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Journal : Pharmaceutical Reports

Formulation and Evaluation of Anti-Acne Activity of Gel Pineapple Peel (Ananas comosus L.) Extract on the Growth of Propionibacterium acnes Latu, Saparuddin; Firman, Imran; Yaqkin-P, Andi Muh.; Musliani, Musliani
Pharmaceutical Reports Vol 3, No 1 (2024): (March) Pharmaceutical Reports
Publisher : Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/pharmrep.v3i1.286

Abstract

Pineapple peel contains many compounds, namely flavonoids, tannins, saponins, phenolics, steroids, alkaloids and bromelin enzymes. Acne is a chronic inflammatory disease of the pilosebaceous glands. One of the bacteria that causes acne is Propionibacterium acne. Preparations that can be made for anti-acne are gel preparations. This study aims to determine whether the ethanol extract of pineapple peel (Ananas comosus L.) can be made into an anti-acne gel preparation and to find out at what concentration the ethanol extract of pineapple peel (Ananas comosus L.) in an anti-acne gel preparation can provide inhibitory activity on the development of Propionibacterium acne bacteria. This research method is true experimental by making anti-acne gel preparations of pineapple peel extract (Ananas Comosus L.) with various concentrations of 2%, 3%, 5% and testing the activity of the preparation against Propionibacterium acne using the agar well method. The results of the gel preparation formula showed that there were significant differences before and after the cycling test in both organoleptic, homogeneity, pH, viscosity, spreadability and adhesion tests. The activity test results obtained were that the largest inhibition zone was the 5% concentration, namely 12.7 mm, which was in the strong category, while the 3% concentration, which was 11.03 mm, and the 2% concentration, which was 8.8 mm, was included in the moderate category.
Determination of Antioxidant Activity of Stem Bark (Manihot esculenta Crantz) by 1,1-Diphenyl-2-picrylhydrazyl (DPPH) Scavenging Method Latu, Saparuddin; Jangga, Jangga; Mansur, Mansur; Gajali, Nurdila
Pharmaceutical Reports Vol 2, No 2 (2023): (October) Pharmaceutical Reports
Publisher : Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/pharmrep.v2i2.273

Abstract

Cassava bark is a part of the cassava plant which is still underutilized besides being used as animal feed and wasted as waste. Each cassava can usually produce 10-15% cassava bark. The amount of waste produced can cause accumulation, resulting in environmental damage if not appropriately utilized. This research aims to determine the antioxidant activity of cassava bark (Manihot esculenta Crantz) using the DPPH (1,1-diphenyl-2-pikrihidrazil) method, measured using a UV-Vis spectrophotometer. Extraction used the maceration method of 96% ethanol as solvent. The determination of antioxidants in ethanol extract of cassava bark by the DPPH method and using vitamin C was used as a reference. Vitamin C was made in four series of concentrations, namely 2, 4, 6, and 8 ppm, while the ethanol extract of cassava bark was 20, 40, 60, and 80 ppm. From several concentration series, 2 ml was taken, and 1 ml of 50 ppm DPPH was added; then, the mixture obtained was incubated for 30 minutes in a place protected from light. The absorbance was measured at a wavelength of 515 nm. The results showed that the ethanol extract of cassava bark has a potent antioxidant activity based on the IC50 value obtained, which is 3.847 mg/L. Therefore, the ethanol extract of cassava bark can be developed as a natural antioxidant.
Criminal Responsibility of the Pharmacist in the Pharmaceutical Services in Indonesia Latu, Saparuddin; K, Aswanto; Arie, Marthen; Alimuddin, Alimuddin
Pharmaceutical Reports Vol 1, No 2 (2022): (October) Pharmaceutical Reports
Publisher : Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (205.047 KB) | DOI: 10.33096/pharmrep.v1i2.171

Abstract

Medical malpractice has a long history in Indonesia, with fatal consequences for patients due to negligence from the health practitioner. This study aims to ensure legal certainty in pharmaceutical practice according to laws and regulations. Also, to provide criminal law sanctions for pharmacists in pharmaceutical practices that lead to criminal acts. The method used was qualitative empirical normative research with a literature study. This research was conducted qualitatively based on data triangulation which resulted from three ways: interview, participant to observation, and review of organizational records (document records). Data collection usually uses qualitative research observation, documentation, and interview methods. This study discusses legal provisions related to health and pharmaceutical services and interviews with ten people at Dr. Wahidin Sudirohusodo Regional General Hospital, Makassar, and five people from Wamena Regional General Hospital, Jayawijaya Regency, Papua. Our study exhibited that implementing a pharmacist's practice was based on the prevailing laws and regulations. The pharmaceutical practice in question starts from planning, procurement, storage, distribution, evaluation, and provision of drug information and monitoring of drug side effects. These practices are based on Government Regulation No. 51 of 2009 article 4. This regulation is stated to protect patients and the public in obtaining and stipulating pharmaceutical preparations and pharmaceutical services. In addition, to maintain and improve the quality of implementation of pharmaceutical work by using developments in science and technology as well as laws and regulations; and provide legal certainty for patients, communities, and pharmaceutical workers. In the criminal responsibility of pharmacists in pharmaceutical services that have resulted in illegal acts, there have not been cases that have reached court proceedings. Nevertheless, there are cases where actions that have resulted in criminal acts have occurred in the field. Still, mediation can resolve them to reach a consensus with unique mediation.
Co-Authors Abdul Wahid Suleman Agus Susanto Aisyah Nur Sapriati Aisyah Nur Saptriati Amir, Arfenti Andi Irdawati Andi Muh Yagkin P Andi Muh Yagkin Padjalangi A Andi Muh. Yaqkin P Andi Muhammad Yaqkin Andi Muhammad Yaqkin Padjalangi Asjur, Asti Vebriyanti Asnah Marzuki Aziz, Yuliana Bahar, Muhammad Yusuf Bambang, Ayu Wulansari Baso, Bachtiar Dewi Marhaeni Diah Herawati Dewi Nurliasari Yulis Firdaus Firdaus Firman, Imran Fitrianingsih, Julia Gaffar, Herry Darsim Gajali, Nurdila Haerawati Idris Haerawati Idris, Haerawati Hasmar, Wahyu Nuraini Hasnany, Hasnany Herman, Sriyana Hilmiati Wahid Ikhsan, Mifta Khaerti Jalal Jalal, Jalal Jangga Jangga, Jangga Junita, Nurfitria K, Aswanto M Fais Satrianegara Ma'ruf, Irham Mahmudah, Rifa’atul Mamat Pratama, Mamat Mansur Mansur Mansur - Mansur Mansur Mansur Marthen Arie Marwan, Ummi Kalsum Muammar Fawwaz Muh. Khaedar Muhammad Basir Muhammad Basir Muhammad Idris Patarai Muhammad Ikbal Muhammad Rifai Musdar, Tamzil Azizi Musliani, Musliani Musnur, Aldha Irjayanti Mustamin Nia Putri Citra Ningsih, Nining Ade Nur Afni Ponseng Nurcholis Panji Bayu Astra Nurhikmah Nurkamilah, Andi Nurul Inayah Nurwijayanti Obed Rame Padjalangi, Andi Muh Yagkin Padjalangi, Andi Muhammad Yaqkin Pakinde, Ayisti Pasinggi, Adinda Sari Patarai, Muhammad Idris Pradila Putri, Hardyanti Eka R. Rusli Rahayu, Rita Rahmaniah, Rahmaniah Rifa’atul Mahmudah Rika Handayani Risnah Rosdiana Rosdiana Rosdiana Rosdiana Rusli Sabillah, Bellona Mardhatillah Safaruddin Santi, Elvira Saputro, Syaifullah Satrianegara, Faiz Sedyatama, Reza Prakosa Siti Helmyati Sri Wulan Rini Sriyanty Sadsyam Supardi, Nurjannah Surya Syarifuddin Syahruddin, Akmal Novrian Syamsidar Syamsuriyati, Syamsuriyati Tamira Tansy Timbuleng Wattimena, Jans Goldman Yagkin Padjalangi, Andi Muh Yagkin, Andi Muh. Yaqkin-P, Andi Muh. Yulianti Yulis, Dian Meiliani Yunaldi Yunaldi Zainuddin