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All Journal HAYATI Journal of Biosciences Natural Science: Journal of Science and Technology Biospecies Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences METAMORFOSA Journal of Biological Sciences Jurnal Pendidikan Matematika dan IPA AL KAUNIYAH Biogenesis: Jurnal Ilmiah Biologi Jurnal Biologi Universitas Andalas Indonesian Journal of Biotechnology TREUBIA JMPM (Jurnal Material dan Proses Manufaktur) Jurnal Biologi Tropis JURNAL KESEHATAN PERINTIS Majalah Kedokteran Andalas Menara Ilmu International Journal of Agricultural Sciences Sainstek : Jurnal Sains dan Teknologi Best Journal (Biology Education, Sains and Technology) Jurnal Ners Journal of Ocean, Mechanical and Aerospace -science and engineering- (JOMAse) Makara Journal of Science
Djong Hon Tjong
Universitas Andalas
Aerospace Engineering Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Cell-Free Therapeutic Mechanisms of AD-MSC Secretome in Type 2 Diabetes Mellitus: Literature Review Padilla, Putri Rahma; Marlina, Marlina; Tjong, Djong Hon
Jurnal Biologi Tropis Vol. 25 No. 4a (2025): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4a.10623

Abstract

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder with a globally increasing prevalence, while conventional therapies often fail to halt disease progression. The secretome derived from adipose-derived mesenchymal stem cells (AD-MSCs) holds great potential as a cell-free therapy strategy, as it contains various bioactive molecules, cytokines, and extracellular vesicles that regulate glucose metabolism and modulate immune responses. This review discusses the molecular components of AD-MSC secretome, its mechanisms in enhancing insulin sensitivity and protecting pancreatic β-cells, as well as the challenges in its clinical application. Based on literature from 2018–2025 in PubMed, Scopus, and Web of Science, AD-MSC secretome has been shown to enhance IRS-1 phosphorylation, activate the PI3K/Akt pathway, and promote GLUT4 translocation while suppressing chronic inflammation. Growth factors (HGF, IGF-1, VEGF) and microRNAs (miR-126, miR-21, miR-146a) contribute to β-cell regeneration. Donor variability, culture conditions, and isolation methods affect secretome quality, which can be optimized through preconditioning or genetic modification.
Co-Authors - Jumawita - Syaifullah Aadrean Aidil, Dyta Rabbani Aldino Fauzil Fanani Almurdi Almurdi Amir Hamidy AMIR HAMIDY Anggraini, Debie Annisya Fitri Anthoni Agustien Anugrah Viona Agesi Arum Setiawan Asnul Fitria Aurora, Dhea Apriano Dahelmi Dahelmi Dahelmi David Gusman Dewi Imelda Roesma Dharmayanthi, Anik Budhi Dian Juliadmi Djoko T. Iskandar Djoko T. Iskandar, Djoko T. Dwitya Elvira, Dwitya Dyta Rabbani Aidil Elli Firdamila fachrul reza, fachrul Fauzan . Feskaharny Alamsjah Firdamila, Elli Fuji Astuti Febria G Gunawarman, G Gusman, David Hadi Addaha, Hadi Hadi Kurniawan Henny Herwina Hirowati Ali Hirowati Ali, Hirowati Ida Ayu Putu Sri Widnyani Ilhamdi, Ilhamdi Indra Junaidi Zakaria Irawati Chaniago Irvan Fadli Wanda Jamsari Jamsari Janra, Muhammad Nazri Jon Affi, Jon Juliadmi, Dian Kevin Origia Kevin Origia Kharisma Putra Liza Aulia Yusfi Mahmudul Hasan Mahmudul Hasan, Mahmudul Marlina Marlina Masayuki Sumida Masayuki Sumida, Masayuki Maulana, Imron Melinda, Annisa Menkher Manjas Meri Wulandari Muhamad Irsyad Muhammad Silmi Nelmi Fitria Netty Marusin Netty Marusin Nia Kurniawan Nia Kurniawan Nofrita Nofrita Nofrita Nofrita Nurul Aida Nurvalinda, Nurvalinda Nuswantoro, Nuzul Ficky Nuzulia Irawati Oktaviana, Dili Padilla, Putri Rahma Prawira, Furqan Dwiki Lintang Putri, Emilya Putri, Fanny Adhy Rahmadina, Shovinda Ravelino Nesty Resti Rahayu Ridho Hendrikos Rifka Rahmat Riska Mayori Rita Permatasari Rivi Hamdani Rizaldi Rizaldi Rizia Irsa Salis, Viola Mutiara Saputri, Rahmi Agu Silvia Indra Sisca Dwi Yarni Sri Wahyuni Handayani Sri Wahyuni Handayani, Sri Wahyuni Syaifullah Syaifullah Syaifullah Syaifullah Syaifullah Syandri, Hafrijal Takeshi Igawa Takeshi Igawa, Takeshi Tesri Maideliza Tofrizal Wilson Novarino Yarni, Sisca Dwi Yelvita Sari Yeni Gusma Yanti Yuliarni Syafrita Yurike Nova Edlin Zil Fadhillah Rahma Zozy Aneloi Noli