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All Journal Saintika Medika: Jurnal Ilmu Kesehatan dan Kedokteran Keluarga. Biology, Medicine, & Natural Product Chemistry Biomedika Bioeksperimen: Jurnal Penelitian Biologi Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement) Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Herb-Medicine Journal MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Surya Medika: Jurnal Ilmiah Ilmu Keperawatan dan Ilmu Kesehatan Masyarakat Open Access Indonesian Journal of Medical Reviews Gemakes: Jurnal Pengabdian Kepada Masyarakat Proceeding ISETH (International Summit on Science, Technology, and Humanity) Prosiding University Research Colloquium Jurnal Pengabdian Masyarakat Medika Biomedika
Riandini Aisyah
Universitas Muhammadiyah Surakarta
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Journal : Biology, Medicine,

 1 
Bio-larvicidal Potential of Betel Leaves (Piper betle L) Ethanolic Extract in Addition of PEG 400 Diluent on Aedes aegypti Larvae Dewi, Listiana Masyita; Ariffah, Hilda Zaniba; Aisyah, Riandini; Nurhayani, Nurhayani
Biology, Medicine, & Natural Product Chemistry Vol 12, No 2 (2023)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2023.122.451-455

Abstract

Dengue hemorrhagic fever (DHF) is a kind of vector transmitted disease, by Aedes aegypti. It is one of major public health problem around the world, including Indonesia, because it may lead to epidemics and death in a short time. The use of plant extracts as bio-larvicidal is thought to be a promising solution, and one of them is the betel leaves (Piper betle L). The addition of polyethylene glycol (PEG) as a diluent is thought may increase the dispersity of plant extract in the water which is larval medium of growth. Objectives: To determine the bio-larvicidal potential of 95% ethanolic extract of betel leaves (EEBL) in addition of PEG 400 diluent on the Aedes aegypti larval mortality. Material and Method: Betel leaves were extracted by maceration using 95% of ethanol. There are two kinds of EEBL concentration used, 0.2% dan 0.4%. PEG 400 was also added as diluent. The samples in this study were Aedes aegypti larvae at instar III-IV, with a total of 400 larvae. Evaluation was performed at 6, 12, 18, and 24 hours. The data obtained was then analyzed by Kruskall Wallis test and post-hoc Mann Whitney test. Result: In all of treatment groups, larval mortality was reached 100% at 24 hours. From the Kruskall Wallis test, p-value obtained was <0.05. From post-hoc Mann Whitney test, the p-value obtained in the comparation between treatment groups and positive control group was >0.05, and the p-value obtained in the comparation between treatment groups and negative control group was <0.05. Conclusion: EEBL in addition of PEG 400 diluent is potential as bio-larvicidal on Aedes aegypti larvae. It is also known that EEBL at concentration of 0.2% and 0.4% in addition of PEG 400 are as effective as temephos as larvicides on Aedes aegypti larvae.
Potential Effect of Orthosiphon aristatus Leaf Extract in Improving Collagen 1 Alpha 1 Expression in Hyperglycemia-Induced Rats Aisyah, Riandini; Risanti, Erika Diana; Jatmiko, Safari Wahyu; Asfarina, Fatin
Biology, Medicine, & Natural Product Chemistry Vol 14, No 1 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.141.357-361

Abstract

Diabetes mellitus involves many mechanisms, the collagen metabolism pathway with very complex interactions and its regulation can contribute to the development of diabetes complications. The collagen 1 alpha 1  (COL1A1) gene plays an important role in the diabetes melitus pathway in adipose tissue by regulating adipocyte function, insulin resistance, and glucose metabolism. COL1A1 expression  is positively correlated with insulin resistance and negatively correlated with insulin sensitivity and is identified as a potential therapeutic target for type 2 diabetes. The cat's whisker plant (Ortosiphon aristatus) pharmacologically has hypoglycemic activity and increases insulin expression. This study aims to observe the potential of cat whisker leaf extract (Ortosiphon aristatus) in increasing the expression of the COL1A1 gene and is protective against increased blood sugar levels in  hyperglycemia-induced Rattus norvegicus. The experimental design with pretest and posttest controlled group design was carried out by dividing 18 test animals into six groups of non-diabetic negative control, diabetic negative control, metformin as positive control, doses of 100, 200, and 400 mg/kgBW. Induction of hyperglycemia with streptozotocin 65 mg/kgBW and nicotinamide 230 mg/kgBW peritoneal injection. The extract treatment is given for 14 days. Blood sugar level measurements were carried out at the treatment’s beginning and end. Adipose tissue was taken to examine COL1A1 gene expression by real time PCR technique by calculating the ratio of the cycle of tresh-hold COL1A1 to the internal ?-actin gene. The results of Kruskall Wallis test showed no significant difference in COL1A1 gene expression between groups and the Spearmen correlation test showed no relationship between blood sugar levels and COL1A1 gene expression (p>0.05). There was a decrease in blood sugar levels before and after treatment for all treatment groups.
Effect of PEG and CMC on Papaya (Carica papaya L.) Extract Against Aedes aegypti Larvae Bestari, Rochmadina Suci; Rif'aini, Fidhia Nur; Aisyah, Riandini; Dewi, Listiana Masyita; Rosyidah, Devi Usdiana; Sintowati, Retno; Karuniawati, Hidayah
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.961-968

Abstract

Dengue haemorrhagic fever (DHF) cases are still high in America and Asia region, including Indonesia. Eradication of DHF can be done by larvacide. Temephos 1%, chemical larvacide used in Indonesia for decades, can cause environment degradation and allergic reaction in human. Papaya stem extract as biolarvacide contains saponins, tannins, alkaloids, flavonoids, papain and essential oils which have larvicidal activity. It can be applicable in all over the world. This study was conducted to determine the better suspending agent between CMC or PEG of papaya stem extract to kill Aedes aegypti larvae. Objective: To determine the better suspending agent to kill Aedes aegypti larvae. Method: This study was true experimental study in laboratory, used post-test only controlled group design. This study used samples consist of Aedes aegypti instar III-IV larvae. There were seven experimental groups, consist of positive control group, negative control group for CMC, negative control group for PEG, extract concentration of 1.5% with CMC suspending agent, extract concentration of 1.5% with PEG suspending agent, extract concentration of 2% with CMC suspending agent, extract concentration of 2% with PEG suspending agent. Each group was repeated 4 times and counted every 6 hours (6th, 12th, 18th, 24th). Data analysis using the SPSS application ver 23. Probit test used to determine the effectiveness of the larvacide, LC50 and LT50 to determine the concentration and time to kill 50% of Aedes aegypti larvae. It used Kruskal Wallis Test to compare four dependent groups. It used Mann Whitney Test to compare the differences of each group. Result: The study showed that LC50 PEG was 0.033%, LC50 CMC was 0.321%, LT50 (PEG+1.5%) was 20.8 hours, LT50 (PEG+2%) was 30.7 hours, LT50 (CMC+1.5%) was 23.5 hours, LT50 (CMC+2%) was 40.7 hours. Based on the probit test, the LC50 and LT50 results showed that papaya stem methanol extract with PEG suspending agent was more effective than CMC suspending agent, it needed lower concentration and lower time to kill 50% of larvae. Kruskall Wallis Test result p<0.05, so there was significantly difference between groups. Post hoc Mann-Whitney Test result p<0.05 between C(-) PEG group with P1, P2, P3, P4 and between C(-) CMC group with P1, P2, P3, P4, so there was significantly difference between C(-) PEG with each group and C(-) CMC with each group. Conclusion: It can be concluded that papaya stem methanol extract with PEG suspending agent was more effective than CMC suspending agent to kill Aedes aegypti larvae.
Co-Authors Ahmad Alrizaldi Alfajri, Asri Anam, Ilham Hafizha Maulana Angesti Atiqah Ranasatri Anggitaratri, Zakia Novi Anggreheni, Putri Dwi Anika Candrasari Anindita Putri Handayani Ariffah, Hilda Zaniba Arrohma, Farah Aryanto Asfarina, Fatin Ayyasi, Quanta Azenta, Moch. Tabriz Bestari, Rochmadina Brilliantama, Fandy Akbar Devi Usdiana Rosyidah Dwi Advina Herdiyanti Dyah Farida Inli Em Sutrisna Erika Diana Risanti Estu Puguh Prabancono Faatiha, Arsyal Wanda Fauzi, Favian Fauzi, Favian Arriella Shabri Ikmal Fitri, Alifah Aulia Graffico Eryza Oldiara Gunawan, Ryan Budi Haliza, Sheli Nur Handayani, Anindita Putri Herdiyanti, Dwi Advina Hidayah Karuniawati Hidayatullah, Muhammad Alim Abdul Majid Iin Novita Nurhidayati Mahmuda Indra Nuroso Jatmiko, Safari Kamila, Aulida Azkia Kumala, Aswa Arsa Kurniati, Yuni Prestyo Lestari, Nining Listiana Masyita Dewi Mapa, Anna Rochim Maulida Rahmah, Maulida Maulida, Amira Hasna Maylafaiza, Annisa Muhamad Irfan Hidayatullah Muhammad Adha Muhammad Alim Abdul Majid Hidayatullah Nafisa, Balqis Najmii, Muhammad Firoos Allaam Novita, Iin Nur Mahmudah Nur Mahmudah Nurhaliza, Sheli Nurhayani Nurhayani nurhayani Nurhayani, N Nuroso, Indra Pambudi, Nasrurrofiq Risvana Bayu Prabancono, Estu Puguh Prabowo, Nurhasan Agung Pratama, Nur Puspitasari, Metana Rahayu, Destri Ramadhani, Marsyanda Ratnasari Bondan Wijayanti Reisya Tiara Kandita Reisya Tiara Kandita, Reisya Tiara Retno Sintowati - Rif'aini, Fidhia Nur Rochmadina Suci Bestari Rohman, Raihan Fadzlur Rohmaniar, Delianti Ryan Budi Gunawan Ryanuranti , Rahma Ghaida Safari Wahyu Jatmiko Salsabila, Nabila Mutia Sella Felina Setiani, Hilda Sholeh, Muhammad Dzikru Irfan Sri Wahyuni Sukardi, Nadya Sulistiyo, Azka Hafiy Sulistyo, Ayu Indah Supraba, Intan Pratiwi Suryani, Latifah Syahida, Safira Tara , Irmanawati Audhina Nirmala Tolibin, Restu Triwulandani Tri Agustina, Tri tri wahyuni Usdiana Rosyidah, Devi Utami, Aurelia Ratna Utami, Indari Wafiq, Muhammad Azzim Wahyu Jatmiko, Safari Wibowo, Haryo Kunto Wijayanti, Ratnasari Bondan Wulandari Berliani Putri Wulandari Berliani Putri, Wulandari Berliani