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All Journal Jurnal Sains dan Teknologi Pangan Satya Widya Acta Pharmaciae Indonesia : Acta Pharm Indo BAREKENG: Jurnal Ilmu Matematika dan Terapan Dinamisia: Jurnal Pengabdian Kepada Masyarakat IJEMS (Indonesian Journal of Environmental Management and Sustainability) Media Farmasi BIOSFER : Jurnal Biologi dan Pendidikan Biologi 2-TRIK: TUNAS-TUNAS RISET KESEHATAN Jurnal Sehat Mandiri JUDIKA (JURNAL PENDIDIKAN UNSIKA) Jurnal Agrotek Indonesia Jurnal Abdimas PHB : Jurnal Pengabdian Masyarakat Progresif Humanis Brainstorming Jurnal Bidang Ilmu Kesehatan Jurnal Pendidikan dan Konseling Jurnal Sekolah Dasar (JSD) Jurnal Ners Jurnal Integrasi Kesehatan dan Sains Lumbung Farmasi : Jurnal Ilmu Kefarmasian Jurnal Penelitian Farmasi dan Herbal Journal of Holistic and Health Sciences (Jurnal Ilmu Holistik dan Kesehatan) Jurnal Ilmiah Wahana Pendidikan Jurnal EduHealth Indonesian Journal of Chemistry and Environment Jurnal Pijar MIPA Prosiding Sesiomadika Jurnal Farmasetis PharmaCine : Journal of Pharmacy, Medical and Health Science Analit: Analytical and Environmental Chemistry Journal of Pharmaceutical and Sciences. Jurnal Budiman: Pembangunan dan Pengabdian Masyarakat Nusantara Medical Sains : Jurnal Ilmiah Kefarmasian
Marsah Rahmawati Utami
Universitas Singaperbangsa Karawang
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COMPARISON OF UV-VIS SPECTROPHOTOMETRIC AND HPLC METHODS IN THE ANALYSIS OF RETINOIC ACID AND HYDROQUINONE CONTENT IN FACE CREAMS: A LITERATURE REVIEW Syifni, Moza Aulia; Utami, Marsah Rahmawati
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 4 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i4.1301

Abstract

UV-Vis spectrophotometry and HPLC are commonly used for the analysis of hydroquinone and retinoic acid, as both instruments offer a combination of accuracy, sensitivity, and ease in detecting and quantifying these compounds. UV-Vis is quick and simple to detect the content of materials based on light absorption, while HPLC is superior in separating and analyzing compounds in complex mixtures with high precision. The purpose of this literature review is to compare UV-Vis Spectrophotometry and HPLC methods for analyzing hydroquinone and retinoic acid, and a comparison was performed by examining method validation data between UV-Vis spectrophotometry and HPLC. The method applied involves a review of various related research journals, utilizing the Publish or Perish application using the Google Scholar and Semantic Scholar search engines. The results and conclusions of this study recommend HPLC as the method of choice for the identification of harmful substances, such as retinoic acid and hydroquinone, in face creams. Keywords: retinoic acid, hydroquinone, face cream, uv-vis spectrophotometry, HPLC
Bioactivity Analysis of Chalcone-Derived Compounds Based on In-Silico Molecular Docking Study Sarie, Aldila Divana; Utami, Marsah Rahmawati
Jurnal Pijar Mipa Vol. 20 No. 2 (2025)
Publisher : Department of Mathematics and Science Education, Faculty of Teacher Training and Education, University of Mataram. Jurnal Pijar MIPA colaborates with Perkumpulan Pendidik IPA Indonesia Wilayah Nusa Tenggara Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jpm.v20i2.8550

Abstract

Chalcone compounds are aromatic ketones and enones that have been found to have several activities, such as antimalarial, antioxidant, anti-inflammatory, anticancer, antiviral, anti-HIV, antifungal, antihyperglycemic, and carboxygenase inhibitors. A ligand's bioactivity can be predicted through in-silico tests using molecular docking. Molecular docking studies are conducted to study the interaction between ligand and receptor and identify the receptor's active site that matches the ligand when the ligand and receptor bind in a stable complex. This study can be a preliminary test before conducting in vitro and in vivo tests. This narrative review aims to analyze information on the bioactivity of chalcone-derived compounds and their derivatives through an in silico molecular docking approach in the form of binding affinity values and amino acid residues that bind. The method used is a literature study of 13 research articles found through the Semantic Scholar and Springer Link databases. The review results showed that the new compounds derived from chalcone compounds have a good range of bioactivity, as seen from the binding affinity values, which show lower values when compared to other test ligands and referenced ligands. The functional groups that have an important role in the interaction between ligands and proteins between ligands and receptors are triazole, methoxy, amine, halogen, carbonyl, hydroxyl, and thiol groups bound to the reactive structure of the α,β unsaturated ketone aromatic ring in the structure of the chalcone compound. The compounds that show promising activity can be further investigated as new drug candidates.
Analisis Kualitatif dan Kuantitatif Merkuri dan Timbal pada Sediaan Krim dan Body Lotion Pemutih dengan Mengunakan Spektrofotometer Serapan Atom (SSA) Haura, Ibtisamah; Utami, Marsah Rahmawati
Jurnal Sehat Mandiri Vol 20 No 1 (2025): Jurnal Sehat Mandiri, Volume 20 Nomor 1 Juni 2025
Publisher : Poltekkes Kemenkes Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33761/jsm.v20i1.1846

Abstract

The use of cosmetics for skin whitening has been widely used by the public, especially made in the form of creams and lotions. Mercury and Lead are included in hazardous materials that if used in large quantities and for a long time will cause harmful side effects. This study aims to assess the qualitative and quantitative analysis methods of mercury (Hg) content in cosmetics based on the data collected. Methods: This research is based on a literature study with an online search for articles with the time of publication of articles from 2014 to 2024 on the Google Scholar database. The results showed that the method of analyzing mercury (Hg) content in cosmetics can be done qualitatively and quantitatively. Qualitative analysis uses KI, NaOH and HCl reagents while quantitative analysis uses Atomic Absorption Spectrophotometry (SSA)/Atomic Absorption Spectrophotometry (AAS) method. Conclusion: analysis of mercury (Hg) content in cosmetics, especially creams and lotions, can be done using qualitative and quantitative analysis using the Atomic Absorption Spectrophotometry (SSA) method because it has good sensitivity to metals. Suggestion: In addition to the use of Atomic Absorption Spectrophotometer (SSA), future studies should consider the use of supporting methods such as Chromatography or UV-Vis Spectrophotometry, ICP and other instruments for comparison, as well as toxicology testing to assess the biological impact of heavy metal content toxicology testing to assess the biological impact of the detected heavy metal content.detected.
SIMPLE ALGORITHM TO CONSTRUCT CIRCULAR CONFIDENCE REGIONS IN CORRESPONDENCE ANALYSIS USING R Lestari, Karunia Eka; Utami, Marsah Rahmawati; Yudhanegara, Mokhammad Ridwan
BAREKENG: Jurnal Ilmu Matematika dan Terapan Vol 16 No 1 (2022): BAREKENG: Jurnal Ilmu Matematika dan Terapan
Publisher : PATTIMURA UNIVERSITY

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (804.913 KB) | DOI: 10.30598/barekengvol16iss1pp065-074

Abstract

Correspondence analysis has been widely applied in various fields as a graphical method to depict the association structure between two categorical random variables on a low-dimensional plot. This study built a simple algorithm to determine the principal coordinates and construct the circular confidence regions on the correspondence plot. In this algorithm, the determination of the standard residual matrix and the principal coordinates is built directly from the contingency table (without calculating a correspondence matrix). The algorithm was developed using R and applied to data on Covid-19 cases in West Java.
Photocatalytic Degradation of Diazinon in Aqueous Solutions Using ZnO Under Visible Light Irradiation: An Advanced Oxidation Process Approach Umam, Hilman Imadul; Pambudi, Teguh; Widianto, Eri; Yuliasari, Fitri; Putri, Fajar Amelia Rachmawati; Nandira, Rantika Sekar; Utami, Marsah Rahmawati
Indonesian Journal of Environmental Management and Sustainability Vol. 9 No. 3 (2025): September
Publisher : Magister Program of Material Science, Graduate School of Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/ijems.2025.9.3.105-114

Abstract

Diazinon is a commonly used organophosphate insecticide in agriculture, but its persistence in water and soil presents significant health and environmental concerns. This study investigates the photocatalytic removal of diazinon from aqueous solutions using zinc oxide (ZnO) nanoparticles activated by visible light irradiation. ZnO was chosen due to its excellent photocatalytic properties, including a direct band gap (~3.1 eV), strong oxidative capability, chemical stability, and non-toxic nature, making it a superior candidate for visible-light-driven environmental remediation. Photocatalytic degradation under sunlight was also assessed for comparison. Key operational parameters, such as photocatalyst dosage, solution pH, initial diazinon concentration, and irradiation time, were systematically optimized. The highest degradation efficiency degradation was achieved with 20 mg of ZnO, neutral pH, 30 mg/L an initial concentration, and 60 minutes of irradiation. Kinetic analysis revealed that the process followed zero-order reaction kinetics (k = 1.118; R2 = 0.9962). Notably, visible light irradiation was more effective than sunlight in degrading diazinon. These findings provide important details about the potential of ZnO nanoparticles as an efficient, low-cost, and environmentally friendly photocatalyst for remediating pesticide-contaminated water under sustainable energy conditions.
Pemanfaatan Beberapa Tanaman sebagai Sumber Antioksidan dan Obat Alternatif untuk Diabetes Melitus Utami, Marsah Rahmawati; Sholih, Mally Ghinan; Kasasiah, Ahsanal
Jurnal Pengabdian Masyarakat Progresif Humanis Brainstorming Vol 6, No 3 (2023): Jurnal Abdimas PHB : Jurnal Pengabdian Masyarakat Progresif Humanis Brainstormin
Publisher : Politeknik Harapan Bersama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30591/japhb.v6i3.4848

Abstract

World Health Organization (WHO) menyatakan bahwa diabetes melitus (DM) termasuk salah satu pembunuh terbesar di Asia tenggara dan Pasifik barat. Salah satu penyebab timbulnya penyakit diabetes melitus adalah Stres oksidatif dan kerusakan oksidatif pada jaringan. Indonesia merupakan negara megabiodiversity yang memiliki jenis tumbuhan yang berkhasiat sebagai obat. diantaranya adalah berkhasiat sebagai sumber antioksidan dan antidiabetes. Namun sayang kekayaan alam tersebut tampaknya masih belum dimanfaatkan secara optimal untuk kesehatan khususnya untuk pengobatan maupun pencegahan penyakit diabetes Mellitus. Desa Sindangmulya merupakan salah satu desa di kabupaten karawang yang tingkat penderita penyakit degenaratifnya cukup tinggi, yang diantaranya adalah diabetes mellitus. Berdasarkan hal itu, kegiatan pengabdian kepada masyarakat ini bertujuan untuk meningkatkan pengetahuan masyarakat tentang  pemanfaatan tanaman herbal  sebagai sumber antioksidan dan antidiabetes. Kegiatan dilakukan dengan metode penyuluhan dan pelatihan. Hasil kegiatan pengabdian masyarakat yang telah dilakukan menunjukkan bahwa setelah dilakukan penyuluhan dan pelatihan, pengetahuan para peserta  tentang tanaman herbal dan pemanfaatannya sebagai sumber antioksidan dan antidiabetes serta cara pembuatannya meningkat dengan rata-rata peningkatan sebesar 127,4%.
Uji Daya Proteksi Losion Minyak Atsiri Daun Mint (Mentha x piperita L.) sebagai Repelan terhadap Nyamuk Aedes aegypti Darmawan, Shiyami Aulia Nur; Utami, Marsah Rahmawati; Ratnasari, Devi
Jurnal Integrasi Kesehatan dan Sains Vol 6, No 2 (2024): Jurnal Integrasi Kesehatan dan Sains
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jiks.v6i2.13726

Abstract

AbstrakGigitan nyamuk merupakan masalah kesehatan umum yang dihadapi banyak orang di seluruh dunia. Selain mengakibatkan ketidaknyamanan dan rasa gatal, gigitan nyamuk juga dapat menyebabkan penularan penyakit seperti DBD dan malaria. Repelan merupakan zat kimia yang mampu mengusir serangga dari manusia. Senyawa kimia yang sering digunakan untuk repelan adalah N,N-Dietil-m-toluamida (DEET). Tujuan penelitian ini adalah mengidentifikasi kandungan senyawa dalam minyak atsiri daun mint, menganalisis karakteristik fisik losion minyak atsiri daun mint, dan menguji daya proteksi sediaan losion daun mint sebagai repelan terhadap nyamuk Aedes aegypti. Metode yang digunakan adalah experimental research. Penelitian ini dilakukan di Laboratorium Farmasi Universitas Singaperbangsa Karawang, Laboratorium Kimia Instrumen Universitas Pendidikan Indonesia, dan Litbangkes Pangandaran selama bulan Desember 2023 sampai April 2024. Subjek penelitian ini menggunakan nyamuk Aedes aegypti dan analisis data yang dilakukan menggunakan microsoft excel. Hasil penelitian ini menunjukkan pada analisis dengan GC-MS komponen terbesar dalam minyak atsiri daun mint (Mentha x piperita L.) adalah carvone, α-ocimene, Limonene, α-terpinolene, dan γ-terpinene. Karakteristik fisik pada losion minyak atsiri daun mint memenuhi syarat berdasar evaluasi yang telah dilakukan. Pada pengujian daya proteksi menunjukkan bahwa pada jam ke-0 losion minyak atsiri daun mint dengan konsentrasi minyak atsiri daun mint 5% daya proteksi tertinggi sebesar 93,72%; konsentrasi minyak atsiri daun mint 10% daya proteksi tertinggi sebesar 94,50%; dan pada konsentrasi minyak atsiri daun mint 15% daya proteksi tertinggi sebesar 97,05%. Daya proteksi dari konsentrasi masing-masing mengalami penurunan pada jam ke-1 sampai dengan jam ke-5. Simpulan, sediaan losion minyak atsiri daun mint konsentrasi 15% merupakan daya proteksi paling tinggi, namun kurang efektif untuk digunakan sebagai repelan.Protective Efficacy Test of Mint Essential Oil Lotion (Mentha x piperita L.) as a Repellent Against Aedes aegypti MosquitoesAbstractMosquito bites are a common health problem many people worldwide face. In addition to causing discomfort and itching, mosquito bites can also cause the transmission of diseases such as dengue and malaria. Repelling is a chemical substance that can repel insects from humans. A chemical compound often used for repelling is N, N-Dietyl-m-toluamide (DEET). The purpose of this study is to identify the content of compounds in mint leaf essential oil, analyze the physical characteristics of mint leaf essential oil lotion, and test the protective power of mint leaf lotion preparations as a repellent against Aedes aegypti mosquitoes. The method used is experimental research. During five months, this research was conducted in the Pharmacy Laboratory of Singaperbangsa University Karawang, the Instrument Chemistry Laboratory of the Indonesian Education University, and Pangandaran Health Research and Development during December 2023 until April 2024. The subject of this study used the Aedes aegypti mosquito, and data analysis was carried out using Microsoft Excel. This study showed that the most significant components in mint leaf essential oil (Mentha x piperita L.) were carvone, α-ocimene, limonene, α-terpinolene, and γ-terpinene. The physical characteristics of the mint leaf essential oil lotion meet the requirements of the evaluation that has been carried out. The protection test showed that at the 0th hour of mint leaf essential oil lotion with a mint leaf essential oil concentration of 5%, the highest protection power was 93.72%, the concentration of mint leaf essential oil was 10%, the highest protection power was 94.50%, and at the concentration of mint leaf essential oil of 15%, the highest protection power was 97.05%. The protection of each concentration decreased from the 1st to the 5th hour. In conclusion, mint leaf essential oil lotion preparations, with a concentration of 15%, are the highest protection but less effective for use as a repellent.
Article Review: Analysis Of Artificial Sweetness In Food And Beverages: English Zakiyah, Wildani; Nurul Sa'adah, Cantika; Prasetyo, Fajar; Febiola Lubis, Christina; Lina Nurfadhila; Marsah Rahmawati Utami
Jurnal EduHealth Vol. 13 No. 02 (2022): Jurnal eduHealth, Periode Oktober - December, 2022
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (366.02 KB)

Abstract

Artificial sweeteners are substances added to food and beverages with the aim of giving a sweet taste, having no nutritional value. The types of artificial sweeteners allowed by the Minister of Health are Cyclamate, Saccharin, Aspartame and Sorbitol. The method used in this paper is a literature review study. The total journals used in this article review are 14 journals. In several studies, the levels of artificial sweeteners contained in related foods are still within the limits permitted by the government, but in some studies there are still foods whose levels of artificial sweeteners exceed the permitted limits.
Study Of Molecular Docking On Compounds With Potential As Anti-Inflammatory Ravelliani, Andien; Nisrina, Hasna'; Sari, Lala Komala; Marisah, Marisah; Agustin, Annastya Eka; Maharani, Dhavina; Utami, Marsah Rahmawati; Nurfadhila, Lina
Jurnal EduHealth Vol. 13 No. 02 (2022): Jurnal eduHealth, Periode Oktober - December, 2022
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (232.665 KB)

Abstract

Inflammation is a protective response caused by damage to certain tissues. Anti-inflammatory is a substance or drug used to treat redness, increased body temperature, swelling, pain and loss of function of an organ. Steroid and non-steroidal anti-inflammatory drugs have many side effects, so studies are needed to develop new drugs to minimize side effects and improve therapeutic effects. The method used is literature review from journals and articles obtained from Google Scholar in 15 journals. The purpose of the literature review is to find out the study of the development of new drugs from several compounds that have potential as anti-inflammatories. Secondary metabolites that have potential as anti-inflammatory include essential oils, flavonoids, alkaloids, terpenoids, and anthocyanins. Secondary metabolites will interact with the cyclooxygenase (COX) enzyme which is the main mediator of inflammation. The results obtained from the 15 compounds contain these secondary metabolites so they have the potential as anti-inflammatory.
Identification Of Carbohydrate, Protein And Fat Levels In Flour, Cheese, Milk And Yoghurt Through Several Test Methods Tyasna, Putri Setya; Agustin, Annastya Eka; Maharani, Dhavina; Utami, Marsah Rahmawati; Nurfadhilah, Lina
Jurnal EduHealth Vol. 13 No. 02 (2022): Jurnal eduHealth, Periode Oktober - December, 2022
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (231.145 KB)

Abstract

Food is incoming substance to in body human and processed in a manner chemical and biological like carbohydrates , proteins, and fats. each of third substance this have very important role for body . Carbohydrate useful as one source energy , increase the sweet taste , regulate the process of glucose blood , and can solve fatty acids. Proteins play a role in metabolic processes , catalysts enzymatic , antibody , and carrier signal in a manner biological . Useful fat as warmer body , adjustment with change temperature , and protect body from crash . For knowing how much many content of fat , protein, and carbohydrates contained in a food or drink so need done testing in a manner qualitative and quantitative , testing this depending on the sample being tested and the effect temperature nor ingredient standard used . The purpose of the literature review is to determine and compare the levels of carbohydrates, proteins and fats in samples of flour, milk, cheese and yogurt through various test methods.
Co-Authors Adela Khasna Fatkhurohmat Agustin, Annastya Eka Ahsanal Kasasiah Ahsanal Kasasiah Aisiyah, Adella Alfian Yuda Krishindardi Alfina Devianti An Nisaa Mutiara Salsabila Andini, Syfa Dwi Anjani, Ratna Dewi Aprida, Cantika Dewi Berliana Apriza Yuswan Ardiyanti, Yusi Aribowo, Audi Ichsani Aryani, Ajeng Nita Audi Ichsani Aribowo Bismar Al Bara Bunga Nur Annisa Cantika Nurul Sa'adah Darmawan, Shiyami Aulia Nur Devi Ratnasari Deviana Farhani Dewi Ratnasari Dwiputra, Rizki Rava Febiola Lubis, Christina Fika Setra Rikantara Fitriana, Nariyyah hanifah hanifah Haura, Ibtisamah Hayatul Rahmi Hendiana, Siti Nurazizah Aghisna Hidayati, Nita Ilmi, Yuniar Fathil Indah Laily Hilmi Indah Laily Hilmi Indah Megasari Juniar Irwansyah, Silvana Lestari Iskandar, Putri Mutiara Karina Nur Dwi Fatonah Karunia Eka Lestari Lely Sulfiani Saula Lina Nurfadhila Lina Nurfadhila Lismawan , Gita Novianti Lubis, Christina Febiola Maharani, Dhavina Maharani, Sekar Ayu Mahiya Mahiya Mally Ghinan Sholih Marisah, Marisah Marlian, Hermin Mokhammad Ridwan Yudhanegara Munir Alinu Mulki Nabila Rubinadzari Nadia Meisya Nur Faedah Nadia Oktaviani Nandira, Rantika Sekar Nena Vauziah Sary Nisrina, Hasna' Nur Annisa, Bunga Nur Sa’diyyah Nurfadhila, Lina Nurfadhilah, Lina Nurul Sa'adah, Cantika Prasetyo, Fajar Puspa Noer Fadilia Putri, Fajar Amelia Rachmawati Rafiq Zulkarnaen Ramadhani , Dwi Arifa Ramadhany, Arifa Salsabilla Ramlah Ratnasari, Devi Ravelliani, Andien Risky Pratama Sa'adah, Cantika Nurul Sakina, Irene Virda salsabilla, Diva rizqi Saputri, Jasmine Rahma Sari, Lala Komala Sarie, Aldila Divana Sary, Nena Vauziah Sholih, Mally Ghinan Slamet Abadi Syifni, Moza Aulia Teguh Pambudi Tiara Destia Fitri Tyasna, Putri Setya Urbaningrum, Lestari Mahardika Vesara Ardhe Gatera Vina Pratiwi Elawati Widianto, Eri Widya Tri Indarti Wiwin Wintia YULIASARI, FITRI Zakiyah, Wildani