of Hb, leukocyte and platelets regularly in stage 5 CKD patients undergoing HD.Methods: Data were collected from patients’ medical record from October to December 2014 and it was characterized based on age, sex, HD frequency, HD period, hemoglobin, iron saturation, ESA (erythropoiesis-stimulating agent), leukocyte level and platelets level. 60 samples were included with the same ratio.Results: The average of age was 45 years old and the average of HD period was 40 months. All patients suffered anemia, however, only 51 patients could be evaluated the iron saturation. From it, 37 patients had the iron saturation of ≥20% which 14 (38%) of them received ESA. There were 14 patients who suffered zinc deficiency anemia with the iron saturation of <20% which 4 (29%) of them received ESA.Conclusion: Most of patients’ leukocyte and platelets levels were normal. Patients who received ESA had higher Hb levels. Platelets levels had a reverse correlation with the longer period of hemodialysis.

Characteristics and Histopathological Grading of Malignant Spiculated Mass in regards to Histopathological Grading of Breast Cancer Based on The Nottingham Grading System Andi Syarti; Ulinta Pasaribu; Dyah Fauziah; Lies Mardiyana; Tri Wulanhandarini
Biomolecular and Health Science Journal Vol. 3 No. 1 (2020): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v3i1.19134

Introduction: Spiculation in mammography is a typical finding for invading breast cancer and is an important criterion in diagnosis and in predicting prognostic and plays an important role in management. The purpose of this research is to determine the characteristics of malignant spiculating mass in mammography in regards to histopathological grading using The Nottingham Grading System.Methods: Patients whom had spiculation in mammography was reviewed using medical record data by two breast imaging consultants and then combined with The Nottingham Grading System criteria obtained from histopathological examination results of core biopsy and surgery specimen. There was 29 cases that met the inclusion criteria.Results: Of the 29 patients that met the inclusion, the spiculated masses grade I, II has mitotic index of 0-12, grade III has mitotic index of 13-25. Histopathologic grade II, III has the most tubular formation of <10%, grade I has 10-75%. Grade I, II has moderate nuclear pleomorphism, grade III has severe nuclear pleomorphism. Most were grade III (44.8%), followed by grade II (37.9%), and minimally grade I (17.2%). Most patients are in stage 3 breast cancer.Conclusion: Malignant spiculated mass with grade I, II has low proliferation index (mitotic index 0-12), histopathological grade II, III had worse cellular differentiation (tubular formation <10%), histopathological grade II, III has moderate to severe nuclear pleomorphism.

Pattern of Perioperative Antibiotic Use in Otorhinolaryngology-Head and Neck Surgery at Third Referral Hospital In Surabaya Nabilah Puspa Utami; Dyah Fauziah; Muhtarum Yusuf
Biomolecular and Health Science Journal Vol. 3 No. 1 (2020): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v3i1.19196

Introduction: Surgical site infection (SSI) often occurs in operation. SSI frequently only affects the superficial tissues, but some more serious infections can affect the deeper tissues or other parts of the body. The majority of SSIs become apparent within 30 days of an operative procedure, when a prosthetic implant is used, SSI may occur several months after the operation. To minimize surgical site infection occurrence, prophylaxis antibiotic is often used. The aim of the study is to evaluate the use of perioperative antibiotics for otorhinolaryngology surgery in third referral hospital in Surabaya.Methods: This study was a retrospective cross-sectional method through the medical record of patients cases from December 2017 to January 2018. All data about sex, age, diagnosis, wound classification, surgical intervention including ICD 9 CM codes, and antibiotics regiments are presented descriptively.Results: Of total 68 patients, 42 (61.8%) were male and 46 (61.8%) were aged 18-65 years old. The most common type of operation was clean surgery 52 (76.5%). The most common prophylactic antibiotic was cefazoline 25 (96.6%). Conclusion: Most of the performed surgery was clean surgery. The use of perioperative antibiotics in most performed operations was in accordance with existing literature. The most widely used prophylactic and therapeutic antibiotic was cefazoline and ceftriaxone, respectively. Further research about risk factor of SSI, the use of prophylaxis antibiotic, and bacterial profile with more samples is needed for more accurate results.

Prevalence Proportion of Patient with Coronary Heart Disease in Inpatient Room of RSUD Dr. Soetomo Surabaya in 2017 Faradila Budi Saputri; Dyah Fauziah; Esti Hindariati
Biomolecular and Health Science Journal Vol. 3 No. 2 (2020): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v3i2.22094

Introduction: Coronary heart disease (CHD) is the most common type of heart disease that causes death. It occurs as a result of hardening of the coronary arteries which supply oxigen-rich blood to the entire heart muscle so that the heart can contract properly. However, many patients neglect the symptoms. Moreover, the risk factor and the comorbides disease worsen the condition. This research aims to study the profile of coronary heart disease patients in the inpatient rooms at Dr. Soetomo General Hospital Surabaya in 2017.Methods: This study was a cross-sectional and retrospective study by assessing patients’ medical record and analyzed descriptively.Results: From total 587, 263 patiens met inclusion criteria, aged between 51-60 years (42.6%) with domination of male (82,13%). %). Risk Factors are into one of the Comorbidities of CHD Patient. There are Risk Factor can be aggravate of CHD Patients. Most of subjects had risk factor hipertension (50,79%), and hypertension with DM (38,7%). Hypertension based on systolic pressure and diastolic pressure obtained that systolic pressure <120 mmhg was 39.6% and diastolic pressure <80 was 37.4%.Conclusion: Most of CHD patients in this study were in age group 51 – 60 years old, male, had risk factor hypertension and DM.

Co-Authors Agung Dwi Suprayitno Agustin, Leonita Alpha Fardah Athiyyah Alphania Rahniayu Anak Agung Gede Sugianthara Anang Endaryanto Andi Syarti Anggoro, Adhitri Anny Setijo Rahaju, Anny Setijo Ariani, Grace Arif Satria Hardika Askandar Tjokroprawiro Barliana Barliana Budi Utomo Cindy Angelina Limantara Cita Rosita Sigit Prakoeswa Deasy Fetarayani Dewi Astuti Kurniawati Dewi Sartika A. W. Dian Yuliartha Lestari Diana Purnamasari Djuanda, Stephanie N. Dwirani Rosmala Pratiwi Dyah Erawati Edi Suyanto Elvin Nuzulistina Emillia Wijayanti Esti Hindariati Faradila Budi Saputri Faroek Hoesin Febrina Diah Puspitasari Ferdiansyah Mahyudin Fira Soraya Fitriana . Gatot Soegiarto Gilang Adi Firmansyah Gondo Mastutik Gunawan, Vania A. Heriyawati, Heriyawati Hermawan Udiyanto Ilmiah, Khafidhotul Imam Susilo INDRA YULIATI, INDRA Ingrid Suryanti Surono Khafidhotul Ilmiah Kusumastuti , Etty Hary Kusumastuti, Etty H. Kusumastuti, Etty Hari KUSUMASTUTI, ETTY HARY Lefi, Achmad Lies Mardiyana, Lies Lilihata, Jilientasia G. Maharani, Andi RK. Mamiek Dwi Putro MANUEL HUTAPEA MANUEL HUTAPEA, MANUEL Marhana, Isnin A. Mega Kahdina Meyta Riniastuti MUHAMMAD RIZKI YAZNIL Nabilah Puspa Utami Nasrun Bakri Nila Kurniasari Nila Kurniasari Nugraha, Ricardo A. Nugroho, Gilang MS. Nunuk Mardiana, Nunuk Prastiya Indra Gunawan Qonitatillah, Ana Rahaju, Anny S. Rahmadewi Rahmadewi Retnani, Diah Prabawati Ridholia Ridholia Ridholia Ridholia, Ridholia Rinjani, Lalu GP. Rizkie T Trisnawaty Rosyid, Alfian N. ROY YUSTIN SIMANJUNTAK ROY YUSTIN SIMANJUNTAK, ROY YUSTIN S.Pd. M Kes I Ketut Sudiana . Sarah Fauzia Sari, Aditya Sita Semedi, Bambang P. SUHATNO - SUHATNO -, SUHATNO Supriadi Supriadi Sutrisno Sutrisno Teguh Prakosa, Teguh Tri Wulanhandarini Ulinta Pasaribu Ummi Maimunah wahjoe djatisoesanto Wahyu, Dwi wihasto suryaningtyas Willy Sandhika Wiratama, Priangga A. Wiratama, Priangga Adi Wirawan, Putu Tanisya Putri Yandi, I KR. Yaznil, Muhammad Rizki Yetti Hernaningsih Yuliana Kurniawati Yusuf, Muhtarum

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