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In vitro Antimicrobial Activity Test of Zingiber officinale var. rubrum Rhizome Extract against Methicillin-Sensitive Staphylococcus aureus (MSSA) and Methicillin-Resistant Staphylococcus aureus (MRSA) Jieputra, Alden; Purwanta, Marijam; Mustika, Arifa; Retnowati, Wiwin
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 15 No. 1 (2024): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V15I12024.57-63

Abstract

Highlights: Staphylococcus aureus, particularly MRSA, had developed rapid resistance against antibiotics like beta-lactams. Red ginger is believed to be antibacterial against MSSA and MRSA in vitro. Red ginger rhizome extracts displayed weak activity against MSSA and MRSA.   Abstract Introduction: Red ginger (Zingiber officinale var. rubrum) is a traditional herb that is believed to possess antibacterial properties. Throughout the years, Staphylococcus aureus has developed resistance to a broad range of antibiotics, including beta-lactams, particularly in the form of Methicillin-Resistant Staphylococcus aureus (MRSA). As treatment options dwindle, it is urgent to formulate novel antibiotics. This study aimed to examine the antibacterial activity of the ginger rhizome ethanol extract against Methicillin-Sensitive Staphylococcus aureus (MSSA) and MRSA. Methods: This study was performed according to the post-test-only control group design. Through a good diffusion assay, the anti-MSSA and anti-MRSA activity of the red ginger extract concentrations (100%, 50%, 25%, 12.5%, and 6.25%) was observed by measuring the diameter of the clear inhibition zones. Dimethyl sulfoxide (DMSO) and an antibiotic disc were added as control groups. Results: The red ginger extracts produced inhibition zones on both MSSA and MRSA. However, the antibacterial activity was considered weak (<12 mm). The concentration of the extract appeared to linearly affect its antibacterial activity against MSSA and MRSA. On MSSA, the 12.5% extract results differed significantly from those of the 100% and 50% extracts. Meanwhile, on MRSA, the extracts seemed to yield significantly different outcomes when compared to each other, except for the comparisons between 50%-25% and 12.5%-6.25%. Conclusion:Zingiber officinale var. rubrum rhizome extracts showed weak antibacterial activity against MSSA and MRSA.
REDUCTION OF CONSTIPATING SCORING SYSTEM AMONG WOMEN AGED 18-25 YEARS OLD AS A RESULT OF DECOCTED TRENGGULI (CASSIA FISTULA L.) Jannah, Isnaini Nur; Mustika, Arifa; Puruhito, Edith Frederika
Journal of Vocational Health Studies Vol. 1 No. 2 (2017): November 2017 | JOURNAL OF VOCATIONAL HEALTH STUDIES
Publisher : Faculty of Vocational Studies, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jvhs.V1.I2.2017.58-62

Abstract

Background: Constipation is a condition when someone has difficulty to defecate. Constipation is indicated by hard and large size stool as well as a decrease frequency of bowel movement. Commonly, constipation is indicated by anxiety during bowel movement due to disruption defecation. Constipation can cause severe stress resulting from discomforts for patient. The severity of the constipation can be measured using the Constipation Scoring System (CSS). CSS is a scoring system for patient, which based on the answers about the symptoms being asked in the questionnaire. One of the herbs to handle the problem of constipation that have a laxative effect is Trengguli (Cassia fistula L.) originate from the family Fabaceae. The part that can be used for a laxative is a Trengguli fruit. A decocta method to Trengguli flesh of the fruit for a laxative, since decocta method generates the highest total anthraquinone glycosides for the use of laxatives. Purpose: The purpose of this study was to prove the effectiveness of decocta pulp of trengguli for the reduction of constipation scoring system among women aged 18- 25 years old with constipation problem. Method: The method used is quasi-experimental design using a design of one group pre-post test. The study was conducted in December at the clinic Battra Airlangga University School of Medicine with 26 responded. Data were analyzed using SPSS with the Wilcoxon test. Result: The results of this study showed that the decocta pulp of trengguli(Cassia fistula L.) has significant effectiveness with p = 0.000 with p <0.05 on a decrease in constipation scoring sytem for constipation treatment among women aged 18-25 years.
THERAPY FOR LOW BACK PAIN WITH ACUPUNCTURE AND TURMERIC Aszar, Farah Dynah Daeq; Imandiri, Ario; Mustika, Arifa
Journal of Vocational Health Studies Vol. 2 No. 2 (2018): November 2018 | JOURNAL OF VOCATIONAL HEALTH STUDIES
Publisher : Faculty of Vocational Studies, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (364.744 KB) | DOI: 10.20473/jvhs.V2.I2.2018.74-79

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Background: Low Back pain (LBP) is the most common musculoskeletal disorder, affecting 70% - 85% of the adult population, and twelve months after onset of LBP, 45% - 75% of patients are still sick. Low back pain in Traditional Chinese Medicine (TCM) is usually associated with kidney or renal meridians. In She syndrome, lower back pain is often caused by pathogen wind, damp, cold, heat and blood stasis, whereas in the Xi syndrome lower back pain usually caused by deficiency of Jing, Qi, Yin, or Yang of the  kidney. Purpose: To know the effect of acupuncture therapy at Pishu (BL 20), Shenshu (BL 23), Dachangshu (BL 25), Waiguan (TE 5) as well as herbal therapy  using turmeric (Curcuma domestica) on low back pain sufferers. Method: Acupuncture therapy at Pishu (BL 20), Shenshu (BL 23), Dachangshu (BL 25), Waiguan (TE 5) were given 12 times, 3 times a week. Herbal therapy was given for 30 days, taken 3 times a day with a dose of turmeric 1 gram. Result: This therapy could reduce the scale of low back pain from scale 8 to 0 and the spasme scale from 3 to 0, that also reducing the frequency of low back pain. Conclusion: Acupuncture therapy at Pishu (BL 20), Shenshu (BL 23), Dachangshu (BL 25), Waiguan (TE 5) and herbal therapy with 3 g of turmeric (Curcuma domestica) could resolve lower back pain.
ACUPUNCTURE AND JIANGHUANG HERBS TREATMENT IN ACNE WITH DAMNESS SYNDROME Agesti, Dyah; Astuti, Suryani Dyah; Mustika, Arifa
Journal of Vocational Health Studies Vol. 4 No. 1 (2020): July 2020 | JOURNAL OF VOCATIONAL HEALTH STUDIES
Publisher : Faculty of Vocational Studies, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jvhs.V4.I1.2020.15-20

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Background : Acne vulgaris is a chronic skin disease that occurs due to chronic inflammation of the pilosebaceous glands. Acne is clinically affected by an increase in sebum, Propionibacterium bacteria acne, hormones, genetic, stress, diet and the environment. In Chinese Medicine, acne vulgaris belongs to categories of Feng Ci, it is caused by wind-heat pathogens that attack the lungs and excessive consumption of spicy and oily foods resulting in accumulation of heat in the stomach and intestines. In Chinese Medicine, sebaceous glands are associated with the Lung and Spleen. Patients classified as acne with differentiation of accumulation of phlegm syndrome. Purpose: To know the effect of acupuncture therapy at LI-4 Hegu, ST-36 Zusanli , ST-40 Fenglong, SP-6 Sanyinjiao and herbal therapy using Jianghuang in patients Acne vulgaris with differentiation of accumulation of phlegm syndrome. Method: Acupuncture therapy at LI-4 Hegu, ST-36 Zusanli , ST-40 Fenglong, SP-6 Sanyinjiao were given 12 times, 3 times a week, with the principle of therapy to reinforce phlegm, strengthen the spleen and raise the spleen. In herbal therapy the patient is given herbal Jianghuang (Curcuma longa.L) dose of 3 grams 12 times, 3 times a week. Result: Compound of curcumin which is antibacterial, anti-inflammatory, antioxidant and wound healing affects acne. Acupuncture and herbal therapy given 12 times, 3 times a week can overcome acne vulgaris. Conclusion: Acupuncture and herbal therapy can overcome the growth of acne.
IMPROVING KNOWLEDGE AND EMPOWERMENT OF PITASIDIA HEALTH CADRES ABOUT MEDICINAL PLANTS IN PATIENTS WITH DIABETES MELLITUS AND HYPERTENSION IN SINGOTRUNAN VILLAGE, BANYUWANGI SUB-DISTRICT, BANYUWANGI DISTRICT Mustika, Arifa; Fatimah, Nurmawati; Herisulistyo, Aldilatama; Dau, Daniel
Jurnal Layanan Masyarakat (Journal of Public Services) Vol. 8 No. 3 (2024): JURNAL LAYANAN MASYARAKAT
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jlm.v8i3.2024.402-411

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Hypertension (HT) and Diabetes Mellitus type 2 (DM2) are the two most common non-communicable diseases in East Java, Indonesia. Therefore, there is a need for outreach about these two diseases and the use of herbal plants as complementary therapy. educational and learning practices are needed to be able to understand these two diseases and be able to make good herbal preparations such as Centella asiatica and Hibiscus sabdariffa so that the chemical compounds are not damaged. To provide education about HT and DM, herbal plant processing practices, and understanding the importance of regular health checks. The activity was conducted in Singotrunan Village, Banyuwangi Sub-district, Banyuwangi Regency, East Java Province. The stages of community service consist of preparation, implementation, and evaluation. The evaluation results showed that there was a 90% increase in the level of understanding after providing education on DM prevention, HT, and medicinal plants. Routine health checks found that most of the correspondents had random blood glucose levels and normal blood pressure. There was an increase in respondents' knowledge about hypertension and diabetes mellitus and the use of medicinal plants in helping the treatment of these diseases.
Efficacy and Safety of Ozoralizumab vs. Moxibustion for Rheumatoid Arthritis Susanti, Luthfiana Rofhani; Mustika, Arifa; Rahmawati, Lita Diah; Wungu, Citrawati Dyah Kencono
Folia Medica Indonesiana Vol. 60 No. 4 (2024): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/fmi.v60i4.64949

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Rheumatoid arthritis is a chronic inflammatory disease that symmetrically damages the synovial membrane, affecting approximately 13% of the global population. Systemic complications and substantial declines in quality of life may result from untreated rheumatoid arthritis. This study investigated the safety and efficacy of moxibustion and ozoralizumab in reducing disease activity scores in rheumatoid arthritis patients. Between July 2023 and February 2025, we conducted a thorough search on four online databases (PubMed, Cochrane, Scopus, and ProQuest) using keywords, reference searches, and other methods following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The obtained randomized controlled trials (RCTs) were assessed using the Cochrane Risk of Bias 2 (ROB2) tool. MetaInsight version 5.2.1 was utilized to perform the indirect network meta-analysis, using mean difference (MD) as the summary statistics. The measurement of the Disease Activity Score 28 (DAS28) indicated that ozoralizumab had a more significant effect on rheumatoid arthritis compared to placebo (MD=-1.88, 95% CI=-2.24-(-1.52)) and moxibustion (MD=-0.69, 95% CI=-1.07-0.31). Ozoralizumab demonstrated mild, moderate, and severe side effects, whereas moxibustion displayed modest side effects in comparison to placebo. In summary, both ozoralizumab and moxibustion reduced DAS28 in patients with rheumatoid arthritis, with ozoralizumab proving to be the more effective treatment. However, the adverse effects of ozoralizumab were more varied than those of moxibustion.
SHORT-TERM TOXICITY TEST OF SINGALAWANG EXTRACT ON MALE WHITE RATS KIDNEY NECROSIS Naibaho, Ardy Hamonangan; Mustika, Arifa; Rahaju, Anny Setijo
Folia Medica Indonesiana Vol. 52 No. 1 (2016): JANUARY - MARCH 2016
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (219.353 KB) | DOI: 10.20473/fmi.v52i1.5212

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Singawalang leaf is used as a traditional medicine by the communities suffering from pneumonia due to TB disease. However, experiments to explain it's toxicity are few. Therefore, this study was conducted to disclose it's toxicity. This was an experimental laboratory study using post–test only control group design. The sampling method was simple random sampling. The animals were randomly divided into 4 (four) groups, each group consisted of 8 (eight) mice, the control group (P0) received distilled water as a solvent material. Treatment group 1 (P1) obtained ethanol extract of singawalang (Petiveria alliaceae) in low doses of 90 mg/kgbw. Treatment group 2 (P2) obtained ethanol extract of singawalang (Petiveria alliaceae) in medium doses of 180 mg/kgbw. Treatment group 3 (P3) obtained ethanol extract of singawalang (Petiveria alliaceae) in high doses of 360 mg/kgbw. Th extracts were given with sonde once a day for 30 days. Results showed that the leaf ethanol extract singawalang (Petiveria alliaceae) does not induce sub-acute necrosis effects on kidney of male white mice (Mus musculus) in doses 90 mg/kgbw, 180 mg/kgbw, and 360 mg/kgbw.
Effect of Celery Extract on Fructose Induced Insulin Resistance Rattus norvegicus Sukarno, Devitya Angielevi; Mustika, Arifa; Rejeki, Purwo Sri
Folia Medica Indonesiana Vol. 56 No. 4 (2020): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1434.387 KB) | DOI: 10.20473/fmi.v56i4.24602

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Diabetes mellitus (DM) is one of the global health problems and in the top 4th ranks as the main cause of death in developing countries (IDF, 2015). The pathogenesis of type II DM involves abnormalities in insulin secretion and activity that leads to insulin resistance. This research aims to study the efficacy of celery (Apiumgraveolens) as a prevention of insulin resistance. In this study, the samples were 45 Wistar rats (Rattus norvegicus), male sex, aged 4-6 weeks, weight 150-175 grams,and had normal fasting blood glucose levels by tested before treatment. The experimental animals were divided into 5 groups, K1 was negative control group (insulin resistance by given 20% fructose 1,86 g/kg BW PO qDay);K2 was positive control group (those given 20% fructose 1,86 g/kg BW PO qDayand standard insulin resistance therapy metformin 500 mg/kg BW PO qDay); the K3 treatment group was given 20% fructose 1,86 g/kg BW PO qDay and celery extract 200 mg/kg BW PO qDay; the K4 treatment group was given fructose 20% 1,86 mg/kg BW PO qDay and celery extract 400 mg/kg BW PO qDay; and the K5 treatment group was given fructose 20% 1,86 mg/kg BW PO qDay and celery extract 600 mg/kg BW PO qDay. The treatment had been given every day for 60 days.Fasting blood glucose levels were measured using a Glucometer. Fasting blood insulin levels were measured using ELISA, HOMA-IR was calculated using a standardized formula, and GLUT4 protein expression was measured using immunohistochemistry. It the end of the intervention, there was a significant decreased in fasting blood glucose (FBG) in K4 group compared with K1 (p <0.05), insulin resistance in K1 was characterized by a higher HOMA-IR value compared to the therapy group, especially K4 and K5 (p <0.05). There was an increase in GLUT-4 expression on K4 and K5 compared with K1 (p <0.05). It can be concluded that celery extract has antihyperglycemia effect and furthermore it can prevent insulin resistance condition.
Chemical Peeling in Skin-Aging Patients: A Retrospective Study Susanto, Ester Chateline; Setyaningrum, Trisniartami; Arifa Mustika; Astari, Linda
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 35 No. 1 (2023): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V35.1.2023.6-14

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Background: Skin aging is a degenerative process that involves a decrease in the structure and function of skin cells and theextracellular matrix due to intrinsic and extrinsic factors. Chemical peeling is one of the skin aging treatments that involvesskin ablation using chemical agents. Purpose: To evaluate the profile of skin-aging patients treated with chemical peeling atthe Dermatology and Venereology Outpatient Unit of Dr. Soetomo General Hospital Surabaya from January throughDecember 2019. Methods: The data were obtained from patients' medical records through a total sampling technique, whichconsisted of age, gender, occupation, history taking, physical examination, diagnosis, therapeutic agents, follow-up frequency,and therapeutic result. Result: The study included 37 patients, the majority of whom were between the ages of 46 and 55(35.1%), female (100%), and private employees (32.4%). In history taking, patients' main complaint is dull skin (94.6%), withthe risk factor of sun exposure (97.3%) and the history of sunscreen usage (81.1%). Pigmentary changes were found in allpatients (100%). The most common diagnoses are photoaging Glogau II and Glogau III, found in 15 patients (40.5%),respectively. The common priming agents were sunscreen (97.3%), cleanser (94.6%), and 8% glycolic acid (75.7%). Themajority of patients (62.2%) received 20% glycolic acid as a peeling agent and sunscreen (86.5%) as a post-peeling agent.The majority of patients (43.2%) did not follow up. Glogau II photoaging (57.1%) was the main therapeutic result.Conclusion: Proper chemical peeling procedures and patients compliance are important factors to improve therapeuticoutcomes.
Efficacy of Ozoralizumab vs. Golimumab for Rheumatoid Arthritis: A Systematic Review Fithriyah, Nathania Elma; Rahmadhani, Khafiyah Hikmah; Susanti, Luthfiana Rofhani; Mustika, Arifa; Lita Diah Rahmawati; Wungu, Citrawati Dyah Kencono
Current Internal Medicine Research and Practice Surabaya Journal Vol. 6 No. 2 (2025): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v6i2.66406

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Introduction: Rheumatoid arthritis, a systemic autoimmune disease, affects 13% of the world population. As a well-established therapy, golimumab provides a key benchmark for assessing novel biological treatments. In contrast, ozoralizumab represents an innovative therapeutic approach. This study aimed to comprehensively elucidate the efficacy of golimumab and ozoralizumab in reducing rheumatoid arthritis disease activity. Methods: Literature searches were conducted throughout PubMed, Cochrane, and Web of Science using Boolean operators, covering available records from database inception until October 2024. The literature search was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The included studies were randomized controlled trials (RCT) evaluating the efficacy of ozoralizumab or golimumab for rheumatoid arthritis. Five studies from 2015 to 2022 were obtained and assessed using the Cochrane Risk of Bias 2 (ROB2) tool. Results: The five studies consisted of two ozoralizumab trials and three golimumab trials conducted in Japan and the United States, involving 2,305 participants. All included studies exhibited a low risk of bias based on assessments undertaken using the ROB2 tool. The differences in Disease Activity Score-28 (DAS28) remission rates between ozoralizumab and placebo were 42.6% in one study and 6.3% in the other, whereas golimumab mainly showed smaller differences versus placebo across three studies (4.6%, 5.9%, and 10.4%). Conclusion: This study demonstrates DAS28 remission in rheumatoid arthritis patients receiving either ozoralizumab or golimumab therapy. Nonetheless, further direct statistical studies are essential to determine which therapy is superior and under what circumstances it should be administered.   Highlights: 1. This study provides robust evidence that establishes ozoralizumab as a novel tumor necrosis factor-alpha (TNF-α) inhibitor for rheumatoid arthritis. 2. According to the findings, ozoralizumab may be a clinician's choice due to its comparable efficacy and potential advantages over golimumab.
Co-Authors Achmad Firdaus Pamudya Wardhana Achmad Ilham Rizwani Adelia Handoko Agesti, Dyah Akbar Kurniawan, Mohammad Alimsardjono, Lindawati Amustikarani, Dewa Ayu Praba Aniek Meidi, Aniek Annette d’Arqom, Annette Anny Setijo Rahaju, Anny Setijo Ario Imandiri, Ario Aszar, Farah Dynah Daeq Athoillah, Nabil Bambang Purwanto Cholis Abrori, Cholis Claudi Artha Dau, Daniel Deby Kusumaningrum Desie Dwi Wisudanti Dewinta, Nena Ristra Diah Mira Indramaya Dinda Dwi Purwati Edith Frederika Puruhito, Edith Frederika Elly Nurus Sakinah, Elly Nurus Faizah Sugiarto Farros Yuftariq Izzad Afla Fatimah, Nurmawati Fedelita Aistania Putri Firsta Wahono Febrianto Firsta Wahono Febrianto Fithriyah, Nathania Elma Gadis M. Sari Gondo Mastutik Halimatus Zahrah Harlina Soetjipto Herisulistyo, Aldilatama Herley Windo Setiawan I'tishom, Reny Indiastuti, Danti Nur Indri Safitri Mukono, Indri Safitri Irda Bella Isnaini Nur Jannah, Isnaini Nur Jieputra, Alden Kartuti Debora, Kartuti Kenconowungu, Citrawati Dyah Khaerunnisa, Siti Kurniawan, Mohammad Akbar Linda Astari, Linda Lukman Hakim Maftuchah Maftuchah Mah Zhook Yueng Miranda Jemyma Mas&#039;ulun MOCHAMMAD THAHA Muhammad Arsy Reza Suyudi Muhammad Faizi, Muhammad Muhammad Hanun Mahyuddin Myrna Adianti Nabila Anisa Harum Naibaho, Ardy Hamonangan Nanang Haryono Nurina Hasanatuludhhiyah Nurlaili Susanti Nurrosyidah, Iif Hanifa Pamudya Wardhana, Achmad Firdaus Prabowo, Gwenny Ichsan Priyo Budi Purwono Purwanta, Marijam Puspa Wardhani Putri Aliya Ahadini Qurnianingsih, Ema Raden Mohamad Herdian Bhakti Rahmadhani, Khafiyah Hikmah Rahmawati, Lita Diah Rania Ratri Fauziyah Rejeki, Purwo Sri Renny I’tishom Rini Hamsidi Rizal, M Masrur Roostantia Indrawati Roostantia Indrawati Roostantia Indrawati, Roostantia Safira Raissa Dwi Putri Sandra Dewi Sitaresmi Sari, Gadis M. Siti Khaerunnisa Sjahjenny Mustokoweni, Sjahjenny Sriwijayanti Sulistyawati Stefanus, Lusiana Sukarno, Devitya Angielevi Sumardiko, Dwi Setiani Supangat Supangat Suryani Dyah Astuti Susanti, Luthfiana Rofhani Susanto, Ester Chateline Syahruna, Pradipta Reza Teguh Wahjudi Trisniartami Setyaningrum Vania Azalia Gunawan Wibsono, Sony WITA SARASWATI, WITA Wiwin Retnowati Wungu, Citrawati Dyah Kencono Wungu, Citrawati Dyah Kencono Yetti Hernaningsih Yuani Setiawati Zharfan, Rahmat Sayyid Zumara Ma'rifah Azzahra Zumara Ma'rifah Azzahra