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All Journal Pharmaciana: Jurnal Kefarmasian Jurnal Sains dan Teknologi Pangan Satya Widya BAREKENG: Jurnal Ilmu Matematika dan Terapan Dinamisia: Jurnal Pengabdian Kepada Masyarakat IJEMS (Indonesian Journal of Environmental Management and Sustainability) Media Farmasi BIOSFER : Jurnal Biologi dan Pendidikan Biologi 2-TRIK: TUNAS-TUNAS RISET KESEHATAN Jurnal Sehat Mandiri JUDIKA (JURNAL PENDIDIKAN UNSIKA) Jurnal Agrotek Indonesia Jurnal Abdimas PHB : Jurnal Pengabdian Masyarakat Progresif Humanis Brainstorming Jurnal Bidang Ilmu Kesehatan Jurnal Pendidikan dan Konseling Jurnal Sekolah Dasar (JSD) Jurnal Ners Jurnal Integrasi Kesehatan dan Sains Lumbung Farmasi : Jurnal Ilmu Kefarmasian Jurnal Penelitian Farmasi dan Herbal Journal of Holistic and Health Sciences (Jurnal Ilmu Holistik dan Kesehatan) Jurnal Ilmiah Wahana Pendidikan Jurnal EduHealth Indonesian Journal of Chemistry and Environment Jurnal Pijar MIPA Prosiding Sesiomadika Jurnal Farmasetis Journal of Pharmaceutical and Sciences. Jurnal Budiman: Pembangunan dan Pengabdian Masyarakat Nusantara Medical Sains : Jurnal Ilmiah Kefarmasian Kolaborasi Masyarakat PharmaCine: Journal of Pharmacy, Medical and Health Science
Marsah Rahmawati Utami
Universitas Singaperbangsa Karawang
Religion Agriculture, Biological Sciences & Forestry Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Physics Public Health Social Sciences Transportation Veterinary Other

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Enzyme-assisted extraction (EAE): efficient and effective green extraction on turmerik (Curcuma longa L.) and temulawak (Curcuma xanthorriza Roxb.) rhizomes for higher yield and content of curcumin Dia Septiani; Marsah Rahmawati Utami; Mally Ghinan Sholih; Tiara Nurayuni; Syifa Khairunnisa
Pharmaciana Vol. 16 No. 1 (2026): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v16i1.29314

Abstract

Curcumin, as the main active compound in Zingiberaceae plants, turmeric and temulawak, with various health benefits. That active compound generally exists in low concentrations, thus an effective and efficient method is needed to extract these compounds, such as Enzyme Assisted Extraction (EAE), one of which involves cellulase enzyme. This study aims to use the Enzyme Assisted-Extraction (EAE) method with cellulase enzyme in the extraction of curcumin from turmeric and temulawak plants, and to evaluate the extraction yield and efficiency of extract, comparing the curcumin content in turmeric and temulawak extracts between EAE and conventional maceration extraction method. The research was conducted using a Randomized Block Design (RBD) experiment with variations in temperature (45°, 50°, 55℃), time (1 hour, 2 hours, 3 hours), and enzyme concentration of 6%. The research stages included determining the water and ash content in the raw materials, water content in the extracts, extraction using maceration and EAE methods, determination of extract yield, extract purification, phenol screening, analysis of curcumin content using UV-Vis Spectrophotometry, and statistical analysis using the Mann-Whitney test. The results showed that the use of cellulase enzyme in the extraction process of turmeric and temulawak successfully increased the extract yield and curcumin content. The highest yield was obtained in turmeric at 34.24%± 0.038, and the highest curcumin content was achieved at a temperature of 45˚C for 2 hours, reaching 56.86% ± 0.090. Meanwhile, in temulawak, the highest yield was 53.11%± 0.385, and the highest curcumin content was obtained at a temperature of 50˚C for 2 hours, reaching 54.10% ± 0.100. There was an increase in curcumin content in turmeric and temulawak EAE extract compared to the conventional maceration extraction method. Statistical analysis using the Mann-Whitney test (p < 0.05,) indicating a significant difference between the EAE and conventional maceration extraction method.
Peningkatan Pemahaman Masyarakat Mengenai Penggunaan Antibiotik untuk Cegah Resistensi di Kampung Rawa Panjang Mulki, Munir Alinu; Sholih, Mally Ghinan; Utami, Marsah Rahmawati; Siboro, Dewi Pratiwi Purba
Kolaborasi Masyarakat Volume 1 Issue 1
Publisher : ETFLIN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/kolmas0101210

Abstract

Antibiotics are substances or compounds that are either synthetically produced or naturally generated by microorganisms, especially fungi. They are used as inhibitors of other microorganisms. The use of antibiotics in humans is based on their minimal toxicity to the human body. Inaccurate and prolonged use of antibiotics can lead to the development of resistance. A step taken to minimize antibiotic resistance is the introduction of the 2023 PITIK (Penyuluhan Informasi Tentang Antibiotik) program. Thirty-three participants from the community around Kampung Rawa Panjang, Gang Pemuda, RT 01/RW 05, Kota Bekasi, attended this antibiotic education program. Education for the community was conducted using a cross-sectional approach and a questionnaire as an instrument. The results of questionnaire data analysis show that public understanding of the definition, how it works, side effects, how to purchase and how to use antibiotics correctly increased from 27.3% to 93.9%. Therefore, it can be concluded that this education program helps improve public awareness of the proper use of antibiotics.
Analisis Kualitatif dan Kuantitatif Merkuri dan Timbal pada Sediaan Krim dan Body Lotion Pemutih dengan Mengunakan Spektrofotometer Serapan Atom (SSA) Ibtisamah Haura; Marsah Rahmawati Utami
Jurnal Sehat Mandiri Vol 20 No 1 (2025): Jurnal Sehat Mandiri, Volume 20 Nomor 1 Juni 2025
Publisher : Poltekkes Kemenkes Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33761/jsm.v20i1.1846

Abstract

The use of cosmetics for skin whitening has been widely used by the public, especially made in the form of creams and lotions. Mercury and Lead are included in hazardous materials that if used in large quantities and for a long time will cause harmful side effects. This study aims to assess the qualitative and quantitative analysis methods of mercury (Hg) content in cosmetics based on the data collected. Methods: This research is based on a literature study with an online search for articles with the time of publication of articles from 2014 to 2024 on the Google Scholar database. The results showed that the method of analyzing mercury (Hg) content in cosmetics can be done qualitatively and quantitatively. Qualitative analysis uses KI, NaOH and HCl reagents while quantitative analysis uses Atomic Absorption Spectrophotometry (SSA)/Atomic Absorption Spectrophotometry (AAS) method. Conclusion: analysis of mercury (Hg) content in cosmetics, especially creams and lotions, can be done using qualitative and quantitative analysis using the Atomic Absorption Spectrophotometry (SSA) method because it has good sensitivity to metals. Suggestion: In addition to the use of Atomic Absorption Spectrophotometer (SSA), future studies should consider the use of supporting methods such as Chromatography or UV-Vis Spectrophotometry, ICP and other instruments for comparison, as well as toxicology testing to assess the biological impact of heavy metal content toxicology testing to assess the biological impact of the detected heavy metal content.detected.
Review Sistematis: Pengaruh Kondisi Penyimpanan Terhadap Stabilitas Tablet Vitamin C Dan Aspirin Arifa Salsabilla Ramadhany; Marsah Rahmawati Utami; Dwi Arifa Ramadhani; Gita Novianti Lismawan
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1165

Abstract

This study aims to determine the most optimal storage conditions for maintaining the stability of vitamin C and aspirin tablets by considering key environmental factors such as temperature, humidity, light exposure, and storage duration. The review was conducted using a systematic review approach based on the PRISMA guidelines. Literature searches were performed through three main sources, namely PubMed, ScienceDirect, and Google Scholar, covering publications from 2015 to early 2025. The search through Google Scholar was carried out to complement the findings and minimize publication bias. A total of 14 research articles that met the inclusion criteria were analyzed in depth. The results indicate that vitamin C tablets exhibit the highest stability at low to room temperature (<30°C), under dry conditions with relative humidity below 75% RH, and protected from direct light exposure. In contrast, aspirin tablets show optimal stability at room temperature (around 25°C), under moderate humidity (<60% RH), and when stored in tightly sealed, light-resistant containers. The degradation of vitamin C is primarily driven by oxidation induced by heat, light, and moisture, whereas aspirin undergoes hydrolysis under humid and high-temperature conditions. Therefore, storing both tablets in a cool, dry place away from direct light is the most effective approach to preserve their stability and therapeutic efficacy throughout their shelf life.
Co-Authors Adela Khasna Fatkhurohmat Adella Aisiyah Agustin, Annastya Eka Ahsanal Kasasiah Ahsanal Kasasiah Aisiyah, Adella Ajeng Nita Aryani Alfian Yuda Krishindardi Alfina Devianti An Nisaa Mutiara Salsabila Andini, Syfa Dwi Anjani, Ratna Dewi Aprida, Cantika Dewi Berliana Apriza Yuswan Ardiyanti, Yusi Aribowo, Audi Ichsani Arifa Salsabilla Ramadhany Aryani, Ajeng Nita Audi Ichsani Aribowo Bismar Al Bara Bunga Nur Annisa Cantika Dewi Berliana Aprida Cantika Nurul Sa&#039;adah Cantika Nurul Sa'adah Christina Febiola Lubis Darmawan, Shiyami Aulia Nur Devi Ratnasari Deviana Farhani Dewi Ratnasari Dia Septiani Diva Rizqi Salsabilla Dwi Arifa Ramadhani Dwiputra, Rizki Rava Febiola Lubis, Christina Fika Setra Rikantara Gita Novianti Lismawan hanifah hanifah Hayatul Rahmi Hendiana, Siti Nurazizah Aghisna Hidayati, Nita Ibtisamah Haura Indah Laily Hilmi Indah Laily Hilmi Indah Megasari Juniar Irene Virda Sakina Irwansyah, Silvana Lestari Iskandar, Putri Mutiara Karina Nur Dwi Fatonah Karunia Eka Lestari Lely Sulfiani Saula Lestari Mahardika Urbaningrum Lina Nurfadhila Lina Nurfadhila Lubis, Christina Febiola Maharani, Dhavina Maharani, Sekar Ayu Mahiya Mahiya Mally Ghinan Sholih Marisah, Marisah Marlian, Hermin Mokhammad Ridwan Yudhanegara Munir Alinu Mulki Nabila Rubinadzari Nadia Meisya Nur Faedah Nadia Oktaviani Nandira, Rantika Sekar Nena Vauziah Sary Nisrina, Hasna' Nur Annisa, Bunga Nur Sa’diyyah Nurfadhila, Lina Nurfadhilah, Lina Nurul Sa'adah, Cantika Prasetyo, Fajar Puspa Noer Fadilia PUTRI MUTIARA ISKANDAR Putri, Fajar Amelia Rachmawati Rafiq Zulkarnaen Ramlah Ratnasari, Devi Ravelliani, Andien Risky Pratama Sa'adah, Cantika Nurul Sakina, Irene Virda salsabilla, Diva rizqi Saputri, Jasmine Rahma Sari, Lala Komala Sarie, Aldila Divana Sary, Nena Vauziah Sekar Ayu Maharani Sholih, Mally Ghinan Siboro, Dewi Pratiwi Purba Silvana Lestari Irwansyah Slamet Abadi Syfa Dwi Andini Syifa Khairunnisa Syifni, Moza Aulia Teguh Pambudi Tiara Destia Fitri Tiara Nurayuni Tyasna, Putri Setya Urbaningrum, Lestari Mahardika Vesara Ardhe Gatera Vina Pratiwi Elawati Widianto, Eri Widya Tri Indarti Wiwin Wintia YULIASARI, FITRI Zakiyah, Wildani