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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Jurnal Kesehatan Andalas Global Medical and Health Communication Biomedical Journal of Indonesia Window of Health : Jurnal Kesehatan Collaborative Medical Journal (CMJ) Bioscientia Medicina : Journal of Biomedicine and Translational Research Health and Medical Journal Human Care Journal Andalas obstetrics and gynecology journal Jurnal Ners Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Ilmu Kesehatan Indonesia (JIKSI) The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Journal of Pharmaceutical and Sciences. Jurnal Otorinolaringologi Kepala dan Leher Indonesia (JOKLI) Neurona Jurnal Sains Farmasi dan Kesehatan Jurnal Sains, Teknologi dan Kesehatan
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Departemen Neurologi, Fakultas Kedokteran, Universitas Andalas
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Engineering Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary

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Journal : Neurona

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ANALISIS KADAR AMILOID BETA PLASMA DENGAN GANGGUAN KOGNITIF PADA DIABETES MELITUS TIPE 2 Syafrita, Yuliarni; Amir, Darwin; Decroli, Eva; Susanti, Restu
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 35 No 1 (2018)
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v35i1.38

Abstract

   ANALYSIS OF PLASMA LEVELS OF BETA AMYLOID WITH COGNITIVE IMPAIRMENT IN TYPE 2 DIABETES MELLITUSABSTRACTIntroduction: Type 2 diabetes mellitus (T2DM) and Alzheimer’s disease are two kind of neurodegenerative disease that related with age. Patients with DM show a tendency to develop Alzheimer’s disease, but there is no single marker for predicting a DM case will develop into Alzheimer’s disease. Amyloid cascade beta disturbance is one factor involved in the pathogenesis of DM disease as well as in Alzheimer’s disease, and still believed to be the main factor causing Alzheimer’s dementia.Aims: This research was aimed to determine the correlation between beta amyloid plasm level and demographic factors with the occurrence of cognitive dysfunction in type 2 diabetes mellitus patients.Methods: This was a cross-sectional design study on patients with DM in special DM clinic at M Djamil and Ibnu Sina hospital, Padang, between August—October 2016. Cognitive function was examined using the Montreal Cognitive Assessment Indonesian version (MoCA-Ina). Beta amyloid level was measured by enzyme-linked immunosorbent assay (ELISA) technique. Beta amyloid diagnostic ability was analyzed by using receiver operating characteristics (ROC). The correlation between the variables were analyze by using Chi-square, and p value p<0.05 was considered to be significant. To determine the strongest variables which correlated to cognitive dysfunction, logistic regression analysis were performed.Result: 65 subjects included in this study, where cognititve dysfuntion were present in 35 patients (58.3%). There were significant correlation between disease duration and low levels of 42 beta amyloid in plasma (Aβ42) with the occur- rence of cognitive dysfunction. The multivariate analysis showed that the disease duration, followed by low levels of Aβ42 and education level were the variables correlated with cognitive dysfunction.Discussion: There were a correlation between low levels of 42 beta amyloid in plasma with the occurrence of cog- nitive dysfunction in type 2 diabetes mellitus patients.Keywords: Beta amyloid, cognitive impairment, demographic factors, type 2 DMABSTRAKPendahuluan: Penyakit diabetes melitus tipe 2 (DM) dan penyakit Alzheimer adalah dua penyakit neurodegeneratif yang sering berhubungan dengan usia. Pasien dengan DM menunjukkan kecenderungan untuk menderita penyakit Alzheimer, namun belum ada satupun penanda untuk memprediksi kasus DM yang akan berkembang menjadi penyakit Alzheimer. Gangguan kaskade amiloid beta merupakan faktor yang terlibat pada patogenesis penyakit DM maupun pada penyakit Alzheimer, dan sampai sekarang masih dipercaya sebagai faktor utama yang menyebabkan demensia Alzheimer.Tujuan: Mengetahui hubungan kadar amiloid beta plasma dan faktor demografi dengan gangguan fungsi kognitif pada penderita DM.Metode: Penelitian dengan desain potong lintang ini, terhadap pasien DM yang berobat di Poliklinik khusus diabetes RSUP Dr. M Djamil dan RS Islam Ibnu Sina, Padang, pada periode Agustus–Oktober 2016. Penilaian gangguan kognitif menggunakan Montreal Cognitive Assesment versi Indonesia (MoCA-Ina), dinyatakan terganggu jika nilai <26.Kadar amiloid beta diperiksa dengan metode enzyme-linked immunosorbent assay (ELISA) dan kemampuan diagnostik amiloid beta dianalisis dengan receiver operating characteristics (ROC). Hubungan antar variabel diuji dengan Chi- square, dikatakan bermakna bila nilai p≤0,05. Dilakukan analisis regresi logistik untuk menentukan variabel yang paling kuat hubungannya dengan gangguan fungsi kognitif.Hasil: Didapatkan 65 subjek dengan rerata usia 61,62+7,6 tahun dan sebanyak 53,8% mengalami gangguan fungsi kognitif. Didapatkan hubungan yang bermakna antara lama sakit dan rendahnya kadar Aβ42 plasma dengan terjadinya gangguan kognitif. Pada analisis multivariat diketahui bahwa urutan kekuatan variabel yang berhubungan dengan terjadinya gangguan fungsi kognitif adalah lama sakit, rendahnya kadar Aβ42 plasma, dan tingkat pendidikan.Diskusi: Terdapat hubungan antara lama sakit dan rendahnya kadar Aβ42 plasma dengan terjadinya gangguan kognitif pada penderita DM.Kata kunci: Amiloid beta, DM tipe 2, faktor demografi, gangguan kognitif
Co-Authors Abdi, Tri Jaya Abdillah, Tegar Afriani, Nita Afriwardi Afriwardi Afriyeni Sri Rahmi Akmal Irsyadi Iswan Almurdi Almurdi Anggrainy, Fenty Arina Widya Murni ATTIYA ISTARINI Aulia Noza Bestari, Reno Darwin Amir, Darwin Dea Rika Putri Purba Dedi Sutia Dedi Sutia Dhani Arief Prandana Dian Pertiwi Alty Dinata, Gunawan Septa Eldi Sauma Eryati Darwin Eva Decroli Fanny Adhy Putri Gusti Revilla Hanny Vidya Sari Harun Harnavi Hasmiwati Hendra Permana Hendra Permana Hirowati Ali Hirowati Ali, Hirowati Husna Yetti Husni Minanda Fikri Ida Rahmah Burhan Ilahi, Fitratul Indra, Syarif Isnindiah Koerniati Isnu Lucky Riandini Isnu Lucky Riandini, Isnu Lucky Istiqomah Jabbar, Ridho Ahmad Kurniawan, Yoga Setia Lenny Arinda Lestari, Novia Riza Lydia Susanti Lydia Susanti, Lydia Marliana, Lesti Melda Yelmaiza Musrizal Adli Nabila Priscilla Putri Nada Utami Prahastiwi Nailatul Fadhilah Nita Afriani Nur Indrawaty Lipoeto Priyanka Prima Putri Putra, Syandrea Prima Putri, Azhara Dhiya Yosse Putri, Fanny Adhy Putri, Nabila Priscilla Rachmat Saleh Eka Putra Reno Bestari Rifki Irsyad Rika Susanti Rizki Muhammad Rananda Rudy Afriant Salsabilah Firdausiah Saptino Miro Selfi Renita Rusjdi Sukri Rahman Sutia, Dedi Syamel Muhammad Syarif Indra Syarif Indra Syarif Indra Tiara Mardalifa Tofrizal Tofrizal Tofrizal Ulya Uti Fasrini Umul Khair Wijaya, Claudia Novi Yoga Setia Kurniawan Yolanda, Meuthia Yulia Trisna Yuliarni Syafrita Yuliarni Syafrita Yulistini, Yulistini Yuniar Lestari Yusri, Elfira Zakiya Ifana Putri