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All Journal Pharmaciana: Jurnal Kefarmasian Jurnal Sains dan Teknologi Pangan Satya Widya Acta Pharmaciae Indonesia : Acta Pharm Indo BAREKENG: Jurnal Ilmu Matematika dan Terapan Dinamisia: Jurnal Pengabdian Kepada Masyarakat IJEMS (Indonesian Journal of Environmental Management and Sustainability) Media Farmasi BIOSFER : Jurnal Biologi dan Pendidikan Biologi 2-TRIK: TUNAS-TUNAS RISET KESEHATAN Jurnal Sehat Mandiri JUDIKA (JURNAL PENDIDIKAN UNSIKA) Jurnal Agrotek Indonesia Jurnal Abdimas PHB : Jurnal Pengabdian Masyarakat Progresif Humanis Brainstorming Jurnal Bidang Ilmu Kesehatan Jurnal Pendidikan dan Konseling Jurnal Sekolah Dasar (JSD) Jurnal Ners Jurnal Integrasi Kesehatan dan Sains Lumbung Farmasi : Jurnal Ilmu Kefarmasian Jurnal Penelitian Farmasi dan Herbal Journal of Holistic and Health Sciences (Jurnal Ilmu Holistik dan Kesehatan) Jurnal Ilmiah Wahana Pendidikan Jurnal EduHealth Indonesian Journal of Chemistry and Environment Jurnal Pijar MIPA Prosiding Sesiomadika Jurnal Farmasetis Journal of Pharmaceutical and Sciences. Jurnal Budiman: Pembangunan dan Pengabdian Masyarakat Nusantara Medical Sains : Jurnal Ilmiah Kefarmasian Kolaborasi Masyarakat PharmaCine: Journal of Pharmacy, Medical and Health Science
Marsah Rahmawati Utami
Universitas Singaperbangsa Karawang
Religion Agriculture, Biological Sciences & Forestry Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Physics Public Health Social Sciences Transportation Veterinary Other

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Pelatihan Teknik Kultur Jaringan Tanaman Kawista di Kelurahan Adiarsa Barat, Kecamatan Karawang Barat Hayatul rahmi; Slamet Abadi; Marsah Rahmawati Utami
Jurnal Budiman: Pembangunan dan Pengabdian Masyarakat Nusantara Vol. 1 No. 2 (2023): November 2023
Publisher : Fakultas Pertanian, Universitas Singaperbangsa Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Kultur jaringan adalah metoda budidaya tanaman secara nonkonvensional. Salah satu tanaman yang punya potensi dibudidayakan dengan teknik ini yaitu kawista, karena memiliki khasiat sebagai tanaman obat. Desa adiarsa barat, Kecamatan Karawang Barat memiliki permasalahan lahan yang terbatas dan rata-rata masyarakat hanya memiliki pekarangan sempit untuk dapat melakukan kegiatan menanam tanaman obat keluarga (TOGA). Sehingga dibutuhkan metoda budidaya tanaman yang tidak membutuhkan lahan yang luas dengan keunggulan bisa mendapatkan bibit yang unggul. Kegiatan pengabdian meliputi pengenalan teknik kultur jaringan, penjelasan cara pembuatan media tanam, dan praktek langsung penanaman eksplan tanaman pada media. Hasil pengabdian diketahui bahwa tingkat pemahaman masyarakat terhadap teknik kultur jaringan sebesar 0% sebelum pelatihan, dan 27% setelah pelatihan dilakukan.
ANALISIS AKTIVITAS TOKSISITAS BEBERAPA MINYAK ATSIRI DENGAN METODE BRINE SHRIMP LETHALITY TEST Utami, Marsah Rahmawati; Ardiyanti, Yusi
Journal of Holistic and Health Sciences (Jurnal Ilmu Holistik dan Kesehatan) Vol. 3 No. 1 (2019): Journal of Holistic and Health Sciences (Jurnal Ilmu Holistik dan Kesehatan)
Publisher : Sekolah Tinggi Ilmu Kesehatan Holistik

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (619.913 KB) | DOI: 10.51873/jhhs.v3i1.34

Abstract

Background: Essential oils are commonly used as raw materials for fragrance oils, medicines and cosmetics. In the pharmaceutical field, essential oils are used as antibacterial, anti-pain and anti-infection. This pharmacological effect is related to secondary metabolites contained in the essential oil. The effectiveness of the active components of secondary metabolites as a drug can be determined by toxicity analysis as a preliminary test. Toxicity analysis that is commonly used is the Brine Shrimp Lethality Test (BSLT). This test illustrates the level of toxicity of extracts against Artemia salina larvae. The results of this test can be used as a preliminary test to identify broader plant bioactivity. Objective: The aim of this study was to analyze the toxicity activities of basil leaf essential oils, galangal rhizome and red betel leaf and their secondary metabolite content. Method: Essential oils were isolated by the steam distillation method, their toxicity activity was tested by the BSLT method, and the contents of the chemical compounds were analyzed by GC-MS. Conclusion: Brine Shrimp Lethality Test results showed that the essential oils of the leaves of the kemanggi, galangal rhizome, and red betel have a level of toxicity with LC50 respectively 57.21 ppm, 110.01 ppm, 360.51 ppm. Based on the results of GC-MS analysis, the main components of the kemanggi leaf essentialoil are lemonal and beta citral, the main components of galangal rhizome essential oil are 2,6-dimethylphenyl borate an 1,8-cineol, while the main components of the red betel essential oil are sabinena and beta mircena.
PENGARUH PROBLEM-BASED LEARNING TERHADAP PENGUASAAN KONSEP DAN KETERAMPILAN BERPIKIR KREATIF SISWA SMK PADA MATERI KARBOHIDRAT Ardiyanti, Yusi; Utami, Marsah Rahmawati; Ratnasari, Dewi
Satya Widya Vol. 36 No. 2 (2020)
Publisher : Fakultas Keguruan dan Ilmu Pendidikan Universitas Kristen Satya Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24246/j.sw.2020.v36.i2.p81-87

Abstract

Penelitian bertujuan untuk mengetahui bagaimana pengaruh pendekatan problem-based learning pada peningkatan penguasaan konsep dan keterampilan berpikir kreatif siswa SMK pada materi karbohidrat. Penelitian ini merupakan penelitian kuasi ekperimen, dengan desain kelompok kontrol non-ekuivalen yang melibatkan dua kelompok. kelas eksperimen yang mendapat pembelajaran dengan pendekatan Problem-Based Learning dan kelas kontrol yang mendapat pembelajaran menggunakan pendekatan pembelajaran konvensional. Instrumen yang digunakan pada penelitian ini adalah pretest, posttest dan angket, innstrumen pretest posttest berupa 20 soal pilihan ganda (untuk menguji kemampuan penguasaan konsep) dan 4 soal essay(untuk menguji keterampilan berpikir kreatif). Sebelum melakukan pengujian hipotesis maka data penelitian harus memenuhi uji prasyarat yang meliputi uji normalitas (uji Shapiro-Wilk), uji homogenitas varians (Lavene test), uji kesamaaan kemampuan awal siswa (uji t), uji hipotesis penelitian pada posttest dan N-gain dilakukan uji t (parametric) atau Mann Whetney (non parametric). Berdasarkan analisis data diperoleh N-Gain keterampilan berpikir kreatif siswa kelas yang mendapatkan pembelajaran dengan PBL lebih tinggi dibandingkan kelas kontrol yaitu sebesar 0,42 (kategori sedang untuk kelas eksperimen). Namun N-Gain kemampuan penguasaan konsep siswa kelas kontrol lebih tinggi dibandingkan kelas ekperimen yaitu sebesar 0,39 (kategori sedang untuk kelas kontrol)
Applications and Future Potential of X-ray Diffraction in Pharmaceutical Polymorphism: A Literature Review Dwiputra, Rizki Rava; Saputri, Jasmine Rahma; Utami, Marsah Rahmawati
Indonesian Journal of Chemistry and Environment Vol. 7 No. 2 (2024): DECEMBER 2024
Publisher : Universitas Negeri Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21831/ijoce.v7i2.79071

Abstract

Polymorphism in drug compounds is a significant phenomenon in pharmacy because it affects physicochemical properties such as solubility, stability, and bioavailability, which impact the effectiveness and safety of drugs. X-ray diffraction (XRD) is one of the methods that can be used to identify and analyze the polymorphic properties of drug compounds. This article reviews the utilization of XRD in various studies, showing that this method is effective for identifying polymorphism, detecting changes in crystal forms, monitoring crystalline phase transitions, and characterizing the formation of new crystalline phases. Although very useful, XRD has limitations in detecting amorphous phases and requires optimal sample preparation. For more comprehensive results, XRD is often combined with other techniques such as DSC and FTIR. Overall, XRD plays an important role in drug development and quality control, and this technology is expected to continue evolving, including its ability to directly monitor the crystallization process to enhance drug quality and stability.
COMPARISON OF UV-VIS SPECTROPHOTOMETRIC AND HPLC METHODS IN THE ANALYSIS OF RETINOIC ACID AND HYDROQUINONE CONTENT IN FACE CREAMS: A LITERATURE REVIEW Syifni, Moza Aulia; Utami, Marsah Rahmawati
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 4 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i4.1301

Abstract

UV-Vis spectrophotometry and HPLC are commonly used for the analysis of hydroquinone and retinoic acid, as both instruments offer a combination of accuracy, sensitivity, and ease in detecting and quantifying these compounds. UV-Vis is quick and simple to detect the content of materials based on light absorption, while HPLC is superior in separating and analyzing compounds in complex mixtures with high precision. The purpose of this literature review is to compare UV-Vis Spectrophotometry and HPLC methods for analyzing hydroquinone and retinoic acid, and a comparison was performed by examining method validation data between UV-Vis spectrophotometry and HPLC. The method applied involves a review of various related research journals, utilizing the Publish or Perish application using the Google Scholar and Semantic Scholar search engines. The results and conclusions of this study recommend HPLC as the method of choice for the identification of harmful substances, such as retinoic acid and hydroquinone, in face creams. Keywords: retinoic acid, hydroquinone, face cream, uv-vis spectrophotometry, HPLC
Bioactivity Analysis of Chalcone-Derived Compounds Based on In-Silico Molecular Docking Study Sarie, Aldila Divana; Utami, Marsah Rahmawati
Jurnal Pijar Mipa Vol. 20 No. 2 (2025)
Publisher : Department of Mathematics and Science Education, Faculty of Teacher Training and Education, University of Mataram. Jurnal Pijar MIPA colaborates with Perkumpulan Pendidik IPA Indonesia Wilayah Nusa Tenggara Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jpm.v20i2.8550

Abstract

Chalcone compounds are aromatic ketones and enones that have been found to have several activities, such as antimalarial, antioxidant, anti-inflammatory, anticancer, antiviral, anti-HIV, antifungal, antihyperglycemic, and carboxygenase inhibitors. A ligand's bioactivity can be predicted through in-silico tests using molecular docking. Molecular docking studies are conducted to study the interaction between ligand and receptor and identify the receptor's active site that matches the ligand when the ligand and receptor bind in a stable complex. This study can be a preliminary test before conducting in vitro and in vivo tests. This narrative review aims to analyze information on the bioactivity of chalcone-derived compounds and their derivatives through an in silico molecular docking approach in the form of binding affinity values and amino acid residues that bind. The method used is a literature study of 13 research articles found through the Semantic Scholar and Springer Link databases. The review results showed that the new compounds derived from chalcone compounds have a good range of bioactivity, as seen from the binding affinity values, which show lower values when compared to other test ligands and referenced ligands. The functional groups that have an important role in the interaction between ligands and proteins between ligands and receptors are triazole, methoxy, amine, halogen, carbonyl, hydroxyl, and thiol groups bound to the reactive structure of the α,β unsaturated ketone aromatic ring in the structure of the chalcone compound. The compounds that show promising activity can be further investigated as new drug candidates.
Analisis Kualitatif dan Kuantitatif Merkuri dan Timbal pada Sediaan Krim dan Body Lotion Pemutih dengan Mengunakan Spektrofotometer Serapan Atom (SSA) Haura, Ibtisamah; Utami, Marsah Rahmawati
Jurnal Sehat Mandiri Vol 20 No 1 (2025): Jurnal Sehat Mandiri, Volume 20 Nomor 1 Juni 2025
Publisher : Poltekkes Kemenkes Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33761/jsm.v20i1.1846

Abstract

The use of cosmetics for skin whitening has been widely used by the public, especially made in the form of creams and lotions. Mercury and Lead are included in hazardous materials that if used in large quantities and for a long time will cause harmful side effects. This study aims to assess the qualitative and quantitative analysis methods of mercury (Hg) content in cosmetics based on the data collected. Methods: This research is based on a literature study with an online search for articles with the time of publication of articles from 2014 to 2024 on the Google Scholar database. The results showed that the method of analyzing mercury (Hg) content in cosmetics can be done qualitatively and quantitatively. Qualitative analysis uses KI, NaOH and HCl reagents while quantitative analysis uses Atomic Absorption Spectrophotometry (SSA)/Atomic Absorption Spectrophotometry (AAS) method. Conclusion: analysis of mercury (Hg) content in cosmetics, especially creams and lotions, can be done using qualitative and quantitative analysis using the Atomic Absorption Spectrophotometry (SSA) method because it has good sensitivity to metals. Suggestion: In addition to the use of Atomic Absorption Spectrophotometer (SSA), future studies should consider the use of supporting methods such as Chromatography or UV-Vis Spectrophotometry, ICP and other instruments for comparison, as well as toxicology testing to assess the biological impact of heavy metal content toxicology testing to assess the biological impact of the detected heavy metal content.detected.
SIMPLE ALGORITHM TO CONSTRUCT CIRCULAR CONFIDENCE REGIONS IN CORRESPONDENCE ANALYSIS USING R Lestari, Karunia Eka; Utami, Marsah Rahmawati; Yudhanegara, Mokhammad Ridwan
BAREKENG: Jurnal Ilmu Matematika dan Terapan Vol 16 No 1 (2022): BAREKENG: Jurnal Ilmu Matematika dan Terapan
Publisher : PATTIMURA UNIVERSITY

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (804.913 KB) | DOI: 10.30598/barekengvol16iss1pp065-074

Abstract

Correspondence analysis has been widely applied in various fields as a graphical method to depict the association structure between two categorical random variables on a low-dimensional plot. This study built a simple algorithm to determine the principal coordinates and construct the circular confidence regions on the correspondence plot. In this algorithm, the determination of the standard residual matrix and the principal coordinates is built directly from the contingency table (without calculating a correspondence matrix). The algorithm was developed using R and applied to data on Covid-19 cases in West Java.
Photocatalytic Degradation of Diazinon in Aqueous Solutions Using ZnO Under Visible Light Irradiation: An Advanced Oxidation Process Approach Umam, Hilman Imadul; Pambudi, Teguh; Widianto, Eri; Yuliasari, Fitri; Putri, Fajar Amelia Rachmawati; Nandira, Rantika Sekar; Utami, Marsah Rahmawati
Indonesian Journal of Environmental Management and Sustainability Vol. 9 No. 3 (2025): September
Publisher : Magister Program of Material Science, Graduate School of Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/ijems.2025.9.3.105-114

Abstract

Diazinon is a commonly used organophosphate insecticide in agriculture, but its persistence in water and soil presents significant health and environmental concerns. This study investigates the photocatalytic removal of diazinon from aqueous solutions using zinc oxide (ZnO) nanoparticles activated by visible light irradiation. ZnO was chosen due to its excellent photocatalytic properties, including a direct band gap (~3.1 eV), strong oxidative capability, chemical stability, and non-toxic nature, making it a superior candidate for visible-light-driven environmental remediation. Photocatalytic degradation under sunlight was also assessed for comparison. Key operational parameters, such as photocatalyst dosage, solution pH, initial diazinon concentration, and irradiation time, were systematically optimized. The highest degradation efficiency degradation was achieved with 20 mg of ZnO, neutral pH, 30 mg/L an initial concentration, and 60 minutes of irradiation. Kinetic analysis revealed that the process followed zero-order reaction kinetics (k = 1.118; R2 = 0.9962). Notably, visible light irradiation was more effective than sunlight in degrading diazinon. These findings provide important details about the potential of ZnO nanoparticles as an efficient, low-cost, and environmentally friendly photocatalyst for remediating pesticide-contaminated water under sustainable energy conditions.
Pemanfaatan Beberapa Tanaman sebagai Sumber Antioksidan dan Obat Alternatif untuk Diabetes Melitus Utami, Marsah Rahmawati; Sholih, Mally Ghinan; Kasasiah, Ahsanal
Jurnal Pengabdian Masyarakat Progresif Humanis Brainstorming Vol 6, No 3 (2023): Jurnal Abdimas PHB : Jurnal Pengabdian Masyarakat Progresif Humanis Brainstormin
Publisher : Politeknik Harapan Bersama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30591/japhb.v6i3.4848

Abstract

World Health Organization (WHO) menyatakan bahwa diabetes melitus (DM) termasuk salah satu pembunuh terbesar di Asia tenggara dan Pasifik barat. Salah satu penyebab timbulnya penyakit diabetes melitus adalah Stres oksidatif dan kerusakan oksidatif pada jaringan. Indonesia merupakan negara megabiodiversity yang memiliki jenis tumbuhan yang berkhasiat sebagai obat. diantaranya adalah berkhasiat sebagai sumber antioksidan dan antidiabetes. Namun sayang kekayaan alam tersebut tampaknya masih belum dimanfaatkan secara optimal untuk kesehatan khususnya untuk pengobatan maupun pencegahan penyakit diabetes Mellitus. Desa Sindangmulya merupakan salah satu desa di kabupaten karawang yang tingkat penderita penyakit degenaratifnya cukup tinggi, yang diantaranya adalah diabetes mellitus. Berdasarkan hal itu, kegiatan pengabdian kepada masyarakat ini bertujuan untuk meningkatkan pengetahuan masyarakat tentang  pemanfaatan tanaman herbal  sebagai sumber antioksidan dan antidiabetes. Kegiatan dilakukan dengan metode penyuluhan dan pelatihan. Hasil kegiatan pengabdian masyarakat yang telah dilakukan menunjukkan bahwa setelah dilakukan penyuluhan dan pelatihan, pengetahuan para peserta  tentang tanaman herbal dan pemanfaatannya sebagai sumber antioksidan dan antidiabetes serta cara pembuatannya meningkat dengan rata-rata peningkatan sebesar 127,4%.
Co-Authors Adela Khasna Fatkhurohmat Adella Aisiyah Agustin, Annastya Eka Ahsanal Kasasiah Ahsanal Kasasiah Aisiyah, Adella Ajeng Nita Aryani Alfian Yuda Krishindardi Alfina Devianti An Nisaa Mutiara Salsabila Andini, Syfa Dwi Anjani, Ratna Dewi Aprida, Cantika Dewi Berliana Apriza Yuswan Ardiyanti, Yusi Aribowo, Audi Ichsani Aryani, Ajeng Nita Audi Ichsani Aribowo Bismar Al Bara Bunga Nur Annisa Cantika Dewi Berliana Aprida Cantika Nurul Sa'adah Cantika Nurul Sa'adah Christina Febiola Lubis Darmawan, Shiyami Aulia Nur Devi Ratnasari Deviana Farhani Dewi Ratnasari Dia Septiani Diva Rizqi Salsabilla Dwiputra, Rizki Rava Febiola Lubis, Christina Fika Setra Rikantara Fitriana, Nariyyah hanifah hanifah Haura, Ibtisamah Hayatul Rahmi Hendiana, Siti Nurazizah Aghisna Hidayati, Nita Ilmi, Yuniar Fathil Indah Laily Hilmi Indah Laily Hilmi Indah Megasari Juniar Irene Virda Sakina Irwansyah, Silvana Lestari Iskandar, Putri Mutiara Karina Nur Dwi Fatonah Karunia Eka Lestari Lely Sulfiani Saula Lestari Mahardika Urbaningrum Lina Nurfadhila Lina Nurfadhila Lismawan , Gita Novianti Lubis, Christina Febiola Maharani, Dhavina Maharani, Sekar Ayu Mahiya Mahiya Mally Ghinan Sholih Marisah, Marisah Marlian, Hermin Mokhammad Ridwan Yudhanegara Munir Alinu Mulki Nabila Rubinadzari Nadia Meisya Nur Faedah Nadia Oktaviani Nandira, Rantika Sekar Nena Vauziah Sary Nisrina, Hasna' Nur Annisa, Bunga Nur Sa’diyyah Nurfadhila, Lina Nurfadhilah, Lina Nurul Sa'adah, Cantika Prasetyo, Fajar Puspa Noer Fadilia PUTRI MUTIARA ISKANDAR Putri, Fajar Amelia Rachmawati Rafiq Zulkarnaen Ramadhani , Dwi Arifa Ramadhany, Arifa Salsabilla Ramlah Ratnasari, Devi Ravelliani, Andien Risky Pratama Sa'adah, Cantika Nurul Sakina, Irene Virda salsabilla, Diva rizqi Saputri, Jasmine Rahma Sari, Lala Komala Sarie, Aldila Divana Sary, Nena Vauziah Sekar Ayu Maharani Sholih, Mally Ghinan Siboro, Dewi Pratiwi Purba Silvana Lestari Irwansyah Slamet Abadi Syfa Dwi Andini Syifa Khairunnisa Syifni, Moza Aulia Teguh Pambudi Tiara Destia Fitri Tiara Nurayuni Tyasna, Putri Setya Urbaningrum, Lestari Mahardika Vesara Ardhe Gatera Vina Pratiwi Elawati Widianto, Eri Widya Tri Indarti Wiwin Wintia YULIASARI, FITRI Zakiyah, Wildani