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Journal : Biota

Modulatory Effects of Fucoidan on Paracetamol-induced Hepatic Damage and Histological Alterations in Rasbora lateristriata Sofyantoro, Fajar; Dafa, Maula Haqul; Primahesa, Alfian; Oktaviana, Shintia; Mayani, Olvita; Simanungkalit, Eben Ezer; Prissandi, Anthera Al Firdaus; Nuriliani, Ardaning; Retnoaji, Bambang; Saragih, Hendry T. S. S. G.; Rohmah, Zuliyati; Widiyanto, Slamet; Wijayanti, Nastiti; Septriani, Nur Indah
Biota Vol 12 No 1 (2026): Jurnal Biota 2026
Publisher : Faculty of Science and Technology Universitas Islam Negeri Raden Fatah Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19109/biota.v12i1.27845

Abstract

Paracetamol overdose is a well-documented cause of hepatic injury across vertebrate species, including teleost fish. This study aimed to evaluate the hepatoprotective potential of fucoidan, a sulfated polysaccharide derived from brown algae, against paracetamol-induced liver damage in Rasbora lateristriata. Fish were divided into five experimental groups and exposed to paracetamol (3 mg/L), either alone or in combination with fucoidan at concentrations of 50, 100, or 300 µg/mL, for seven days. Histopathological evaluation of liver tissues was performed using hematoxylin–eosin staining, with semi-quantitative scoring focused on hydropic degeneration, nuclear pyknosis, and necrosis. The results demonstrated that paracetamol exposure induced moderate hepatocellular injury, characterized by cytoplasmic vacuolization, apoptotic nuclear alterations, and necrotic lesions. Co-treatment with fucoidan at 300 µg/mL was associated with reduced severity across all histopathological parameters, indicating partial hepatoprotective effects. In contrast, the 50 µg/mL fucoidan group exhibited paradoxically severe hydropic degeneration despite the absence of pyknosis and necrosis, suggesting a delayed or altered injury profile. Intermediate outcomes were observed at 100 µg/mL. Overall, fucoidan exhibited dose-dependent but inconsistent hepatoprotective effects. The observed histological variability across concentrations suggests that protection may be influenced by factors such as bioavailability, cellular uptake, or interactions with intracellular stress pathways. These findings highlight the need for further mechanistic investigations before fucoidan can be considered a reliable hepatoprotective agent in aquatic toxicology.
Co-Authors Abdul Rachman Adania, Baik Aisyah Adaninggar, Ascarti Adelfiani, Adelfiani Adi Susanto Adi Susanto Adi Susanto Aeniah, Siti Agus Hermawan Allimi, Hayu Swari Almunawar, Muhammad Fikri Andi Mahendra Andriyani, Eka Fitri Siti Anisya, Alifia Anita Restu Puji Raharjeng Aprilianti, Suci Hari Aprilianti, Suci Hari Utami Apriliyani, Tia Ariesti, Wiwin Arif Luthfi Nurul Huda Artik, Arba' Ramadhani Ascarti Adaninggar Ashfiya Hanif Hasnadewi Asih Purwestri, Yekti Aswi A. Rofiqoh Bambang Retnoaji Bima Mahendra Bima Mahendra Bima Mahendra Cios Conara , Flafiani Conara, Flafiani Cios Dafa, Maula Haqul Della Blatama Eka Putri Empra, Desi Empra, Desi Eka Putri Endar Pertiwi, Anggita Fajar Sofyantoro Faulana, Arum Fahmi Firdiana, Vykra Aulia Flafiani Cios Conara Flafiani Cios Conara Flafiani Cios Conara Gunanegara, Rimonta Febby Halim, Shuha Ma’muriyah Haris Setiawan Hayu Swari Alimi Hendry Saragih Hendry Saragih Hendry Saragih Hendry T.S.S.G. Saragih Hendry T.S.S.G. Saragih Hendry Tri Sakti Saragih Hendry Tri Sakti SG Saragih Hidayah, Lailly Tsania Nur Hidayat, Rheina Faticha Asyamsa Ibnu Agus Ariyanto Illiyin, Sirayya Jessy Octavia Harahap Johanes Sugiyanto Karlina, Ina Karmilah, Karmilah Laili Mufli Zusrina Lailly Tsania Lailly Tsania Nur Hidayah Lailly Tsania Nur Hidayah Larasshita Putri Adhitya Sani Lisna Hidayati, Lisna Luthfi Nurhidayat Maharesi, Chesa Ekani Manesta Edelweis Jingga Mataram, Made Bagus Auriva Mayani, Olvita Mei Ria Santi Moli Podhi, Felisitas Mulyati Mulyati Murtiadi Erlan Supraitno Mutiyani, Novita Nastiti Wijayanti Nasution, Nurlita Putri Bela Ni Wayan Erly Sintya Dewi Nurhidayah, Septika Nurhidayat, Luthfi Oktaviana, Shintia Oktavya, Galuh Prasasti, Filosofia Florista Tesla Aulia Pratiwi, Arini Dian Primahesa, Alfian Prissandi, Anthera Al Firdaus Pusparini, Nur Ainun Oktavia Puteri, Nabila Ramiza Putri, Raden Roro Risang Ayu Dewayani Rahayu, Fadiah Sri Rahayu, Sekar Rahmadian, Desti Rarastoeti Pratiwi Retno Wulandari Ria Vena Septhay Sari Roesma Narulita Rohmah, Zuliyati Ruth Liananda Citra Dolok Saribu Sadewo, Imran Sadiman Sadiman Saeed, Faisal Samparisna Rumansara, Papuani Sandi Francisco Pratama Saragih, Hendry Saragih, Hendry T. S. S. G. Saragih, Hendry T.S. Saragih, Hendry T.S.S.G Saragih, Hendry Tri Sakti SG Sari, Dini Wahyu Kartika Saribu, Ruth Liananda Citra Dolok Sari’ah Cintami Damayanti Septriani, Nur Indah Septriani, Nur Indah Setyo, Agnessia Asian Budi Shalihah, Fianicha Simanungkalit, Eben Ezer Siwi Dwi Rahayu Slamet Widiyanto Sofyantoro, Fajar Sudarsi, Nurini Aru Sularsah, Sais Sunarti Susilo Hadi, Susilo Syam, Adi Mazdi T.S.S.G. Saragih, Hendry Tia Apriliyani Utami, Zidni Meirizka Wardani, Ester Dewanti Yovita Woro Anindito Sri Tunjung Yekti Asih Purwestri Yuny Erwanto Yuvita, Arneta Zeyna Listy Zulfatin Zuliyati Rohmah Zusrina, Laili Mufli