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All Journal Jurnal Veteriner Jurnal Kedokteran Syiah Kuala Althea Medical Journal Indonesian Journal of Urology Berkala Ilmu Kesehatan Kulit dan Kelamin Jurnal Biosains Pascasarjana Jurnal Farmasi Klinik Indonesia Indonesian Journal of Tropical and Infectious Disease Journal of Agromedicine and Medical Sciences Health Notions Molecular and Cellular Biomedical Sciences (MCBS) Journal Of Vocational Health Studies Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Jurnal Medik Veteriner J-Dinamika: Jurnal Pengabdian Kepada Masyarakat JURNAL ILKES (Jurnal Ilmu Kesehatan) Biomolecular and Health Science Journal JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Jurnal Layanan Masyarakat (Journal of Public Service) CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL Indian Journal of Forensic Medicine & Toxicology Indonesian Archives of Biomedical Research (InABR) Indonesian Andrology and Biomedical Journal Journal of Innovation Research and Knowledge Jurnal Pengabdian Masyarakat Bhinneka Jurnal Pengabdian Masyarakat Bangsa Folia Medica Indonesiana
Arifa Mustika
Faculty Of Medicine, Universitas Airlangga
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Efek Ekstrak Daun Singawalang (Petiveria alliacea) dalam Menurunkan Kadar Glukosa Darah melalui Peningkatan Ekspresi AMPK-α1 pada Tikus Model Diabetes Melitus Arifa Mustika; Roostantia Indrawati; Gadis M. Sari
Indonesian Journal of Clinical Pharmacy Vol 6, No 1 (2017)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (274.998 KB) | DOI: 10.15416/ijcp.2017.6.1.22

Abstract

Singawalang (Petiveria alliaceae) adalah tumbuhan yang banyak ditemukan di Indonesia dan secara empiris digunakan oleh penduduk untuk mengobati diabetes melitus. Hingga saat ini, penelitian tentang pengaruh dan mekanisme ekstrak daun Singawalang dalam menurunkan kadar glukosa darah belum banyak dilakukan. Tujuan penelitian ini adalah untuk mengetahui pengaruh ekstrak daun Singawalang terhadap penurunan kadar glukosa darah dan ekspresi AMPK-α1 pada hati. Jenis penelitian ini adalah penelitian eksperimental dengan rncangan acak lengkap. Penelitian dilakukan di Laboratorium Farmakologi dan Terapi dan Laboratorium Patologi Anatomi Fakultas Kedokteran Universitas Airlangga pada bulan April–Agustus 2015. Hewan coba tikus strain Rattus norvegicus dibuat model diabetes melitus, diinduksi dengan Streptozotocin. Sebanyak 25 tikus model diabetes melitus dibagi secara acak menjadi 5 kelompok. Kelompok perlakuan 1, 2 dan 3 adalah kelompok yang memperoleh ekstrak daun Singawalang dengan dosis 90 mg/kgbb, 180 mg/kgbb dan 360 mg/kgbb. Kelompok kontrol positif adalah kelompok yang memperoleh metformin dengan dosis 150 mg/kgbb dan kontrol negatif adalah kelompok tikus yang memperoleh vehikulum. Ekstrak dan metformin diberikan sehari sekali, personde selama 14 hari. Pada hari ke-15 setelah terapi, tikus diperiksa kadar glukosa darah dan dieuthanasia untuk diambil organnya. Ekspresi AMPK-α1 dinilai menggunakan imunohistokima. Data yang terkumpul dianalisis dengan ANAVA dan Wilcoxon (α=0,05). Hasil penelitian menunjukkan adanya perbedaan kadar glukosa darah yang bermakna antara kontrol negatif dengan dosis 90 mg/kgbb, dosis 360 mg/kgbb, dan kontrol positif, antara dosis 180 mg/kgbb dengan dosis 360 mg/kgbb dan kontrol positif. Analisis terhadap ekspresi AMPK-α1 pada hati tikus menunjukkan perbedaan yang bermakna antara dosis 180 mg/kgbb dengan dosis 360 mg/kgbb dan kontrol positif. Simpulan dari penelitian ini adalah ekstrak Singawalang dapat menurunkan kadar glukosa darah pada tikus model diabetes melitus melalui aktivasi AMPK-α1.Kata kunci: AMPK-α1, diabetes melitus, kadar glukosa darah, Singawalang Effect of Petiveria alliacea Leaves Extract in Decreasing Serum Level of Blood Glucose Level Through Activation of AMPK-α1 in Diabetes Mellitus Rat ModelsAbstractSingawalang (Petiveria alliaceae) is a medicinal herb that is used traditionally as folk medicine for various diseases. The plant has been used as an antidiabetic agent in Indonesian society. Until now, the effect and mechanism of action of Petiveria alliaceae as antidiabetic agent is not clear. The aim of the study was to determine the effect of Petiveria alliaceae to blood glucose level and to identify expression of AMPK-α1 in rat liver. The research was experimental study with randomized and was conducted at Laboratory Pharmacology and Therapy, and Laboratory Patology Anatomy, Faculty of Medicine, Universitas Airlangga, on April until August 2015. Twenty five male rats were injected by Streptozotocin to create diabetic rat models and randomly divided into 5 groups. The group 1, 2 and 3 are treatment groups that were given the ethanol extract of Petiveria alliaceae at dose 90 mg/kgbw, 180 mg/kgbw, and 360 mg/kgbw, orally, once daily for fourteen days. The fourth group is a negative control who were given distilled water and the fifth group is a positive control who were given metformin at dose 150 mg/kgbw. On the 15th day, blood glucose level were measured by glucometer and the rats were sacrificed to collect the liver. Expression of AMPK-α1 were assessed by immunohistochemistry. Data were analyzed by ANAVA and Wilcoxon (α=0,05). The results have been showed that there were significant differences in glucose blood level between negative control with the group were given the extract at dose 90 mg/kgbw, 360 mg/kgbw and positive control, between dose 180 mg/kgbw with dose 360 mg/kgbw and positive control. A significant differences of expression of AMPK-α1 showed between dose 180 mg/kgbw with dose 360 mg/kgbw and positive control. The conclusion of this study was the extract ethanol of Singawalang leaves reduce blood glucose level in diabetes mellitus rat models through increase in the expression of AMPK-α1.Keywords: AMPK-α1, blood glucose level, diabetes mellitus, Singawalang
Penurunan Kerusakan Jaringan Paru Terinfeksi Tuberkulosis oleh Ekstrak Pegagan Melalui Peningkatan Ekspresi Tissue Inhibitor of Matrix Metalloproteinase-1 (SUPLEMENTATION OF EFFECT ANILYSIS OF CENTELLA ASIATICA EXTRACT IN REDUCE LUNG TUBERCULOSIS TISSUE D Arifa Mustika; Anny Setijo Rahaju; Roostantia Indrawati
Jurnal Veteriner Vol 15 No 4 (2014)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (257.428 KB)

Abstract

Centella asiatica is a medicinal plant used for wound healing through increasing of collagen synthesis.This evidence generates a new expectation that it could be used for therapy of tuberculosis infection,especially for healing lung tissue damage. Until now, the effects and mechanisms onC. asiatica to cure thelung tissue damage due to M. tuberculosis infection remains unclear. The aim of this study was to prove theeffect and mechanism of ethanol extract of C. asiatica to repair the rats lung tissue damaged throughexpression of the enzimmatrix metalloproteinase-1(MMP-1)danenzimtissue inhibitor of matrixmetalloproteinase-1 (TIMP-1). The study was conducted in male rats. Twenty four rats were infected withM. tuberculosis through intratrachea and randomly divided into four groups. Group 1, 2 and 3 were thetreatment groups that they were given the ethanol extract of C. asiatica at dose 375mg/kgbw, 750 mg /kgbw, and 1500 mg / kgbw, orally and once a day for fourteen days. The fourth group was a control groupthat given distilled water. On day 15 rats were euthanized and lungs tissue have been taken. Evaluationof lungs tissue damage were assessed by the Dorman’s score in Hematoxylin Eosin and evaluation of the expression of MMP - 1 and TIMP 1 were performed by immunohistochemistry. Data of TIMP-1 wereanalyzed with ANOVA and data of lung tissue damage and MMP–1 were analyzed with Mann WhitneyU (á = 0.05). The results showed that there was a significant differences in the lungs tissue damagebetween the dose groups of 375 mg / kgbw and controls (p = 0.006), the dose groups at dose 750 mg / kgbwand controls (p = 0.004 ), the dose groups of 1500 mg / kgbw and controls (p = 0.043). There wasn’t asignificant difference between the treatment groups and control in the expression of MMP-1. In the expressionof TIMP – 1, there was a significant difference between the treatment group at dose of 750 mg / kg andcontrol. The conclusion of the study is the ethanol extract of C. asiatica has the ability to reduce lung tissuedamage of rats infected with M. tuberculosis, through increasesthe expression of TIMP-1
Aktivitas Antibakteri dan Perubahan Morfologi dari Propionibacterium Acnes Setelah Pemberian Ekstrak Curcuma Xanthorrhiza Halimatus Zahrah; Arifa Mustika; Kartuti Debora
Jurnal Biosains Pascasarjana Vol. 20 No. 3 (2018): JURNAL BIOSAINS PASCASARJANA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (413.391 KB) | DOI: 10.20473/jbp.v20i3.2018.160-169

Abstract

AbstrakPenatalaksanaan utama pada masalah akne vulgaris adalah penggunaaan antibotik baik topikal maupun oral. Akan tetapi penggunaan antibiotik dinilai telah menimbulkan dugaan resistensi terhadap P. acnes sebagai agent penyebab akne sehingga mendorong berbagai pihak untuk mengembangkan preparat antiinflamasi yang dapat diberikan topical ataupun sistemik. Curcuma xanthorrhiza Roxb. memiliki senyawa utama xanthorrizol yang dinilai potensial untuk dikembangan sebagai antibakteri. Tujuan penelitian ini adalah untuk mengetahui kadar hambat minimum dan kadar bunuh minimum serta perubahan struktur dinding sel dari Curcuma xanthorrhiza Roxb. terhadap pertumbuhan Propionibacterium acnes. Desain penelitian yang di gunakan adalah eksperimen dengan sampel P. acnes berupa isolate stock culture (ATCC® 11827™) yang selanjutnya ditumbuhkan pada media MHA. Jumlah replikasi yang digunakan sebanyak 4 ulangan. Konsentrasi ekstrak Curcuma xanthorrhiza Roxb. masing-masing 6,25 µg/ml, 12,5 µg/ml, 25 µg/ml, 50 µg/ml dan 100 µg/ml. Pengukuran aktivitas antibakteri didasrkan pada KHM, KBM dan pengamatan struktur dinding sel bakteri melalui metode Microscop Electron Screening (MES). Pemberian ekstrak Curcuma xanthorrhiza Roxb. memiliki efek antibakteri terhadap bakteri P. acnes secara in vitro. Konsentrasi ekstrak 25 µg/ml merupakan kadar minimum yang mampu menghambat pertumbuhan P.acnes melalui dilusi cair, sedangkan konsentrasi minimal yang mampu membunuh P.acnes adalah 50 µg/ml. Bakteri P. acnes yang dipapar dengan ekstrak etanol Curcuma xanthorrhiza Roxb. mengalami perubahan morfologi berupa timbulnya dinding sel kasar kasar akibat penyusutan serta adanya dinding sel yang hancur sehingga sitoplasma keluar dan tampak seperti meleleh. Respon daya hambat pertumbuhan bakteri yang dihasilkan Curcuma xanthorrhiza Roxb. dipengaruhi oleh senyawa aktif yang terkandung didalamnya seperti minyak atsiri, alkaloid, flavonoid, tanin, kurkuminoid dan terpenoid. Kandungan xanthorrizol yang dimiliki mampu menghambat pertumbuhan P.acnes mampu merusak aktivitas enzim sel, selain itu kandungan Curcuminoid turut berperan dalam menghambat pertumbuhan bakteri dengan cara mendenaturasi dan merusak membran sel sehingga proses metabolisme sel terganggu  Kata Kunci: Antibakteri, Akne vulgaris, Curcuma xanthorriza Roxb., MES
The Effect of Eccentric Activity on Glucose Transporter Type 4 in Gastrocnemius Muscle of Streptozotocin-induced Diabetes Mellitus Mice Adelia Handoko; Bambang Purwanto; Arifa Mustika
Journal of Agromedicine and Medical Sciences Vol 3 No 3 (2017)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v3i3.6144

Abstract

Diabetes mellitus (DM) is a metabolic disorder with increasing mortality rate. Decrease in GLUT-4 levels was found in diabetics resulting in an increase in postprandial blood glucose levels. Various innovative treatment have been developed, one of them is exercise. Exercise is growing fast today, especially eccentric contraction based exercise that potentially increase GLUT-4 muscle’s level. The aim of the present study was to investigate the effect of eccentric activity on glucose transporter type 4 in gastrocnemius muscle of streptozotocin-induced diabetes mellitus mice. Diabetic mice were grouped randomly into 2 groups. One group was given single bout of eccentric excercise by downhill running on 10o degree decline treadmill and the other group was given eccentric activity by downhill running on 0o degree. The GLUT-4 muscle’s level were measured after treadmill. Data obtained from each group were then analyzed using independent t-test, significant results were found (p<0.05). The conclusion of this study is single bout eccentric downhill running activity with 10o angel increases the levels of GLUT-4 muscles. Key words: Glucose Transporter Type 4, eccentric, Diabetes Mellitus, Muscle
Hypoglicemic and Antioxidant Activity of Petiveria alliacea in Diabetic Rat Models Vania Azalia Gunawan; Harlina Soetjipto; Arifa Mustika
Biomolecular and Health Science Journal Vol. 3 No. 1 (2020): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v3i1.19129

Abstract

Introduction: Diabetes mellitus is a degenerative disease characterized by chronic hyperglycemia conditions in the body. Various complications of diabetes mellitus are caused by oxidative stress condition. Petiveria alliacea (P. alliacea) is a potential plant and easy to grow in hot regions. Leaf extracts of P. alliacea contain flavonoids and tannins which work as antidiabetic and antioxidant. In addition, other compounds found in P. alliacea leaf extracts like linoleic acid and allantoin show an increase in insulin secretion. Therefore, this study aimed to determine the antidiabetic activity of ethanolic extract of P. alliacea. Methods: We investigated the hypoglycemic and antioxidant effect of P. alliacea on STZ-induced diabetic rats. Rats were randomly divided into six groups named normal control, diabetes control, metformin (150 mg/kg/d), low dose of P. alliacea (90 mg/kg/d), intermediate dose (180 mg/kg/d), and high dose (360 mg/kg/d). Rats were orally given the treatment daily in the morning for fourteen days. At the end of the study, blood glucose level was measured and rats were sacrificed to measure blood malondialdehyde level.malondialdehydeResults: P. alliacea extract dose of 90 mg/kg and 360 mg/kg, and also metformin significantly decrease blood glucose levels. P. alliacea extract dose of 360 mg/kg was able to lower blood malondialdehyde level significantly which were not obtained on metformin. Conclusion: This finding suggests that ethanolic extract of P. alliacea possess antidiabetic effect at least on rats.
Therapeutic Potency of Mangosteen (Garcinia mangostana) Peel Extract For Shigella dysenteriae Infected Mice’s Colon Mucosal Destruction Achmad Ilham Rizwani; Arifa Mustika; Lindawati Alimsardjono
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 10 No. 1 (2019): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (813.144 KB) | DOI: 10.20473/juxta.V10I12019.5-10

Abstract

Introduction : Antibiotics treatment for bacillary dysentery due to Shigella dysenteriae infection have shown resistancy. Mangosteen (Garcinia maangostana) peel have a therapy potency for Shigella dysenteriae infection due to its antibacterial and antiinflamation activity.Methods : This research was an experimental research, 30 mice was used which divided to 5 groups. The mice was infected with Shigella dysenteriae intraperitoneally, then azithromycin, aquadest, and 3 different doses of mangosteen (Garcinia mangostana) peel was given for each group for 5 days, which then the mice’s colon was collected and made into histopathology slide and its mucosal destruction was observed in 3 fields of view in each slide, 1 – 4 score was given acording to its mucosal destruction. Kruskal-Wallis test is used to analyze the data and then Mann Whitney test also used for further analysis.Result : there was a healing effect obeserved when mangosteen (Garcinia mangostana) peel extract was given to the mice’s colon mucosal, 100 mg/Kg body mass dose of mangosteen (Garcinia mangostana) peel extract already given a positive effect on mice’s mucosal colon histopathological appearance, no difference observed between 3 dose given.Conclusion : Mangosteen (Garcinia mangostana) peel extract consumption gave healing appearance to destruction of colon mucosal wall of mice with Shigella dysenteriae infection at 100 mg/Kg body mass.
CEMARAN BAHAN KIMIA BERBAHAYA UNTUK MENINGKATKAN KUALITAS KESEHATAN MASYARAKAT INDONESIA Teguh Wahjudi; Arifa Mustika; Nanang Haryono
Jurnal Layanan Masyarakat (Journal of Public Services) Vol. 1 No. 2 (2017): Jurnal Layanan Masyarakat
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (652.838 KB) | DOI: 10.20473/jlm.v1i2.2017.98-104

Abstract

The purpose of science and technology program for the public identification of hazardous food materials from contaminated drugs and hazardous chemicals on youth and mothers PKK Mojokerto regency through testing the content of formalin in foodstuffs, especially salted fish, wet fish, shrimp, chicken, raw tofu, wet noodles, meatballs Using formalin main reagent. Science and technology for the community to be transferred is a method of spot test. Food is a necessity for all living things including humans. Food is needed to obtain energy used for daily activities. In general, food is only able to survive within a few days or a few hours until the meal is no longer consumable and should be discarded. Partners in this program are youth and mothers PKK Kelurahan Sawahan, Mojokari District Mojokerto District. Each group consists of five cadres. This method is the application of existing chemical analysis methods for determination of formalin content, borax, and hazardous dyes. Spot test method is chemical analysis method by using reagent. This method has the features of fast, cheap, sure and does not require complicated equipment and can be done anytime and anywhere. The working principle is to add liquid (reagent) to the foodstuffs that are suspected to use the material under investigation, with the final result of a distinctive color change. Formalin main reagent is one type of formalin tester kit tester.AbstrakTujuan program IbM identifikasi bahan berbahaya makanan dari cemaran obat dan bahan kimia berbahaya pada karang taruna dan ibu PKK Kabupaten Mojokerto melalui pengujian kandungan formalin pada bahan makanan khususnya ikan asin, ikan basah/udang, ayam potong, tahu mentah, mi basah, bakso menggunakan FMR (formalin main reagent). Iptek bagi masyarakat yang akan di transfer adalah metode spot test. Makanan merupakan kebutuhan bagi semua mahluk hidup termasuk manusia. Makanan dibutuhkan untuk memperoleh energi yang digunakan untuk beraktifitas sehari-hari. Secara umum makanan hanya mampu bertahan dalam waktu beberapa hari atau beberapa jam sampai makan tidak lagi dapat dikonsumsi sehingga harus dibuang. Mitra dalam program IbM ini adalah Karangtaruna dan Ibu PKK Kelurahan Sawahan, Kecamatan Mojosari Kabupaten Mojokerto. Masing-masing kelompok terdiri atas lima kader. Metode ini adalah penerapan metode analisa kimia yang sudah ada untuk penetapan kandungan formalin, borak, dan zat pewarna berbahaya. Metode spot test yaitu metode analisa kimia dengan menggunakan reagent kit (kit tester). Metode ini mempunyai keistimewaan antara lain cepat, murah, pasti dan tidak memerlukan peralatan yang rumit dan dapat dilakukan kapanpun dan dimanapun. Prinsip kerjanya adalah dengan menambahkan cairan (reagent) pada bahan makanan yang diduga menggunakan bahan yang diselidiki, dengan hasil akhir terjadinya perubahan warna khas. FMR (formalin main reagent) merupakan salah satu jenis kit tester kandungan formalin. 
Correlation of Serum Nitric Oxide and Urine Malondialdehyde Levels in Non-Hemodialysis Chronic Kidney Disease Patients Dinda Dwi Purwati; Arifa Mustika; Lukman Hakim; Mochammad Thaha
Molecular and Cellular Biomedical Sciences Vol 6, No 1 (2022)
Publisher : Cell and BioPharmaceutical Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21705/mcbs.v6i1.226

Abstract

Background: In 2017, about 1.2 million people died because of Chronic Kidney Disease (CKD). Patients with CKD are known to have increased levels of oxidative stress which leads to decrease in NO production. NO is a highly reactive signaling molecule and a major determinant of vascular homeostasis. Thus, the decreased NO can be a risk factor for the development of atherosclerosis and increased cardiovascular risk. Meanwhile, Malondialdehyde (MDA) is known as excellent biomarker for oxidative stress. This study aims to determine the correlation of serum total nitric oxide (NO) and urine MDA levels in non-hemodialysis CKD patients.Materials and Methods: This study was an observational clinical study with a cross sectional design. Fourty-nine CKD subjects were selected by consecutive sampling. The samples for laboratory tests were collected from urine. MDA concentration was measured using the High-Performance Liquid Chromatography (HPLC) kit. NO concentration was measured with Griess reaction method and Total Nitric Oxide Parameter kit. The data were analyzed using the Statistic Package for Social Science (SPPS) software version 16.Results: The data showed significant negative correlations between MDA with NO (r=-0.294; p=0.041).Conclusion: There was a correlation between serum total NO and urine MDA levels in non-hemodialysis CKD patients.Keywords: chronic kidney disease, malondialdehyde, nitric oxide, non-hemodialysis
Effect of Kembang Bulan Leaf (Tithonia diversifolia) Ethanolic Extract to SGOT and SGPT Levels in Diabetic Rats (Rattus norvegicus) Achmad Firdaus Pamudya Wardhana; Arifa Mustika; Citrawati Dyah Kenconowungu
Indonesian Andrology and Biomedical Journal Vol. 2 No. 1 (2021): June
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (625.089 KB) | DOI: 10.20473/iabj.v2i1.56

Abstract

Introduction: Kembang Bulan (Tithonia diversifolia) is one of Indonesian traditional medicine that contains saponins, flavonoids, and, tannins and is predicted has a lowering effect on blood-glucose. Diabetes mellitus (DM) is a disease caused by insufficient insulin secretory by the pancreas or ineffective usage of insulin that produced by the body thus cause a hyperglycemia condition. Hyperglycemia can cause an increase in Reactive Oxygen Species which can cause free radicals. Free radicals can cause damage to liver cells. Method: This was an experiment with posttest control group design. Samples were 40 rats, divided into five different groups (P1, P2, P3, P4 and P5). Each group were induced by multiple low doses STZ. P1 (give the extract of Tithonia diversifolia at a dose 50 mg/100 gr BB), P2 (give the extract of Tithonia diversifolia at a dose 150 mg/100 gr BB), and P3 (give the extract of Tithonia diversifolia at a dose 450 mg/100 gr BB), P4 was treated with metformin, P5 was not treated. After STZ induction and give the extract to diabetic rat model, the resulting liver cell damage will be measured using the SGOT and SGPT measurement methods. Result: On the average results of SGOT levels in the five treatments, using the ANOVA test p value was 0.877 (p> 0.05) which means there were no significant differences. Furthermore, on the average results of SGPT levels in all five treatments, using the ANOVA test p value was 0.822 (p> 0.05) which means there were no significant differences. But from all results obtained P4 (given metformin) with the results closest to normal levels (SGOT: 197.5 ± 37.25; SGPT: 90.33 ± 29.36). From the treatment given Tithonia diversifolia extract obtained P1 (with a dose of 50 mg / 200gr BB) with the results closest to normal levels compared to P2 and P3. Conclusion: The Extract of kembang Bulan Leaf (Tithonia diversifolia) obtained less significant results compared to the untreated group. However, there is no significant difference. And giving ethanol extract of the leaves of kembang Bulan (Tithonia diversifolia) at a dose of 50 mg / 100gr BB is the most effective way to reduce levels of SGOT and SGPT.
Neratinib a MST 1 inhibitor coated with Chitosan-alginate nanocarrier as a promising oral drug to inhibit pancreas cell apoptosis, stimulate insulin secretion, and restore Glycemia in type 1 Diabetes Mellitus Nabila Anisa Harum; Zumara Ma'rifah Azzahra; Faizah Sugiarto; Arifa Mustika
Indonesian Archives and Biomedical Sciences Vol 1 No 2 (2021): Indonesian Archives of Biomedical Research (InABR). 1(2): 2021
Publisher : Konsorsium Ilmu Biomedik Indonesia (KIBI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (210.789 KB) | DOI: 10.55392/indarcbiores.v1i2.17

Abstract

Type 1 Diabetes Mellitus (T1DM) is a polygenic disorder in which autoimmunity destroys pancreatic beta cells, culminating in an absolute insulin secretion deficiency. Neratinib is an MST1 inhibitor to improve β-cell survival cells coated with alginate calcium nanocarrier encapsulated with chitosan that allows the retention of the packaged oral drug until it reaches specific target cells. This review aims to determine the potential of Neratinib as a Mammalian sterile 20-like kinase 1 Inhibitor, which is carried by nanocarrier chitosan-alginate as an alternative cutting edge oral drug for T1DM by preventing the apoptosis of beta cells.. Neratinib coated with chitosan-alginate nanocarrier and packaged in the form of an oral drug can be used as an advanced T1DM therapy. Future perspective needs further experimental and clinical trials to obtain concrete scientific evidence.
Co-Authors Achmad Firdaus Pamudya Wardhana Achmad Ilham Rizwani Adelia Handoko Agesti, Dyah Ahadini, Putri Aliya Akbar Kurniawan, Mohammad Alimsardjono, Lindawati Amustikarani, Dewa Ayu Praba Aniek Meidi, Aniek Annette d’Arqom, Annette Anny Setijo Rahaju, Anny Setijo Ario Imandiri, Ario Aszar, Farah Dynah Daeq Athoillah, Nabil Bambang Purwanto Cholis Abrori, Cholis Claudi Artha Dau, Daniel Deby Kusumaningrum Desie Dwi Wisudanti Dewinta, Nena Ristra Diah Mira Indramaya Dinda Dwi Purwati Edith Frederika Puruhito, Edith Frederika Elly Nurus Sakinah, Elly Nurus Faizah Sugiarto Farros Yuftariq Izzad Afla Fatimah, Nurmawati Fedelita Aistania Putri Firsta Wahono Febrianto Firsta Wahono Febrianto Fithriyah, Nathania Elma Gadis M. Sari Gondo Mastutik Halimatus Zahrah Harlina Soetjipto Herisulistyo, Aldilatama Herley Windo Setiawan I'tishom, Reny Indiastuti, Danti Nur Indri Safitri Mukono, Indri Safitri Irda Bella Isnaini Nur Jannah, Isnaini Nur Jieputra, Alden Kartuti Debora, Kartuti Kenconowungu, Citrawati Dyah Khaerunnisa, Siti Kurniawan, Mohammad Akbar Linda Astari, Linda Lukman Hakim Maftuchah Maftuchah Mah Zhook Yueng Miranda Jemyma Mas&#039;ulun MOCHAMMAD THAHA Muhammad Arsy Reza Suyudi Muhammad Faizi, Muhammad Muhammad Hanun Mahyuddin Myrna Adianti Nabila Anisa Harum Naibaho, Ardy Hamonangan Nanang Haryono Nurina Hasanatuludhhiyah Nurlaili Susanti Nurrosyidah, Iif Hanifa Pamudya Wardhana, Achmad Firdaus Prabowo, Gwenny Ichsan Priyo Budi Purwono Purwanta, Marijam Puspa Wardhani Putri Aliya Ahadini Qurnianingsih, Ema Raden Mohamad Herdian Bhakti Rahmadhani, Khafiyah Hikmah Rahmawati, Lita Diah Rania Ratri Fauziyah Rejeki, Purwo Sri Renny I’tishom Rini Hamsidi Rizal, M Masrur Roostantia Indrawati Roostantia Indrawati Roostantia Indrawati, Roostantia Safira Raissa Dwi Putri Sandra Dewi Sitaresmi Sari, Gadis M. Sitaresmi, Sandra Dewi Siti Khaerunnisa Sjahjenny Mustokoweni, Sjahjenny Sriwijayanti Sulistyawati Stefanus, Lusiana Sukarno, Devitya Angielevi Sumardiko, Dwi Setiani Supangat Supangat Suryani Dyah Astuti Susanti, Luthfiana Rofhani Susanto, Ester Chateline Syahruna, Pradipta Reza Teguh Wahjudi Trisniartami Setyaningrum Vania Azalia Gunawan Wibsono, Sony WITA SARASWATI, WITA Wiwin Retnowati Wungu, Citrawati Dyah Kencono Wungu, Citrawati Dyah Kencono Yetti Hernaningsih Yuani Setiawati Zharfan, Rahmat Sayyid Zumara Ma'rifah Azzahra Zumara Ma'rifah Azzahra