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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Kedokteran Brawijaya Majalah Kesehatan FKUB Medical Laboratory Technology Journal Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Jurnal Biomedika dan Kesehatan Bioscientia Medicina : Journal of Biomedicine and Translational Research MMJ (Mahakam Midwifery Journal) Journal of Issues in Midwifery Jurnal Aisyah : Jurnal Ilmu Kesehatan Bioscientia Medicina : Journal of Biomedicine and Translational Research Malang Respiratory Journal Jurnal Klinik dan Riset Kesehatan Jurnal Locus Penelitian dan Pengabdian Zona Kebidanan : Program Studi Kebidanan Universitas Batam
Eviana Norahmawati
Department Of Anatomic Pathology, Faculty Of Medicine, Brawijaya University, Malang, East Java
Aerospace Engineering Agriculture, Biological Sciences & Forestry Automotive Engineering Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Education Electrical & Electronics Engineering Environmental Science Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary Other

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Membranous β-Catenin Expression Inversely Correlates with WHO/ISUP Grading in Clear Cell Renal Cell Carcinoma: An Indonesian Cross-Sectional H-Score Study Rifka Ulfa Rosyida; Kenty Wantri Anita; Ihda Dian Kusuma; Eviana Norahmawati; Rachmad Sarwo Bekti
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 7 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i7.1625

Abstract

Background: Clear cell renal cell carcinoma (ccRCC) is the most common adult renal malignancy and exhibits heterogeneous clinical behavior that is currently stratified by the WHO/ISUP nuclear grading system. β-catenin, the terminal effector of canonical Wnt signaling and an integral component of the cadherin–catenin adhesion complex, has been implicated in epithelial–mesenchymal transition (EMT) and tumor progression, but its quantitative relationship with WHO/ISUP grade in Indonesian ccRCC has not been reported. Methods: This analytic observational cross-sectional study examined 73 archived formalin-fixed, paraffin-embedded ccRCC specimens collected at the Anatomical Pathology Installation of Dr. Saiful Anwar Regional General Hospital Malang between January 2019 and May 2025. Immunohistochemistry for β-catenin (Dako Clone 14, dilution 1:200) was scored independently and blindly by two anatomical pathologists using the H-score methodology across ten 400× high-power fields per case. Results: The overall mean H-score was 236.4 ± 50.6 (range 20–295). Spearman rank correlation revealed a strong, statistically significant inverse association between membranous β-catenin H-score and WHO/ISUP grade (ρ = –0.664; 95% CI –0.778 to –0.503; p < 0.001). Mean H-scores declined monotonically from Grade 1 (285 ± 28) through Grade 2 (270 ± 32), Grade 3 (228 ± 30), to Grade 4 (175 ± 32), and Receiver Operating Characteristic analysis distinguished high-grade (G3–G4) from low-grade (G1–G2) tumors with an area under the curve of 0.84. Conclusion: These findings support membranous β-catenin H-score as a biologically grounded, accessible immunohistochemical adjunct to WHO/ISUP grading and motivate further translational evaluation of the Wnt/β-catenin pathway as a stratification and therapeutic target in ccRCC.
Membranous β-Catenin Expression Inversely Correlates with WHO/ISUP Grading in Clear Cell Renal Cell Carcinoma: An Indonesian Cross-Sectional H-Score Study Rifka Ulfa Rosyida; Kenty Wantri Anita; Ihda Dian Kusuma; Eviana Norahmawati; Rachmad Sarwo Bekti
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 7 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i7.1625

Abstract

Background: Clear cell renal cell carcinoma (ccRCC) is the most common adult renal malignancy and exhibits heterogeneous clinical behavior that is currently stratified by the WHO/ISUP nuclear grading system. β-catenin, the terminal effector of canonical Wnt signaling and an integral component of the cadherin–catenin adhesion complex, has been implicated in epithelial–mesenchymal transition (EMT) and tumor progression, but its quantitative relationship with WHO/ISUP grade in Indonesian ccRCC has not been reported. Methods: This analytic observational cross-sectional study examined 73 archived formalin-fixed, paraffin-embedded ccRCC specimens collected at the Anatomical Pathology Installation of Dr. Saiful Anwar Regional General Hospital Malang between January 2019 and May 2025. Immunohistochemistry for β-catenin (Dako Clone 14, dilution 1:200) was scored independently and blindly by two anatomical pathologists using the H-score methodology across ten 400× high-power fields per case. Results: The overall mean H-score was 236.4 ± 50.6 (range 20–295). Spearman rank correlation revealed a strong, statistically significant inverse association between membranous β-catenin H-score and WHO/ISUP grade (ρ = –0.664; 95% CI –0.778 to –0.503; p < 0.001). Mean H-scores declined monotonically from Grade 1 (285 ± 28) through Grade 2 (270 ± 32), Grade 3 (228 ± 30), to Grade 4 (175 ± 32), and Receiver Operating Characteristic analysis distinguished high-grade (G3–G4) from low-grade (G1–G2) tumors with an area under the curve of 0.84. Conclusion: These findings support membranous β-catenin H-score as a biologically grounded, accessible immunohistochemical adjunct to WHO/ISUP grading and motivate further translational evaluation of the Wnt/β-catenin pathway as a stratification and therapeutic target in ccRCC.
Comprehensive Clinical and Pathological Analysis of Chondroblastic Osteosarcoma Masquerading as an Aneurysmal Bone Cyst in an Adolescent Patient: A Multidisciplinary Diagnostic Journey Belinda Azhari Siswanto; Bima Mahardika Aji; Istan I. Irsan; Satria P. Persada Isma; Dandy D. Adiwignyo; Eviana Norahmawati
Jurnal Locus Penelitian dan Pengabdian Vol. 5 No. 5 (2026): JURNAL LOCUS: Penelitian dan Pengabdian
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/locus.v5i5.5820

Abstract

Osteosarcoma is the most common primary malignant bone tumor, primarily affecting adolescents and young adults during periods of rapid skeletal growth. Chondroblastic osteosarcoma (COS) is a histological variant that poses a diagnostic challenge due to its extensive cartilaginous matrix, which can obscure the critical diagnostic feature: malignant osteoid production. This diagnostic complexity is further exacerbated when the tumor exhibits secondary aneurysmal bone cyst (ABC) changes, often leading to an initial misdiagnosis as a benign lesion. To analyze a case of chondroblastic osteosarcoma with secondary ABC changes, highlighting the importance of a multidisciplinary approach in diagnosing and managing high-grade bone tumors in adolescent patients. A case study of a 17-year-old male presenting with progressive pain and swelling in the right thigh. Diagnosis was confirmed through incisional biopsy, immunohistochemical profiling (positive for SATB2, P53, S100, and Osteocalcin), and MRI findings, which initially suggested an ABC. MRI findings indicated an aggressive bone tumor with fluid-fluid levels characteristic of ABC. However, after biopsy and immunohistochemical analysis, the final diagnosis was confirmed as high-grade chondroblastic osteosarcoma with secondary ABC changes. The patient underwent neoadjuvant MAP chemotherapy and limb-salvage surgery. This case underscores the importance of maintaining a high index of suspicion for malignancy in adolescent patients presenting with cystic bone lesions. A multidisciplinary approach involving clinical, radiological, and pathological correlation is crucial to prevent diagnostic delays and ensure the initiation of appropriate high-grade sarcoma therapy.
Co-Authors A.A. Ketut Agung Cahyawan W Adilah Ulfiati Adilah Ulfiati, Adilah Adiwignyo, Dandy Drestanto Agil Dananjaya Aina Angelina Ainun Ganisia Aliesya Patricia Amalia Pradanti Widarso, Amalia Pradanti Ardhian Wardana Ardhian Wardana, Ardhian Aris Rosidah Asmiragani, Syaifullah Belinda Azhari Siswanto Bima Mahardika Aji Dandy D. Adiwignyo Dian Sutarini, Ni Luh Gede Didiek Darmadi Ts Dwi Yuni Nur Hidayati Ega Prosfera, Rahma Haryunita Elisa Danik Kurniawati Endah Wijayanti Erawati, Dini Ervina, Rita Fadli, Muhammad Luqman Fitriana Nugraheni Fitriana Nugraheni, Fitriana Frenty Hadiningsih, Eka Hamka Muhammad Nasir Laitupa Harun Al Rasyid Harun Al Rasyid Herpan Syafii Harahap Ihda Dian Kusuma Ineke Permatasari Irmansyah, Istan Irsan, Istan Irmansyah Isharanto, Artono Istan I. Irsan Kenty Wantri Anita, Kenty Wantri Kurnia Penta Seputra Laitupa, Hamka Muhammad Nasir Loeki Enggar Fitri lumban gaol, andy Miftahul Jannah MIFTAHUL JANNAH Mochammad Dalhar Nabila, Astrid Hanan Nanik Setijowati Ni Putu Sri Haryati Noorhamdani Nur Fahma Pradiptasari Nur Fahma Pradiptasari, Nur Fahma Nurdiana Nurdiana Phatama, Krisna Yuarno Pratama, Yudit Alfa` Pratista Adi Krisna, Pratista Adi Pratiwi, Suryanti Dwi Putra, Ngakan Putra, Ngakan Putu Putri Ardela, Mayasari RA Rose Khasana Dewi Rachmad Sarwo Bekti Rahmana, Rahima Azzahra Retnani, Diah Prabawati Retty Ratnawati Rifka Ulfa Rosyida Ririn Handayani Rose Dewi Satria P. Persada Isma Satria Pandu Persada Isma Sawitri, Lia Setyawan, Ungky Sri Winarsih Sujarot Dwi Sasmito sujarot dwi sasmito, sujarot dwi SURYANTI Tanti Tri Lestary Tatit Nurseta Teguh Prihanto Teguh Wahju Sardjono Teguh Wahju Sardjono Tinny Endang Endang H Ulfaningtyas, Kiki Wati, Linda Ratna Wiyasa, I Wayan Arsana Yahya Irwanto Yudhanto, Hendy Setyo Zakiyah Zulaifa Zakiyah Zulaifa, Zakiyah