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All Journal Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Jurnal Kedokteran Brawijaya Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Jurnal Kesehatan Jurnal Farmasi Klinik Indonesia Pharmacon MPI (Media Pharmaceutica Indonesiana) Pharmascience JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Pharmasipha PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) JFIOnline Pharmaceutical Journal of Indonesia JFM (Jurnal Farmasi Malahayati) JURNAL FARMASIMED (JFM) Majalah Farmasetika Jurnal Ilmiah Farmasi Farmasyifa Budapest International Research in Exact Sciences (BirEx Journal) Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang Jurnal Farmasi dan Sains Indonesia (JFSI) Indonesian Journal of Pharmaceutical Education Jurnal Riset Farmasi Journal of Global Pharma Technology Journal of Tropical Pharmacy and Chemistry Jurnal Sains dan Kesehatan Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Folia Medica Indonesiana
Didik Hasmono
Department Of Clinical Pharmacy, Faculty Of Pharmacy, Universitas Airlangga
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Transportation Other

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Journal : JURNAL FARMASIMED (JFM)

 1 
Evaluation of Pioglitazone Vildagliptin Combination on Lipid Profiles for Outpatients with Type II Diabetes Mellitus Kusumaningrum, Yunita Dyah; Firandi, Adelia; Hasmono, Didik; Aryani, Dhita; Wardhani, Firdha Aprillia
Jurnal FARMASIMED (JFM) Vol 7 No 2 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i2.2645

Abstract

Pioglitazone and vildagliptin combination is one of the recommended alternatives as antidiabetic therapy to achieve the therapeutic target. This combination with complementary mechanisms of action can improve lipid profiles. This study aims to evaluate lipid profile achievement for outpatients with Type II DM on administering pioglitazone/vildagliptin combination therapy. Methods of the study were an observational prospective study in outpatients with Type II DM who use pioglitazone/vildagliptin combination at RS. Bhayangkara Surabaya during November 2021 – April 2022. Patients were included if aged between 18-80 y.o, used this combination ? 3 months before the study, HbA1C >7%, and were voluntarily involved by signing the informed consent. Laboratory examination of HbA1c, HDL-C, and triglycerides was done initially when patients were voluntarily involved as baseline data and after 3 months as post-data. The final sample in this study consisted of 25 patients who met the inclusion and exclusion criteria. The results of the study show mean value of HDL-C significantly increases from baseline to endpoint (p < 0.05). At the end of 3 months, the lipid profile of HDL-C and triglyceride increases by 30% and 4%, respectively, in patients who achieve the target compared to baseline conditions. The combination therapy of pioglitazone and vildagliptin improved lipid profile control in patients with type 2 diabetes mellitus after 3 months of treatment.
Evaluation of Fondaparinux Use on Kidney Function in Hospitalized COVID-19 Patients with Decreased eGFR Putri Nurhidayah, Eka; Didik Hasmono; Ruddy Hartono
Jurnal FARMASIMED (JFM) Vol 7 No 2 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i2.2731

Abstract

Background: The COVID-19 pandemic has resulted in increased hospitalization rates among patients with multisystem complications, including coagulation disorders and decreased renal function. Fondaparinux, a synthetic anticoagulant with a lower risk of thrombocytopenia, is often used as an alternative to heparin. However, its use in patients with reduced glomerular filtration rate (eGFR) remains debatable, as its elimination is dependent on renal function. Objective: This study aims to evaluate the impact of fondaparinux on renal function, specifically examining changes in eGFR and serum creatinine levels in COVID-19 patients with impaired renal function during treatment at Bhayangkara South Surabaya Hospital. Methods: This research employed a retrospective observational quantitative approach, involving COVID-19 patients who received fondaparinux at the inpatient facility of Bhayangkara Hospital from June 2020 to October 2021. Data were collected from the medical records of patients during their hospitalization, including fondaparinux dosage and eGFR and serum creatinine values, as well as other relevant clinical parameters. Statistical analysis using the Wilcoxon test was conducted to assess significant differences in serum creatinine and eGFR values following fondaparinux administration. Results: Of the 535 patients analyzed, 56 medical records met the inclusion criteria. The results of the Wilcoxon test analysis showed that there was a significant increase in eGFR (p-value 0.012, CI 95%; p-value 0.043, CI 95%; p-value 0.000, CI 95%), a substantial decrease in SCr (p-value 0.035, CI 95%; p-value 0.043, CI 95%; p-value 0.000, CI 95%) based on each degree of COVID-19 severity. Conclusion: The use of fondaparinux may improve kidney function, as indicated by significant decrease in serum creatinine and an increase in eGFR. Furthermore, no bleeding incidents were observed during the use of fondaparinux.
Co-Authors Adinugraha Amarullah Aghnia Fuadatul Inayah Agriawan Sudirman Agriawan Sudirman Agus Sunarko Agus Sunarko Alfa Frista Arta Alfin Giovani Amanda, Anita Tria Amarullah, Adinugraha Andilusia, Sindy Ardianty, Nonie Arina Dery Puspitasari Aryani, Dhita Aryani, Dhita Evi Astutik, Widi Atika Putri Kusumaningtyas Atmajani, Wanudya Awdisma, Wien Maryati Ayumuyas, Nur Palestin Ayumuyas, Nur Palestin Ayunda Nur Hidayatiningsih Badriyah, Rani Nur Bambang Sidharta Binti Muzayyanah Budi Suprapti Budiatin, Aniek Setiya Bura, Ursula Dua Klowe Chrysnanda Maryska Claudia Tiffany Dea Ayu Nabilah Dinda Monika Nusantara Ratri Dini Setiya Praja Dini Setiya Praja, Dini Setiya Donsu, Yosefien Christania Elisabeth Kasih Fadlilah, Umul Firandi, Adelia Ganesha T Trengginas Giovani, Alfin Hadiyanti, Nur Hanum, Putri Safitri Hariyati, Fera Hariyati, Fera Hartono, Ruddy Hasbi As-Shiddiq Hendra Yadi Heni Pujiastuti Hidajah Rachmawati Hidajah Rachmawati Hidayah Karuniawati Hidayah, Ana Nurlaili IGD Ugrasena Ilfi Hanna, Az Zahra Insyirah Idris, Anissah Irianto, Jimmy Setiawan Irsan Fahmi Almuhtarihan Irsan Fahmi Almuhtarihan Ismawati Isparnadi, Erwien Issaura, Issaura Jenggo Suwarko Joko Semedi Junaidi Khotib Khairil Armal Kuntaman Kuntaman Kusumaningrum , Yunita Dyah Kusumaningtyas, Atika Putri Lilik Yusetyani Lilik Yusetyani Ma'rifah, Nurul Machin, Abdulloh Mahardian Rahmadi Mareta Rindang Andarsari Maria Angelia Yoshida Meiliana, Made Laksmi Meo, Maria Lettisia Mia Melinda Mohammad Saiful Islam Mohammad Saiful Islam, Mohammad Saiful Mohammad Subhan Mohammad Subhan Mohammad Subhan Mohammad Subkhan Muhammad Nashrullah Muktamiroh Muktamiroh Muzayyanah, Binti Nadriatul Utami Nadriatul Utami Nailis Syifa Ni Made Eravikania Putri Darmawan Nun Zairina, Nun Nur Hadiyanti Nuraida Wisudani Nurfausiah, Nurfausiah Nurmainah Nurmainah Nurul Ma'rifah Paulus Sugianto Pharmasinta Putri Hapsari Pramadani, Yana Puri Safitri Hanum Puspitasari, Diny Putri Nurhidayah, Eka Ramdani, Dewi Retna Dwi Puspitarini Rino Wahyudi, Rino Risa Septinia Rizki Lisya Nugraha Roni Subagyo RR. Ella Evrita Hestiandari Ruddy Hartono Ruddy Hartono Ruddy Hartono Ruddy Hartono Ruhaya Fitrina, Ruhaya Samirah Samirah Sandra J. Parambang Sandra, Pipit Semedi, Joko Sendi Lia Yunita Setiawan, Landia Siti Surdijati Siti Surdijati, Siti Sofiati Diah Baisuni Subagyo, Roni Suharjono Suharjono, Suharjono Sumarno Sumarno Syifa', Nailis Syifa, Nailis' Tanasy, Marledy Taufiqur Rahman, Taufiqur Thayyib, Muqoddar Tista Ayu Fortuna Trengginas, Ganesha T Ugrasena, IGD Ulfa Syafli Nosa Usman Hadi Utami, Nadriatul Wardhani, Firdha Aprillia Wardhani, Hety Setya Widi Astutik Widi Astutik Wien Maryati Awdisma Wiranata, I Made Wisudani, Nuraida Worotikan, Natania Imanuella Yosefien Christania Donsu Yudi Agung Wibisono Yudistira Nurrizky Grahitaning Putra Rohmaana Yulistiani Yulistiani Yulistiani Yulistiani, Yulistiani Yulistiani, . Yuni, Santi Eka Yuni, Santi Eka