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Pengaruh Pemberian Sinbiotik, Probiotik, dan Prebiotik terhadap Depresi, Stres, dan Mood pada Orang Dewasa: Systematic Review dan Meta-Analisis: Effects of Synbiotic, Probiotic, and Prebiotic Supplementation on Depression, Stress, and Mood in Adults: A Systematic Review and Meta-Analysis Habibi, Nur Ahmad; Gusnedi, Gusnedi; Nindrea, Ricvan Dana; Hasniyati, Rina; Afriza, Renita; Rusydi, Riska; Yuska, Defniwita; Darningsih, Sri; Zulkifli, Zulkifli; Ismanilda, Ismanilda; Handayani, Marni; Utami, Citra Tristi; Umar, Hermita Bus; Dwiyanti, Defriani; Yuniritha, Eva
Amerta Nutrition Vol. 9 No. 1SP (2025): AMERTA NUTRITION SUPPLEMENTARY EDITION Special 5th Amerta Nutrition Conferenc
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/amnt.v9i1SP.2025.420-430

Abstract

Background: Psychobiotics, including probiotics, prebiotics, and synbiotics, have been proposed to improve mental health through modulation of the gut–brain axis. However, findings from randomized controlled trials (RCTs) remain inconsistent, Objectives: To systematically review and synthesize evidence on the effects of probiotics, prebiotics, and synbiotics on depression, stress, and mood in adult populations. Methods: A comprehensive search was conducted in PubMed, yielding 531 articles, of which 14 RCTs met the inclusion criteria. Risk of bias was assessed using the Cochrane Risk of Bias Tool. Meta-analyses were performed using both fixed- and random-effects models in RevMan. The study protocol was registered in PROSPERO (CRD420251103338). Discussions: Ten RCTs (n = 881) assessing depression did not show consistent benefits (SMD = –0.72; 95% CI: –1.42 to –0.01; p-value = 0.05; I² = 96%). Six RCTs (n = 444) evaluating stress also showed non-significant effects (MD = –1.35; 95% CI: –3.70 to 1.01; p-value = 0.26; I² = 73%). Conversely, six RCTs (n = 376) demonstrated significant improvements in mood (MD = 0.73; 95% CI: 0.25 to 1.20; p-value = 0.003; I² = 75%). Meta-regression indicated that larger sample sizes were associated with more consistent improvements in mood (p-value = 0.04). Sensitivity analyses confirmed the stability of the findings, and no evidence of publication bias was detected. Conclusions: Probiotic, prebiotic, and synbiotic supplementation may provide beneficial effects on mood and could serve as a potential nutritional intervention to enhance psychological health. However, effects on depression and stress inconsistent.
INTERAKSI TOBACCO DENGAN OBAT DAN PENYAKIT Aulia Nabila Fajarini; Ghea Abelisa Ananda; Jelita Suwandi; Kharina Frizzilya Arralova; Maulida Hafni; Najwatul Izzati; Nayshilia Bulan Rizky; Rahmi Rahayu; Ziva Elminora. G G; Defniwita Yuska; Eva Yuniritha; Deri Andika Putra
Medical Studies and Health Journal (SEHAT) Vol. 3 No. 1 (2026): Medical Studies and Health Journal
Publisher : Penelitian dan Pengembangan Ilmu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62207/neheqt22

Abstract

Asap rokok dan nikotin berinteraksi dengan obat-obatan dengan mempengaruhi penyerapan, distribusi, metabolisme, dan eliminasi obat sehingga menyebabkan perubahan pada respon obat itu sendiri, sehingga perokok biasanya memerlukan dosis obat yang lebih tinggi. Pencarian artikel dilakukan melalui fitur pencarian lanjutan berbasis ScienceDirect, PubMed, Google Scholar. Yang akhirnya 6 artikel digunakan dalam penelitian ini. Kami menemukan bahwa obat-obatan dapat berinteraksi satu sama lain saat mengkonsumsi beberapa obat sekaligus, tetapi interaksi ini tidak selalu dipengaruhi oleh obat itu sendiri. Terkadang interaksi dapat disebabkan oleh reaksi obat dengan makanan, minuman, dan tembakau. Perokok harus mengkonsumsi dosis obat yang lebih tinggi untuk pengobatan dalam jangka Panjang, yang menyebabkan lebih banyak efek samping. Dalam jangka panjang, tubuh seseorang bisa menjadi resistensi obat dan harus ditingkatkan dosisnya. Penggunaan obat yang berlebihan menyebabkan seseorang mengalami lebih banyak gejala emosional dan fisik. Rokok juga dapat memiliki efek farmakokinetik pada beberapa obat (clozapine, olanzapine dan kokain).
Macronutrient Iintake and Body Mass Index as Determinants of VO2 Max in Football Athletes at BBC Batuang Taba, Padang City Dewi, Ghinna Alfitri; Kasmiyetti, Kasmiyetti; Hasneli, Hasneli; Dwiyanti, Defriani; Yuniritha, Eva
Jurnal Ilmu Gizi dan Dietetik Vol 5 No 2 (2026)
Publisher : Departemen Gizi Masyarakat, Fakultas Ekologi Manusia, IPB dan PERGIZI PANGAN Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25182/jigd.2026.5.2.493-502

Abstract

Maximal oxygen uptake (VO₂ Max) is a key indicator of physical fitness in football athletes, reflecting the body's ability to uptake, transport, and utilize oxygen during intense physical activity. Nutritional factors, particularly macronutrient intake (carbohydrates, proteins, and fats), as well as body mass index (BMI), may influence aerobic endurance. This study aimed to determine the association between macronutrient intake, BMI, and VO₂ Max among football athletes at BBC Batuang Taba Football School, Padang City. A quantitative study with a cross-sectional design was conducted involving 35 athletes selected through purposive sampling. Macronutrient intake was assessed using a 3×24-hour dietary recall, BMI was determined through anthropometric measurements, and VO₂ Max was measured using the beep test. Macronutrient adequacy was evaluated based on the nutritional recommendations of the International Society of Sports Nutrition (ISSN). Data were analyzed using the Chi-square test. The results showed that 65.7% and 57.1% of the athletes had adequate protein and fat intake, respectively, whereas all participants (100%) had inadequate carbohydrate intake. In addition, 57.1% had abnormal BMI, and 51.4% had low VO₂ Max. Chi-square analysis revealed no significant association between macronutrient intake, BMI, and VO₂ Max (p=1.000). Nevertheless, descriptive findings indicated that athletes with adequate protein and fat intake and a normal BMI tended to have better VO₂ Max values. Although no statistically significant associations were identified, adequate nutrient intake and normal nutritional status remain important for maintaining physical fitness and optimizing athletic performance. Regular nutritional assessment and nutrition education are therefore recommended to support the fitness and endurance of football athletes.